姓名： 郭宏骞 性 别: 男 院 系： 中西医结合临床医学院（南京鼓楼医院）
行政职务： 主任 专业技术职称： 教授 任职年月：2004

导师类别： 专业博导 最后学历： 最后学位： 博士
任硕导年月： 任博导年月： 2014 是否院士： 否
是否国务院学科评议组成员： 否 毕业院校： 北京大学 毕业专业： 100210 外科学
毕业时间： 1999 办公电话： -10 E-mail： drguohongqian@gmail.com
◇ 本人从事的主要研究方向特点、意义及水平及其他：

◇ ：近三年在国内外核心期刊上发表学术论文情况
论文题目 刊物名称 刊物国家 收录情况 卷期 排名
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy. Oncotarget. 国外 SCI 2015 Oct 13;6(31):32177-92.
Preparation and Identification of a Monoclonal Antibody Against Cystatin C. Monoclon Antib Immunodiagn Immunother. 国外 SCI 2015 Oct;34(5):334-40.
Visualized intravesical floating hydrogel encapsulating vaporized perfluoropentane for controlled drug release. Drug Deliv. 国外 2015 Oct 30:1-7.
High-efficiency secretory expression of human neutrophil gelatinase-associated lipocalin from mammalian cell lines with human serum albumin signal peptide. Protein Expr Purif. 国外 SCI 2016 Feb;118:105-12.
Focal cryoablation for unilateral low-intermediate-risk prostate cancer: 63-month mean follow-up results of 41 patients. Int Urol Nephrol. 国外 SCI 2016 Jan;48(1):85-90.
Three-Dimensional Aggregates Enhance the Therapeutic Effects of Adipose Mesenchymal Stem Cells for Ischemia-Reperfusion Induced Kidney Injury in Rats. Stem Cells Int. 国外 SCI 2016;2016:**.
Laparoscopic Radiofrequency Ablation versus Partial Nephrectomy for cT1a Renal Tumors: Long-Term Outcome of 179 Patients. Urol Int. 国外 SCI 2016;96(3):345-53.
Comparative efficacy and safety of first-line treatments in patients with metastatic renal cell cancer: a network meta-analysis based on phase 3 RCTs. Oncotarget. 国外 SCI 2016 Mar 29;7(13):15801-10.
The Therapeutic Effect of Adipose-Derived Mesenchymal Stem Cells for Radiation-Induced Bladder Injury. Stem Cells Int. 国外 SCI 2016;2016:**.
Transient expression of Fc-fused human glycoprotein 130 in Expi293F suspension cells. Protein Expr Purif. 国外 SCI 2016 Apr 23;124:41-47.
Salvage cryotherapy with third-generation technology for locally recurrent prostate cancer after radiation therapy. Int Urol Nephrol. 国外 SCI 2016 Jun 14. [Epub ahead of print]
TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT. Sci Rep. 国外 SCI 2015 Jul 8;5:11924.
Neutrophil Gelatinase Associated Lipocalin is an Independent Predictor of Poor Prognosis in Cases of Papillary Renal Cell Carcinoma. J Urol. 国外 SCI 2015 Apr 25. pii: S0022-5347(15)03862-8.
δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. PLoS One. 国外 SCI 2015 Apr 7;10(4):e**.
Free-hand transperineal targeted prostate biopsy with real-time fusion imaging of multiparametric magnetic resonance imaging and transrectal ultrasound: single-center experience in China. Int Urol Nephrol. 国外 SCI 2015 May;47(5):727-33.
The Comparison of R.E.N.A.L., PADUA and Centrality Index Score in Predicting Perioperative Outcomes and Complications after Laparoscopic Radio Frequency Ablation of Renal Tumors. J Urol. 国外 SCI 2015 Mar 23. pii: S0022-5347(15)03397-2.
The application of PADUA scoring system for predicting complications of laparoscopic renal cryoablation. Int Urol Nephrol. 国外 SCI 2015 May;47(5):781-8.
Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice. J Transl Med. 国外 SCI 2015 Jan 27;13:28.
Radiofrequency ablation versus partial nephrectomy for clinical T1a renal-cell carcinoma: long-term clinical and oncologic outcomes based on a propensity score analysis. J Endourol. 国外 SCI 2015 May;29(5):518-25.
Salvage cryosurgery for locally recurrent prostate cancer after primary cryotherapy. Int Urol Nephrol. 国外 SCI 2015 Feb;47(2):301-5.
Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. Protein Expr Purif. 国外 SCI 2014 Sep 26;104C:14-19.
Mucinous tubular and spindle cell carcinoma of the kidney: the contrast-enhanced ultrasonography and CT features of six cases and review of the literature. Int Urol Nephrol. 国外 SCI 2014 Dec;46(12):2311-7.
Radio frequency ablation versus partial nephrectomy for clinical T1b renal cell carcinoma: long-term clinical and oncologic outcomes. J Urol. 国外 SCI 2015 Feb;193(2):430-5.
Retroperitoneoscopic-guided cool-tip radiofrequency ablation of adrenocortical aldosteronoma. J Endourol. 国外 SCI 2014 Oct;28(10):1208-14.
Improved split renal function after percutaneous nephrostomy in young adults with severe hydronephrosis due to ureteropelvic junction obstruction. J Urol. 国外 SCI 2015 Jan;193(1):191-5.
Laparoscopic Radiofrequency Ablation of Renal Tumors: 32-Month Mean Follow-up Results of 106 Patients Urology 国外 SCI 2011; 77(4):798-802 通信作者
Single-center comparison of complications in laparoscopic and percutaneous radiofrequency ablation with ultrasound guidance for renal tumors Urology 国外 SCI 2012;80 (1):119- 124 通信作者
Minimally invasive percutaneous nephrolithotomy in preschool age children with kidney calculi (including stones induced by melamine-contaminated milk powder) Pediatr Surg Int 国外 SCI Pediatr Surg Int 通信作者
Radiofrequency ablation of synchronous bilateral renal cell carcinoma Int J Urol 国外 SCI 2012;19(3):241-247 通信作者
Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma: Experience with 42 Patients J Urol. 国外 SCI 2012;188(4):1095-1101 通信作者
Laparoscopic radiofrequency ablation with intraoperative contrast-enhanced ultrasonography for T1bN0M0 renal tumors: initial functional and oncologic outcomes Journal of endourology 国外 SCI 2014;28(1):4-9 通信作者
The application of R.E.N.A.L. nephrometry scoring system in predicting the complications after laparoscopic renal radiofrequency ablation Journal of endourology 国外 SCI 2014;28(4):424-9 通信作者
Gender disparity of living donor renal transplantation in East China Clinical transplantation 国外 SCI 2013;27(1):98-103 通信作者
Improved outcome of percutaneous radiofrequency ablation in renal cell carcinoma: a retrospective study of intraoperative contrast-enhanced ultrasonography in 73 patients Abdom Imaging 国外 SCI 2012;37(5):885-891 通信作者


◇ ：出版专著教材情况(注：在书名后注明教材或专著)
名称 类别 出版单位 日期 排名


◇ ： 成果获奖情况
成果名称 颁奖部门 等级 完成日期 证书号 排名
射频消融治疗肾肿瘤的临床应用研究 其他 其它 南京市科学技术进步奖二等奖 第一



◇ ：主持重大工程设计情况
项目名称 任务来源 完成形式 完成日期 鉴定验收单位 主要结论 排名
射频消融治疗肾癌诱导特异性T细胞介导抗肿瘤机制的研究 校级


◇ ：目前承担的主要项目
项目名称及下达编号 项目级别 项目来源 起讫时间 科研经费(万元) 本人承担任务
外泌体长链非编码RNA的差异筛选和检测在膀胱无创早期诊断中的应用研究 其他 部省级 2016-2019 10
异染色质蛋白HP1γ介导间充质干细胞对于膀胱癌细胞的干 性维持调控机制研究 国家自然科学基金项目 国家级 2016-2019 65
多西紫杉醇白蛋白纳米粒对膀胱癌治疗作用的研究 其他 部省级 2014-2016 3
江苏省卫生厅创新团队 其他 部省级 2012 100 负责人
江苏省六大高峰人才 其他 部省级 2012 8 负责人
南京市医学重点学科 其他 部省级 2012 200 负责人