报告人：Dr. ZhanYun Tang
　　主持人：孙正龙

　　报告时间(Date)：2016年1月14日（星期四）上午10：00

　　报告地点(Add)：A3行政综合楼516会议室

　　报告摘要（Abstract）：Human body contains more than 200 cell types, which is developed from a single fertilized cell, with the same genome sequence but morphology and function differently. Each cell type employs an elaborated mechanism that controls its cell identity. For example, muscle is muscle but not neuron. It is well known that tissue (cell type)-specific gene expression “on” and “off” is essential for cell growth, proliferation, and differentiation during human development. The mechanism that regulates gene expression beyond genome sequence is called epigenetics, including DNA methylation, histone modifications, chromatin remodeling, as well as non-coding RNAs. Mis-regulation of epigenetic mechanism is involved in human diseases such as diabetes, heart disorder, and cancers. However, the molecular mechanism involved in regulation of gene expression by epigenetics is still elusive.

　　Using a powerful cell-free system that is reconstituted by highly purified transcription factors, chromatin remodeling factors, as well as histone modifiers on recombinant chromatin, I have defined a novel mechanism of histone modifications in regulating gene-specific transcription. Thus, the presentation will include: (1) how to develop cell-free system in detail; (2) how histone modification is established and its function in transcriptional regulation both in vitro and vivo.

　　报告人简历（CV）：Dr. Tang obtained his Ph.D. in Medical Molecular Biology from Shanghai Jiao Tong University School of Medicine in 1998. He performed his first postdoctoral work with Dr. Hongtao Yu at UT Southwestern Medical Center in Dallas from 1999 to 2003. Due to his tremendous work in the field, he was promoted as instructor in 2003.During the period time, Dr. Tang had defined several critical mechanisms that control accurate chromosome segregation during cell division with very productive publications in top international journals. In 2006, he moved to New York City and joined in Dr. Robert G. Roeder laboratory, a pioneer in transcription field and development of cell-free system, at The Rockefeller University. Using a powerful cell-free system, he has defined a novel mechanism in regulating histone H3 lysine 4 trimethylation (H3K4me3), the hallmark of both active and poised transcription, and its function in gene-specific transcriptional regulation. This work was published in Cell recently (2013). With his remarkable work, he has established his great leadership in the field by drawing a variety of collaborations.

　　欢迎大家踊跃参加！

　　科研管理处

　　2016年1月13日