李斌?博士??
动物学方向 ?教授、博导
实验室：昆虫生理与功能基因组学??生科院西-203室
Email：??libinlb@hotmail.com，?libin@njnu.edu.cn
联系地址：南京市栖霞区文苑路1号南京师范大学生命科学学院
邮??编：210023
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李斌，男，汉族，1971年7月生， 四川武胜人，博士，教授，博士生导师。2004年获重庆市高校优秀中青年骨干教师计划资助，2009年3月获南京师范大学优秀高层次引进人才计划资助。多种昆虫基因组计划成员，先后加入中国昆虫学，中国蚕学会，中国遗传学会，中国生化与分子生物学会、美国昆虫学会，日本蛋白质科学学会，日本蚕丝昆虫学会等学术团体。作为负责人完成国家自然科学基金2项、国家教育部课题1项，省市项目4项。参与国家科技部973、863、国家自然科学基金重点与面上、国家教育部、以及日本文部省与美国国家NIH及USDA项目等10余项。目前主持国家自然科学基金2项。
主要从事昆虫基因组与功能基因组学，蛋白质组学，分子、发育与神经生理学等研究。目前研究重点：1）利用基因组学，转录组学，蛋白组学及生物信息学对未知功能基因（或基因家族）进行鉴定与分析；2）对神经肽及其受体基因进行大规模解析，对孤儿受体进行鉴定，探讨神经肽基因及其受体基因的信号传导及其协同进化关系，并利用RNAi等手段探讨昆虫羽化，蜕皮，能量代谢，促心动，肌动，泌尿等发育、代谢调控的分子机制；3）昆虫抗药性及抗胁迫机理及其分子调节机制研究，利用基因组学与生物信息学手段等对昆虫抗药性及抗胁迫机理及其环境适应机制进行解析，探索其信号传导途径，进而阐明其进化适应机制及其在免疫与昆虫防治研究中的重要作用。
在国际著名学术期刊Genome Research（第1作者）、 Science、Nature、DNA Research、Frontiers in Neuroendocrinology、Pest Management Science 、Insect Molecular Biology、Genomics 、Journal of Insect Physiology等国内外知名专业核心期刊上发表研究论文70余篇，另外在国际会议发表论文或摘要等 20余篇。
简历:
2009.3~至今，教授，南京师范大学优秀高层次引进人才
2005.11~2009.9，Research Associate, Kansas State University（美国）
2004.10~2005.10，高级访问研究员，九州大学（日本）
2001.7~2005.10，副研究员与讲师, 西南农大
1998.9~2001.6，博士，遗传与分子生物学，西南农大与日本九州大学联合培养
1996.9~1998.9，硕士，生物化学与分子生物学，西南农大
1989.9~1993.7，本科，蚕学，西南农大
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在研国家自然科学基金委项目：
1. 无脊椎动物新型受体 Parathyroid hormone receptor like(PTHRL) 的鉴定及其对赤拟谷盗表皮发育的调控
2. 赤拟谷盗蛛毒素受体Latrophilin的鉴定及其生理功能与进化适应性分析
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近5年内发表论文（* 为通讯作者）：
1. Wenfeng Xiong#, Shanshan Gao#, Jinjuan Mao, Luting Wei, Jia Xie, Juanjuan Liu, Jingxiu Bi, Xiaowen Song and Bin Li*. CYP4BN6 and CYP6BQ11 mediate insecticide susceptibility and their expression is regulated by Latrophilin in Tribolium castaneum. Pest Management Science. 2019，doi: 10.1002/ps.5384. (SCI, 2018 IF= 3.249)
2. Wei Wu, Mengfan Zhai, Chengjun Li, Xiaojuan Yu, Xiaowen Song, Shanshan Gao, Bin Li*. Multiple functions of miR-8-3p in the development and metamorphosis of the red flour beetle, Tribolium castaneum. Insect Molecular Biology. 2018, doi:10.1111/imb.12539. (SCI, 2018 IF= 2.492)
3. Xiaowen Song^#, Fei Huang^#, Juanjuan Liu, Chengjun Li, Shanshan Gao, Wei Wu, Mengfan Zhai, Xiaojuan Yu, Wenfeng Xiong, Jia Xie and Bin Li*. Genome-wide DNA methylomes from discrete developmental stages reveal the predominance of non-CpG methylation in Tribolium castaneum. DNA Research. 2017, 24(5): 445-457. (SCI, 2018 IF= 5.415)
4. Luting wei#, Shanshan Gao#, Wenfeng Xiong, Juanjuan Liu, Jinjuan Mao, Yaoyao Lu, Xiaowen Song, Bin Li*. Latrophilin mediates insecticides susceptibility and fecundity through two carboxylesterases, esterase4 and esterase6, in Tribolium castaneum. Bulletin of Entomological Research. 2018，1-10. doi:10.1017/S0895. (SCI, 2018 IF= 1.721)
5. Shanshan Gao, Wenfeng Xiong, Luting Wei, Juanjuan Liu, Xing Liu, Jia Xie, Xiaowen Song, Jingxiu Bi, Bin Li*. Transcriptome profiling analysis reveals the role of latrophilin in controlling development, reproduction and insecticide susceptibility in Tribolium castaneum. Genetica. 2018, 146(3):287-302. (SCI, 2018 IF= 1.366)
6. Chengjun Li, Juanjuan Liu, Peng Lü, Shangshang Ma, Keming Zhu, Lu Gao, Bin Li*, Keping Chen*. Identification, expression and function of myosin heavy chain family genes in Tribolium castaneum. Genomics. 2018, S0888-7543(18)30238-6. (SCI, 2018 IF= 2.91)
7. Chengjun Li, Yaoyao Lu, Shangshang Ma, Peng Lü, Bin Li*, Keping Chen*. Crinkled employs wingless pathway for wing development in Tribolium castaneum. Archives of insect biochemistry and physiology. 2018, 99(2):e21496. (SCI, 2018 IF= 1.316)
8. ChengJun Li, XiaoPei Yun, XiaoJuan Yu, Bin Li*. Functional analysis of the circadian clock gene timeless in Tribolium castaneum. Insect Science. 2018, 25, 418–428. (SCI, 2018 IF= 2.091)
9. Jia Xie#, Wenfeng Xiong#, Xingxing Hu, Shasha Gu, Sisi Zhang, Shanshan Gao, Xiaowen Song, Jingxiu Bi, Bin Li*. Characterization and functional analysis of hsp21.8b: An orthologous small heat shock protein gene in Tribolium castaneum. Journal of applied entomology. 2018, 142(7): 654-666. (SCI, 2018 IF= 1.629)
10. Wenfeng Xiong#, Jia Xie#, Luting Wei, Sisi Zhang, Xiaowen Song, Shanshan Gao, Bin Li*. Transcriptome analysis of hsp18.3 functions and regulatory systems using RNA-sequencing in the red ?our beetle, Tribolium castaneum. Journal of Integrative Agriculture. 2018, 17(5): 1040–1056. (SCI, 2018 IF= 1.042)
11. Jia Xie, XingXing Hu, MengFan Zhai, XiaoJuan Yu, XiaoWen Song, ShanShan Gao, Wei Wu, Bin Li*. Characterization and functional analysis of hsp18.3 gene in the red flour beetle, Tribolium castaneum. Insect Science. 2017, 26(2):263-273. (SCI, 2018 IF= 2.091)
12. Wenfeng Xiong, Mengfan Zhai, Xiaojuan Yu, Luting Wei, Jinjuan Mao, Juanjuan Liu, Jia Xie, Bin Li*. Comparative rna-sequencing analysis of ER-based hsp90 functions and signal pathways in Tribolium castaneum. Cell Stress & Chaperones. 2017, 23(1):29-43. (SCI, 2018 IF= 2.571)
13. Wei Wu, Wenfeng Xiong, Chengjun Li, Mengfan Zhai, Yao Li, Fei Ma, Bin Li*, MicroRNA-dependent regulation of metamorphosis and identification of microRNAs in the red flour beetle, Tribolium castaneum. Genomics. 2017, 109(5-6):362-373. (SCI, 2018 IF= 2.91)
14. Chengjun Li, Bin Li*, Shangshang Ma, Peng Lv, Keping Chen*, Dusky works upstream of Four-jointed and Forked in wing morphogenesis in Tribolium castaneum. Insect Molecular Biology. 2017, 26(6):677-686. (SCI, 2018 IF= 2.492)
15. Shanshan Gao, Xing Liu, Juanjuan Liu, Wenfeng Xiong, Xiaowen Song, Wei Wu, Luting Wei, Bin Li*, Identification and evolution of latrophilin receptor gene involved in Tribolium castaneum devolopment and female fecundity. Genesis. 2017, 55(12). doi: 10.1002/dvg.23081. (SCI, 2018 IF= 2.667)
16. Chengjun Li, Xiaopei Yun, Bin Li*. Dusky-like is required for epidermal pigmentation and metamorphosis in Tribolium castaneum. Scientific Reports. 2016, 6:20102. (SCI, 2018 IF= 4.122)
17. Xuhong Chen, Wenfeng Xiong, Chengjun Li, ShanshanGao, Xiaowen Song, Wei Wu, Bin Li*. Comparative RNA-sequencing profiling reveals novel Delta-class glutathione S-transferases relative genes expression patterns in Tribolium castaneum. Gene. 2016, 593(1):13-20. (SCI, 2018 IF= 2.498)
18. Ming Sang, Chengjun Li, Wei Wu, Bin Li*. Identification and evolution of two insulin receptor genes involved in Tribolium castaneum development and reproduction. Gene. 2016, 585(2):196–204. (SCI, 2018 IF= 2.498)
19. Ming Sang, Jiaxin Zhang, Bin Li*, Yuqing Chen*. TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein, Protein expression and purification. 2016, 122, 82-9. (SCI, 2018 IF= 1.338)
20. Chengjun Li, Xiaopei Yun, Xiaojuan Yu, Bin Li*. Functional analysis of the circadian clock gene timeless in Tribolium castaneum. Insect science. 2016, 25(3):418-428. (SCI, 2018 IF= 2.091)
21. Yanyun Wang, Chengjun Li, Ming Sang, Bin Li*. Tcmof regulates larval/pupal development and female fecundity in red flour beetle, Tribolium castaneum. Archives of Insect Biochemistry and Physiology. 2015, 88(2):111-22. (SCI, 2018 IF= 1.316)
22. Chengjun Li, Yi Zhang, Xiaopei Yun, Yanyun Wang, Ming Sang, Xing Liu, Xingxing Hu and Bin Li*. Methuselah-like genes affect development, stress resistance, lifespan and reproduction in Tribolium castaneum. Insect Molecular Biology. 2014, 23(5): 587-597. (SCI, 2018 IF= 2.492)
23. Chengjun Li, Wei Wu, Ming Sang, Xing Liu, Xingxing Hu, Xiaopei Yun and Bin Li*. Comparative RNA-sequencing analysis of mthl1 functions and signal transductions in Tribolium castaneum. Gene. 2014, 547: 310-318 (SCI, 2017 IF= 2.415) (SCI, 2018 IF= 2.498)
24. Yi Zhang, Shasha Gu, Chengjun Li, Wei Wu, Xiaopei Yun, Xingxing Hu, Bin Li*. Identification and characterization of novel ER-based hsp90 gene in the red flour beetle, Tribolium castaneum. Cell Stress and Chaperones. 2014, 19(5): 623-633. (SCI, 2018 IF= 2.571)
25. Chengjun Li, Xiaowen Song, Xuhong Chen, Xing Liu, Ming Sang, Wei Wu, Xiaopei Yun, Xingxing Hu and Bin Li*. Identification and comparative analysis of G protein-coupled receptors in Pediculus humanus humanus. Genomics. 2014, 104: 58-67 (SCI, 2018 IF= 2.91)
26. Yaping Liu, Chengjun Li, Jingkun Gao, Wenlong Wang, Li Huang, Xuezhu Guo, Bin Li, Jianjun Wang*. Comparative characterization of two intracellular Ca2+-release channels from the red flour beetle, Tribolium castaneum. Scientific reports. 2014, 4: 6702. (SCI, 2018 IF= 4.122)
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5年以外的代表性论著（* 为通讯作者）
1. Bin Li, Reinhard Predel, Susanne Neupert, Frank Hauser, Yoshiaki Tanaka, Giuseppe Cazzamali, Michael Williamson, Yasuyuki Arakane, Peter Verleyen, Liliane Schoofs, Joachim Schachtner, Cornelis J.P. Grimmelikhuijzen, Yoonseong Park*. Genomics, transcriptomics, and peptidomics of peptide and protein hormones in the red flour beetle Tribolium castaneum, Genome Research, 2008, 18: 113-122. (SCI, 2018 IF= 10.101)
2. Tribolium Genome Sequencing Consortium (Richards S., et al., Bin Li et al. One of 100+ Authors), The genome of the model beetle and pest Tribolium castaneum. Nature. 2008, 452 (7190): 949-955. (SCI, 2018 IF= 41.577)
3. Biology analysis group, Qingyou Xia, Zeyang Zhou, Cheng Lu, Daojun Cheng, Fangyin Dai, Bin Li et al. (One of 100+ Authors) 2004, A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori). Science. 306(5703): 1937-1940. (SCI, 2018 IF= 41.058)