博士研究生导师简介
姓名
刘昭
研究方向：
血管外科


联系方式
Liuzhao83@gmail.com, **


学术兼职：
国际血管外科联盟（IUA） 青年委员
中国医师协会介入学大血管介入诊疗专业委员
中华医学会江苏省血管外科分会 青年委员
中华医学会江苏省介入分会 委员
中国医师学会腔内血管学专业委员会主动脉夹层分委会 委员
中国医师协会血管外科医师分会腹主动脉学组委员
国家心血管病专家委员会青年委员



个人简介

外科学博士,副主任医师，副教授，博士研究生导师，现工作于南京大学医学院附属鼓楼医院血管外科。南京大学-美国斯坦福大学联合培养博士，曾赴西澳大利亚大学皇家佩斯医院接受过血管外科培训。主要从事血管组织工程血管研究、主动脉瘤的综合治疗、动脉疾病的基因多态性等研究。擅长血管外科疑难病例的诊治，包括胸主动脉瘤、腹主动脉瘤、主动脉夹层、动脉硬化闭塞症、颈动脉狭窄、内脏动脉瘤等的手术和微创治疗，致力于复杂主动脉弓部疾病、胸腹主动脉瘤及夹层的微创治疗。


代表性论文[近5年通讯作者和第一作者]

Kwang-Hsiao Sun,Zhao Liu,Chang-Jian Liu,Tong Yu,Tao Shang,Chen Huang,Min Zhou,Cheng Liu,Feng Ran,Li-Jia Pan.Alginate Hydrogel Conglutinate Cells on the Surface of Polycaprolactone Vascular Scaffolds Fabricated by Electrospinning.J Biomater Tiss Eng,2015,5(1):64-70.
Hanfei Tang,Tong Yu,Kwang-Hsiao Sun,Wenwen Zhang,Yepeng Zhang,Chu Zhou,Cheng Liu,Changjian Liu,Min Zhou,Zhao Liu. Development of a Cell-Seeding Technique Using Electric Field Force Onto Polycaprolactone Scaffolds for Vascular Tissue Engineering.J Biomater Tiss Eng,2015,5(8):647-654.
Wenwen Zhang,Tao Shang,Chen Huang,Tong Yu,Chen Liu,Tong Qiao,Dian Huang,Zhao Liu,Changjian Liu.Plasma microRNAs serve as potential biomarkers for abdominal aortic aneurysm.Clin Biochem,2015,48(15):988-992.
Wenwen Zhang,Zhao Liu,Changjian Liu.Effect of lipid-modifying therapy on long-term mortality after abdominal aortic aneurysm repair: a systemic review and meta-analysis.World J Surg,2015,39(3):794-801.
WenwenZhang,MinZhou,ChengLiu,ChenLiu,TongQiao,DianHuang, FengRan,WeiWang,ChangjianLiu,ZhaoLiu.A Novel Mutation of SMAD3 Identified in a Chinese Family with Aneurysms-Osteoarthritis Syndrome.Biomed Res Int,2015,968135:1-6.
Chen Huang, Zhao Liu,Dian Huang,Tong Qiao,Min Zhou,Changjian Liu.Application of Unibody Single-Branch Endografts in Stanford Type B Dissections with Primary Entry Tear Adjacent to the Left Subclavian Artery: A Computed Tomography-Based Planning Study,Ann Vasc Surg,2015,29:1174-1180.
Kwang-Hsiao Sun,Zhao Liu,Changjian Liu,Tong Yu,Tao Shang,Chen Huang,Min Zhou,Cheng Liu,Feng Ran,Yun Li,Yi Shi,Lijia Pan.Evaluation of in vitro and in vivo biocompatibility of a myo-inositol hexakisphosphate gelated polyaniline hydrogel in a rat model.Sci Rep,2016,6:23931:1-11.
Wenwen Zhang,Zhao Liu,Min Zhou,Long Yi,Changjian Liu.SDF1-3'A polymorphism is associated with size but not occurrence of abdominal aortic aneurysm in a Chinese population.J Vasc Surg,2016,64(2):479–483.
Yiming Zhang,Zhao Liu,Min Zhou,Changjian Liu.MicroRNA-129-5p inhibits vascular smooth muscle cell proliferation by targeting Wnt5a.Exp Ther Med,2016,12(4):2651–2656.
Zhao Liu,Yepeng Zhang,Chen Liu,Dian Huang,Ming Zhang,Feng Ran,Wei Wang,Tao Shang,Tong Qiao,Min Zhou,Changjian Liu.Treatment of serious complications following endovascular aortic repair for type B thoracic aortic dissection.J Int Med Res,2017,45 (5) :1574-1584.
Wenwen Zhang,Qian Han,Min Zhou,Feng Ran,Tong Qiao,Long Yi,Changjian Liu,Zhao Liu.Identification of a missense mutation of COL3A1 in a Chinese family with atypical Ehlers-Danlos syndrome using targeted next-generation sequencing.Mol Med Rep,2017,15(2):936-940.
Kwang-Hsiao Sun,Zhao Liu,Chang-Jian Liu,Tong Yu,Min Zhou,Cheng Liu,Feng Ran,Li-Jia Pan,Huan Zhang.In vivo study of alginate hydrogel conglutinating cells to polycaprolactone vascular scaffolds fabricated by electrospinning.J Biomed Mater Res.2017,105(8):2443–2454.
Qian Han,Wenwen Zhang, Changjian Liu,Min Zhou,Feng Ran,Long Yi,Xitai Sun,Zhao Liu.Whole Exome Sequencing Identifies FBN1 Mutations in Two Patients with Early-onset Type B Aortic Dissection.Mol Med Rep,2017,16(5):6620-6625.
Wenwen Zhang,Qian Han,Zhao Liu,Wei Zhou,Qing Cao,Weimin Zhou.Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection.BMC Med Genet,2018,19:218:1-5.
Wenwen Zhang,Qian Han,Zhao Liu,Wei Zhou,Qing Cao,Weimin Zhou.Whole exome sequencing reveals a stop-gain mutation of PKD2 in an autosomal dominant polycystic kidney disease family complicated with aortic dissection.BMC Med Genet,2018,19(1):1-5.
Yiming Zhang,Zhao Liu,Min Zhou,Changjian Liu.Therapeutic effects of fibroblast growth factor-21 against atherosclerosis via the NF-κB pathway.Mol Med Rep,2018,17(1):1453–1460.
Xianchen Huang,Zhao Liu,Liming Shen,Yiqi Jin,Guoxiong,Zhixuan Zhang,Changwen Fang,Wenxian Guan,Changjian Liu.Augmentation of miR‐202 in varicose veins modulates phenotypic transition of vascular smooth muscle cells by targeting proliferator–activated receptor‐γ coactivator‐1α.J Cell Biochem,2018,120(6): 1-12.
Wenwen Wang,Xin Zhang,Changjian Liu,Yuelin Zhu,Tong Yu,Chen Liu,Xiaoqiang Li,Zhao Liu.A Novel Internal and External Bypass Method to Safeguard Cerebral Blood Flow During Aortic Arch Endovascular Repair Requiring Triple In Situ Fenestrations.J Endovasc Ther,2019,26(5):652-657.
Hai-Zhen Ni,Zhao Liu,Li-Li Sun,Min Zhou,Chen Liu,Wen-Dong Li,Xiao-Qiang Li.Metformin inhibits angiogenesis of endothelial progenitor cells via miR-221-mediated p27 expression and autophagy.FutureMed.Chem,2019,11(17),2263–2272.
Yuanhao Tong,Yi Qin,Tong Yu,Min Zhou,Chen Liu,Changjian Liu,Xiaoqiang Li,Zhao Liu.Three-Dimensional Printing to Guide the Application of Modified Prefenestrated Stent Grafts to Treat Aortic Arch Disease.Ann Vasc Surg,2020.
Yan-Hao Tong,Tong Yu,Min-Jie Zhou,Chen Liu,Min Zhou,Qing Jiang,Chang-Jian Liu,Xiao-Qiang Li,Zhao Liu.Use of 3D Printing to Guide Creation of Fenestrations in Physician-Modified Stent-Grafts for Treatment of Thoracoabdominal Aortic Disease.J Endovasc Ther,2020.
LiLu,YuanhaoTong,WenwenWang,Yayi Hou,Huan Dou,ZhaoLiu.Characterization and Significance of Monocytes in Acute Stanford Type B Aortic Dissection.Journal of Immunology Research,2020.
Xu-Ran Li, Yuan-Hao Tong, Xiao-Qiang Li, Chang-Jian Liu, Chen Liu, Zhao Liu, Total endovascular repair of an intraoperative stent-graft deployed in the false lumen of Stanford type A aortic dissection: A case report. World J Clin Cases. 2020 Mar 6;8(5):954-962.
刘长建,刘昭.小腿肌肉静脉血栓的诊断与治疗[J].中国实用外科杂志,2015,35(12):1276-1279.
刘长建,刘昭.无症状颈动脉狭窄治疗中药物能否替代手术的探讨[J].血管与腔内血管外科杂志,2016,2(1):1-5,30.
刘长建,刘昭.静脉血栓栓塞的腔内治疗现状[J].临床外科杂志,2016,24(8):577-579.
刘长建,刘昭.腹主动脉瘤规范化治疗争议与共识[J].中国实用外科杂志,2017,37(12):1345-1349.
刘长建,刘昭.3D打印技术引导预开窗治疗复杂主动脉弓部病变[J].中国实用外科杂志,2018,38(12):1381-1384.
于同,刘昭,刘晨,刘长建,李晓强.3D打印引导下预开窗联合原位开窗治疗主动脉支架植入术后内漏一例[J].中华血管外科杂志,2018,3(4):249-251.
刘昭,韩潜,于同,周敏,童垣皓,刘晨,李晓强,刘长建.复合支架技术全腔内修复胸腹主动脉瘤及三年随访一例[J].中华血管外科杂志,2018,3(4):243-245.
刘昭,童垣皓,周敏,于同,王炜,张明,冉峰,刘晨,李晓强,刘长建.三维打印引导预束径支架开窗技术在全腔内主动脉弓和三分支重建术中的应用[J].中华血管外科杂志,2019;4(1):89-94.
刘昭,童垣皓,于同,周敏捷,冉峰,王炜,张明,刘晨,周敏,蒋青,刘长建,李晓强.3D打印引导下采用开窗或分支支架治疗胸腹主动脉疾病[J].中华普通外科杂志,2019;34(3): 211-215.
刘昭,李旭冉,张明,周敏捷,蒋青,周敏,刘长建,李晓强.3D打印结合支架束径技术预三开窗治疗Stanford A型主动脉夹层1例[J].中国血管外科杂志,2019,11(2):142-144.
刘昭,王文闻,朱月琳,于同,张馨,刘晨,周敏,刘长建,李晓强.内转流结合外转流技术在主动脉弓部原位三开窗术中的应用[J].中华普通外科杂志,2020,35(2):116-119.
王文闻,刘昭,冉峰,周敏,乔彤,李晓强. 开窗分支支架技术修复胸腹主动脉瘤.中华普通外科杂志,2020;35(3):242-243.



承担科研项目[项目负责人]

江苏省社会发展项目，BE**，AI指导3D打印治疗复杂主动脉疾病，2020-2024，在研，主持
南京市****项目，QXRC201621, 弹力蛋白原基因缓释微粒弹力蛋白原基因缓释微粒的制备及其对腹主动脉瘤的治疗研究，2018-2022，在研，主持
江苏省“科教兴卫人才培养项目”青年人才，2016-2021， 在研，主持
国家自然基金青年项目，**，SMAD3基因缓释微粒的制备及其治疗腹主动脉瘤的实验研究，2017-2019,结题中，主持
江苏省自然科学基金青年项目，BK**，纤维连接蛋白包被聚吡咯水凝胶纳米组织工程血管的实验研究，2014-2017，结题，主持



获奖情况

医学新技术引进奖（复杂主动脉疾病的腔内及杂交治疗技术）江苏省卫生厅 一等奖 2012 第三完成人
江苏省科学技术奖（小口径生物人工血管的基础研究及临床应用）江苏省人民政府 三等奖 2012 第二完成人
南京市科学技术奖（小口径生物人工血管的系列研究与开发）南京市人民政府 二等奖 2011 第三完成人
医学新技术引进奖（新型泡沫硬化剂治疗下肢静脉曲张）江苏省卫生厅 二等奖 2013 第三完成人
医学新技术引进奖 （复杂主动脉弓部疾病的分支及开窗支架修复技术） 江苏省卫生厅 二等奖 2019 第三完成人
江苏省医学奖 青年科技奖（主动脉扩张性疾病的基础及临床研究） 江苏省医学会 2019 第一完成人