博士研究生导师简介
姓名
周正扬
研究方向：
1、肿瘤和淋巴结病变的分子和功能MR成像研究
2、自身免疫性疾病的分子和功能MR成像研究


专 业：
影像医学与核医学

联系方式
zyzhou@nju.edu.cn

学术兼职：
中国医师协会胃肠道肿瘤影像专委会委员；江苏省中西医结合影像学分会常务委员；江苏省放射学会磁共振学组委员

个人简介

南京大学医学院附属鼓楼医院医学影像中心行政主任，南京大学医学院教授，博士生导师。苏州大学医学院硕士，南京大学医学院博士，美国爱默蕾大学（Emory）医学院放射学系访问教授。近五年主持国家自然科学基金面上项目三项，省部级基金四项；入选江苏省“六大人才高峰”培养计划，南京市中青年学科带头人；以第一作者/通信作者发表SCI论文65篇，累计影响因子230，其中3篇IF>13、11篇5<IF<10；以第一完成人获江苏省医学三等奖和南京市科学进步三等奖各一项。

研究兴趣：
（1）功能MR成像在消化道肿瘤TNM分期和疗效评估中的临床研究
（2）自身免疫性疾病功能MR和分子成像研究
（3）肿瘤及转移淋巴结的诊疗一体化研究

代表性论文（第一或通讯作者，IF>3）

Liu S, Shi H, Ji C, Guan W, Chen L, Sun Y, Tang L, Guan Y, Li W, Ge Y, He J, Liu S, Zhou Z.CT textural analysis of gastric cancer: correlations with immunohistochemical biomarkers.Sci Rep. 2018 Aug 7;8(1):11844. IF:4.122
Meng J, Liu S, Zhu L, Zhu L, Wang H, Xie L, Guan Y, He J, Yang X, Zhou Z. Texture Analysis as Imaging Biomarker for recurrence in advanced cervical cancer treated with CCRT.Sci Rep. 2018 Jul 30;8(1):11399. IF:4.122
Shi H, Yan R, Wu L, Sun Y, Liu S, Zhou Z, He J, Ye D.Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis.Acta Biomater. 2018 May;72:256-265. IF: 6.383
Zheng H, Ren W, Pan X, Zhang Q, Liu B, Liu S, He J, Zhou Z. Role of intravoxel incoherent motion MRI in early assessment of the response of esophageal squamous cell carcinoma to chemoradiotherapy: A pilot study.J Magn Reson Imaging. 2018 Jan 3.doi: 10.1002/jmri.25934.IF:3.612
Liu S, Zheng H, Zhang Y, Chen L, Guan W, Guan Y, Ge Y, He J, Zhou Z. Whole-volume apparent diffusion coefficient-based entropy parameters for assessment of gastric cancer aggressiveness.J Magn Reson Imaging. 2018 Jan;47(1):168-175. IF:3.612
Huo D, Liu S, Zhang C, He J, Zhou Z, Zhang H, Hu Y. Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced Radiotherapy.ACS Nano. 2017 Oct 24;11(10):10159-10174.IF: 13.709
Liu S, Zhang Y, Chen L, Guan W, Guan Y, Ge Y, He J, Zhou Z. Whole-lesion apparent diffusion coefficient histogram analysis: significance in T and N staging of gastric cancers.BMC Cancer. 2017 Oct 2;17(1):665. IF:3.288
Zhu L, Wang H, Zhu L, Meng J, Xu Y, Liu B, Chen W, He J, Zhou Z, Yang X. Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy.Sci Rep.2017 Sep 14;7(1):11635. IF:4.122
Ren S, Cheng X, Chen M, Liu C, Zhao P, Huang W, He J, Zhou Z, Miao L. Hypotoxic and Rapidly Metabolic PEG-PCL-C3-ICG Nanoparticles for Fluorescence-Guided Photothermal/Photodynamic Therapy against OSCC.ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31509-31518. IF:8.097
Xu Y, Zhu L, Liu B, Ru T, Wang H, He J,Liu S, Yang X, Zhou Z,Liu T. Strain Elastography Imaging for Early Detection and Prediction of Tumor Response to Concurrent Chemo-Radiotherapy in Locally Advanced Cervical Cancer: Feasibility Study. BMC Cancer2017 Jun 19;17(1):427.IF:3.288
Hu Y, Cheng H, Zhao X, Wu J, Muhammad F, He J, Zhou L, Zhang C, Deng Y, Wang P,Zhou Z, Nie S, Wei H. Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme Mimicking Activities for Measuring Glucose and Lactate in Living Tissues. ACS Nano.2017 Jun 27;11(6):5558-5566IF:13.709
Liu S, Liu S, Ji C, Zheng H, Pan X, Zhang Y, Guan W, Chen L, Guan Y, Li W, He J, Ge Y, Zhou Z. Application of CT texture analysis in predicting histopathological characteristics of gastric cancer. Eur Radiol.2017 Dec;27(12):4951-4959. IF: 4.027
Chu C, Zhang H, Zhou N, Dou X, Li M, Liu S, Zhu Y, Wang C, Chen W, Chan Q, Sun L, He J, Zhou Z.Diffusional kurtosis imaging of parotid glands in Sj?gren's syndrome: Initial findings.J Magn Reson Imaging. 2017 Nov;46(5):1409-1417. IF:3.612
Chen B, Chen W, Chan Q, Zhou N, He J, Zhou Z. Functional MRI of human pancreas using BOLD contrast: Responses following glucose ingestion.J Magn Reson Imaging.2017 Sep;46(3):831-836. IF:3.612
Zheng M, Wang Y, Shi H, Hu Y, Feng L, Luo Z, Zhou M, He J,Zhou Z, Zhang Y, Ye D. Redox-Mediated Disassembly to Build Activatable Trimodal Probe for Molecular Imaging of Biothiols.ACS Nano.2016 Nov 22;10(11):10075-10085. IF: 13.709
Yu H, He J, Lu Q, Huo D, Yuan S, Zhou Z, Xu P, Hu Y. .Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway.ACS Appl Mater Inter. 2016 Nov 9;8(44):29950-29959. IF:8.097
Zhou N, Chu C, Dou X, Li M, Liu S, Zhu L, Liu B, Guo T, Chen W, He J, Yan J, Zhou Z, Yang X, Liu T. Early evaluation of irradiated parotid glands with intravoxel incoherent motion MR imaging: correlation with dynamic contrast-enhanced MR imaging.BMC Cancer.2016 Nov 8;16(1):865. IF:3.288
Chu C, Zhou N, Zhang H, Dou X, Li M, Liu S, Zhu Y, Chen W, Chan Q, He J, Sun L, Zhou Z. Use of T1ρMR imaging in Sj?gren's syndrome with normal appearing parotid glands: Initial findings.J Magn Reson Imaging.2017 Apr;45(4):1005-1012. IF:3.288
Zhang Y, Chen J, Liu S, Shi H, Guan W, Ji C, Guo T, Zheng H, Guan Y, Ge Y, He J,Zhou Z, Yang X, Liu T.Assessment of histological differentiation in gastric cancers using whole-volume histogram analysis of apparent diffusion coefficient maps.J Magn Reson Imaging.2017 Feb;45(2):440-449. IF:3.612
Zhu L, Zhu L, Shi H, Wang H, Yan J, Liu B, Chen W, He J,Zhou Z, Yang X, Liu T. Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging.BMC Cancer.2016 Feb 10;16:79. IF:3.288
He J, Shi H,Zhou Z, Chen J, Guan W, Wang H, Yu H, Liu S,Zhou Z, Yang X, Liu T.Correlation between apparent diffusion coefficients and HER2 status in g astric cancers: pilot study.BMC Cancer. 2015 Oct 20;15:749. IF: 3.288
Yu H, Chen J, Liu S, Lu Q, He J,Zhou Z, Hu Y. Enzyme sensitive, surface engineered nanoparticles for enhanced delivery of camptothecin.J Control Release.2015 Oct 28;216:111-20. IF: 7.877
Liu S, Wang H, Guan W, Pan L,Zhou Z, Yu H, Liu T, Yang X, He J,Zhou Z.Preoperative apparent diffusion coefficient value of gastric cancer by diffusion-weighted imaging: Correlations with postoperative TNM staging.J Magn Reson Imaging. 2015 Sep;42(3):837-43. IF:3.612
Huo D, He J, Li H, Huang AJ, Zhao HY, Ding Y, Zhou ZY, Hu Y.X-ray CT guided fault-free photothermal ablation of metastatic lymph nodes with ultrafine HER-2 targeting W18O49 nanoparticles.Biomaterials.2014 Nov; 35(33): 9155-66. IF:8.806
Huo D, Ding J, Cui YX, Xia LY, Li H, He J, Zhou ZY, Wang HW, Hu Y. X-ray CT and pneumonia inhibition properties of gold-silver nanoparticles for targeting MRSA induced pneumonia.Biomaterials.2014 Aug;35(25):7032-41. IF:8.806
Huo D, He J, Li H, Yu H, Shi T, Feng Y,Zhou Z, Hu Y. Fabrication of Au@Ag core-shell NPs as enhanced CT contrast agents with broad antibacterial properties.Colloid Surface B. 2014 May 1;117:29-35. IF:3.997


承担科研课题

国家自然科学基金面上项目（项目编号：**）：荧光导航下双靶向纳米粒子介导的光热&Tregs清除治疗对胃癌转移淋巴结免疫抑制微环境的调控
国家自然科学基金面上项目（项目编号：**）：胃癌转移淋巴结微环境响应性诊疗一体化智能探针构建及术中荧光导航下精准光热治疗
江苏省自然科学基金面上项目（项目编号：BK**）：胃癌转移淋巴结微环境响应性诊疗一体化智能探针的构建及术中荧光导航下光热治疗的实验研究
江苏省省重点研发计划（项目编号：BE**）基于HER-2抗体修饰负载阿霉素的金纳米笼粒子对胃癌淋巴结的诊疗一体化研究。
国家自然科学基金面上项目（项目编号：**）：基于磁性荧光多功能探针USPIO- Cy5.5双模态成像精确清扫胃癌淋巴结研究

获奖情况

1、2017年南京市科技进步三等奖（第一完成人）
2、2017年江苏医学科技三等奖（第一完成人）