姓名：李祥瑞性别：男
毕业院校：河南农学院最高学位：博士
办公地址：逸夫楼 4005
办公电话：84399000
电子邮箱：lixiangrui@njau.edu.cn
研究方向：分子与免疫寄生虫学 兽医公共卫生
个人简介：博士，教授，博士生导师，国务院政府特殊津贴获得者，南京农业大
学“133
重点人才工程”优秀学术带头人。曾任动物医学院副院长、院长。现任全国兽医专业学位研究生教育指导委员会委员兼秘书长，农业部兽药评审专家,全国动物卫生标准化技术委员会委员,中国畜牧兽医学会兽医寄生虫学分会副
理事长，中国兽医协会理事，中国畜牧兽医学会兽医食品卫生分会常务理事,兽医公共卫生分会常务理事，中国动物学会寄生虫学分委员会常务理事，《亚洲兽医病例报告》、《中国兽医师》、《南京农业大学学报》（自然科学
版）、《畜牧与兽医》、
《寄生虫与医学昆虫学报》、《中国兽药杂志》、《中国动物传染病学报》、《动物医学进展》等期刊编委。曾任教育部高等学校动物医学类教学指导委员会委员
（2003-2013），农业部全国动物防疫专家委员会委员，农业部血吸虫病防治专家咨询委员会委员，国家自然基金委员会第十二届、十三届专家评审组成员。
1981.12 河南农学院本科毕业，获学士学位，1988 南京农业大学兽医系获硕士学位，1993 年北京农业大学兽医学院获博士学位。1993~1995
年中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室从事博士后研究。 1996.12~1997.12，韩国国立汉城大学生物系分子遗传实验室从事博士后研究。
2002.7 ~2003.1，去美国麻省大学医学院分子遗传与微生物学系访问，从事基因芯片研究。先后赴英国、丹麦、蒙古等国访问交流。
科研项目：
在研项目
1.鸡艾美耳球虫侵入部位特异性关键分子研究 国家自然基金
2.寄生虫免疫逃避重要分子的鉴定与功能 国家 973 课题
3.鸡球虫树突状细胞刺激性抗原的确定及其应用 国家自然科学基金国际合作与
交流项目 NSFC-PSF(中巴)

已结题项目：
1．禽重要病毒的遗传变异分析 国家攀登计划
2.IBD-白细胞介素-2 复合疫苗的研制 江苏省重点攻关项目 A
3.白细胞介素-2 增强机体免疫力机理研究 教育部回国人员科学基金A
4.畜禽新型高效免疫佐剂和疫苗的产业化 863 计划子课题
5.重组牛、羊白细胞介素-2 下游处理技术的研究和动物区域试验上海市科技兴
农重点攻关项目
6.毛滴虫诊断规程 农业部行业标准
7.禽用抗球虫基因工程疫苗的研究 863 计划
8.捻转血矛线虫半乳糖结合凝集素在免疫和疾病发生中的作用及机理研究 国
家自然基金
9.捻转血矛线虫半胱氨蛋白酶新基因 Hc58 生物学特性研究 国家自然基金
10.鸡球虫猪囊虫病基因工程疫苗研究创制 863 计划子课题
11.捻转血矛线虫排泄分泌抗原蛋白组研究 江苏省自然基金
12.堆型艾美耳球虫免疫功能基因组研究 国家自然基金
13.鸡球虫免疫调节型多价 DNA 疫苗的研制 江苏省科技支撑计划
14.日本血吸虫病、包虫病、弓形虫病、附红细胞体病等重要人畜共患寄生虫病的防控技术研究子课题 农业部行业专项 15.捻转血矛线虫重组
galectin 抑制山羊外周血淋巴细胞细胞因子转录的通路研究 国家自然基金
16.家畜口蹄疫新型疫苗研制与生产工艺创新子课题偶蹄动物用新型免疫佐剂创制与产业化 十二五“863”计划子项目
17.日本血吸虫病、包虫病、弓形虫病、附红细胞体病等重要人畜共患寄生虫病的防控技术研究子课题 农业部行业专项
18.牛毛滴虫病诊断技术 农业部行业标准修订荣誉奖项：
国务院政府特殊津贴获得者 南京农业大学优秀研究生导师
全国兽医专业学位研究生教育先进工作者江苏省优秀硕士学位论文指导教师
大北农科技奖-促进奖

发明专利：
1、李祥瑞, 严若峰, 赵光伟, 徐立新. 用于预防反刍动物捻转血矛线虫病的 DNA
疫苗，ZL 200510124045.0，2008 年 7 月 2 日授权。
2、李祥瑞, 徐前明, 严若峰, 徐立新. 用于预防鸡球虫病的免疫调节型DNA 疫苗，
ZL 200510124048.4 2008 年 7 月 2 日授权。
3、李祥瑞,严若峰, 徐立新, 宋小凯, 张娜. 预防鸡毒害艾美耳球虫的免疫调节型
DNA 疫苗，ZL 200810155080.2，2010 年 12 月 8 日授权。
4、 李祥瑞, 宋小凯, 严若峰, 徐立新. 一种鸡柔嫩艾美耳球虫复合免疫调节型
DNA 疫苗，ZL200710191695.6，2011 年 5 月 4 日授权。
5、李祥瑞, 徐立新, 宋小凯, 严若峰, 宋鸿雁. 预防鸡堆型艾美耳球虫的免疫调节型 DNA 疫苗，ZL200810155079.X，2012 年年 7 月 4 日授权。
6、李祥瑞, 宋小凯, 严若峰, 徐立新, 雷晨昱, 宋鸿雁. 预防鸡巨型艾美耳球虫的免疫调节型 DNA 疫苗，ZL200810234982.5，2012 年 7 月 4 日授权。
7、李祥瑞, 宋小凯, 严若峰, 徐立新, 任喆. 一种鸡艾美耳球虫免疫调节型多价多表位 DNA 疫苗 ，ZL201110307305.3，2014 年 9 月 3 日授权。
8、李祥瑞, 徐立新, 严若峰, 宋小凯, 李锐. 一种用于弓形虫感染的诊断抗原及其制备方法和应用. ZL201310124956.8，2015 年 9 月 16 日授权。
9、李祥瑞, 严若峰, 徐立新, 宋小凯, 高云路. 一种鸡球虫多价重组蛋白亚单位疫苗及其应用. ZL201310273603.4，2015 年 2 月 18 日授权。
近年代表性论著：
1. 李祥瑞主编， 动物寄生虫病彩色图谱，第二版。中国农业出版社，北京,2011年 10 月（国家出版基金项目现代农业科技专著大系）
2. 汪明主编 李祥瑞副主编，兽医大辞典，第二版。中国农业出版社，北京，
2013 年 12 月
3. 李祥瑞 严若峰 徐立新 宋小凯 陈闻，兽医寄生虫学数字课程。高等教育出版社 高等教育电子音像出版社，北京，2016 年 10 月
4. Shuai Wang, Zhenchao Zhang, Yujian Wang, Javaid A. Gadahi, Lixin Xu, Ruofeng Yan,
Xiaokai Song and Xiangrui Li. Toxoplasma gondii Elongation Factor1-Alpha (TgEF-1a) Is
a Novel Vaccine Candidate Antigen against Toxoplasmosis. Frontiers in Microbiology,
2017, 8: Article 168. doi: 10.3389/fmicb.2017.00168

5. Gadahi JA, Wang S, Bo G, Ehsan M, Yan R, Song X, Xu L, Li X. Proteomic
Analysis of the Excretory and Secretory Proteins of Haemonchus contortus (HcESP) Binding
to Goat PBMCs In Vivo Revealed Stage-Specific Binding Profiles. PLoS One. 2016, 11(7):
e0159796.
6. Javaid Ali Gadahi1, Baojie Li, Muhammad Ehsan1, Shuai Wang, Zhenchao Zhang, Yujian
Wang, Muhammad Waqqas Hasan, Ruofeng Yan, Xiaokai Song, Lixin Xu and Xiangrui Li.
Recombinant Haemonchus contortus 24 kDa excretory/ secretory protein (rHcES-24) modulate
the immune functions of goat PBMCs in vitro. Oncotarget, 2016, doi: 10.18632/oncotarget.13487
7. Xiaokai Song, Zeyang Zhang, Chang Liu, Lixin Xu, Ruofeng Yan, Xiangrui Li. Evaluation of
the persistence, integration, histopathology and environmental release of DNA vaccine
encoding Eimeria tenella TA4 and chicken IL-2. Veterinary Parasitology, 2016, 229: 22-30
8. ZhenChao Zhang, XinChao Liu, XinChao Yang, LianRui Liu, Shuai Wang, MingMin Lu,
Mohammad Ehsan, Javaid A. Gadahi, XiaoKai Song, LiXin Xu, RuoFeng Yan & XiangRui Li.
The Molecular Characterization and Immunity Identification of Microneme 3 of Eimeria
acervulina. Journal of Eukaryotic Microbiology 2016, 0, 1–13
9. Javaid Ali Gadahi, Bu Yongqian, Muhammad Ehsan, Zhen Chao Zhang, Shuai WANG, Ruo
Feng Yan, Xiao Kai Song, Li Xin Xu and Xiang Rui Li. Haemonchus contortus
excretory and secretory proteins (HcESPs) suppress functions of goat PBMCs in vitro.
Oncotarget, 2016, 7(24): 35670–35679. doi: 10.18632/oncotarget.9589
10. Yan Li, Cheng Yuan, LiKun Wang, MingMin Lu, YuJian Wang, YuLing Wen, RuoFeng Yan,
LiXin Xu, XiaoKai Song and XiangRui Li. Transmembrane protein 147 (TMEM147): another
partner protein of Haemonchus contortus galectin on the goat peripheral blood mononuclear
cells (PBMC). Parasites & Vectors, 2016, 9:355 DOI 10.1186/s13071-016-1640-0
11. Shuai Wang, YuJian Wang, XiaoNi Sun, ZhenChao Zhang, TingQi Liu, Javaid Ali Gadahi, Ibrahim
Adam Hassan, LiXin Xu, RuoFeng Yan, XiaoKai Song and XiangRui Li. Protective immunity
against acute toxoplasmosis in BALB/c mice

induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1-alpha. BMC
Infectious Diseases (2015) 15:448 DOI
10.1186/s12879-015-1220-5
12. Shuai Wang, Yujian Wang, Xiaoni Sun, Zhenchao Zhang, Tingqi Liu, Javaid Ali Gadahi, Lixin Xu,
Ruofeng Yan, Xiaokai Song, Xiangrui Li. Protective immunity against acute toxoplasmosis in
BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii 10 kDa
excretory–secretory antigen (TgESA10). Veterinary Parasitology, 2015, 214: 40–48
doi:10.1016/j.vetpar.2015.09.016
13. Jingwei Huang, Zhenchao Zhang, Menghui Li, Xiaokai Song, Ruofeng Yan, Lixin Xu &
Xiangrui Li. Immune protection of Microneme 7 (EmMIC7) against Eimeria maxima challenge in
chickens. Avian Pathology, 2015, 44, (5): 392–400 DOI: 10.1080/03079457.2015.1071780
14. Xiaokai Song, Lixin Xu, Ruofeng Yan, Xinmei Huanga, Xiangrui Li.
Construction of Eimeria tenella multi-epitope DNA vaccines and their protective efficacies
against experimental infection. Veterinary Immunology and Immunopathology,
2015, 166:79-87
http://dx.doi.org/10.1016/j.vetimm.2015.05.005
15. Cheng Yuan, Hui Zhang, Wang Wang, Yan Li, RuoFeng Yan, LiXin Xu, XiaoKai Song and XiangRui
Li*.Transmembrane protein 63A is a partner protein of Haemonchus contortus galectin in
the regulation of goat peripheral blood mononuclear cells.
Parasites & Vectors 2015, 8:211 doi:10.1186/s13071-015-0816-3
16. 208. Xiaokai Song, Zhe Ren, Ruofeng Yan, Lixin Xu, Xiangrui Li*. Induction of protective
immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and Eimeria acervulina
infections using multivalent epitope DNA vaccines. Vaccine, 2015, 33: 2764–2770
17. Qing Xie, Julia Klesney-Tait, Kathy Keck, Corey Parlet, Nicholas Borcherding, Ryan Kolb,
Wei Li, Lorraine Tygrett, Thomas Waldschmidt, Alicia Olivier, Songhai Chen, Guang-Hui Liu,
Xiangrui Li1&, Weizhou Zhang. Characterization of a novel mouse model with genetic deletion
of CD177. Protein Cell, 2015, 6(2):117–126 DOI 10.1007/s13238-014-0109-1

18. ZhenChao Zhang, JingWei Huang, MengHui Li, YuXia Sui, Shuai Wang, LianRui Liu, LiXin Xu,
RuoFeng Yan, XiaoKai Song, XiangRui Li*. Identification and molecular characterization of
microneme 5 of Eimeria acervulina. PLOS ONE | DOI:10.1371/journal.pone.0115411 December 22, 2014
19. I. A. HASSAN, S. WANG, L. XU, R. YAN, X. SONG & L. XIANGRUI. Immunological
response and protection of mice immunized with plasmid encoding Toxoplasma gondii
glycolytic enzyme malate dehydrogenase. Parasite Immunology, 2014, 36, 674–683 DOI:
10.1111/pim.12146
20. Ruofeng Yan, Lixin Xu, Jingjing Wang, Xiaokai Song, Xiangrui Li. Cloning and characterization
of aldolase from parasitic nematode Haemonchus contortus. Journal of Animal and Veterinary
Advances, 2013,12(4):478-486
21. C. I. Muleke1, Yan Ruofeng2, Sun Yanming2, I. M. Osuga3, R. S. Shivairo1, Li Xiangrui.
Cellular Immune Response and Abomasum worm burden in Goats Vaccinated with HC58cDNA Vaccine
gainst H. contortus Infection. Advances in Life Science and Technology, 2013，13：26-33
22. Meng Zhang1, Zhen Yang1, Shuai Wang, LongFei Tao, LiXin Xu, RuoFeng Yan,
XiaoKai Song, XiangRui Li. Detection of Toxoplasma gondii in shellfish and fish in parts of China.
Veterinary Parasitology, 2014, 200, 1-2: 85-89
23. Shuai Wang, GuangWei Zhao, Wang Wang, Qing Xie, Meng Zhang, Cheng Yuan, Ibrahim Adam Hassan,
XinChao Liu, LiXin Xu, RuoFeng Yan, XiaoKai Song, and XiangRui Li. Pathogenicity of two
Toxoplasma gondii strains in chickens of different ages infected via intraperitoneal injection.
Avian Pathology, 2014, 43, 1: 1–5
24. Wang Wang, Cheng Yuan, Shuai Wang, XiaoKai Song, LiXin Xu, RuoFeng Yan,
I.A. Hasson, XiangRui Li. Transcriptional and proteomic analysis reveal recombinant
galectins of Haemonchus contortus down-regulated functions of goat PBMC and modulation
of several signaling cascades in vitro. Journal of Proteomics, 2014, 98, 26:123–137
25. Tran Duc Hoan, Doan Thi Thao , Javaid Ali Gadahi, Xiaokai Song, Lixin Xu, Ruofeng
Yan, Xiangrui Li. Analysis of humoral immune response and cytokines in chickens
vaccinated with Eimeria brunetti apical membrane

antigen-1(EbAMA1) DNA vaccine. Experimental Parasitology. 2014,144: 65–72
26. Wang Wang, Shuai Wang, Hui Zhang, Cheng Yuan, RuoFeng Yan, XiaoKai Song, LiXin Xu and
XiangRui Li. Galectin Hco-gal-m from Haemonchus contortus modulates goat monocytes and T cell
function in different patterns. Parasites & Vectors 2014, 7:342
http://www.parasitesandvectors.com/content/7/1/342
27. Ruofeng Yan, Jingjing Wang, Lixin Xu, Xiaokai Song and Xiangrui Li*. DNA vaccine
encoding Haemonchus contortus Actin induces partial protection in Goats. Acta Parasitologica, 2014,
59(4), 698–709 DOI: 10.2478/s11686-014-0298-z
28. Ibrahim A Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song and Xiangrui
Li. DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate
Aldolase (TgDPA) induces partial protective immunity against lethal challenge in
mice. Parasites & Vectors 2014, 7:431
http://www.parasitesandvectors.com/content/7/1/431
29. Yanhui Han, Zhiqiang Fu, Yang Hong, Min Zhang, Hongxiao Han, Ke Lu, Jianmei Yang,
Xiangrui Li?, and Jiaojiao Lin*. Inhibitory Effects and Analysis of RNA Interference on
Thioredoxin Glutathione Reductase Expression in Schistosoma japonicum. J. Parasitol.,
2014,100(4): 463–469
30. Ibrahim A. Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song, XiangRui Li.
Immunoglobulin and cytokine changes induced following immunization with a
DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase
protein. Experimental Parasitology, 2014, 146: 1–10
31. Tang F, Xu L, Yan R, Song X, Li X. A DNA vaccine co-expressing Trichinella spiralis MIF
and MCD-1 with murine ubiquitin induces partial protective immunity in
mice. J Helminthol. 2013, 87:24-33
doi:10.1017/S0022149X1100068X
32. Hongyan Song, Baofeng Qiu, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li . The
protective efficacy of chimeric SO7/IL-2 DNA vaccine against coccidiosis in
chickens. Research in Veterinary Science. 2013, 94: 562–567.
http://dx.doi.org/10.1016/j.rvsc.2012.11.006
33. Tao Lin, Xiangrui Li, Huochun Yao, Zuhang Wei, Runxia Liu, Yu Deng, Shaolun

Zhai, Wenliang Li, Lichang Sun, Jinxue Long, Hongbiao Zhang, Jiaqi Lu and Shishan Yuan.
Phylogenetic Diversity of Classical Swine Fever Virus(CSFV) Field Isolates from Outbreaks in
China Between 2008 and 2011. Asian Journal of Animal and Veterinary Advances, 2013,
8, (3):449-460 DOI: 10.3923/ajava.2013
34. Ruofeng Yan, Wei Sun, Xiaokai Song, Lixin Xu, Xiangrui Li.Vaccination of goats with DNA
vaccine encoding Dim-1 induced partial protection against Haemonchus contortus:
A preliminary experimental study. Res. Vet. Sci. 2013, 95:189–199
http://dx.doi.org/10.1016/j.rvsc.2013.02.020
35. F. Tang, L. Xu, R. Yan, X. Song and X. Li. Evaluation of the immune response induced by DNA
vaccines expressing MIF and MCD1genes of Trichinella spiralis in BALB/c mice. J
Helminthol. 2012, 86:430–439 DOI: 10.1017/S0022149X11000654,
36. GuangWei Zhao, RuoFeng Yan, Charles I. Muleke YanMing Sun, LiXin Xu, XiangRui Li,
Vaccination of goats with DNA vaccines encoding H11 and IL-2 induces partial
protection against Haemonchus contortus infection. The Veterinary Journal, 2012, 191:
94–100
37. Kaikai Han, Lixin Xu, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Molecular cloning,
expression and characterization of enolase from adult Haemonchus contortus. Research in
Veterinary Science, 2012, 92: 259–265
38. GuangWei Zhao, Bo Shen, Qing Xie, Li Xin Xu, Ruo Feng Yan, Xiao Kai Song,
I.A. Hassan, Xiang Rui Li ?Detection of Toxoplasma gondii in free-range chickens
in China based on circulating antigens and antibodies. Veterinary Parasitology, 2012, 18,
572–577 doi:10.1016/j.vetpar.2011.10.031
39. Wei Sun, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li. Cloning and
characterization of a selenium-independent glutathione peroxidase (HC29) from adult
Haemonchus contortus. J Vet Sci, 2012, 13(1), 49-58
40. Han K, Xu L, Yan R, Song X, Li X. Vaccination of goats with
glyceraldehyde-3-phosphate dehydrogenase DNA vaccine induced partial protection
against Haemonchus contortus. Vet Immunol Immunopathol. 2012, 149: 177-185
http://dx.doi.org/10.1016/j.vetimm.2012.06.016

41. Zhu Z, Fu Z, Zhang M, Han Y, Hong Y, Li D, Zhao Z, Shi Y, Li X, Lin J.
Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma
japonicum emulsified with three different adjuvants. Parasite Immunol.2012,
34(6):341-344. doi: 10.1111/j.1365-3024.2012.01357.x.
42. Tao Lin ? Xiangrui Li ? Huochun Yao ? Zuzhang Wei ? Feifei Tan ?Runxia Liu ? Lichang Sun ?
Rong Zhang ? Wenliang Li ? Jiaqi Lu ?Guangzhi Tong ? Shishan Yuan. Use of reverse genetics to
develop a novel marker porcine reproductive and respiratory syndrome virus. Virus
Genes, 2012, 45:548–555 DOI 10.1007/s11262-012-0812-z
43. ZHAO Guang-wei, SHEN Bo, XIE Qing, XU Li-xin, YAN Ruo-feng, SONG Xiao-kai, Hassan
Ibrahim Adam and LI Xiang-rui. Isolation and Molecular Characterization of Toxoplasma
gondii from Chickens in China. Journal of Integrative Agriculture, 2012, 11(8): 1347-1353
44. Huili Zhu, Ruofeng Yan, Song Wang, Xiaokai Song, Lixin Xu, Xiangrui Li.
Identification and molecular characterization of a novel antigen of Eimeria acervulina.
Molecular and Biochemical Parasitology, 2012, 186: 21-28
http://dx.doi.org/10.1016/j.molbiopara.2012.09.002
45. HUILI ZHU, LIXIN XU, RUOFENG YAN, XIAOKAI SONG, FANG TANG, SONG WANG and XIANGRUI LI.
Identification and characterization of a cDNA clone-encoding antigen of Eimeria
acervulina. Parasitology, 2012, 139: 1711–1719. doi:10.1017/S0031182012001163
46. Muhammad Ali A. Shah, Xiaokai Song, Lixin Xu, Ruofeng Yan, Xiangrui Li *, Construction of DNA
vaccines encoding Eimeria acervulina cSZ-2 with chicken IL-2 and IFN-c and their efficacy
against poultry coccidiosis. Research in Veterinary Science, 2011, 90: 72–77
47. Geriletu, Lixin Xu, Xurihua, Xiangrui Li, Vaccination of chickens with DNA vaccine
expressing Eimeria tenella MZ5-7 against coccidiosis. Veterinary Parasitology, 2011,
177: 6–12
48. Liu Wen-xing,1,2 Hu Sen,2 Qiao Zu-jian,2 Chen Wei-ye,2 Liu Lin-tao,2 Wang Fang-kun,2
Hua Rong-hong,2 Bu ZHi-gao,2? and Li Xiang-rui1?, Expression, purification, and improved
antigenic specificity of a truncated recombinant bp26

protein of Brucella melitensis M5-90: a potential antigen for differential
serodiagnosis of brucellosis in ship and goats. Biotechnology and Applied Biochemistry,
2011,58(1): 32-38
49. K. Han, L. Xu, R. Yan, X. Song and X. Li*. Cloning, expression and
characterization of NAD1-dependent glyceraldehyde-3-phosphate dehydrogenase of adult Haemonchus
contortus. Journal of Helminthology, 2011, 85: 421–429
50. Wei Sun, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li ?. Vaccination of
goats with a glutathione peroxidase DNA vaccine induced partial protection against
Haemonchus contortus infection. Veterinary Parasitology, 2011, 182: 239-247
51. Yang Hong, Jinbiao Peng, Weibin Jiang, Zhiqiang Fu , Jinming Liu , Yaojun Shi, Xiangrui
Li *, Jiaojiao Lin*. Proteomic analysis of Schistosoma japonicum schistosomulum proteins
that are differentially expressed among hosts differing in their susceptibility to the
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