姓名：姚火春性别：男 毕业院校：南京农业大学最高学位：博士 办公地址：逸夫楼 4053 办公电话：025-84395328 电子邮箱：yaohch@njau.edu.cn 研究方向：动物及人兽共患疫病病原学、细菌及病毒致病机理、病原与宿主互作关系、动物疾病防控 个人简介： 姚火春：男，1963 年 2 月出生，籍贯浙江湖州研究工作经历： 2009/12-至今，南京农业大学，动物医学院预防兽医系，教授 2006/10-2006/12，德国,Erlangen-Nuernberg 大学，合作科研 2005/11-2006/01，德国,Erlangen-Nuernberg 大学，合作科研 2003/02-2003/05，德国,InWent 研究所，兽医流行病学培训 1997/09-2009/12，南京农业大学，动物医学院预防兽医系，副教授 1992/09-1997/09，江苏省太仓市畜牧兽医站，兽医师、高级兽医师 1987/09-1992/11，南京农业大学，动物医学院预防兽医系，助教、讲师受教育经历： 1999/09-2009/12，南京农业大学，动物医学院预防兽医系，博士 1984/07-1987/08，南京农业大学，兽医系，硕士 1980/08-1984/07，北京农业大学，兽医系，学士 姚火春，现任南京农业大学动物医学院教授，博士生导师，世界动物卫生组织猪链球菌病参考实验室主任、预防兽医学教学实验中心主任。1984 年毕业于北京农业大学兽医系，1987 年于南京农业大学兽医微生物学与免疫学专业硕士毕业， 2009 年 12 月获博士学位。多年来一直从事兽医微生物学与免疫学的教学与科研工作，在兽医微生物的病原学、诊断技术、致病机理及免疫预防等方面具有丰富的经验，作为通讯作者发表 SCI 论文近 30 篇。主讲动物医学本科“兽医微生物学”和研究生的“高级兽医免疫学”等课程，参与建设的“兽医微生物学”被评为国家级精品课程，主持建设的“兽医微生物学”被评为国家级资源共享精品课程。任“江 苏省免疫学会”、“江苏省畜牧兽医学会”、“江苏省禽业协会”和“中国畜牧兽医学会兽医公共卫生分会”理事。 科研项目： (1)国家自然基金面上项目，31372455，应用基因组学和蛋白组学研究禽致病性大肠杆菌 VI 型分泌系统效应因子的作用机制，2014/01-2017/12，85 万元，主持 (2)教育部博士点基金，20130097110019，鼠源 Ptx3 蛋白的真核表达及其对感染猪链球菌 2 型小鼠保护机制的研究，2014/01-2016/12，12 万元，主持 (3)农业部 948 项目，2014-S11，应用于猪链球菌等动物病原保护性抗原筛选的 "En-passent"修饰技术的引进，2014/01-2014/12，60 万元，主持 (4)公益性行业（农业）科研专项，201303041，猪链球菌病防控技术研究， 2013/01-2017/12，1553 万元，首席专家 (5)国家转基因专项，2009ZX08009-1546，猪抗重要病原微生物抗病基因的克隆、鉴定子项目—小鼠抗猪链球菌 2 型基因筛选，2009/01-2010/12，34 万元，主持 (6)公益性行业（农业）科研专项，200803020，猪鸡主要疫病综合免疫技术研究与示范子专题，2008/01-2010/12，246 万元，主持 (7)公益性行业（农业）科研专项，200803016，猪链球菌病生物灾害防控技术研究与示范，2008/01-2010/12，1860 万元，参加 (8)国家自然基金面上项目，30671558，应用绿色荧光蛋白标记研究猪链球菌 2 型感染机制，2007/01-2009/12，26 万元，主持 荣誉奖项： (1)“嗜水气单胞菌毒力因子的研究”，教育部科技进步二等奖（第三完成人）； (2)“猪链球菌病研究与防控技术”，国家科技进步二等奖（第四完成人）。 (3)“猪链球菌病快速诊断与免疫预防及其致病机理研究”江苏省科技进步二等奖（第四完成人）。 (4)“猪链球菌病灭活疫苗（马链球菌兽疫亚种+猪链球菌 2 型）的研制”上海市技术发明二等奖（第四完成人）。 发明专利： (1)姚火春，张炜，潘子豪，胡伟娟，全基因合成鸡 α 干扰素基因及蛋白表达， 2010.12.29，中国，201010125002 (2)姚火春，张炜，潘子豪，胡伟娟，全基因合成鸭 α 干扰素基因及蛋白表达， 2010.10.27，中国，201010125041 (3)姚火春，张炜，潘子豪，胡伟娟，全基因合成犬 α 干扰素基因及蛋白表达， 2010.08.11，中国，201010125025 专著： (1)主编《兽医微生物学实验指导》（第二版）； (2)副主编《动物免疫学》（第二版）； (3)参编《兽医微生物学》第三、四、五版、《现代中国养猪》及《现代实用兽医 词典》。 近年代表性论著：*通讯作者 (1)Xiaojun Zhong, Yue Zhang, Yinchu Zhu, Wenyang Dong, Jiale Ma, Zihao Pan, Shipra Roy, Chengping Lu, Huochun Yao*. The two-component signaling system VraSRSS is critical for multidrug resistance and full virulence inStreptococcus suis serotype 2.Infection and Immunity.2018, Epub ahead of print. (2)Jiale Ma, Min Sun, Zihao Pan, Chengping Lu, Huochun Yao*.Diverse toxic effectors are harbored by vgrG islands for interbacterial antagonism in type VI secretion system, Biochimica et Biophysica Acta-General Subjects.2018,1862(7):1635-1643. (3)Jiale Ma, Min Sun, Zihao Pan, Wenchao Song, Chengping Lu, Huochun Yao*.Three Hcp homologs with divergent extended loop regions exhibit different functions in avian pathogenic Escherichia coli, Emerging Microbes & Infections. 2018, 7(1):1-13. (4)Wenyang Dong, Yinchu Zhu, Ye Ma, Jiale Ma, Yue Zhang, Lvfeng Yuan, Zihao Pan, Zongfu Wu, Huochun Yao*.Multilocus sequence typing and virulence genotyping of Streptococcus suis serotype 9 isolates revealed high genetic and virulence diversity.FEMS Microbiol Lett. 2017, 364(22): 1-8. (5)Jiale Ma, Min Sun, Wengyang Dong, Zihao Pan, Chengping Lu, Huochun Yao*. PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems. Environmental Microbiology. 2017, 19(1):345-360. (6)Jiale Ma, Zihao Pan, Jinhu Huang, Min Sun, Chengping Lu, Huochun Yao*. The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems. Virulence. 2017, 8(7):1189-1202. (7)Min Sun, Zeyanqiu Yu, Jiale Ma, Zihao Pan, Chengping Lu, Huochun Yao*. Down-regulating heat shock protein 27 is involved in porcine epidemic diarrhea virus escaping from host antiviral mechanism. Veterinary Microbiology.2017, 205:6-13. (8)Min Sun, Jiale Ma, Zeyanqiu Yu, Zihao Pan, Chengping Lu, Huochun Yao*. Identifcation of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from diferent pathways.Veterinary Research. 2017, 48(1):44. (9)Yinchu Zhu#, Wenyang Dong#, Jiale Ma, Lvfeng Yuan, Hassan M.A. Hejair, Zihao Pan, Guangjin Liu, Huochun Yao*.Characterization and virulence clustering analysis of extraintestinal pathogenic Escherichia coli isolated from swine in China. BMC Veterinary Research. 2017, 13(1):94. (10)Zihao Pan, Ye Ma, Jiale Ma, Wenyang Dong., Huochun Yao*. Acute meningitis of piglets and mice caused by co-infected with Streptococcus suis and Aerococcus viridans. Microbial Pathogenesis.2017, 106:60-64. (11)Zihao Pan, Jin Liu, Jiale Ma, Qiuli Jin, Huochun Yao*, Nikolaus Osterrieder.The recombinant EHV-1 vector producing CDV hemagglutinin as potential vaccine against canine distemper.Microbial Pathogenesis.2017, 111:388-394. (12)Hassan M.A. Hejair, Yinchu Zhu, Jiale Ma, Yue Zhang, Zihao Pan, Wei Zhang, Huochun Yao*. Functional role of ompF and ompC porins in pathogenesis of avian pathogenic Escherichia coli.Microbial Pathogenesis.2017, 107:29-37. (13)Hassan M.A. Hejair, Jiale Ma, Yingchu Zhu, Min Sun, Wenyang Dong, Yue Zhang, Zihao Pan,Wei Zhang,Huochun Yao*. Role of outer membrane protein T in pathogenicity of avian pathogenic Escherichiacoli.Research in Veterinary Science.2017, 115:109-116. (14)Zihao Pan#, Jiale Ma#, Wenyang Dong, Wenchao Song, Kaicheng Wang, Chengping Lu*, Huochun Yao*. Novel variant serotype of Streptococcus suis isolated from piglets with meningitis.Applied and Environmental Microbiology. 2015, 81(3):976-985. (15)Min Sun, Jiale Ma, Yanan Wang, Ming Wang, Wenchao Song, Wei Zhang, Chengping Lu, Huochun Yao*. Genomic and epidemiological characteristics provide new insights into the phylogeographical and spatiotemporal spread of porcine epidemic diarrhea virus in Asia. Journal of Clinical Microbiology. 2015, 53(5): 1484-1492. (16)Wenyang Dong#, Jiale Ma#, Yinchu Zhu, Jielian Zhu, Lvfeng Yuan, Yanan Wang, Jueqiong Xu, Zihao Pan, Zongfu Wu, Wei Zhang, Chengping Lu, Huochun Yao*. Virulence genotyping and population analysis of Streptococcus suis serotype 2 isolates from China. Infection Genetics and Evolution.2015, 36:483-489. (17)Jueqiong Xu, Yanjuan Mu, Yue Zhang, Wenyang Dong, Yinchu Zhu,Jiale Ma, Wenchao Song, Zihao Pan, Chengping Lu, Huochun Yao*. Antibacterial effect of porcine PTX3 against Streptococcus suis type 2 infection. Microbial Pathogenesis.2015, 89: 128-139. (18)Hongying Jia, Wenyang Dong, Lvfeng Yuan, Jiale Ma, Qinqin Bai, Zihao Pan, Chengping Lu, Huochun Yao*.Characterization and complete genome sequence analysis of Staphylococcus aureus bacteriophage JS01. Virus Genes. 2015, 50(2):345-8. (19)Jiale Ma, Yinli Bao, Min Sun, Wenyang Dong, Zihao Pan, Wei Zhang, Chengping Lu, Huochun Yao*. Functional type VI secretion systems in avian pathogenic Escherichia coli are involved in different pathogenic pathways. Infection and Immunity.2014, 82:3867-3879. (20)Jiale Ma, Min Sun, Yinli Bao, Zihao Pan, Wei Zhang, Chengping Lu, Huochun Yao*. Genetic diversity and features analysis of type VI secretion systems loci in avian pathogenic Escherichia coli by wide genomic scanning. Infection Genetics and Evolution.2013, 20:454-464. (21)Jia Hongying, Bai Qinqin, Yang Yongchun, Huochun Yao*.Complete Genome Sequence of Staphylococcus aureus SiphovirusPhage JS01. Genome Announcements.2013, 1(6): e00797-13 (22)Tao Chen, Qin Huang, Zhaolong Li, Wei Zhang, Chengping Lu, Huochun Yao*. Constructionand Characterization of aStreptococcussuis Serotype 2 RecombinantExpressing EnhancedGreen Fluorescent Protein. PLoS one. 2012, 7(7):1-10. (23)Jie Rong, Wei Zhang, Xiaohui Wang, Hongjie Fan, Chengping Lu, Huochun Yao*. Identification of Candidate Susceptibility and Resistance Genes of Mice Infected with Streptococcus suis Type 2. PLoS one, 2012, 7(2), 1-12. (24)Lei Wu, Ya-nan Jiang, Qian Tang, Hui-xing Lin, Cheng-ping Lu, Huo-chun Yao*. Development of an Aeromonas hydrophila recombinant extracellular proteasevaccine.Microbial Pathogenesis.2012,53:183-188. (25)Wei Zhang, Jing Shao, Guangjin Liu, Fang Tang, Yan Lu, Zhipeng Zhai, Yang Wang, Zongfu Wu, Huochun Yao*and Chengping Lu. Immunoproteomic analysis of bacterial proteins of Actinobacillus pleuropneumoniae serotype 1.Proteome Science. 2011, 9:32, 1-11.