姓名：吴蕾性别：女
毕业院校：Oklahoma State University
最高学位：博士
办公地址：逸夫楼 3022
电子邮箱：leiwu@njau.edu.cn
研究方向：肠道微生物与慢性病发病机制研究

个人简介：
2008-2013：南京农业大学 -动物医学专业 -农学学士
2013-2015：Oklahoma State University -Nutritional Science -MS 2015-2018：Oklahoma State
University -Nutritional Science -PhD

科研项目：荣誉奖项：
北美华人营养学会优秀研究生俄克拉荷马州立大学优秀博士美国营养学会优秀研究生

发明专利：

近年代表性论著：
第一作者及共同第一作者已发表论文

1. Yi Lyu*, Lei Wu*, Fang Wang, Xinchun Shen and Dingbo Lin. Carotenoid
supplementation and retinoic acid in immunoglobulin A regulation of the gut
microbiota dysbiosis. Experimental Biology and Medicine. 2018; DOI: 10.1177/1535370218763760。

2. Lei Wu, Xin Guo, Yi Lyu, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith,
Deana Hildebrand, Weiqun Wang, Denis M. Medeiros, Xinchun Shen, Dingbo Lin.
Targeted metabolomics reveals abnormal hepatic energy metabolism by depletion of
β-Carotene oxygenase 2 in mice. Scientific Reports. 2017 Nov; doi:10.1038/s41598-017-15222-x.

3. Xin Guo*, Lei Wu*, Yi Lyu, Winyoo Chowanadisai, Stephen L. Clarke, Edralin A. Lucas, Brenda
J. Smith, Hui He, Weiqun Wang, Denis M Medeiros, Dingbo Lin. Ablation of β, β-carotene -9’,
10’-oxygenase 2 remodels the hypothalamic metabolome leading to metabolic disorders in mice.
Journal of Nutritional Biochemistry. 2017 Apr; 12(46):74-82.

4. Lei Wu, Xin Guo, Steven Hartson, Abby Davis, Hui He, Denis M Medeiros, Weiqun
Wang, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith, Johannes von Lintig, Dingbo Lin. Lack
of β,β-carotene -9’, 10’-oxygenase leads to hepatic mitochondrial dysfunction and cellular
oxidative stress in mice. Molecular Nutrition and Food Research. 2017 May;61(5).

5. Lei Wu, Xin Guo, Wenqun Wang, Denis M Medeiros, Stephen L Clarke, Edralin A
Lucas, Brenda J Smith, Dingbo Lin. Molecular aspects of β, β-carotene-9’, 10’-oxygenase
2 in carotenoid metabolism and diseases. Experimental Biology and Medicine. 2016 Nov;
241 (17) :1879-1887.

6. Lei Wu, Ya-nan Jiang, Qian Tang, Hui-xing Lin, Cheng-ping Lu, Huo-chun
Yao. Development of an Aeromonas hydrophila recombinant extracellular protease
vaccine.Microbial Pathogenesis. 2012 Nov-Dec; 53(5-6):183-8.

合作发表的论文：

1. Jennifer L Graef, Elizabeth Rendina-Ruedy, Erica K Crockett, Ping Ouyang, Lei Wu, Jarrod B
King, Robert H Cichewicz, Dingbo Lin, Edralin A Lucas and Brenda J Smith. Osteoclast
Differentiation is Downregulated by Select Polyphenolic Fractions from Dried Plum via
Suppression of MAPKs and Nfatc1 in Mouse C57BL/6 Primary Bone Marrow Cells. Current Developments
in Nutrition. 2017 September, cdn.117.000406.

2. Babajide Ojo, Ashley J. Simenson, Crystal O’Hara, Lei Wu, Xin Gou, Sandra K.
Peterson, Daniel Lin, Brenda J. Smith and Edralin A. Lucas. Wheat germ supplementation
alleviates insulin resistance and cardiac mitochondrial dysfunction in an animal model of
diet-induced obesity. British Journal of Nutrition. 2017 Aug;118(4):241-249. (IF2017=3.657)

3. Xin Guo, Lei Wu, Weiqun Wang, Denis M Medeiros, Stephen Clarke, Edralin Lucas, Brenda J
Smith, Winyoo Chowanadisai, Dingbo Lin. Hypothalamic mitochondria in energy
homeostasis and obesity. Integrative Molecular Medicine. 2016. 3(2):590-599.

4. Xueyan Fu, Yu Huang, Xiaolan Kang, Tingting Li, Xin Jia, LinDong，Lei Wu, Dingbo Lin. The
wolfberry bud tea has enhanced antioxidant activities. Austin Journal of Nutrition and Food
Science. 2014. 2(3):5.