姓名：马家乐性别：男 毕业院校：南京农业大学最高学位：博士 办公地址：教学楼 B421-1 OIE 猪链球菌参考实验室电子邮箱：jialema@njau.edu.cn 研究方向：（1）细菌分泌系统功能研究 （2）微生物群落种间交流与对抗机制研究 （3）致病菌免疫逃避蛋白筛选及机制研究 个人简介： 马家乐：博士，副研究员，硕士生导师 研究工作经历： 2019/12-今，南京农业大学，动物医学院预防兽医系，副研究员 2018/12-2019/12, 南京农业大学，动物医学院预防兽医系，助理研究员 2017/07-2020/08，南京农业大学，动物医学院预防兽医系，师资博后 2015/03-2017/03，美国 Iowa State University 兽医学院，访问学者 受教育经历： 2011/09-2017/06，南京农业大学，动物医学院预防兽医系，硕博连读 2006/09-2011/06，南京农业大学，动物医学院，学士 科研项目： (1) 国家自然基金青年项目，31802187，六型分泌系统脱谷氨酰胺酶效应子 Hcp-ET5 靶向 NF-κB 信号通路抑制宿主炎症应答的分子机制，2019/01-2021/12， 25 万元，主持 (2) 江苏省自然科学基金青年项目，BK20180530，六型分泌系统穿孔素效应子 Rhs-WTIP 诱导巨噬细胞焦亡促进细菌系统感染的分子机制，2018/07-2021/06， 20 万元，主持 (3) 中国博士后基金特别资助， 2018T110517 ， T6SS 分泌金属肽酶靶向 JNK-MAPK 抑制细胞凋亡的分子机制，2018/07-2020/06，15 万元，主持 (4) 中国博士后基金面上一等资助，2017M620216，vgrG 基因岛编码多样效应因子介导致病菌定殖及疾病发展，2017/11-2019/10，8 万元，主持 (5) 中央高校基本科研业务费青年项目，KJQN201932，VI 型分泌系统效应子逃避宿主先天免疫应答的分子机制，2019/01-2019/12，10 万元，主持 (6) 家畜疫病病原生物学国家重点实验室（中国农业科学院兰州兽医研究所）开 放基金课题，SKLVEB2019KFKT014, VI 型分泌系统 M35 金属肽酶效应子靶向 NF-κB 抑制宿主炎症应答的分子机制，2019/12-2021/11, 8 万元，主持 近年代表性论著： (1) Qiankun Bai#, Jiale Ma#,*, Ze Zhang, Xiaojun Zhong, Zihao Pan, Yinchu Zhu, Yue Zhang, Zongfu Wu, Guangjin Liu, Huochun Yao*. YSIRK-G/S-directed translocation is required for Streptococcus suis to deliver diverse cell wall anchoring effectors contributing to bacterial pathogenicity, Virulence. 2020, 11(1):1539-1556. (2) Jiale Ma, Zhixin Cheng, Qiankun Bai, Kejie Zhao, Zihao Pan, Huochun Yao*. Screening virulence factors of porcine extraintestinal pathogenic Escherichia coli (an emerging pathotype) required for optimal growth in swine blood, Transboundary and Emerging Diseases. 2020, doi: 10.1111/tbed.13848. (3) Jiale Ma, Xinming Pan, Xiaojun Zhong, Qiankun Bai, Guangjin Liu, Huochun Yao*. Preferential use of carbon central metabolism and anaerobic respiratory chains in porcine extraintestinal pathogenic Escherichia coli during bloodstream infection, Veterinary Microbiology. 2020, 249:108830. (4) Jiale Ma, Ze Zhang, Zihao Pan, Qiankun Bai, Xiaojun Zhong, Yinchu Zhu, Yue Zhang, Zongfu Wu, Guangjin Liu, Huochun Yao*. Streptococcus suis Uptakes Carbohydrate Source from Host Glycoproteins by N-glycans Degradation System for Optimal Survival and Full Virulence during Infection, Pathogens. 2020, 9(5). (5) Zihao Pan, Qian Zhou, Hui Ma, Qianmei Gong, Suchun Wang, Huochun Yao, Jiale Ma*, Kaicheng Wang*. Identification of a novel bacterial taxon associated with bovine mastitis showing a close evolutionary relationship with Elizabethkingia sp. Microbiological Research. 2020, 236:126443. (6) Jiale Ma, Jin Liu, Yue Zhang, Dan Wang, Runxia Liu, Guangjin Liu, Huochun Yao, Zihao Pan*. Bacitracin resistance and enhanced virulence of Streptococcus suis via a novel efflux pump, BMC Veterinary Research. 2019, 15(1):377. (7) Jiale Ma, Xuwang Cai, Yinli Bao, Huochun Yao, Ganwu Li*. Uropathogenic Escherichia coli preferentially utilize metabolites in urine for nucleotide biosynthesis through salvage pathways, International Journal of Medical Microbiology. 2018, 308:990-999. (8) Jiale Ma, Chunxia An, Fengwei Jiang, Huochun Yao, Catherine Logue, Lisa K. Nolan, Ganwu Li*. Extraintestinal Pathogenic Escherichia coli Increase Polysaccharide Biosynthesis for Serum Resistance in Response to Bloodstream Signals, Molecular Microbiology. 2018, 110(5):689-706. (9) Jiale Ma, Min Sun, Zihao Pan, Chengping Lu, Huochun Yao*. Diverse toxic effectors are harbored by vgrG islands for interbacterial antagonism in type VI secretion system, Biochimica et Biophysica Acta-General Subjects. 2018, 1862(7):1635-1643. (10) Jiale Ma, Min Sun, Zihao Pan, Wenchao Song, Chengping Lu, Huochun Yao*. Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli, Emerging Microbes & Infections. 2018, 7(1):1-13. (11) Jiale Ma, Min Sun, Wengyang Dong, Zihao Pan, Chengping Lu, Huochun Yao*. PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems. Environmental Microbiology. 2017, 19(1):345-360. (12) Jiale Ma, Zihao Pan, Jinhu Huang, Min Sun, Chengping Lu, Huochun Yao*. The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems. Virulence. 2017, 8(7):1189-1202. (13) Jiale Ma, Yinli Bao, Min Sun, Wenyang Dong, Zihao Pan, Wei Zhang, Chengping Lu, Huochun Yao*. Functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infection and Immunity. 2014, 82:3867-3879. (14) Jiale Ma, Min Sun, Yinli Bao, Zihao Pan, Wei Zhang, Chengping Lu, Huochun Yao*. Genetic diversity and features analysis of type VI secretion systems loci in avian pathogenic Escherichia coli by wide genomic scanning. Infection Genetics and Evolution. 2013, 20:454-464. (15) Zihao Pan#, Jiale Ma#, Wenyang Dong, Wenchao Song, Kaicheng Wang, Chengping Lu*, Huochun Yao*. Novel variant serotype of Streptococcus suis isolated from piglets with meningitis. Applied and Environmental Microbiology. 2015, 81(3):976-985. (16) Wenyang Dong#, Jiale Ma#, Yinchu Zhu, Jielian Zhu, Lvfeng Yuan, Yanan Wang, Jueqiong Xu, Zihao Pan, Zongfu Wu, Wei Zhang, Chengping Lu, Huochun Yao*. Virulence genotyping and population analysis of Streptococcus suis serotype 2 isolates from China. Infection Genetics and Evolution. 2015, 36:483-489. (17) Min Sun, Jiale Ma, Zeyanqiu Yu, Zihao Pan, Chengping Lu, Huochun Yao*. Identifcation of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from diferent pathways. Veterinary Research. 2017, 48(1):44. (18) Min Sun, Jiale Ma, Yanan Wang, Ming Wang, Wenchao Song, Wei Zhang, Chengping Lu, Huochun Yao*. Genomic and epidemiological characteristics provide new insights into the phylogeographical and spatiotemporal spread of porcine epidemic diarrhea virus in Asia. Journal of Clinical Microbiology. 2015, 53(5): 1484-1492.