博士研究生导师简介

姓名
闫福华
研究方向：
组织工程与牙周再生治疗；
牙周病与全身系统性疾病的关系；
牙周病的种植修复治疗。


联系方式
电话：
Email: fhyan2005@126.com；yanfh@nju.edu.cn

学术兼职：
中国医师协会口腔医师分会 副会长
中华口腔医学会牙周病学专业委员会 候任主任委员
中华口腔医学会口腔生物医学专业委员会 常务委员
江苏省口腔医学会 副会长

个人简介

1. 工作学习简历
1980,9-1985,6遵义医学院口腔医学系学习，获学士学位；
1985,8-1989,8遵义医学院口腔医学系担任助教；
1989,9-1993,6北京大学（原北京医科大学）口腔医学院学习，获博士学位；
1993,7-1998,4遵义医学院口腔医学系担任助教、讲师、副教授；
1998,5-1999,5澳大利亚昆士兰大学牙学院访问****；
1999,6-2000,3福建医科大学口腔医学院副教授。
2000,4-2002,3福建医科大学口腔医学院副教授、教授、副院长（主持工作）；2002,4-2012,4福建医科大学口腔医学院教授，院长；
2012,4-2012,10福建医科大学研究生教育学院院长；
2012,11-至今 南京大学医学院附属口腔医院教授、副院长。
2. 科研情况简介
主持完成省部级及以上科研项目18项（其中国家自然科学基金项目5项），现正主持省部级及以上科研项目5项（其中国家自然科学基金项目2项）。入选江苏省“双创人才”、江苏省“六大人才高峰”高层次人才和江苏省特聘医学专家，享受国务院特殊津贴专家。相关工作发表在Biomaterials, Theranostics, Cell Research & Therapy, International Journal of Nanomedicine Inflammation,Journal of Periodontal Research等杂志上。
3.研究兴趣
近年的研究工作主要集中在组织工程与牙周再生治疗、牙周病的种植修复治疗，以及牙周病与全身系统性疾病的关系。

代表性论文（近5年通讯作者和第一作者）

LiL, JiangH, ChenR, ZhouJ, XiaoY, ZhangY,YanF. Human β-defensin 3 gene modification promotes the osteogenic differentiation of human periodontal ligament cells and bone repair in periodontitis [J]. International Journal of Oral Science, 2020,12:(13)1-6
Ni C, Zhou J, Kong N, Bian T, Zhang Y, Huang X, Xiao Y, Yang W, Yan F. Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment[J]. Biomaterials, 2019,206:115-132.
Zhang Q, Chen L, Chen B, Chen C, Chang J, Xiao Y, Wu C, Yan F. Lithium-calcium-silicate bioceramics stimulating cementogenic/osteogenic differentiation of periodontal ligament cells and periodontal regeneration[J]. Applied Materials Today, 2019,16:375-387.
Liu J, Chen B, Bao J, Zhang Y, Lei L, Yan F. Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration[J]. Stem Cell Research & Therapy, 2019,10(1):320.
Li L, Su W, Xie X, Lei L, Bao J, He S, Chen S, Yang Y, Yan F, Li H. A novel in situ bone elevation method to achieve vertical periodontal augmentation in dogs: a pilot study[J]. Journal ofOral Rehabilitation, 2019,46(8):756-764.
Zhang J, Liu J,Li J, Chen B, Yan F. The clinical efficacy of subgingival debridement by ultrasonic instrumentation compared with subgingival air polishing during periodontal maintenance: a systematic review[J]. Journal of Evidence Based Dental Practice, 2019, 19(4):101314.
Zhou J, Zhang Y, Li L, Fu H, Yang W, Yan F. Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments[J]. InternationalJournalof Nanomedicine. 2018,13:555-567.
Chen B, Ni Y, Liu J, Zhang Y, Yan F. Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets[J]. Stem Cells International. 2018,2018:**.
Li J, Ke X, Yan F, Lei L, Li H. Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.[J]. Oral Diseases, 2018, 24(6): 900-907.
Zhang Y, Wang X, Li H, Ni C, Du Z, Yan F. Human oral microbiota and its modulation for oral health[J]. Biomedicine &Pharmacotherapy. 2018,99:883-893.
Bian T, Li H, Zhou Q, Ni C, Zhang Y, Yan F. Human β-Defensin 3 Reduces TNF-α-Induced Inflammation and Monocyte Adhesion in Human Umbilical Vein Endothelial Cells[J]. Mediators of Inflammation, 2017, 2017:8529.
Chen C, Cheng Q, Yang M, Chen B, Yan F. Effects of different powers and the duration of Er:YAG laser therapy on the early osteogenic differentiation of human periodontal ligament cells [J]. International Journal of Clinical and Experimental Medicine, 2017,10(2):2566-2573.
Li Y, Ma S, Guo J, Jiang J , Luo K , Yan F, Xiao Y. Effect of local hIL-10 gene therapy on experimental periodontitis in ovariectomized rats[J]. Acta Odontologica Scandinavica, 2017,75(4):268-279.
Liu J, Chen B, Yan F, Yang W. The Influence of Inflammatory Cytokines on the Proliferation and Osteoblastic Differentiation of MSCs[J]. Current Stem Cell Research & Therapy, 2017,12(5):401-408.
Lyu J, Bian T, Chen B, Cui D, Li L, Gong L, Yan F. β-defensin 3 modulates macrophage activation and orientation during acute inflammatory response to Porphyromonas gingivalis lipopolysaccharide[J]. Cytokine, 2017, 92:48-54.
Zhang Y, Kong N, Zhang Y, Yang W, Yan F. Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells[J]. Theranostics, 2017, 7(5):1214-1224.
Cui D, Lyu J, Li H, Lei L, Bian T, Li L, Yan F. Human β-defensin 3 inhibits periodontitis development by suppressing inflammatory responses in macrophages[J]. Molecular Immunology, 2017, 91:65-74.
Chen B, Li L, Ren W, Yi L, Wang Y, Yan F. A novel missense mutation in the ALPL gene causes dysfunction of the protein[J]. Molecular Medicine Reports, 2017, 16(1):710-718.
Zheng B, Jiang J, Chen Y, Lin M, Du Z, Xiao Y, Luo K, Yan F. Leptin Overexpression in Bone Marrow Stromal Cells Promotes Periodontal Regeneration in a Rat Model of Osteoporosis[J]. Journal of Periodontology, 2017, 88(8):808-818.
Chen C, Li H, Jiang J, Zhang Q, Yan F. Inhibiting PHD2 in bone marrow mesenchymal stem cells via lentiviral vector-mediated RNA interference facilitates the repair of periodontal tissue defects in SD rats[J]. Oncotarget, 2017,8(42):72676-72699.
Li H, Hong F, Pan S, Lei L, Yan F. Silencing Triggering Receptors Expressed on Myeloid Cells-1 Impaired the Inflammatory Response to Oxidized Low-Density Lipoprotein in Macrophages[J]. Inflammation, 2016, 39(1):199-208.
Ke X, Lei L, Li H, Li H, Yan F. Manipulation of necroptosis by Porphyromonas gingivalis in periodontitis development.[J]. Molecular Immunology, 2016, 77:8-13.
Zhang Q, Chen B, Zhu D, Yan F. Biomarker levels in gingival crevicular fluid of subjects with different periodontal conditions: A cross-sectional study.[J]. Archives of Oral Biology, 2016, 72:92-98.
Jiang S, Tang K, Chen B, Yan F. Regenerative effect of hOPG gene-modified autologous PDLs in combination with cell transplantation on periodontal defection in beagle dogs[J]. Cytotechnology, 2016, 68(6): 2613-2623.
Bian T, Li L, Lyu J, Cui D, Lei L, Yan F. Human β-defensin 3 suppresses Porphyromonas gingivalis lipopolysaccharide-induced inflammation in RAW 264.7 cells and aortas of ApoE-deficient mice[J]. Peptides, 2016, 82: 92-100.
Li L, Bian T, Lyu J, Cui D, Lei L, Yan F. Human β-defensin-3 alleviates the progression of atherosclerosis accelerated by Porphyromonas gingivalis lipopolysaccharide[J]. International Immunopharmacology, 2016, 38:204-213.
Cui D, Li H, Lei L, Chen C, Yan F. Nonsurgical periodontal treatment reduced aortic inflammation in ApoE?/? mice with periodontitis[J]. SpringerPlus, 2016, 5(1): 940-940.
Chen Y, He S, Yan F, Zhou P, Luo K, Zhang Y, Xiao Y, Lin M. Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue[J]. International Journal of Oral Science, 2016, 8(4): 213-222.
Zhang Y, Liu J, Li D, Yan F, Wang X, Yang W. Self-Assembly of Ultrathin Gold Nanowires and Single Walled Carbon Nanotubes as a Highly Sensitive Substrate for Surface Enhanced Raman Spectroscopy[J]. New Journal of Chemistry, 2016,40:7286-7289.


承担科研项目（项目负责人）

1.牙周致病菌肠道异位定植对高脂血症状态下骨免疫微环境和骨重建的影响及其机制研究（**）国家自然科学基金 主持 2020,01-2023,12
2.PHD2基因沉默促进牙周膜细胞和骨髓间充质干细胞修复牙周组织缺损的研究(**)国家自然科学基金 主持 2018,01-2021,12
3.重度牙周炎患牙保存和多学科联合治疗,江苏省医学领军人才与创新团队（CXTDB**） 主持 2016,01-2020,12
4.炎症微环境下抗菌肽β防御素3及其基因修饰的金纳米颗粒修复牙周组织缺损的实验研究（**） 国家自然科学基金 主持2016,01-2019,12


获奖情况

1.“组织工程技术用于治疗牙周疾病的实验与临床研究”获福建省科学技术进步二等奖（排名第一，2010年）
2. “牙龈卟啉单胞菌脂多糖对泡沫细胞表达动脉粥样硬化相关基因的影响”获2011年福建省优秀博士学位论文奖 （指导老师）
3.“牙周炎与全身疾病相关关系及相应治疗方案的研究” 获中华口腔医学会科技奖二等奖（排名第四，2014年）
4.“牙周炎与全身疾病相关关系及相应治疗策略的研究”获北京市科学技术奖三等奖（排名第四，2014年）