姓名： 张健 性 别: 男 院 系： 第三临床医学院（江苏省中西医结合医院）
行政职务： 副主任 专业技术职称： 研究员 任职年月：2011.1

导师类别： 科学硕导 最后学历：博士研究生 最后学位： 博士
任硕导年月： 2011.9 任博导年月： 2011.6 是否院士： 否
是否国务院学科评议组成员： 否 毕业院校： 中国药科大学 毕业专业： 100701 药物化学
毕业时间： 2011.7 办公电话： E-mail： zjwonderful@hotmail.com
◇ 本人从事的主要研究方向特点、意义及水平及其他：
从事中药化学物质、有效物质基础研究，特别从事药食两用中药的药效、物质基础和机制探讨，目前主要研究的中药有青钱柳、绞股蓝、芦荟和肉苁蓉。发表SCI论文70余篇，主持国家省部级课题十余项，研究结果获得江苏省科技进步奖、江苏省中医药科技进步奖，以及国际会议奖项。
◇ ：近三年在国内外核心期刊上发表学术论文情况
论文题目 刊物名称 刊物国家 收录情况 卷期 排名
Evaluation of necrosis avidity of radioiodinated 5-hydroxytryptophan and its potential applications in myocardial infarction imaging Chinese Chemical Letters 国内 SCI 通讯作者
Target exploration of rhein as a small-molecule necrosis avid agent by post-treatment click modification New Journal of Chemistry 国内 SCI 通讯作者
Facile synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones via cyclization of N-alkoxy α-halogenoacetamides with N-(2-chloromethyl)aryl amides Organic &Biomolecular Chemistry 国内 SCI 通讯作者
Cyclocarya paliurus Triterpenoids Improve Diabetes-Induced Hepatic In?ammation via the Rho-Kinase Dependent Pathway Frontiers in Pharmacology 国内 SCI 通讯作者
Updated developments on molecular imaging and therapeutic strategies directed against necrosis Acta Pharmaceutica Sinica B 国内 SCI 通讯作者
SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein Molecular Imaging and Biology 国内 SCI 通讯作者
Rhein‐based necrosis‐avid MRI contrast agents for early evaluation of tumor response to microwave ablation therapy Magnetic Resonance in Medicine 国内 SCI 通讯作者
Ultrasensitive fluorescence detection of sequence-specific DNA via labeling hairpin DNA probes for fluorescein o-acrylate polymers Analytica Chimica Acta 国内 SCI 通讯
Cyclocarya paliurus triterpenic acids fraction attenuates kidney injury via AMPK-mTOR-regulated autophagy pathway in diabetic rats Phytomedicine 国内 SCI 通讯作者
Evaluation of necrosis avidity of radioiodinated 5-hydroxytryptophan and its potential applications in myocardial infarction imaging Chinese Chemical Letters 国内 SCI 通讯
Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents. Contrast Media Mol Imaging 国内 SCI 通讯
Base-mediated [2 + 4] cycloadditions of in situ formed azaoxyallyl cations with N-(2-chloromethyl)aryl amides Organic & Biomolecular Chemistry 国内 SCI 通讯
"Triterpenic acids-enriched fraction from Cyclocarya paliurus attenuates nonalcoholic fatty liver disease via improving oxidative stress and mitochondrial dysfunction" Biomedicine & Pharmacotherapy 国内 SCI 通讯
"SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein" Mol Imaging Biol 国内 SCI 通讯
"Evaluation of necrosis avidity of radioiodinated 5-hydroxytryptophan and its potential applications in myocardial infarction imaging" Chinese Chemical Letters 国内 SCI 通讯
Synthesis and Biological Evaluation of Rhein-Based MRI Contrast Agents for in Vivo Visualization of Necrosis Analytical chemistry 国内 SCI 通讯
Pentacyclic triterpenoids from Cyclocarya paliurus and their antioxidant activities in FFA-induced HepG2 steatosis cells Phytochemistry 国内 SCI 通讯
131I-Evans blue: evaluation of necrosis targeting property and preliminary assessment of the mechanism in animal models Acta Pharmaceutica Sinica B 国内 SCI 通讯
Evaluation of Necrosis Avidity and Potential for Rapid Imaging of Necrotic Myocardium of Radioiodinated Hypocrellins Molecular imaging and biology 国内 SCI 通讯
Evaluation of radioiodinated 1, 4-naphthoquinones as necrosis avid agents for rapid myocardium necrosis imaging Molecular imaging and biology 国内 SCI 通讯
First Evaluation of Radioiodinated Flavonoids as Necrosis-Avid Agents and Application in Early Assessment of Tumor Necrosis. Molecular Pharmaceutics 国内 SCI 通讯
C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells. Steroids 国外 SCI 2016;106:55-61
An Integrative Folate-Based Metal Complex Nanotube as a Potent Antitumor Nanomedicine as Well as an Efficient Tumor-Targeted Drug Carrier Bioconjug Chem. 国外 SCI 2016;27(12):2863-2873
The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats Phytomedicine 国外 SCI 2016;23(12):1475-1483
Fluorescence detection of DNA based on non-covalent π-π stacking interaction between 1-pyrenebutanoic acid and hypericin Analytical Science 国外 SCI 2016;32(5):523-527
Effects of Glycosylation on Biodistribution and Imaging Quality of Necrotic Myocardium of Iodine-131-Labeled Sennidins Mol Imaging Biol 国外 SCI 2016;18(6):877-886
Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model Oncotarget 国外 SCI 2016; 7(36): 58133-58141
A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides. Chinese Journal of Natural Medicines. 国内 SCI 2013, 11(3): 274-276.
Flavonoids from Trachelospermum jasminoides. Chemistry of Natural Compounds. 国外 SCI 2013, 49(3): 507–508.
Antihyperglycemic, Antihyperlipidemic and Antioxidant Effects of Ethanol and Aqueous Extracts of Cyclocarya paliurus Leaves in Type 2 Diabetic Rats. Journal of Ethnopharmacology. 国外 SCI 2013, 150: 1119-1127.
Necrosis Affinity Evaluation of 131I-hypericin in a Rat Model of Induced Necrosis. Journal of Drug Targeting. 国外 SCI 2013, 21(6): 604-610.
Cyclocarya paliurus Prevents High-Fat Diet-Induced Hyperlipidemia and Obesity in Sprague Dawley Rats. Canadian Journal of Physiology and Pharmacology. 国外 SCI 2015, 93(8): 677-686
Cholesterol-lowering Effects and Potential Mechanisms of Different Polar Extracts from Cyclocarya paliurus Leave in Hyperlipidemic Mice. Journal of Ethnopharmacology. 国外 SCI 2015, 176(24):17-26.
PD806: a Novel Oral Vascular Disrupting Agent Shows Antitumor and Antivascular Effects in Vitro and in Vivo. Anti-cancer Drugs. 国外 SCI 2015, 26(2): 148-159.
Biliary and Duodenal Drainage for Reducing Radiotoxic Risk of Antineoplastic 131I-hypericin in Rat Models. Experimental Biology and Medicine. 国外 SCI 2015, 240(12):1763-1773
Effects of Skeleton Structure on Necrosis Targeting and Clearance Properties of Radioiodinated Dianthrones. Journal of Drug Targeting 国外 SCI 2016，24(6):566-77
Synthesis and Preclinical Evaluation of Radioiodinated Hypericin Dicarboxylic Acid as a Necrosis Avid Agent in Rat Models of Induced Hepatic, Muscular, and Myocardial Necroses. Molecular Pharmaceutics 国外 SCI 2016, 13(1): 232-240
Synthesis and Evaluation of 131I-skyrin as a Necrosis Avid Agent for Potential Targeted Radionuclide Therapy of Solid Tumors. Molecular Pharmaceutics 国外 SCI 2016, 13(1): 180-189
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium. Scientific Reports 国外 SCI 2016;6:21341
C21 steroidal glycosides from Cynanchum stauntonii induce apoptosis in HepG2 cells Steroids 国外 SCI 2016,106: 55-61
Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice J Ethnopharmacol 国外 SCI 2014, 153(2): 344-351 通讯
Hypericin as a marker for determination of myocardial viability in a rat model of myocardial infarction Photochemistry and Photobiology 国外 SCI 2014, 90(4): 867-872 通讯
Trapping effect on a small molecular drug with vascular disrupting agent CA4P in rodent H22 hepatic tumor model:in vivo magnetic resonance imaging and postmortem inductively coupled plasma atomic emis Journal of drug Targeting 国外 SCI 2015, 23(5): 436-443 通讯
Evaluation of Hypericin: Effect of Aggregation on Targeting Biodistribution Journal of pharmaceutical sciences 国外 SCI 2015, 104(1): 215-222 通讯
Biodistribution and antitumor efficacy of intraumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models Journal of drug targeting 国外 SCI 2015, 23(4): 371-379 通讯
Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction Drug Delivery 国外 SCI 2015, 22(3): 427-435 通讯
FLAVONOIDS FROM Trachelospermum jasminoides Anti-cancer Drugs 国外 SCI 2015, 26(2)：148-159
Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice Journal of Ethnopharmacology 国外 SCI 2015 26;166:286-96
Necrosis-targeted combinational theragnostic approach to treat cancer Oncotarget 国外 SCI 2014,5(10): 2934-2946
Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo Tumor Biology 国外 SCI 2015 PMID:**
Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis Journal of Drug Targeting 国外 SCI 2014, 22(4): 304-312 通讯
Radiopharmaceutical study on Indine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis Radiol Med 国外 SCI 2015, 120(2): 213-221 通讯
Necrosis targeted combinational theragnostic approach using radioiodinated Sennidin A in rodent tumor models. Oncotarget 国外 SCI 2014, 5(10): 2934-2946 通讯
Radiopharmaceutical Evaluation of 131I-protohypericin as a Necrosis Avid Compound Journal of drug targeting 国外 SCI 2015, 23(5): 417-426 通讯
Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent[J]. Journal of Drug Targeting Journal of Drug Targeting 国外 SCI 2015, 23(2): 180-190 通讯
Antihyperlipidemic effect of Cyclocarya paliurus(Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice Journal of ethnopharmacology 国外 SCI 2015, 166: 286-296 通讯


◇ ：出版专著教材情况(注：在书名后注明教材或专著)
名称 类别 出版单位 日期 排名


◇ ： 成果获奖情况
成果名称 颁奖部门 等级 完成日期 证书号 排名
蒽醌类分子探针用于坏死组织诊断和治疗 省部 二等奖 科技进步奖 2019-02-07-zy 1
治疗性同位素标记的依文思蓝及其衍生物在制备肿瘤靶向放射治疗药物中应用 国家 其它 其他 CN B 1
放射性同位素标记的日照蒽酮类或萘并二蒽酮类化合物用于制备抗结核药物应用 国家 其它 其他 CN B 1
放射性同位素标记日照二蒽酮类化合物用于制备抗肿瘤药物的用途 国家 其它 其他 CN B 1
江苏十五种地道中药资源标准物质库及指纹图谱质量评价体系的建立 国家 其它 其他 200903-26 ZY-03-R-06 6
萘并二蒽酮类化合物及其盐在制备胆道及胆石显像剂中应用 国家 其它 其他 CN B 1
一种全新靶向治疗新策略(坏死组织靶向) 校厅 其它 科技进步奖 -D1 1
江苏十五种地道中药资源标准物质库及指纹图谱质量评价体系的建立 省部 其它 科技进步奖 2008-2-019-06 5



◇ ：主持重大工程设计情况
项目名称 任务来源 完成形式 完成日期 鉴定验收单位 主要结论 排名
百合活性成分的筛选 部省级 现场答辩 省科技厅 按计划完成 4
梯次双靶向放射治疗实体瘤及其机理研究 厅局级 提交材料 国家自然基金委 按计划完成 2
血管阻断药联合坏死亲和性药物放射治疗实体瘤研究 部省级 函审 省科技厅 按计划完成 1
冬仙胶囊抗肿瘤作用的实验研究 部省级 现场答辩 省科技厅 按计划完成 4
江苏十五种地产中药资源标准物质库的建立 部省级 现场答辩 省科技厅 按计划完成 5
天然小分子靶向放疗药物研究 部省级 函审 省科技厅 按计划完成 1
单体化学成分组合法研究酸枣仁中催眠活性成分 部省级 函审 省中管局 按计划完成 1
口服锰磁共振造影剂对肝脏病变的诊断研究 部省级 现场答辩 省科技厅 按计划完成 3
肿瘤坏死组织靶向性双蒽核蒽醌的发现、合成、构效关系及其在肿瘤诊治上的应用研究 厅局级


◇ ：目前承担的主要项目
项目名称及下达编号 项目级别 项目来源 起讫时间 科研经费(万元) 本人承担任务
变通天天胶囊安全性研究 企事业合作 其它 201910-202209 30.00 主持
基于金丝桃素靶向死亡细胞的磁共振分子探针对肿瘤治疗效果评价 其他 部省级 201901-202101 5.00 主持
基于金丝桃素构建靶向死亡细胞的磁共振分子探针评价肿瘤近期疗效及作用机制研究 江苏省基础研究计划（自然科学基金） 部省级 201706-202006 10.00 主持
131I-金丝桃素靶向坏死肿瘤清除肝癌动脉栓塞后残留病灶及其机制研究 国家自然科学基金项目 国家级 201801-201812 55.00 参加
构建中位二蒽酮类分子探针靶向E-DNA用于心肌活性评价研究 其他 部省级 201901-202012 5.00 主持