2.基于组学技术研究结直肠癌的发生发展机制
个人简介
刘晶晶，博士，讲师。主要从事肠道疾病早期诊断以及发病机理研究。发表学术论文13篇，其中SCI收录11篇。长期担任Scientific Reports, Journal of Mass Spectrometry等学术期刊审稿人，为美国质谱学会会员，中国计算机学会会员。
学术成果
1.Liu, J., Hao, C., Wu, L., Madej, D., Chan, W. and Lam, H., 2020. Proteomic analysis of thioproline misincorporation in Escherichia coli. Journal of Proteomics, 210, p.103541.
2.Liu, J., Wu, J., Lin, J., Zhao, J., Xu, T., Yang, Q., Zhao, J., Zhao, Z. and Song, X., 2019. Changes in the Microbial Community Diversity of Oil Exploitation. Genes, 10(8), p.556.
3.Liu, J., Meng, X. and Chan, W., 2016. Quantitation of Thioprolines in Grape Wine by Isotope Dilution–Liquid Chromatography–Tandem Mass Spectrometry. Journal of agricultural and food chemistry, 64(6), pp.1361-1366.
4.Liu, J., Cheng, X. and Fu, L., 2012. LC-MS based assay method for DPP-IV inhibitor screening and substrate discovery. Analytical Methods, 4(6), pp.1797-1805.
5.Liu, J. and Chan, W., 2014. Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography–Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity. Chemical research in toxicology, 28(3), pp.394-400.
6.Liu, J., Chan, K.J. and Chan, W., 2016. Identification of protein Thiazolidination as a novel molecular signature for oxidative stress and formaldehyde exposure. Chemical research in toxicology, 29(11), pp.1865-1871.
7.Song, H., Dong, C., Qin, M., Chen, Y., Sun, Y., Liu, J., Chan, W. and Guo, Z., 2016. A thiamine-dependent enzyme utilizes an active tetrahedral intermediate in vitamin K biosynthesis. Journal of the American Chemical Society, 138(23), pp.7244-7247.
8.Liu, J., Jiang, F., Jin, Y., Zhang, Y., Liu, J., Liu, W. and Fu, L., 2012. Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors. European journal of medicinal chemistry, 57, pp.10-20.
9.Li, Y., Liu, J., Wang, Y., Chan, H.W., Wang, L. and Chan, W., 2015. Mass spectrometric and spectrophotometric analyses reveal an alternative structure and a new formation mechanism for melanin. Analytical chemistry, 87(15), pp.7958-7963.
10.Chan, W., Pavlovic?, N.M., Li, W., Chan, C.K., Liu, J., Deng, K., Wang, Y., Milosavljevic?, B. and Kostic?, E.N., 2016. Quantitation of aristolochic acids in corn, wheat grain, and soil samples collected in Serbia: identifying a novel exposure pathway in the etiology of Balkan endemic nephropathy. Journal of agricultural and food chemistry, 64(29), pp.5928-5934.
11.Liu, J., Jiang, F., Jiang, X., Zhang, W., Liu, J., Liu, W. and Fu, L., 2012. Synthesis and antimicrobial evaluation of 3-methanone-6-substituted-benzofuran derivatives. European journal of medicinal chemistry, 54, pp.879-886.
承担项目
1.国家自然科学基金青年项目，**，氧化应激致肠道菌群失调诱发结直肠癌的分子机制，2021/01-2023/12，主持2.中央高校基本科研，NS**，多维组学探索氧化应激下肠道菌结构和功能，2020/01-2021/12，主持
