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南京大学化学化工学院导师教师师资介绍简介-陆红健

本站小编 Free考研考试/2021-02-15

职务: 博士生导师
联系电话:
办公地址: 化学楼E502
电子邮箱: hongjianlu@nju.edu.cn

课题组主页: https://hysz.nju.edu.cn/luhj/





个人简介


陆红健 教授,江苏省****,博士生导师,南京大学“功能有机小分子合成”课题组组长。2006年毕业于上海有机化学研究所,导师李超忠教授。2007-2012年在美国南佛罗里达大学从事博士后研究。2012年7月任南京大学化学化工学院副教授。2019年1月起任南京大学化学化工学院教授。拥有200左右平方面积的实验室, 现指导包括4名博士研究生、5名硕士研究生、1名助理研究员及若干本科生组成的研究团队,并与国外著名院校的一流课题组进行广泛的交流合作(波士顿大学,北卡罗来纳大学教堂山分校,加州大学伯克利分校),是我校化学化工学院,化学与生物医学科学研究所的独立课题研究团队。主持三项国家自然科学基金面上项目(**;**;**)并作为子课题负责人参与一项国家自然科学基金重点项目(**)。获聘2014年江苏省“青蓝工程”科技创新团队带头人(BK**),促进化学和药物化学研究的衔接,培养具有原创能力的有机合成化学和生物医学科学复合型研究人才。2012年获聘“江苏省****”,考核成绩优秀并获得2015年“江苏省****续聘”资格。


展示全部

工作经历


01/2019 -至今 南京大学化学化学化工学院,教授,博导,江苏省****

6/2012 - 12/2018南京大学化学化学化工学院,副教授,江苏省****,博导


5/2007 - 04/2012 博士后, 美国南佛罗里达大学,导师: Peter X. Zhang 教授




08/2006 - 04/2007 助理研究员,中国科学院上海有机所,导师: 李超忠 研究员



09/2001 - 07/2006 博士,中国科学院上海有机所,导师: 李超忠 研究员



09/1996 - 07/2001 高分子化学理学学士和计算机软件工学学士,中国科学技术大学


展示全部

研究方向





学术成果


62. Yipin Zhang,?Xia Ge,? Hongjian Lu*and Guigen Li, “Catalytic Decarboxylative C–N Formation to Generate Alkyl, Alkenyl and Aryl AminesAngew. Chem. Int. Ed., 2020, DOI: 10.1002/anie..

61. Xunqing Dong,?Panpan Ma,?Tao Zhang, Hitesh B. Jalani, Guigen Li and Hongjian Lu* “Iridium-Catalyzed C?H Amination of Weinreb Amides: A Facile Pathway towards Anilines and Quinazolin-2,4-dionesJ. Org. Chem. 2020, 85, 13096–13107.

60. Yanan Wu, Ken Chen, Xia Ge, Panpan Ma, Zhiyuan Xu, Hongjian Lu*and Guigen Li, “Redox-Neutral P(O)–N Coupling between P(O)?H Compounds and Azides via Dual Copper and Photoredox CatalysisOrg. Lett., 2020, 22, 6143–6149.

59. Haiyang Fei, Zheyuan Xu, Hongmiao Wu, Lin Zhu, Hitesh B. Jalani, Guigen Li, Yao Fu* and Hongjian Lu*Stereospecific Electrophilic Fluorocyclization of α,β-Unsaturated Amides with SelectfluorOrg. Lett., 2020, 22, 2651-2656.

58. Yang Hu, Kai Lang, Chaoqun Li, Joseph B. Gill, Isaac Kim, Hongjian Lu, Kimberly B. Fields, McKenzie Marshall, Qigan Cheng, Xin Cui, Lukasz Wojtas and X. Peter Zhang* “Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C?H AminationJ. Am. Chem. Soc., 2019, 141, 45, 18160-18169.

57. Yanrong Li, Fen Qian, Xia Ge, Tao Liu, Hitesh B. Jalani, Hongjian Lu*and Guigen Li* “Copper and Cobalt Co-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling Reaction of (Benzo)AzolesGreen Chem., 2019, 21, 5797-5802.

56. Wangshui Cai, Junxian Wu, Haowei Zhang, Hitesh B. Jalani, Guigen Li*and Hongjian Lu*Rh-Catalyzed Chemoselective [4+1] Cycloaddition Reaction towards Diverse 4-MethyleneprolinesJ. Org. Chem., 2019, 84, 10877-10891.

55. Yanan Wu, Yipin Zhang, Mingjie Jiang, Xunqing Dong, Hitesh B. Jalani, Guigen Li and Hongjian Lu* “Synergistic Combination of Visible-Light Photo-Catalytic Electron and Energy Transfer Facilitating Multicomponent Synthesis of ?-Functionalized α,α-DiarylethylaminesChem. Commun., 2019, 55, 6405-6408.

54. Tao Zhang, Xunqing Dong, Hitesh B. Jalani, Jiaqi Zou, Guigen Li, and Hongjian Lu* “Iridium-Catalyzed C–H Amination/Cyclization for Medium to Large N-Heterocycle-Fused DihydroquinazolinonesOrg. Lett., 2019, 21, 3706-3710.

53. Min Zheng, Guigen Li, and Hongjian Lu* “Photoredox- or Metal-Catalyzed in Situ SO2-Capture Reactions: Synthesis of β-Ketosulfones and AllylsulfonesOrg. Lett., 2019, 21, 1216-1220.

52. Xunqing Dong, Qun Li, Guigen Li* and Hongjian Lu* “Cobalt-Catalyzed Secondary Alkylation of Arenes and Olefins with Alkyl Ethers through the Cleavage of C(sp2)–H and C(sp3)–O BondsJ. Org. Chem., 2018, 83, 13402–13413.

51. Chaoqun Li, Kai Lang, Hongjian Lu,Yang Hu, Xin Cui, Lukasz Wojtas and X. Peter Zhang* “CatalyticRadicalProcessforEnantioselectiveAminationof C(sp3)–H BondsAngew. Chem. Int. Ed.2018, 57, 16837-16841.

50. Tao Zhang, Xuejiao Hu, Xunqing Dong, Guigen Li and Hongjian Lu* “Iridium-Catalyzed Unreactive C(sp3)–H Amination with 2,2,2-Trichloroethoxycarbonyl AzideOrg. Lett., 2018, 20, 6260–6264.

49. Yipin Zhang,Xunqing Dong,Yanan Wu,Guigen Li andHongjianLu* “Visible-Light-Induced Intramolecular C(sp2)–H Amination and Aziridination of Azidoformates via a Triplet Nitrene PathwayOrg. Lett.,2018,20,4838-4842.

48. Meng Yu,Tao Zhang,Hitesh B. Jalani,Xunqing Dong,HongjianLu,* and Guigen Li “Iridium-Catalyzed Aryl C–H Sulfonamidation and Amide Formation Using a Bifunctional Nitrogen SourceOrg. Lett.,2018, 20, 4828-4832.

47. Wangshui Cai,Shuang Wang,Hitesh B. Jalani,Junxian Wu,Hongjian Lu*andGuigen Li“Oxidative Cascade Reaction of N-Aryl-3-alkylideneazetidines and Carboxylic Acids: Access to Fused PyridinesOrg. Lett., 2018,20, 3833-3837.

46. Mengzhe Wang, He Zhang, Hui Wang, Huijuan Feng, Huaifu Deng, Zhanhong Wu, Hongjian Lu* and Zibo Li,* “The development of [18F]AlF-NOTA-NT as PET agents of neurotensin receptor-1 positive pancreatic cancerMol. Pharmaceutics, 2018, 15, 3093-3100.

45. Lizheng Yang, Yipin Zhang, Xiaodong Zou, Hongjian Lu* and Guigen Li “Visible-Light-Promoted Intramolecular C–H Amination in Aqueou Solution: Synthesis of CarbazolesGreen Chem., 2018, 20, 1362-1366.

44. Yanrong Li, Fen Qian, Mengshi Wang, Hongjian Lu* and Guigen Li* “Cobalt-Catalyzed Decarboxylative C–H (Hetero)Arylation for the Synthesis of Arylheteroarenes and Unsymmetrical Bihet-eroarylsOrg. Lett., 2017,19,5589-5592.

43. Qun Li,Weipeng Hu,Renjian Hu,HongjianLu*andGuigen Li* “Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction between Unactivated C(sp2)–H and C(sp3)–H BondsOrg. Lett., 2017,19,4676-4679.


42. Huiling Jiang, Kai Lang, Hongjian Lu, Lukasz Wojtas and X. Peter Zhang* “Asymmetric Radical Bicyclization of Allyl Azidoformates via Cobalt(II)-Based Metalloradical CatalysisJ. Am. Chem. Soc., 2017, 139, 9164-9167.

41. Bin Yang, Kantapat Chansaenpak, Hongmiao Wu, Lin Zhu, Mengzhe Wang, Zibo Li* and Hongjian Lu* “Silver-Promoted (Radio)fluorination of Unsaturated Carbamates via a Radical ProcessChem. Commun.2017, 53, 3497-3500.

40. Benjamin C. Giglio, Haiyang Fei, Mengzhe Wang, Hui Wang, Liu He, Huijuan Feng, Zhanhong Wu,Hongjian Lu* and Zibo Li* “Synthesis of 18F-5F-α-Methylated Tryptophan and Others: Construction of New Trp Based PET AgentsTheranostics, 2017, 7, 1524-1530.

39. Xiaodong Zou, Jiaqi Zou, Lizheng Yang, Guigen Li and Hongjian Lu* “Thermal Rearrangement of Sulfamoyl Azides: Reactivity and Mechanistic StudyJ. Org. Chem. 2017, 82,4677-4688.

38. Hitesh B. Jalani, Wangshui Cai and Hongjian Lu* Copper-Catalyzed One-pot Synthesis of Pyrimidines from Amides, DMF–DMA and EnamineAdv. Synth. Catal., 2017, 359,2509-2513.

37. Huiling Jiang, Kai Lang, Hongjian Lu, Lukasz Wojtas and X. Peter Zhang*“Intramolecular Radical Aziridination of Allylic Sulfamoyl Azides by Cobalt(II)-Based Metalloradical Catalysis: Effective Construction of Strained Heterobicyclic Structures” Angew. Chem. Int. Ed. 2016, 55, 11604-11608.

36.Yanrong Li,Mengshi Wang,Wei Fan,Fen Qian,Guigen Li* andHongjianLu*“Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers”J. Org. Chem.,2016, 81,11743-11750.

35. Hongmiao Wu, Bin Yang, Lin Zhu, Ronghua Lu, Guigen Li* and Hongjian Lu* “High-Valent Palladium-Promoted Formal Wagner?Meerwein Rearrangement” Org. Lett. 2016,18,5804-5807.

34. Lizheng Yang, Hao Li, Haifei Zhang andHongjian Lu* “Palladium-Catalyzed Intramolecular C–H Amination in Water” Eur. J. Org. Chem. 2016, 34, 5611-5615.

33.Hongjian Lu,*Kai Lang,Huiling Jiang,Lukasz WojtasandX. Peter Zhang* “Intramolecular 1,5-C(sp3)–H radical amination viaCo(II)-based metalloradical catalysis for five-membered cyclic sulfamides” Chem. Sci., 2016, 7, 6934-6939.

32. Qun Li, Yanrong Li, Weipeng Hu, Renjian Hu, Guigen Li,* and Hongjian Lu* “Cobalt-Catalyzed C(sp2)-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor” Chem. Eur. J. 2016, 22, 12286-12289.

31. Haowei Zhang, Bing Yang, Zhen Yang, Hongjian Lu, and Guigen Li* “Asymmetric Synthesis of Chiral α-Methyl-α,β-diamino Acid Derivatives via Group-Assisted Purification Chemistry Using N-Phosphonyl Imines and a Ni(II)-Complexed Alanine Schiff BaseJ. Org. Chem., 2016, 81, 7654–7661.

30. Tao Zhang, Zhen Wang, Xuejiao Hu, Meng Yu, Tianning Deng, Guigen Li and Hongjian Lu*“Cesium Carboxylate-Promoted Iridium Catalyzed C?H Amidation/Cyclization with 2,2,2-Trichloroethoxycarbonyl Azide“ J. Org. Chem.2016, 81, 4898–4905.

29. Md Ashif Ali, Xiayin Yao, Guigen Liand Hongjian Lu*“Rhodium-Catalyzed Selective Mono- and Diamination of Arenes with Single Directing Site “On Water””Org. Lett. 2016, 18, 1386-1389.

28. Tao Zhang, Xuejiao Hu, Zhen Wang, TianTian Yang, Hao Sun, Guigen Li and Hongjian Lu* “Carboxylate-assisted Iridium-Catalyzed C?H Amination of Arenes with Biologically Relevant Alkyl Azides” Chem. Eur. J. 2016, 22, 2920-2924.

27. Monalisa Goswami, Volodymyr Lyaskovskyy, Sérgio R. Domingos, Wybren Jan Buma, Sander Woutersen, Oliver Troeppner, Ivana Ivanovi?-Burmazovi?, Hongjian Lu, Xin Cui, X. Peter Zhang,* Edward J. Reijerse, Serena DeBeer, Matti M. van Schooneveld, Florian Felix Pfaff, Kallol Ray and Bas de Bruin* “Characterization of Porphyrin-Co(III)-‘Nitrene Radical’ Species Relevant in Catalytic Nitrene Transfer ReactionsJ. Am. Chem. Soc.,2015,137, 5468-5479.


26. Ke Yang, Xinyong Chen, Yuqi Wang, Wanqing Li, Adnan A. Kadi, Hoong-Kun Fun, Hao Sun,* Yan Zhang, Guigen Li* and Hongjian Lu* “Cobalt-Catalyzed Decarboxylative 2-Benzoylation of Oxazoles and Thiazoles with α-Oxocarboxylic AcidsJ. Org. Chem., 2015,80, 11065-11072.

25. Xiaodong Zou, Lizheng Yang, Xiangli Liu, Hao Sun and Hongjian Lu*Silver Tetrafluoroborate-Catalysed Oxa-Diels-Alder Reaction Between Electrically Neutral Dienes and Aldehydes Adv. Synth. Catal., 2015, 357, 3040-3046.

24.Hongmiao Wu, Weiwei Zi, Guigen Li,Hongjian Lu* andF. Dean Toste* “Gold(I)-Catalyzed Desymmetrization of 1,4-Dienes by an Enantioselective Tandem Alkoxylation/Claisen Rearrangement” Angew. Chem. Int. Ed. 2015, 54, 8529-8532.

23. Ke Yang, Yuqi Wang,Xinyong Chen,Adnan A. Kadi,Hoong-Kun Fun, Hao Sun, Yan Zhangand Hongjian Lu* “Nickel-Catalyzed and Benzoic Acid-Promoted Direct Sulfenylation of Unactivated Arenes” Chem. Comm., 2015, 51, 3582-3585.

22. Md Ashif Ali, Xiayin Yao,Hao Sun and Hongjian Lu* “[RhCp*Cl2]2 Catalyzed Directed N-Boc Amidation of Arenes on Water” Org. Lett.2015, 17, 1513-1516.

21. Hongjian Lu,* Chaoqun Li, Huiling Jiang, Christopher L. Lizardi and X. Peter Zhang* “Chemoselective Amination of Propargylic C(sp3)-H Bonds by Cobalt(II)-Based Metalloradical Catalysis” Angew. Chem. Int. Ed. 2014, 53, 7028.

20. Ke Yang, Peng Wang, Cheng Zhang, Adnan A. Kadi, Hoong-Kun Fun, Yan Zhang* andHongjian Lu* “Nickel-Catalyzed Decarboxylative Arylation of Heteroarenes through sp2 C–H Functionalization” Eur. J. Org. Chem. 2014, 34, 7586-7589.

19. Li-Mei Jin, Hongjian Lu, Yuan Cui, Christopher L. Lizardi, Thiago N. Arzua, Lukasz Wojtas, Xin Cui and X. Peter Zhang* “Selective radical amination of aldehydic C(sp2)–H bonds with fluoroaryl azides viaCo(II)-based metalloradical catalysis: synthesis of N-fluoroaryl amides from aldehydes under neutral and nonoxidative conditions ”Chem. Sci. 2014. 5, 2422-2427.

18. Nanda D. Paul, M. Sc. Andrei Chirila,Hongjian Lu,X. Peter Zhangand Bas de?Bruin*“Carbene Radicals in Cobalt(II)–Porphyrin-Catalysed Carbene Carbonylation Reactions; A Catalytic Approach to KetenesChem.- Eur. J.2013, 19, 12953.

17. Limei Jin, Xue Xu, Hongjian Lu, Xin Cui, Lukasz Wojtasand X. Peter Zhang*“Effective Synthesis of Chiral N-Fluoroaryl Aziridines through Enantioselective Aziridination of Alkenes with Fluoroaryl Azides”, Angew. Chem. Int. Ed.2013,52, 5309.

16. Hongjian. Lu, Yang Hu, Huiling Jiang, Lukas Wojtasand X. Peter Zhang*Stereoselective Radical Amination of Electron-Deficient C(sp3)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α-Amino Acid Derivatives via α-C–H AminationOrg. Lett., 2012, 14, 5158-5161.

15. Hongjian Lu,Wojciech I. Dzik, Xue Xu, Lukasz Wojtas, Bas de Bruin*and X. Peter Zhang*“Experimental Evidence for Cobalt(III)-Carbene Radicals: Key Intermediates in Cobalt(II)-Based Metalloradical CyclopropanationJ. Am. Chem. Soc. 2011, 133, 8518-8521.


14. Hongjian Lu andX. Peter Zhang*“Catalytic C–H Functionalization by Metalloporphyrins: Recent Developments and Future DirectionsChem. Soc. Rev.2011,40, 1899-1909.

13. Hongjian Lu, Huiling Jiang, Yang Hu, Lukasz Wojtasand X. Peter Zhang* “Chemoselective Intramolecular Allylic C-H Amination versus C=C Aziridination through Co(II)-Based Metalloradical CatalysisChem. Sci.2011,2, 2361-2366.


12. Xue Xu, Hongjian Lu, Joshua V. Ruppel, Xin Cui, Silke Lopez de Mesa, Lukasz Wojtas, X. Peter Zhang*“Highly Asymmetric Intramolecular Cyclopropanation of Acceptor-Substituted Diazoacetates by Co(II)-Based Metalloradical Catalysis: Iterative Approach for Development of New-Generation CatalystsJ. Am. Chem. Soc.2011,133, 15292-15295.

11. Volodymyr Lyaskovskyy, Alma I. Olivos Suarez, Hongjian Lu, Huiling Jiang, X. Peter Zhang* and Bas de Bruin*“Mechanism of Cobalt(II) Porphyrin-Catalyzed C?H Amination with Organic Azides: Radical Nature and H-Atom Abstraction Ability of the Key Cobalt(III)-Nitrene IntermediatesJ. Am. Chem. Soc.2011, 133, 12264-12273.

10. Xin Cui, Xue Xu,Hongjian Lu, Shifa Zhu, Lukasz Wojtasand X. Peter Zhang*Enantioselective Cyclopropenation of Alkynes with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical CatalysisJ. Am. Chem. Soc.2011, 133, 3304-3307.

9. Hongjian Lu, Huiling Jiang, Lukasz Wojtas and X. Peter Zhang*. “Selective Intramolecular C-H Amination through the Metalloradical Activation of Azides: Synthesis of 1,3-Diamines under Neutral and Nonoxidative ConditionsAngew. Chem. Int. Ed.2010, 49, 10192-10196.

8. Hongjian Lu, Jingran Tao, Jess E. Jones, Lukasz Wojtas and X. Peter Zhang*“Co(II)-Catalyzed Intramolecular C–H Amination of Phosphoryl Azides: Formation of 6- and 7-Membered CyclophosphoramidatesOrg. Lett.2010, 12, 1248-1251.

7. Hongjian Lu, Velusamy Subbarayan, Jingran Tao and X. Peter Zhang*“Cobalt(II)-Catalyzed Intermolecular Benzylic C–H Amination with 2,2,2-Trichloroethoxycarbonyl Azide (TrocN3)Organometallics2010, 29, 389-393.

6.Shifa Zhu, Joshua V. Ruppel, Hongjian Lu, Lukasz Wojtasand X. Peter Zhang*“Cobalt-Catalyzed Asymmetric Cyclopropanation with Diazosulfones: Rigidification and Polarization of Ligand Chiral Environment via Hydrogen Bonding and CyclizationJ. Am. Chem. Soc. 2008, 130, 5042-5043.

5. Yuanjia Pan, Hongjian Lu, Yewen Fang, Xinqiang Fang, Liqun Chen, Junlu Qian, Junhua Wangand Chaozhong Li*“Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with BromoenonesSynthesis2007, 8,1242-1246.

4. Hongjian Lu, Xinting Yuan, Shana Zhu, Changhui Sunand Chaozhong Li* “Copper-Catalyzed Intramolecular N-Vinylation of Sulfonamides: General and Efficient Synthesis of Heterocyclic Enamines and MacrolactamsJ. Org. Chem. 2008,73, 8665-8668.

3. Hongjian Lu,Qian Chen and Chaozhong Li*“Control of the Regioselectivity of Sulfonamidyl Radical Cyclization by Vinylic Halogen SubstitutionJ. Org. Chem. 2007,72, 2564-2569.

2. Hongjian Luand Chaozhong, Li*“General and Highly Efficient Synthesis of 2-Alkylideneazetidines and β-Lactams via Copper-Catalyzed Intramolecular N-VinylationOrg. Lett. 2006, 8,5365-5367.

1. Hongjian Lu and Chaozhong Li* “Facile Cyclization of Amidyl Radicals Generated from N-acyltriazenesTetrahedron Lett.2005, 46, 5983-5985.



课程名称、上课时间地点


1. 研究生课程“合成化学概论”;合成化学概论.zip

2. 本科生课程“有机化学”


教学大纲、考试要求


1. 研究生课程“合成化学概论”;
2. 本科生课程“有机化学”

教学资源(上课讲义、参考资料等)


课件.zip合成化学概论课件


课题组风采


课题组现有在读博士研究生5名,硕士研究生2名,研究助理2名。已毕业博士生3名,硕士生11名。

当前课题组成员:

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