姓名YongsamJung性别M出生日期籍贯SouthKorea毕业院校PaiChaiUniversity,SouthKorea研究方向:Posttranslationalmodificationsmodulateproteinfunctionandhaveaubiquitousroleinadiverserangeofcellularfunctions.Identification,characterization,andmappingofthesemodificationstospecificaminoacidresiduesonproteinsarecriticaltowardsunderstandingtheirfunctionalsignificanceinabiologicalcontext.MystudywasfocusedonDNApolymeraseeta(PolH)whichisimportantforDNArepair.OurgroupwasthefirsttodiscoveranovelmechanismwhichisresponsibleforthefunctionalswitchingofPolHprotein.Mostinterestingly,wefoundthatubiquitination-deadPolHmutantsmimicthemodeofaction/interactionofPolHwithPirh2E3ubiquitinligase.

Ubiquitin/ubiquitin-likemodificationsplayanimportantroleintheregulationofmanycellularpathways,includingproteinstability,cellcycle,transcription,DNArepairandantiviralimmunity.Consequently,manyviruseshaveevolvedstrategiestoutilizeorsuppressubiquitinandubiquitin-likepathwaysduringinfectioninordertoenhancetheirreplication.

Currently,myresearchaimstodefinehowpathogenicvirusesengagewiththesemodificationpathwayswithrespecttocellularantiviralimmunity,bothatthemolecularandbiochemicallevels,inordertodevelopnovelavenuesforfuturepreventiveandtherapeuticintervention.
个人简历:Ph.D.,Professor
2001–2005PaiChaiUniversity,GeneticEngineering(Ph.D.)
2005–2007InstituteofBiotechnologyatChungnamNationalUniversity,Researcher
2007–2013UniversityofCaliforniaatDavis,VeterinaryMedicine,PostdoctoralScholar
2013–presentNanjingAgriculturalUniveristy,PreventiveVeterinaryMedicine,Professor

代表性论著:1stAuthorResearchArticles:
1.JungYS,QianY,YanW,andChenX.Pirh2E3ubiquitinligasemodulateskeratinocytedifferentiationthroughp63.JInvestiDermatol2013;133,1178-1187.(*Top1inthedermatologyfield).

2.QianY*,JungYS*,andChenX.DEC1controlstheresponseofp53-dependentcellsurvivalversuscelldeathtoastresssignalthroughmacrophageinhibitorycytokine-1.ProcNatlAcadSciUSA2012;109,11300-11305.(*Theseauthorscontributedequallytothework).

3.JungYS,QianY,andChenX.DNApolymeraseetaistargetedbyMdm2forpolyubiquitinationandproteasomaldegradationinresponsetoultravioletirradiation.DNARepair(Amst)2011;11(2),177-184.

4.JungYS,QianY,andChenX.Thep73tumorsuppressoristargetedbyPirh2RINGfingerE3ubiquitinligasefortheproteasome-dependentdegradation.JBiolChem2011;286,35388-35395.

5.JungYS,HakemA,HakemR,andChenX.Pirh2E3ubiquitinligasemonoubiquitinatesDNApolymeraseetatosuppresstranslesionDNAsynthesis.MolCellBiol2011;31,3997-4006.

6.JungYS,LiuG,andChenX.Pirh2E3ubiquitinligasetargetsDNApolymeraseetafor20Sproteasomaldegradation.MolCellBiol2010;30,1041-1048.

7.JungYS,KimHY,LeeMG,PouyssegurJ,andKimE.PhysicalinteractionandfunctionalcouplingbetweenDaxxandsodiumhydrogenexchangerisoform1,animplicationregardingDaxxroleinischemicstress-inducedcelldeath.JBiolChem2008;283,1018-1025.

8.JungYS,KimHY,LeeYJ,andKimE.SubcellularlocalizationofDaxxdeterminesitsopposingfunctionsinischemiccelldeath.FEBSLett2007;581,843-852.

9.JungYS,LeeDH,LimH,YiKY,YooSE,andKimE.KR-31378protectscardiacH9c2cellsfromchemicalhypoxia-inducedcelldeathviainhibitionofJNK/p38MAPKactivation.JpnJphysiol2004;54,575-583.

10.JungYS,JungYS,KimMY,andKimE.Identificationofcaspase-independentPKCε-JNK/p38MAPKsignalingmoduleinresponsetometabolicinhibitioninH9c2cells.JpnJphysiol2004;54,23-29.

11.JungYS,Kim,KS,Kim,KD,Lim,JS,Kim,JW,andKim,E.Apoptosis-linkedgene2bindstothedeathdomainofFasanddissociatesfromFasduringFas-mediatedapoptosisinJurkatcells.BiochemBiophysResCommun2001;288,420-426.

CollaboratedResearchArticles:
1.ChoSJ,JungYS,andChenX.Poly(C)-BindingProtein1Regulatesp63ExpressionthroughmRNAStability.PLoSOne2013;8,e71724.

2.ZhangY,YanW,JungYS,andChenX.PUMACooperateswithp21toRegulateMammaryEpithelialMorphogenesisandEpithelial-To-MesenchymalTransition.PLoSOne2013;8,e66464.

3.ChoSJ,RossiA,JungYS,YanW,LiuG,ZhangJ,ZhangM,andChenX.Ninjurin1,atargetofp53,regulatesp53expressionandp53-dependentcellsurvival,senescence,andradiation-inducedmortality.ProcNatlAcadSciUSA2013;110,9362-9367.

4.YanW,ChenX,ZhangY,ZhangJ,JungYS,andChenX.ArsenicsuppressescellsurvivalviaPirh2-mediatedproteasomaldegradationofΔNp63protein.JBiolChem2013;288,2907-2913.

5.YanW,ZhangJ,ZhangY,JungYS,andChenX.P73expressionisregulatedbyRNPC1,atargetofthep53family,viamRNAstability.MolCellBiol.2012;32,2336-2348.

6.ZhangY,YanW,JungYS,andChenX.Mammaryepithelialcellpolarityisdifferentiallyregulatedbyp73isoformsviaepithelial-to-mesenchymaltransition.JBiolChem2012;287(21),17746-17753.

7.ChoSJ,JungYS,ZhangJ,andChenX.TheRNA-bindingProteinRNPC1StabilizesthemRNAEncodingtheRNA-bindingProteinHuRandCooperateswithHuRtoSuppressCellProliferation.JBiolChem2012;287(18),14535-14544.

8.HakemA,BohgakiM,LemmersB,TaiE,SalmenaL,Matysiak-ZablockiE,JungYS,KaraskovaJ,KaustovL,DuanS,MadoreJ,BoutrosP,ShengY,ChesiM,BergsagelPL,Perez-OrdonezB,Mes-MassonAM,PennL,SquireJ,ChenX,JurisicaI,ArrowsmithC,SanchezO,BenchimolS,andHakemR.RoleofPirh2inMediatingtheRegulationofp53andc-Myc.PLoSGenet2011;11,e1002360.

9.QianY,JungYS,andChenX.DeltaNp63,atargetofDEC1andhistonedeacetylase2,modulatestheefficacyofhistonedeacetylaseinhibitorsingrowthsuppressionandkeratinocytedifferentiation.JBiolChem2011;286,12033-12041.

10.HwangIS,JungYS,andKimE.InteractionofALG-2withASK1influencesASK1localizationandsubsequentJNKactivation.FEBSLett2002;529,183-187.

11.KimES,YooSE,YiKY,LeeS,NohJS,JungYS,KimE,andJeongN.Design,SynthesesandBiologicalEvaluationsofNonpeptidicCaspase3Inhibitors.BullKoreanChemSoc2002;23,1003-1010.

12.ChoSJ,LeeNS,JungYS,LeeH,LeeKJ,KimE,andChaeSK.IdentificationofstructuraldomainsaffectingtransactivationpotentialofNm23.BiochemBiophysResCommun2001;289,738-743.

InvitedReviewArticles:
1.QianY,JungYS,andChenX.DEC1andMIC-1:newplayersofp53-dependentcellfatedecision.2012Cellcycle2012;11,3525-3526.

2.JungYS,QianY,andChenX.Pirh2RING-fingerE3ubiquitinligase:itsroleintumorigenesisandcancertherapy.FEBSLett2012;586,1397-1402.

3.JungYS,QianY,andChenX.Examinationoftheexpandingpathwaysfortheregulationofp21expressionandactivity.CellSignal2010;22,1003-1012.

IssuedPatents:
1.JungYS,KimE,KimNJ,LeeYS,SuhJH,SuhKimHY,YiKY,andYooSE.Aminopyrazolederivatives,processforthepreparationthereof,andcompositionforpreventingortreatingischemicdiseasescontainingthesame.2011,Canada,266975.

2.JungYS,KimE,KimNJ,LeeYS,SuhJH,SuhKimHY,YiKY,andYooSE.Aminopyrazolederivatives,processforthepreparationthereof,andcompositionforpreventingortreatingischemicdiseasescontainingthesame.2011,USA,7939550.

3.JungYS,KimE,KimNJ,LeeYS,SuhJH,SuhKimHY,YiKY,andYooSE.Aminopyrazolederivatives,processforthepreparationthereof,andcompositionforpreventingortreatingischemicdiseasescontainingthesame.2011,Australia,2007309854.

4.SeoJH,YooSE,YiKY,KimN,KimE,JungYS,LeeYS,SuhKimHY.BenzofuranandBenzothiophenederivativessubstitutedbyamide,processforthepreparationthereof,andpharmaceuticalcompositionscontainingthesame.2010,Koreapatentno.10-2007-0103244.

5.SeoJH,YooSE,YiKY,KimN,KimE,JungYS,LeeYS,SuhKimHY.Compositionforpreventingortreatinganischemicdiseasecontainingaminothiophenederivatives.2008,Koreapatentno.10-0860539.

6.SeoJH,YooSE,YiKY,KimN,KimE,JungYS,Lee,YS,SuhKimHY.N-phenylamidederivativesandpreparationmethodthereof.2008,Koreapatentno.10-0832751.

7.SeoJH,YooSE,KimN,KimE,JungYS,LeeYS,SuhKimHY.CompositionforpreventingortreatinganischemicdiseasecontainingN-phenylamidederivatives.2008,Koreapatentno.10-0832750.

8.JungYS,KimE,KimN,LeeYS,SeoJH,SuhKimHY,YiKYandYooSE.Aminopyrazolederivatives,processforthepreparationthereof,andcompositionforpreventingortreatingischemicdiseasescontainingthesame.2008,Koreapatentno10-0832747.

9.KimE,LeeYS,JungYS,YooSE,SeoJH,ChaeSK,andLeeKJ.CompositionfortreatinganischemicdiseasecomprisingahumanFAF1proteininhibitorasanactiveingredient.2008,Koreapatentno.10-0818752.

10.JungYS,LeeDH,KimE,andLimH.HumanDaxxproteinandafragmentthereofasbindingagentsofhumanNHE1ionchannelprotein.2006,Koreapatentno.10-0597615-0000.
科研项目：荣誉及奖项：1.KoreaResearchFoundationPostdoctoralFellowship,2005-2006.

2.BestPosterAward,2006KSBMB(KoreaSocietyforBiochemistryandMolecularBiology)Conference,Seoul,Korea.
联系方式：Address:No.1Weigang,Nanjing
Zipcode:210095
Office:02584399102
Email:yongsjung@gmail.com