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联系电话： **
办公地址： 仙林化学楼C-509
电子邮箱： heweij69@nju.edu.cn

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个人简介


南京大学化学化工学院教授、博士生导师。1991、1997和2001年分别获得南京大学化学专业学士、硕士和博士学位。2001-2002年在德国马普胶体与界面研究所从事博士后研究。2003年起在南京大学配位化学研究所工作。研究方向为无机信号小分子和生命关键过渡金属离子的探针设计、成像及其化学生物学；金属配合物的生物学效应，分子光物理、光化学效应的生物医药应用。在包括J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; ACS Nano, Chem. Commun.; Chem. Sci.等国际知名学术刊物上发表论文近百篇。曾受邀为Chem. Soc. Rev 及Elsevier系列丛书撰写分子影像学综述和专章。先后主持国家自然科学基金面上项目6项，省面上项目1项；参加973项目2项，参加国家自然科学基金重点项目3项。曾获江苏省第五届优秀博士论文奖，2009年中美药协(SAPA)优秀研究生论文导师，2015年教育部自然科学奖一等奖（第2完成人）。


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工作经历


1991,07-1994,07江阴农药厂研究所，研发工程师
2002,01-2002,12德国马普胶体与界面研究所，博士后
2003,03-2009,11南京大学化学化工学院副教授，硕士生导师
2009,12-至今 南京大学化学化工学院教授，博士生导师

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研究方向


无机信号小分子、生命金属离子的分子探针构建、成像及相关化学生物学研究
发光材料设计及其光化学/光物理效应的生物医药应用研究
抗肿瘤无机金属药物设计、机制研究



学术成果


2020

1. Q. Chen, H. Fang, X. Shao, Z. Tian, S. Geng, Y. Zhang, H. Fan, P. Xiang, J. Zhang, X. Tian, K. Zhang,* W. He,* Z. Guo,* J. Diao.* A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells. Nat. Commun., 2020, 11, 6290.
2. M. A. Masood, Y. Chen*, S. Yao, S. Li, W. He,* Z. Guo.* A new palladium complex as a dual fluorometric and colorimetric probe for rapid determination of sulfide anion. J. Photochem. & Photobiol. A: Chem. 2021, 404,112885.
3. Y. Zhang, Y. Chen,* Y. Bai, X. Xue, W. He,* Z. Guo. FRET-based fluorescent ratiometric probes for the rapid detection of endogenous hydrogen sulphide in living cells. Analyst, 2020, 145, 4233–4238.
4. Y. Zhang, Y. Chen,* H. Fang, X. Shi, H. Yuan, Y. Bai, W. He,* Z. Guo. A ratiometric fluorescent probe for imaging enzyme dependent hydrogen sulfide variation in the mitochondria and in living mice. Analyst, 2020, 145,5123–5127.
5. Z. Han, Y. Wang, Y. Chen,* H. Fang, H. Yuan, X. Shi, B. Yang, Z. Chen, W. He,* and Z. Guo.* A novel luminescent Ir(III) complex for dual mode imaging: synergistic response to hypoxia and acidity of the tumor microenvironment, Chem. Commun. 2020, 56,8055-8058.
6. H. Xu, C. Zhu, Y. Chen,* Y. Bai, Z. Han, S. Yao, Y. Jiao, H. Yuan, W. He,* and Z. Guo.* A FRET-based fluorescent Zn²⁺sensor: 3D ratiometric imaging, flow cytometric tracking and cisplatin-induced Zn²⁺fluctuation monitoring. Chem. Sci., 2020,11,11037–11041.
7. Y. Jiao, J. Hong, Y. Chen,* Y. Zhang, Z. Guo,* Z. Han and W. He.* A novel binuclear Pd(II) complex displaying synergic peptide cleavage behavior. Dalton Trans.,2020, 49, 3164–3173.
8. Z. Han, Y. Chen,* Y. Wang, X. Shi, H. Yuan, Y. Bai, Z. Chen, W. He,* Z. Guo.* Photoinduced synergistic cytotoxicity towards cancer cells via Ru(II) complexes. Dalton Trans., 2020, 49, 13954–13957.
9. J. Gao, Y. Chen,* Z. Guo, W. He.* Recent Endeavors on Molecular Imaging for Mapping Metals in Biology. Biophys. Rep.2020, 6(5),159–178.
10. J. Gao, Y. He, Y. Chen,* D. Song, Y. Zhang, Fen Qi, Z. Guo, W. He.* Reversible FRET Fluorescent Probe for Ratiometric Tracking of Endogenous Fe³⁺in Ferroptosis. Inorg. Chem. 2020, 59, 10920?10927.
11. H. Fang, Y. Chen,* Y. Wang, S. Geng, S. Yao, D. Song1, W. He,* & Z. Guo.*A dual-modal probe for NIR fluorogenic and ratiometric photoacoustic imaging of Cys/Hcy in vivo.Sci. China, Chem., 2020, 63(5), 699–706.


2019
1.X. Xue, C. Qian, H. Fang, H Liu,* H. Yuan, Z. Guo,* Y. Bai, and W. He.* Photoactivated LysosomalEscape of a Monofunctional Pt^IIComplex Pt-BDPA for Nucleus Access, Angew. Chem. Int. Ed. 2019, 58,12661-12666.
2.H. Fang, S. Yao, Q. Chen, C. Liu, Y. Cai, S. Geng, Y. Bai, Z. Tian, A. L. Zacharias, T. Takebe, Y.Chen,* Z. Guo, W. He,* and J. Diao.* De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids, and in Vivo.ACS Nano 2019, 13,14426?14436.
3.Z. Chen, X. Mu, Z. Han, S. Yang, C. Zhang, Z. Guo,* Y. Bai, and W. He.* AnOptical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H₂SUpregulation in Mice. J. Am. Chem. Soc. 2019, 141, 17973-17977.
4.Q. Chen, X. Shao, Z. Tian, Y. Chen, P. Mondal, F. Liu, F. Wang, P. Ling,* W. He,* K. Zhang,* Z.Guo, and J. Diao.* Nanoscale monitoring of mitochondria and lysosome interactions for drug screening anddiscovery, Nano Res. 2019, 12(5), 1009-1015.
5.J. Guo, H. Yuan, Y. Chen,* Z. Chen, M. Zhao, L. Zou, Y. Liu, Z. Liu, Q. Zhao, Z. Guo & W. He.*A ratiometric fluorescent sensor for tracking Cu(I) fluctuation in endoplasmic reticulum. Sci. China. Chem.2019, 62, 465–474.
6.H. Fang, Y. Chen,* X. Shi, Y. Bai, Z. Chen, Z. Han, Y. Zhang, W. He * and Z. Guo. Tuninglipophilicity for optimizing the H₂S sensing performance of coumarin merocyanine derivatives, New J.Chem. 2019, 43, 14800-14805.

2018
1.Changli Zhang,* Minsheng Liu, Shaoxian Liu, Hui Yang, Qiang Zhao, Zhipeng Liu,* and Weijiang He* Phosphorescence Lifetime Imaging of Labile Zn²⁺in Mitochondria via a Phosphorescent Iridium(III) Complex, Inorg. Chem. 2018, 57, 10625?10632.
2.Yang Bai, Xiangchao Shi, Yuncong Chen, Chengcheng Zhu, Yang Jiao, Zhong Han, Weijiang He,* and Zijian Guo*, Coumarin/BODIPY Hybridisation for Ratiometric Sensing of Intracellular Polarity Oscillation, Chem. Eur. J. 2018, 24, 7513 – 7524
3.Yang Bai, Danyang Liu, Zhong Han, Yuncong Chen, Zhongyan Chen, Yang Jiao, Weijiang He* & Zijian Guo*, BODIPY-derived ratiometric fluorescent sensors: pH-regulated aggregation-induced emission and imaging application in cellular acidification triggered by crystalline silica exposure, Sci China Chem, 2018, 61, 1413-1422(Front cover).
4.Changli Zhang,* Zhong Han,b Mengjia Wang, Zhenghao Yang, Xueqin Ran and Weijiang He*, A new BODIPY-derived ratiometric senor with internal charge transfer (ICT) effect: colorimetric/fluorometric sensing of Ag⁺, Dalton Trans., 2018, 47, 2285-2291.
5.Chengcheng Zhu, Mengjia Wang, Lin Qiu,* Shuangying Hao, Kuanyu Li,* Zijian Guo, Weijiang He,* A mitochondria-targeting fluorescent Fe3+ probe and its application in labile Fe³⁺monitoring via imaging and flow cytometry, Dyes and Pigments, 2018, 157, 328-333.
6.Ruyue Xiao, Lan Yuan, Weijiang He and Xiaoda Yang *, Zinc ions regulate opening of tight junction favouring efflux of macromolecules via the GSK3b/snail-mediated pathway, Metallomics, 2018, 10, 169-179.
7.Jakob Kljun, Ignacio E. León, ?pela Per?i?, Juan F. Cadavid-Vargas, Susana B. Etcheverry, Weijiang He, Yang Bai, Iztok Turel,?Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines, J. Inorg. Biochem. 2018,186, 187-196.
2017
1.Y. Jiao, J. Zhu, Y. Guo, W. He * and Z. Guo* Synergetic effect between spin crossover and luminescence in the [Fe(bpp)₂][BF₄]₂ (bpp = 2,6-bis(pyrazol-1-yl)pyridine) complex, J. Mater. Chem. C, 2017, 5, 5214—5222.
2.X. Xue, C. Zhu, H. Chen, Y. Bai, X. Shi, Y. Jiao, Z. Chen, Y. Miao, W. He,* and Z. Guo.* A New Approach to Sensitize Antitumor Monofunctional Platinum(II) Complexes via Short Time Photo-Irradiation (Front Cover), Inorg. Chem. 2017, 56, 3754?3762.
3.S. Wang, J.-H. Ye,* Z. Han, Z. Fan, C. Wang, C. Mu, W. and W. He.* Highly efficient FRET from aggregation-induced emission to BODIPY emission based on host–guest interaction for mimicking the light-harvesting system. RSC Adv., 2017, 7, 36021–36025.
4.郝忆岗, 王晓勇*, 何卫江, 郭子建. 线粒体中无机物种的探测与线粒体功能的干预, 中国科学：化学，2017，47，220 ~ 232。
2016
1.Z. Fan, J H Ye,* Y. Bai, S. Bian, X. Wang*, W. Zhang, W. He*, A new dual-channel ratiometric fluorescent chemodosimeter for Cu²⁺and its imaging in living cells, Tetrahedron Lett. 2016, 57, 5281 - 5285;
2.X. Xue，H. Fang, H. Chen, C. Zhang, C. Zh认Y. Bai, W . He*, Z. Guo*. In vivo fluorescence imaging for Cu2t in live mice by a new NIR fluorescent sensor, Dyes and Pigments 2016, 130, 116-121;
3.T. Li , H. Chen, Y. Jing, H. Han, X. Liang, Y. Zheng *, W. He *, Cyclometallated iridium phosphors with amino acid ancillary ligand for intracellular imaging, Chin. Chem. Letter, 2016, 27,1582 -1585;
4.Q. Liu, C. Zhang, X. Wang,* S Gong,* W. He, Z. Liu*,Benzothiazole Pyimidine Based BF2 Complex for Selective Detection of Cysteine Chem. Asian J. 2016, 11, 202 - 206.
2015
1.H. Chen, J. Tian, W. He,* Z. Guo.* H₂0₂-Activatable and 02-Evolving Nanoparticles for Highly Efficient and Selecltive Photodynamic Therapy against Hypoxic Tumor Cells, J. Am. Chem. Soc. 2015, 137, 1539-1547;
2.Y. Chen, Y. Bai, Z. Han, W. He,* and Z. Guo.* Photoluminescence imaging of Zn²⁺in living systems, Chem. Soc. Rev.,2015, 44, 4517-4546；
3.Y. Chen, C. Zhu, J. Cen, Y. Bai, W. He,* and Z. Guo.*Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor, Chem. Sci., 2015, 6, 3187–3194.
4.X. Wang, Q. Liu, H. Yan, Z. Liu,* M. Yao,* Q. Zhang, S. Gong and W. He.* Piezochromic luminescence behaviors of two new benzothiazole–enamido boron difluoride complexes: intra- and inter-molecular effects induced by hydrostatic compression, Chem. Commun., 2015, 51, 7497-7500.
5.S. Gong, Qingsong Liu, Xiaoqing Wang,* Bo Xia, Zhipeng Liu,* and Weijiang He.* AIE-active organoboron complexes with highly efficient solid-state luminescence and their application as gas sensitive materials. Dalton Trans., 2015, 44, 14063–14070.
6.Y. Wu, Z. Li, Q. Liu, X. Wang,* H. Yan, S. Gong, Z. Liu* and W. He.* High solid-state luminescence in propeller-shaped AIE-active pyridine–ketoiminate–boron complexes. Org. Biomol. Chem., 2015, 13, 5775–5782.

2014.
1.Z. Liu, C. Zhang, Y. Chen, F. Qian, Y. Bai, W. He* and Z. Guo*. In vivo ratiometric Zn2+ imaging in zebrafish larvae using a new visible light excitable fluorescent sensor, Chem. Commun. 2014, 50, 1253-1255;
2.陈韵聪, 朱成成, 何卫江*, 郭子建.* 基于缩硫醛脱保护机制的比例计量型Hg2+荧光探针及其斑马鱼活体造影应用, 中国科学: 化学; 2014, 44, 631 ~ 638;
3.J.-H. Ye,* Y. Wang, Y. Bai, W. Zhang and W. He.* A highly selective turn-on fluorescent chemodosimeter for Cr(VI) and its application in living cell imaging,RSC Adv., 2014, 4, 2989-2992;
4.H. Chen, W. He* and Z. Guo.* An H₂O₂-responsive nanocarrier for dual-release of platinum anticancer drugs and O2: controlled release and enhanced cytotoxicity against cisplatin resistant cancer cells, Chem. Commun., 2014, 50, 9714-9717;
5.Lin Qiu,ab Chengcheng Zhu,a Huachao Chen,a Ming Hu,a Weijiang He*a and Zijian Guo.* A turn-on fluorescent Fe³⁺sensor derived from an anthracene-bearing bisdiene macrocycle and its intracellular imaging application, Chem. Commun., 2014, 50, 4631-4634;
6.Xiaoqing Wang, Hou-ting Liu, Jichun Cui, Yanping Wu, Hua Lu,* Jing Lu, Zhipeng Liu* and Weijiang He.* Synthesis and fluorescence properties of isoindoline-benzazole-based boron difluoride complexes, New J. Chem., 2014, 38, 1277-1283;
7.邱琳，季一帆，朱成成，陈韵聪，何卫江,* 郭子建.* 一种基于BODIPY荧光团的Zn²⁺荧光探针：ICT增强效应，无机化学学报，2014, 30, 169-178.
2013
1.Y. Chen, C. Zhu, Z. Yang, J. Chen, Y. He, Y. Jiao, W. He,* L. Qiu, J. Cen, and Z. Guo.* A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria, Angew. Chem. Int. Ed. 2013, 52, 1688-1691;
2.Z. Liu, W. He* and Z. Guo.* Metal coordination in photoluminescent sensing, Chem. Soc. Rev. 2013, 42, 1568-1600.
3.Y. Chen, C. Zhu, J. Cen, J. Li, W. He,* Y. Jiao and Z. Guo.* A reversible ratiometric sensor for intracellular Cu²⁺imaging: metal coordination-altered FRET in a dual fluorophore hybrid,Chem. Commun., 2013, 49, 7632-7634;
4.C. Zhang, Z. Liu, Y. Li, W. He,* X. Gao and Z. Guo.* In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn²⁺ fluorescent sensor with nuclear envelope penetrability, Chem. Commun. 2013, 49, 11430-11432；
5.黄彬，陈韵聪，郭子建，何卫江.* 一种基于同配合物的高灵敏硫化氢荧光探针，无机化学学报，2013, 29, 2283-2288；
6.李静，朱成成，何卫江.* 一种基于NBD-NH₂荧光团的增强型pH荧光探针及其细胞造影研究，无机化学学报，2013, 29, 2528-2534;
7.W. He and Z Guo, Molecular imaging: chemistry and applications in Comprehensive Inorganic Chemistry II, Vol 8, p733-780. Ed. by J. Reedijk, Oxford, 2013 Elsiver.
8.Y. Zhao,^*T. Gong, Z. Yu, S. Zhu, W. He.^*T. Ni, Z. Guo. Oxidative DNA cleavage promoted by polynuclear copper complexes bearing iminodiacetate chelator, Inorg. Chim. Acta 2013, 399, 112-118.
9.L. Zhou, C. Zhu, Y. Xue, W. He , H. Du,* X. You, Y. Li.Two fluorescent 2,6-substituted pyridyl boron-dipyrromethene dyes for selective sensing of cuprous ions, Inorg. Chem. Commun. 2013, 35, 355-359.
2012
1．Di Liu, Jialiu Ma, Wen Zhou, Weijiang He*, Zijian Guo*，Synthesis and photoactivity of a Pt(II) complex based on an o-nitrobenzyl-derived ligand Inorg. Chim. Acta 2012, 393, 198-203.
2．Zhenghao Yang, Zhipeng Liu,* Yuncong Chen, Xiaoqing Wang, Weijiang He* and Yi Lu, Org. Biomol. Chem., 2012, 10, 5073-5076.
3．Yuncong Chen, Chengcheng Zhu, Zhenghao Yang, Jing Li, Yang Jiao, Weijiang He,* Junjie Chen and Zijian Guo*, A new “turn-on” chemodosimeter for Hg2+: ICT fluorophore formation via Hg2+-induced carbaldehyde recovery from 1,3-dithiane, Chem. Commun., 2012, 48, 5094–5096.
4．Zhipeng Liu, Changli Zhang, Yuncong Chen, Weijiang He* and Zijian Guo*, An excitation ratiometric Zn2+ sensor with mitochondria-targetability for monitoring of mitochondrial Zn2+ release upon different stimulations, Chem. Commun., 2012, 48, 8365–8367.
5．Jia-Hai Ye*, Lingjun Duan, Congcong Yan, Whenchao Zhang, Weijiang He*, A new ratiometric Ag+ ?uorescent sensor based on aggregation-induced emission, Tetrahedron Lett. 2012, 53, 593–596.
6．Zhijun Xie, Zhen Yu, Yuncong Chen, Guoyuan Lu, Zijian Guo and Weijiang He*, DNA cleavage behavior of a new p-xylyl spaced bisCu(BPA)Cl2 complex: the steric effect of a bulky p-xylyl-derived spacer, New J. Chem., 2012, 36, 644–649.
7．Zhipeng Liu,* Changli Zhang, Xiaoqing Wang, Weijiang He,* and Zijian Guo, Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore Hybridization approach, Org. Lett. 2012, 14, 4378-4381.

2011
1.Shengde Wu, Chengcheng Zhu, Changli Zhang, Zhen Yu, Weijiang He,* Yafeng He, Yizhi Li, Jing Wang, and Zijian Guo.* In Vitro and in Vivo Fluorescent Imaging of a Monofunctional Chelated Platinum Complex Excitable Using Visible Light, Inorg. Chem. 2011, 50, 11847?11849.
2.Zhenghao Yang, Chongchong Yan, Yuncong Chen, Chengcheng Zhu, Changli Zhang, Xindian Dong, Weiqi Yang, Zijian Guo, Yi Lu and Weijiang He.* A novel terpyridine/benzofurazan hybrid fluorophore: metal sensing behavior and application, Dalton Trans., 2011, 40, 2173–2176 (Invited paper for themed issue new talent asia)
3.Changli Zhang, Yuming Zhang, Yuncong Chen, Zhijun Xie, Zhipeng Liu, Xindian Dong, Weijiang He,* Chen Shen, Zijian Guo, Sulfonamidoquinoline-derived Zn²⁺fluorescent sensor with 1:1 Zn²⁺binding stoichiometry, Inorg. Chem. Commun. 2010, 14 ,304-307.
4.Zhijun Xie, Kai Wang, Changli Zhang, Zhenghao Yang, Yuncong Chen,Zijian Guo, Guo-Yuan Lu and Weijiang He.* A fluorometric/colorimetric dual-channel Hg²⁺sensor derived from a 4-amino-7-nitro-benzoxadiazole (ANBD) fluorophore, New J. Chem. 2011, 35, 607–613.
5.一个具有大Stokes唯一的苯并噻唑类pH荧光探针；刘超，孙辉，杨晓亮，何卫江*, 无机化学学报，2011，27，2121-2127.
6.铜配合物促进的DNA氧化断裂; 孙辉，余臻，杨玮琪，何卫江*，郭子建*,高等学校化学学报，2011，32，437-450
2010
1.Zhipeng Liu, Changli Zhang, Weijiang He,* Zhenghao Yang, Xiang Gao and Zijian Guo.* A highly sensitive ratiometric fluorescent probe for Cd²⁺detection in aqueous solution and living cells, Chem. Commun., 2010, 46, 6138–6140
2.Jin Hong, Yang Jiao, Weijiang He,* Zijian Guo, Zhen Yu, Junfeng Zhang, and Longgen Zhu. His-Oriented Peptide Hydrolysis Promoted by cis-[Pt(en)(H₂O)₂]₂: a New Specific Peptide Cleavage Site, Inorg. Chem. 2010, 49, 8148–8154.
3.Jin Hong, Yang Jiao, Jianbin Yan, Weijiang He,* Zijian Guo, Longgen Zhu,* Junfeng Zhang, DNA cleavage promoted by trigonal-bipyramidal zinc(II) and copper(II) complexes formed by asymmetric tripodal tetradendate-[bis(2-aminoethyl)amino]ethanol; Inorg. Chim. Acta 2010, 363, 793–798.
4.Z. Liu, C. Zhang, W. He*, F. Qian, Z. Yang, X. Gao, Z. Guo*. A charge transfer type pH responsive fluorescent probe and its intracellular application; New J. Chem., 2010, 34, 656–660.
2009
1.F. Qian, C. Zhang, Y. Zhang, W. He*, X. Gao, P. Hu, Z. Guo*. Visible Light Excitable Zn²⁺Fluorescent Sensor Derived from an Intramolecular Charge Transfer Fluorophore and Its in Vitro and in Vivo Application; J. Am. Chem. Soc. 2009, 131, 1460-1468.
2.Z. Liu, C. Zhang, Y. Li, Z. Wu, F. Qian, Z. Yang, W. He*, Gao, Guo*. A Zn²⁺ Fluorescent Sensor Derived from 2-(Pyridin-2-yl)benzoimidazole with Ratiometric Sensing Potential, Org. Lett., 2009, 11, 795-798.
3.G. Su, Z. Liu, Z. Xie, F. Qian, W. He*, Z. Guo*. A visible light excitable fluorescent sensor for triphosphate/pyrophosphate based on a diZn2+ complex bearing an intramolecular charge transfer fluorophore; Dalton Trans. 2009, 7888-7890.
4.T. Li, H. Lin, T. Li, W. He*, Y. Li , Y. Zhang, Y. Zhu, Z. Guo*. Binuclear monofunctional platinum(II) complexes formed by hexaazamacrocyclic bisdien ligands: Crystal structure, DNA binding and cytotoxicity studies; Inorg. Chim. Acta 2009, 362, 967–974.
5.W. He,* Z. Liu, C. Zhang, Z. Guo. Ratiometric Zn2+ fluorescent sensor based on 4-amino-7-subsituted -2,1,3-benzoxadiazole (ASBD), J. Biol. Inorg. Chem. 2009, 14（S1），163.
6.J. Zhu, Y. Zhao, Y. Zhu, Z. Wu, M. Lin, W. He, Y. Wang, G. Chen, L. Dong, J. Zhang, Y. Lu, Z. Guo.* DNA Cross-Linking Patterns Induced by an Antitumor-Active Trinuclear Platinum Complex and Comparison with Its Dinuclear Analogue, Chem. Eur. J. 2009, 15, 5245;
7.J. Zhao, Y.Zhang, R. Li, W. He. Theoretical Studies on the Preferential Binding of Anions to a Benzimidazole Based Anion Receptor. Pol. J. Chem., 2009, 83, 651;
8.洪瑾，焦阳，张峻峰，何卫江.* 2-(二(2-氨乙基)氨基)乙醇Pd(II)配合物与小肽的相互作用, 无机化学学报, 2009, 25, 2105.

2008-2001
1.T. Li, J. Du, T. Li, Z. Wu, W. He*, Y. Zhu, Z. Guo*.Synthesis, Crystal Structure, and DNA-Cleaving Behavior of 5-Substituted Benzene-1,3-bis(methylene)-Spaced Dinuclear Copper(II) Complexes; Chem. & Biodivers. 2008, 5, 1495-1504.
2.L. Liu, H. Zhang, B. Shen, W. He*, Y. Liu, G. Lu*, J. Zhu, pH-induced fabrication of DNA/chitosan/α-ZrP nanocompositeand DNA release; Nanotechnology, 2010, 21, 105102.
3.J. Hong, Y. Jiao, Yan, W. He*, Z. Guo, L. Zhu*, DNA cleavage promoted by trigonal-bipyramidal zinc(II) and copper(II) complexes formed by asymmetric tripodal tetradendate 2-[bis(2-aminoethyl)amino]ethanol, Zhang, Inorg. Chim. Acta 2010, 363, 793–798
4.T. Li, J. Du, T. Li, Z. Wu, W. He,* J. Zhu, Z. Guo.* Synthesis,CrystalStructure,andDNA-CleavingBehaviorof5-SubstitutedBenzene-1,3-bis(methylene)-Spaced Dinuclear Copper(II) Complexes, Chem. Biodivers. 2008, 5, 1495;
5.万丹丹, 苏光余, 许子华, 张玉明, 吴正轶, 何卫江,* 郭子建.* Ratiometric sensing of Zn2+ by 2(2-pyridin-2’-yl)-1H-benzo[d]imidazole, 无机化学学报, 2008, 24, 1253;
6.Y. Zhao, S. Zhu,* M. Shao, T. Jia, M. Li, W. Lu, W. He. Synthesis,crystal structures and selective oxygenation of dinuclear copper(II) complexes of N,N,N’,N’-xylylenediaminetetraacetate, Inorg. Chem. Commun. 2008, 11, 925.
7.L. Qiu, P. Jiang, W. He,* C. Tu, J. Lin, Y. Li, X. Gao, Z.Guo.* Structural and ?uorescent study of zinc complexes of dansyl aminoquinoline, Inorg. Chim Acta, 2007, 360, 431-438;
8.张玉明，赵永梅，邱琳，吴正轶，何卫江，* 张宇，刘德军. 5-amino-1,10-phenanthroline: A prototype of tautomeric heterocyclic aromatic chelating fluorophore as ratiometric fluorescent sensor for Zn^II, Chin. J. Inorg. Chem. 2007, 23, 1309-1314;
9.Yongmei Zhao, Jianhui Zhu, Weijiang He,* Zhen Yang, Yangguang Zhu, Yizhi Li, Junfeng Zhang, and Zijian Guo.* Oxidative DNA Cleavage Promoted by Multinuclear Copper Complexes: Activity Dependence on the Complex Structure. Chem. Eur. J. 2006, 12, 6621- 6629;
10.Yongmei Zhao, Weijiang He,* Pengfei Shi, Jianhui Zhu, Lin Qiu, Liping Lin and Zijian Guo.* A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity, Dalton Trans., 2006, 2617-2619;
11.邱琳，刘德军,张宇,何卫江.* 蒽衍生物自组装膜的制备及其对金属离子的识别作用, 无机化学学报，2006, 10(22), 1745-1749.
12.HE, Wei-Jiang*, QIU, Lin, LI, Jun-Bai, ZHANG,Yu, GUO, Zi-Jian, ZHU, Long-Gen. Structural Effects on the Langmuir Monolayers of Calix[4]arene Induced by Lower Rim Aromatic Substitution, Chinese Journal of Chemistry, 2006, 24, 800-806.
13.D. Vollhardt,*, F. Liu, R. Rudert, and W. He. Interfacial Molecular Recognition of Dissolved Thymine by Medium Chain Dialkyl Melamine-Type Monolayers, J. Phys. Chem. B 2005, 109, 10849-10857;
14.Fang Liu, Guo-Yuan Lu,* Wei-Jiang He, Ming-Hua Liu, Long-Gen Zhu. Enantioselective recognition of calix[4]arene derivatives bearing chiral bicyclic guanidinium for D/L-phenylalanine zwitterions at the air–water interface, Thin Solid Films, 2004, 468, 244–249;
15.何卫江,* 朱龙根，郭子建. Langmuir 膜和LB膜中的金属参与，无机化学学报，2004, 20, 753-762；
16.Weijiang He, Dieter Vollhardt,* Rainer Rudert, Longgen Zhu, and Junbai Li. Phase Transition and Domain Morphology in Langmuir Monolayers of a Calix[4]arene Derivative Containing No Alkyl Chain, Langmuir 2003, 19, 385-392;
17.Weijiang He, Chaoyang Jiang, Fang Liu, Zihou Tai, Yingqiu Liang, Zijian Guo, and Longgen Zhu. Monolayer Formation of Alkyl Chain-Containing Phosphoric Acid Amphiphiles at the Air/Water (pH 5.6) Interface: Influence of Temperature and Cations, Journal of Colloid and Interface Science 2002, 246, 335-342;
18.Fang Liu, Guo-Yuan Lu,* Wei-Jiang He, Ming-Hua Liu,* Long-Gen Zhu and Hou-Ming Wu. Molecular recognition of nucleotides by a calix[4]arene derivative with two alkyl guanidinium groups at the air–water interface, New J. Chem., 2002, 26, 601-606;
19.Fang Liu, Guo-yuan Lu,,* Wei-jiang He, Min-hua Liu, Long-gen Zhu. Supramolecular interaction of diamino calixw4xarene derivative with nucleotides at the air–water interface, Thin Solid Films 2002, 414, 72–77;
20.Weijiang He, Fang Liu, Chunying Duan, Zijian Guo, Shaozhen Zhou, Yongjiang Liu, and. Longgen Zhu.* Construction of a Square-Planar Molecular Box: Self-Assembly of Palladium(II) Complexes of 3,6,9,16,19,22-Hexaazatricyclo[22.2.2.211,14]triacon-11,13,24,26(1),27,29-hexaene through Hydrogen-Bonding Interactions. Inorg. Chem. 2001, 40, 7065-7071;
21.Weijiang He, Fang Liu, Zhifeng Ye, Yu Zhang, Zijian Guo, and Longgen Zhu*, Monolayers of Novel Calix[4]arene Derivative and Its Palladium(II) Complexes Formed at the Air-Water Interface, Langmuir 2001, 17, 1143-1149;
22.Weijiang He, Fang Liu, Yuhua Mei, Zijian Guo and Longgen Zhu.*Synthesis and electrospray mass spectrometry study of Pd(II) complexes of low-rim amino acid substituted calix [4] arenes, New J. Chem., 2001, 25, 1330-1336;
23.HE, Wei-Jiang, LIU, Fang, YE, Zhi-Feng, MEI, Yu-Hua, GUO, Zi-Jian, ZHU, Long-Gen.* Electrospray Mass Spectrometry Study on Polynuclear Pd(II) and Ni(II) Complexes of 3,6,9,16,19,22-Hexaazatricyclo[22.2.2.211,14]triacon-11,13,24,26(1),27,29-Hexaene, Chinese Journal of Chemistry, 2001, 19, 757-765.
24.Fang Liu, Guo-Yuan Lu,* Wei-Jiang He, Jun Hu, Yu-Hua Mei, Long-Gen Zhu. Synthesis of the Calix[4]arene Derivatives with Alkyl Guanidinium or Chiral Bicyclic Guanidinium, Synthesis( stuttgart), 2001, 4, 607.
25.Zhifeng Ye, Shufeng Pang, Weijiang He, Xianfa Shi,* Zijian Guo, Longgen Zhu.* Copper (II) Ion Induced Monolayer Formation of p-tert-Butylthiacalix[4]arene at the Air-water Interface. Spectrochimica Acta Part A, 2001, 57, 1443-1447;
26.Ye Zhifeng, Pan Zhigang, He Weijiang, Shi Xianfa,* Zhu Longgen.* Synthesis and properties of new thiacalixarene derivatives with palladium ion,Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2001, 40, 89-93;
27.Liu Fang, Lu GuoYuan, He WeiJiang, Wang ZengShen, Zhu LongGen.* Enantioselective recognition of calix[4]arene derivative bearing bicyclic guanidinium for D/L amino acid zwitterions, Chinese Journal of Chemistry, 2001, 19(3), 317-320;
28.Wei-Jiang He, Fang Liu, Zhi-Feng Ye, Zi-Jian Guo, Jun-Bai Li, Long-Gen Zhu.* A New Strategy for Architecture of Robust Monolayer Based on Binuclear Palladium (II) Complex of Calix[4]arene Derivative, Chinese Chemical Letter, 2000, 11, 1027-1030;
29.Wei-Jiang He, Zhi-Feng Ye, Yan Xu, Zi-Jian Guo, Long-Gen Zhu.* 3,6,9,16,19,22-Hexaazatricyclo-[22.2.2.211,14]triaconta-11,13,24,26(1),27,29-hexaene pentahydrate; Acta Crystallographical Section C–Crystal Structure Communications, 2000, 56, 1019-1020;
30.Chaoyang Jiang, Weijiang He, Jianguo Huang, Zihou Tai, Yingqiu Liang.* FT-IR Studies of N-hexadecyl-5-iminomethyl-8-hydroxyquinoline Langmuir-Blodgett Films, Materials Chemistry and Physics, 2000, 62, 236-240;
31.Chaoyang Jiang, Weijiang He, Zihou Tai,* Jianming Ouyang, Spectral Behavior and PH Dependence of N-hexadecyl-5-iminomrthyl-8- hydroxyquinoline,Spectrochimica Acta Part A, 2000, 56, 1399-1407;
32.Zhifeng Ye, Weijiang He, Xianfa Shi, Longgen Zhu, Interaction of Metal Ions with Two New Calix[4,8]arene Derivatives, Journal of Coordination Chemistry, 2001, 54(2), 105-116;
33.Wei Hua, He Wei-Jiang, Zhang Yu, Zhu Long-Gen.*Theoretical Investigation of Hydrolytic Cleavage of Peptides, Chinese Journal of Inorganic Chemistry, 2000, 16, 653-657.



课程名称、上课时间地点


《高等无机化学》(本科生,生物无机化学部分)
《基础有机化学实验》(本科生)

教学大纲、考试要求


《高等无机化学》之生物无机化学
第一章 生物无机化学概论 2学时
1. 生物无机化学的起源与概念
2. 生物无机化学中的金属研究
3. 生物无机化学研究中物理化学方法
第2章 铁的生物无机化学 6学时
1. 含铁蛋白的分类和生理功能
2. 天然氧载体及其小分子模拟物
4. 血红素铁蛋白的结构和功能
5. 非血红素载氧铁蛋白和电子传递传递铁蛋白
6. 铁的吸收、转运和储备
第 3章 锌的生物无机化学 4 学时
1. 锌离子化学、生物学意义和存在形式
2. 含锌酶的分类与功能
3. 羧肽酶A以及嗜热菌蛋白酶的结构和功能
4. 碳酸酐酶的结构和功能及化学模拟
5. 碱性磷酸酯酶AP和核酸酶P1的结构和功能
6. 锌指蛋白的结构和功能
7. 金属硫蛋白的生物功能及锌离子吸收、转运和储备
第4章 铜的生物无机化学 3学时
1. 铜离子的存在形式和生物学功能
2. 含铜蛋白、酶分类和功能
3. I型铜蛋白的结构和电子传递功能
4. II型铜蛋白
5. III型铜蛋白
6. 多铜蛋白
7. 铜蛋白的化学模拟 (自学)
第5章 金属抗肿瘤药物 3 学时
1. 无机药物的起源和崛起
2. 医药中重要金属离子和功能
3. 金属抗肿瘤药物
第6章 分子影像学 6学时
1. Molecular Imaging: a brief introduction
2. Magnetic resonance imaging (MRI) and Gd3+-based contrast agents (GBCAs)
(磁共振成像与钆基磁共振对比剂)
3. PET/SPECT and the metal complex-based radiotracers
(正电子发射断层成像/单光子断层计算机成像和金属基核素示踪剂)
4. Optical imaging and probe design
(光学发射成像与探针设计)
5. Multimodal imaging agents and probe construction
(多模态成像与探针构建)
6. Photoacoustic imaging and its application in multimodal imaging
(光声成像及其在多模式成像中的应用）



教学资源（上课讲义、参考资料等）


《高等无机化学》生物无机化学部分参考书目：
1. 生物无机化学，郭子建　孙为银主编，科学出版社，2006，北京
2. 生物无机化学导论；毛宗万、计亮年、黄锦汪等，中山大学出版社，2001，广州
3. 生物无机化学原理，[美] Stephen J. Lippard，Jeremy M. Berg，席振峰、姚光庆、项斯芬、任宏伟译，北京大学出版社，2000， 北京
4. 高等无机化学，陈慧兰，高等教育出版社，2005，北京




课题组风采