姓名：吴 宗 福 出生日期：1981.08籍贯：福建古田
单位：南京农业大学
职称：教 授、博士生导师
联系方式：
电话：025-84398606

Email: wuzongfu@njau.edu.cn
研究方向：猪链球菌等动物细菌性病原致病机理与疫苗研制


教育背景和工作履历：
1999.09-2003.07 福建农林大学 动物科学 本科
2003.09-2006.07 福建农林大学 临床兽医学 硕士
2006.09-2009.06 南京农业大学 预防兽医学 博士
导师 陆承平教授，从事猪链球菌致病机制及疫苗研制
2009.06-2011.12 南京农业大学动物医学院 讲师
2010.01-2011.02 法国巴斯德研究所 博士后
Pascale Cossart 教授实验室，从事单增李斯特菌小 RNA 调控细菌毒力研究
2012.01-2017.12 南京农业大学动物医学院 副教授
2014.09-2015.09 法国国家科学研究中心 访问学者
Pascale Romby 博士实验室，从事金黄色葡萄球菌小 RNA 调控细菌毒力研究
2018.01-至今 南京农业大学动物医学院 教授


代表性著作、专利（*表示通讯作者）：
1. 《猪链球菌病》，陆承平、吴宗福 主编，北京：中国农业出版社，2015.11

2. 国家发明专利：专利名称“ 制备猪链球菌 GZ0565 株无痕缺失突变株的
方法”(专利号 ZL201210467416.5)；发明人：吴宗福、邵靓、琚存祥、王卫雪、唐敏、陆承平
3. Jinhu Huang, Xi Liu, Hao Chen, Li Chen, Xueping Gao, Zihao Pan, Jian Wang, Chengping Lu,
Huochun Yao, Liping Wang*, Zongfu Wu*. Identification of six novel capsular polysaccharide loci
(NCL) from Streptococcus suis multidrug resistant non-typeable strains and the pathogenic
characteristic of strains carrying new NCLs. Transboundary and Emerging Diseases, 2019, 66:
995–1003.
4. Jiao Dai, Liying Lai, Huanyu Tang, Weixue Wang, Shuoyue Wang, Chengping Lu, Huochun Yao,
Hongjie Fan, Zongfu Wu*. Streptococcus suis synthesizes deoxyadenosine and adenosine
by 5’-nucleotidase to dampen host immune responses. Virulence, 2018, 9(1): 1509-1520.
5. Shouming Zhang, Xueping Gao, Genhui Xiao, Chengping Lu, Huochun Yao, Hongjie Fan,
Zongfu Wu*. Intracranial Subarachnoidal Route of Infection for Investigating Roles of
Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model. Journal of Visualized
Experiments, 2018 (137), e57658.
6. Liying Lai, Jiao Dai, Huanyu Tang, Shouming Zhang, Chunyan Wu, Wancen Qiu, Chengping Lu,
Huochun Yao, Hongjie Fan, Zongfu Wu*. Streptococcus suis serotype 9 strain GZ0565 contains a
type VII secretion system putative substrate EsxA that contributes to bacterial virulence and
a vanZ-like gene that confers resistance to teicoplanin and dalbavancin in Streptococcus
agalactiae, Veterinary Microbiology, 2017, 205:26-33.
7. Genhui Xiao, Huanyu Tang, Shouming Zhang, Haiyan Ren, Jiao Dai, Liying Lai, Chengping Lu,
Huochun Yao, Hongjie Fan, Zongfu Wu*. Streptococcus suis small RNA rss04 contributes to the
induction of meningitis by regulating capsule synthesis and by inducing biofilm formation in
a mouse infection model. Veterinary Microbiology, 2017, 199: 111-119.
8. 唐欢宇，任海燕，吴宗福*，陆承平. DNA核酸酶与猪链球菌9型毒力的关系
.微生物学报. 2017, 57(4): 1-10.

9. Zongfu Wu, Jing Shao, Haiyan Ren, Huanyu Tang, Mingyao Zhou, Jiao Dai, Liying Lai,
Huochun Yao, Hongjie Fan, Dai Chen, Jie Zong, Chengping Lu. A Streptococcus suis LysM domain
surface protein contributes to bacterial virulence. Veterinary Microbiology, 2016, 187: 64-69.
10. Zongfu Wu, Chunyan Wu, Jing Shao, Zhenzhen Zhu, Weixue Wang, Wenwei Zhang, Min Tang, Na Pei,
Hongjie Fan, Jiguang Li, Huochun Yao, Hongwei Gu, Xun Xu, Chengping Lu. The Streptococcus suis
transcriptional landscape reveals adaptation mechanisms in pig blood and cerebrospinal
fluid. RNA, 2014, 20(6):882-898.
11. Zongfu Wu, Weixue Wang, Min Tang, Jing Shao, Chen Dai, Wei Zhang, Hongjie Fan, Huochun
Yao, Jie Zong, Dai Chen, Junning Wang, Chengping Lu. Comparative genomic analysis
shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105K genomic island.
Gene, 2014, 535(2):156-164.
12. Zongfu Wu, Wei Zhang, Yang Wang, Yan Lu, Chengping Lu. Identification of Antigens Common to
Streptococcus suis Serotypes 2 and 9 by Immunoproteomic Analysis. Journal of Integrative
Agriculture, 2012, 11(9):1517-1527.
13. Zongfu Wu, Wei Zhang, Jing Shao, Yang Wang, Yan Lu, Chengping Lu. Immunoproteomic assay of
secreted proteins of Streptococcus suis serotype 9 with convalescent sera from pigs. Folia
microbiologica, 2011, 56(5): 423-430.
14. Zongfu Wu, Wei Zhang, Yan Lu, Chengping Lu. Transcriptome profiling of zebrafish due to
Streptococcus suis infection. Microbial Pathogenesis, 2010, 48(5):178-187.
15. Zongfu Wu, Wei Zhang, Chengping Lu. Comparative proteome analysis of secreted
proteins of Streptococcus suis serotype 9 isolates from diseased and healthy pigs.
Microbial Pathogenesis, 2008, 45(3): 159-166.
16. Zongfu Wu, Wei Zhang, Chengping Lu. Immunoproteomic assay of surface proteins of
Streptococcus suis serotype 9. FEMS Immunology and Medical Microbiology, 2008, 53(1): 52-59.
17. Zihao Pan, Jin Liu, Yue Zhang, Shenshen Chen, Jiale Ma, Wenyang Dong,

Zongfu Wu, Huochun Yao. A novel integrative conjugative element mediates transfer of multi-drug
resistance between Streptococcus suis strains of different serotypes. Veterinary Microbiology,
2019, 229: 110-116.
18. Genhui Xiao, Zongfu Wu, Shouming Zhang, Huanyu Tang, Fengqiu Wang, Jiao Dai, Chengping Lu.
Mac Protein is not an Essential Virulence Factor for the Virulent Reference Strain
Streptococcus suis P1/7. Current Microbiology, 2017, 74 (1): 90-96.
19. Wenyang Dong, Yinchu Zhu, Ye Ma, Jiale Ma, Yue Zhang, Lvfeng Yuan, Zihao
Pan, Zongfu Wu, Huochun Yao. Multilocus sequence typing and virulence genotyping of
Streptococcus suis serotype 9 isolates revealed high genetic and virulence diversity. FEMS
Microbiology Letters, 2017, 364 (22): fnx192.
20. Delphine Bronesky, Zongfu Wu, Stefano Marzi, Philippe Walter, Thomas Geissmann, Karen
Moreau, Fran?ois Vandenesch, Isabelle Caldelari, Pascale Romby. Staphylococcus aureus RNAIII
and Its Regulon Link Quorum Sensing, Stress Responses, Metabolic Adaptation, and Regulation
of Virulence Gene Expression. Annual Review of Microbiology, 2016, 70: 299-316.
21. Pierre Fechter, Delphine Parmentier, Zongfu Wu, Olivier Fuchsbauer, Pascale Romby, Stefano
Marzi. Traditional Chemical Mapping of RNA Structure In Vitro and In Vivo. Methods in Molecular
Biology, 2016, 1490: 83-103.
22. Xiangkai Zhuge, Fang Tang, Hongfei Zhu, Xiang Mao, Shaohui Wang, Zongfu Wu, Chengping Lu,
Jianjun Dai, Hongjie Fan. AutA and AutR, Two Novel Global Transcriptional Regulators,
Facilitate Avian Pathogenic Escherichia coli Infection. Scientific Reports, 2016, 6: 25085
23. Sandeep Kumar Misra, Francine Moussan Désirée Aké, Zongfu Wu, Eliane Milohanic,
Thanh Nguyen Cao, Pascale Cossart, Josef Deutscher, Véronique Monnet, Cristel Archambaud,
Céline Henry . Quantitative Proteome Analyses Identify PrfA-Responsive Proteins and
Phosphoproteins in Listeria monocytogenes. Journal of Proteome Research, 2014,
13(12):6046-6057.

24. Jing Shao, Wei Zhang, Zongfu Wu, Chengping Lu. The Truncated Major Pilin Subunit Sbp2 of the
srtBCD Pilus Cluster Still Contributes to Streptococcus suis Pathogenesis in the Absence of
Pilus Shaft. Current microbiology, 2014, 69(5):703-707.
25. Christophe Bécavin, Christiane Bouchier, Pierre Lechat, Cristel Archambaud, Sophie
Creno, Edith Gouin, Zongfu Wu, Andreas Kühbacher, Sylvain Brisse, M. Graciela Pucciarelli,
Francisco García -del Portillo, Torsten Hain, Daniel A. Portnoy, Trinad Chakraborty, Marc
Lecuit, Javier Pizarro-Cerdá, Ivan Moszer, Hélène Bierne, Pascale Cossart. Comparison
of widely used Listeria monocytogenes strains EGD, 10403S, and EGD-e highlights genomic
variations underlying differences in pathogenicity. mBio, 2014, 5(2):e00969-00914.
26. Yang Wang, Li Yi, Zongfu Wu, Jing Shao, Guangjin Liu, Hongjie Fan, Wei Zhang,
Chengping Lu. Comparative proteomic analysis of Streptococcus suis biofilms and
planktonic cells that identified biofilm infection-related immunogenic proteins.
PLoS One, 2012, 7(4):e33371.
27. Haodan Zhu, Dongyan Huang, Wei Zhang, Zongfu Wu, Yan Lu, Hongying Jia, Ming Wang,
Chengping Lu. The novel virulence-related gene stp of Streptococcus suis serotype 9
strain contributes to a significant reduction in mouse mortality. Microbial Pathogenesis, 2011,
51(6):442-53.
28. Yang Wang, Wei Zhang, Zongfu Wu, Chengping Lu.Reduced virulence is an important
characteristic of biofilm infection of Streptococcus suis. FEMS microbiology letters,
2011, 316(1): 36-43.
29. Yang Wang, Wei Zhang, Zongfu Wu, Xianglei Zhu, Chengping Lu.Functional analysis of luxS in
Streptococcus suis reveals a key role in biofilm formation and virulence. Veterinary
microbiology, 2011, 152 (1-2): 151-160.


科研项目（负责人）：
1. 科技部 2018 年度“中法杰出青年科研人员交流计划”，农业领域（国科外函[2018]17）

2. 主持 国家自然科学基金面上项目 “双功能小 RNA rss03 促进猪链球菌在猪血
中存活的分子机制” （2019.01-2022.12）（No. 31872469）
3. 主持 南京农业大学中央高校基本科研业务费“猪链球菌 RNA 结合蛋白的鉴定及其调控细菌毒力机制”（2018.01-2018.12）（No. KYZ201847）
4. 子课题负责人 国家重点研发计划“畜禽重要疫病病原学与流行病学研究”子课题“猪链球菌病原学与流行病原研究”（2017.07-2020.12）（No.
2017YFD0500102）
5. 主持 家畜疫病病原生物学国家重点实验室开放课题 “猪链球菌小 RNA rss06 调控细菌毒力的分子机制”（2017.07-2019.07）（No. SKLVEB2016KFKT005）
6. 主持 国家自然科学基金面上项目 “猪链球菌小 RNA rss04 促进脑膜炎形成的分子机制” （2016.01-2019.12）（No. 31572544）
7. 主持 国家青年科学基金“LysM 结构蛋白在猪链球菌 9 型脑膜炎分离株中的分子致病机制” （2012.1-2014.12） (No.31101828)
8. 主持 教育部留学回国人员科研启动基金 “DNA 核酸酶在猪链球菌 9 型脑膜炎分离株中的分子致病 机制” （2013.05-2015.05）（教外司留[2013]693）
9. 主持 江苏省自然科学基金“丝氨酸裂解酶等胞外酶在猪链球菌 9 型脑膜炎分离株中的分子致病机理” （2011.7-2014.6）(No.BK2011644)
10. 主持 教育部 2011 年度高等学校博士学科点专项科研基金——新教师类“5’-核苷酸酶在猪链球菌 9 型脑膜炎分离株中的分子致病机制”（2012.1-
2014.12）(No. 20110097120016)
11. 主持 南京农业大学基本科研业务费专项基金 “猪链球菌 Mac-1 结构蛋白抗吞噬对致病力的影响”（2013.5-2016.5）（No.KYZ201314）
12. 主持 南京农业大学青年科学基金“核苷酸酶等胞外酶在猪链球菌 9 型脑膜炎分离株中的分子致病机理” （2011.7-2013.6）(No.KJ2011012)


邀请报告
1. 2019.06.04，加拿大蒙特利尔，第四届猪链球菌国际研讨会，报告题目“The competitive advantage of Streptococcus suis novel
capsular polysaccharide locus

(NCL) 4 strain WUSS351 and the identification of six new NCLs of S. suis”
2. 2018.11.26，法国斯特拉斯堡，法国国家科学研究中心 RNA 结构与反应研究所，报告题目“Roles of small RNAs and novel surface proteins
in Streptococcus suis virulence”
3. 2018.04.13，上海，第九届长三角预防兽医学博士论坛，报告题目“猪链球菌新的毒力调控因子——小 RNA”
4. 2016.09.08 ， 德国布伦瑞克， 第三届猪链球菌国际研讨会， 报告题目 “Streptococcus suis Small RNA rss04 Contributes to
Meningitis in Mouse Infection Model”
5. 2011.11.12，江苏徐州，江苏省微生物学会，报告题目“应用免疫蛋白组学方法鉴定猪链球菌 2 型与 9 型共同抗原”
6. 2009.03.29，法国巴黎 巴斯德研究所，报告题目“Identifying Immunogenic Proteins and Revealing Putative
Virulence-associated Factors of Streptococcus suis Serotype 9”


荣誉及奖项：
1. 南京农业大学动物医学院 2017 年度先进工作者
2. 南京农业大学动物医学院 2015 年“勃林格殷格翰”奖教金
3. 2013 年第五届欧洲微生物学会青年科学家会议资助奖（中国唯一获奖人）
4. 江苏省微生物学会 2011 年会暨青年学术报告会优秀论文
5. 南京农业大学动物医学院 2011 年获“生泰尔”奖教金