姓名：王丽平性别：女
毕业院校：南京农业大学最高学位：博士
办公地址：逸夫楼 2021办公电话：
电子邮箱：wlp71@163.com
研究方向：细菌耐药机制和兽用药物口服吸收机制个人简介：
王丽平，基础兽医系教授，博导。动物药学专业负责人，中国畜牧兽医学会兽医药理学与毒理学分会常务理事，江苏省毒理学会兽医毒理专业委员会委员，中国微生物学会会员。
1997 年兽医药理学及毒理学专业硕士毕业后留校工作至今，2005 年获得博士学位，专业为兽医微生物学与免疫学，2006.9-2007.8 于 Iowa State University
兽医学院做访问学者。2014 年入选江苏省高校“青蓝工程”中青年学术带头人。科研项目：
近几年主持的主要科研项目如下：
1. 国家重点研发计划专项 “畜禽重要病原耐药性检测与控制技术研究”子课题，2016YFD0501309，动物常用药物的生物药剂学分类技术及应用研究， 2016/01-2019/12,在研，主持
2. 国家自然科学基金面上项目，31572567，ICESa2603 家族可移动遗传元件介导猪链球菌 ermB/tetO 基因水平传播的分子机制，2016/01-2019/12，在研，主持
3. 横向课题：不同氟苯尼考制剂在猪体内的药动学比较，2016.9-2016.12，已结题，主持
3. 江苏省高校“青蓝工程”中青年学术带头人，2014/06-2017/05，基础兽医学
4. 江苏省自然基金项目， BK2012771， 介导猪链球菌大环内酯类耐药基因水平传播的可移动基因元件分析， 2012/07-2015/06，已结题、 主持
5. 中央高校基本科研业务费，KYZ201105，介导猪链球菌耐药基因 mefA 和 ermB 水平传播的可移动基因元件分析，2011/08-2014/07，已结题、主持
6. 国家自然科学基金面上项目，30972220，双重外排泵 Mef/Msr 介导猪链球菌对大环内酯类抗生素耐药的分子机制， 2010/01-2012/12，已结题、主持
7. 教育部重点项目，109081，砷制剂选择性压力下空肠弯曲杆菌耐药性及毒力的变异，2009/01-2012/12，已结题、主持
近 5 年代表性论著：
1. Jinhu Huang, Li Chen, Zuowei Wu, Liping Wang*. Retrospective analysis of

genome sequences revealed the wide dissemination of optrA in Gram-positive bacteria.
Journal of Antimicrobial Chemotherapy, 2017, 72(2): 614-616.
2. Huang J, Ma J, Shang K, Hu X, Liang Y, Li D, Wu Z, Dai L, Chen L and Wang L*. Evolution
and Diversity of the Antimicrobial Resistance Associated Mobilome in Streptococcus
suis: A Probable Mobile Genetic Elements Reservoir for Other Streptococci. 2016, Front.
Cell. Infect. Microbiol. 6:118. doi: 10.3389/fcimb.2016.00118
3. Tingting Guo, Jinhu Huang, Hongyu Zhang, Lingling Dong, Dawei Guo, Li Guo, Fang He, Zohaib
Ahmed Bhutto, Liping Wang*. Abcb1 in Pigs: Molecular cloning, tissues distribution,
functional analysis, and its effct on pharmacokinetics of enroflxacin.2016, Sci. Rep. 6, 32244;
doi: 10.1038/srep32244
4. Mengjie Guo, Xiaohua Dai, Dongming Hu, Yu Zhang, Yong Sun, Weilong Ren, Liping Wang*.
Potential Pharmacokinetic effect of rifampicin on enrofloxacin in broilers ： Roles of
P-glycoprotein and BCRP induction by rifampicin. 2016, Poultry Science, 95（9）： 2129-2135
5. Yong Sun, Tingting Guo, Dawei Guo, Li Guo, Li Chen, Yu Zhang, Liping Wang* Establishment and
Characterization of A MDCK Cell Line Stably-Transfected with Chicken Abcb1 Encoding
P-glycoprotein. Research in Veterinary Science 106 (2016) 37-44
6. Huang J, Liang Y, Guo D, Shang K, Ge L, Kashif J and Wang L* Comparative Genomic Analysis
of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable
89K-Subtype ICEs in Swine and Bovine Isolates in China. Front. Microbiol. (2016) 7:55. doi:
10.3389/fmicb.2016.00055
7. Dawei Guo, Dandan Dou, Lin Ge, Zhihai Huang, Liping Wang*, Ning Gu**. A caffeic acid
mediated facile synthesis of silver nanoparticles withpowerful anti-cancer activity.
Colloids and Surfaces B: Biointerfaces, 2015, 134 (2015) 229–234
8. Jinhu Huang, Kexin Shang, JamKashif and LipingWang*. Genetic diversity of
Streptococcus suis isolated from three pig farms of China obtained by acquiring antibiotic
resistance genes. J Sci Food Agric, 2015. DOI 10.1002/jsfa.6841 (1.879)
9. Xiaolu Qian, Shang Kexin, Jam Kashif, Huang Jinhu and Wang Liping*. Dual efflux
pumps satA and satB are associated with ciprofloxacin resistance in Streptococcus suis
isolates. Pak Vet J, 2014, 34(4): 438-443
10. Jie Yao, Kexin Shang, Jinhu Huang, Wei Ran, Jam Kashif, Liping Wang*.

Overexpression of an ABC transporter and mutations of GyrA, GyrB and ParC in contributing to
high-level ciprofloxacin resistance in Streptococcus suis type 2. BioScience Trends 2014,
8(2):84-92
11. Zhangqi Shen, Taradon Luangtongkum, Zhiyi Qiang, Byeonghwa Jeon, Liping Wang, and
Qijing Zhang. Identification of a Novel Membrane Transporter Mediating Resistance to
Organic Arsenic in Campylobacter jejuni. Antimicro Agent and Chemothera, 2014, 58(4):2021-9
12. Mengjie Guo, Yong Sun, Yu Zhang, Shamsuddin Bughio, Xiaohua Dai Weilong Ren, Liping
Wang*. E. coli Infection Modulates the Pharmacokinetics of Oral Enrofloxacin by Targeting
P-Glycoprotein in Small Intestine and CYP450 3A in Liver and Kidney of Broilers.
PLOS ONE, 2014, 9(1): e87781. doi:10.1371/journal.pone.0087781
13. Huang Jinhu, Yingxia Li, Kexin Shang, Jam Kashif1, Xiaolu Qian and Liping Wang*.
Efflux Pump, Methylation and Mutations in the 23S rRNA Genes Contributing to the
Development of Macrolide Resistance in Streptococcus suis Isolated from Infected Human
and Swine in China. Pakistan Veterinary Journal, 2014, 34(1):82-86
14. L. SU, L. DONG, S. BUGHIO, M. GUO, L. WANG*. Effect of colibacillosis or coccidiosis on
expression of breast cancer resistance protein in small intestine and liver of chickens. J. Vet.
Pharmacol. Ther. 2014, 37(1):53-58
15. Guo Mengjie, Shamsuddin Bughio, Sun Yong, Zhangyu, Dong Lingling, Wang Liping*.
Age-related P-glycoprotein expression in the intestine and affecting the pharmacokinetics of
orally administered enrofloxacin in broilers. PLOS ONE, 2013，8(9):e74150.
doi:10.1371/journal.pone.0074150
16. Jam Kashif, Rehana Buriro, Javed Memon, Muhammad Yaqoob, Jamila Soomro,
Diao Dongxue, Huang Jinhu and Wang Liping*. Detection of Class 1 and 2 Integrons,
β-Lactamase Genes and Molecular Characterization of Sulfonamide Resistance in Escherichia
coli Isolates Recovered from Poultry in China. Pak Vet J, 2013, 33(3):321-324
17. Javed Memon, Yongchun Yang, Jam Kashif, Muhammad Yaqoob, Rehana Buriro, Jamila Soomroa, Wang
Liping and Fan Hongjie*. Genotypes, Virulence Factors and Antimicrobial Resistance Genes of
Staphylococcus aureus Isolated in Bovine Subclinical Mastitis from Eastern China. Pak Vet J, 2013,
33(4):486-491
18. Guo Dawei, Wang Liping*, Lu Chengping. In vitro biofilm forming potential of

Streptococcus suis isolated from human and swine in China. Brazilian Journal of Microbiology, 2012,
43 (3):993-1004
19. M. Yaqoob, L. P. Wang, S. Wang, S. Hussain, J. Mamon, J. Kashif and C.-P. Lu. Associations
Between Anti-Microbial Resistance Phenotypes, Anti-Microbial Resistance Genotypes and
Virulence Genes of Escherichia coli Isolates from Pakistan and China. Transboundary and
Emerging Diseases, 2012,60(5): 416-424