余书勤教授。生物学（生理学专业）研究生导师。药学（微生物与生化制药专业）研究生导师。
研究方向：以细胞膜上p-糖蛋白（p-gp）为切入点，围绕它的表达、细胞膜定位、线粒体功能、p-gp-ATP酶的相互作用，对抗癌药物与环境内分泌干扰物(EDCs)的吸收、分布与毒性进行探讨。以此为基础，主要在两个方向进行研究。在药学领域，研究方向为逆转癌症多药耐药（Multidrug resistance, MDR）的新型纳米递药系统（Nano-drug delivery system, NDDS）的生物效应与机理研究。在抗癌药物的靶向与共递药、细胞核递药以及MDR细胞内精准药物释放与逆转MDR方面进行探讨。在毒理学领域，对食品乳化剂与肠道微生物互作影响EDCs的吸收、毒性靶器官分布与毒效机理方面进行探讨。
科研成果：2011年以来，以通讯作者发表21篇SCI学术榜论著，包括11篇TOP论文。单篇最高IF 8.097（发表时5.93）。1 篇ESI热点与高被引论文，1篇ESI高被引论文。获得8项与新药有关的发明专利，其中3 项国际专利公开PCT。参与2 项新药研发被批准临床研究。
科研项目：作为负责人主持国家自然科学基金一项（在研）。作为子题负责人参与国家科技重大专项（新药创制）项目一项（完成）。
研究生培养：毕业人数30人。近5 年来，其中1人获得国家奖学金。 2 人获得江苏省优秀硕士研究生论文 (2015年度，2016年度)，4 人获得朱敬文奖学金， 3人获得校级优秀研究生毕业论文奖，7人次获得优秀毕业研究生。研究生毕业后多在大型制药公司与药物研发公司, 或高级中学工作。目前在培研究生7人。
学术链接：作者：ORCID:0000-0002-2824-4651。ResearcherID:?K-5982-2012。ScopusID：。审稿人：Publons：**/
联系方式：通讯地址:?江苏省南京市栖霞区文苑路1号，南京师范大学生命科学学院(210046)，电话**;?Email：yushuqin@njnu.edu.cn
科研成果（2011-）
论著（仅列入作为通讯作者的论文，IF与分区为发表时）
Shan-Shan?Qi,?Ling-Yuan?Guo,?Shu-Zhen?Yan,?Robert?J.?Lee,?Shu-Qin?Yu*,?Shuang-Lin?Chen*.Hypocrellin?A-based?photodynamic?action?induces?apoptosis?in?A549?cells?through?ROS-mediated?mitochondrial?signaling?pathway. ActaPharmaceuticaSinicaBdoi.org/10.1016/j.apsb.2018.12.004【SCI, TOP, IF=6.014】
Jia-Hui Sun, Chong Ye, En-He Bai, Ling-Ling Zhang, Shao-JieHuo, Hao-Han Yu, Su-Yun Xiang*, Shu-Qin Yu*. Co-delivery nanoparticles of doxorubicin and chloroquine for improving the anti-cancer effect in vitro. Nanotechnology 2019;30(8):85101 【SCI, TOP, IF=3.404】
Hai-TaoGao,?RunXu, Wei-XinCao, Qian-NanDi, Rui-XianLi,LingengLu,?QianXu, Shu-Qin Yu*.Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology and Applied Pharmacology 341:2018, 87–97【SCI, IF=3.616】
Shan-Shan Qi, Jia-Hui Sun, Hao-Han Yu,?Shu-Qin Yu*. Co-delivery nanoparticles of anti-cancer drugs forimproving chemotherapy efficacy.Drug Delivery.?2017; 24(1)：1909-1926【SCI, TOP, IF=6.40】
Xi Lin, Shun-Zhen Yan, Shan-Shan Qi, QiaoXu, Shuang-Shuang Han, Ling-Yuan Gu, Ning Zhao, Shuang-Lin Chen*,Shu-Qin Yu*. Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A.?Frontiers in Pharmacology.2017;8:0815【SCI,IF=4.40】
Ling-Yuan Guo,?Shu-Zhen Yan,??Qiang Li,??QiaoXu,??Xi Lin,?Shan-Shan Qi,?Shu-Qin Yu*, Shuang-Lin Chen*. Poly(lactic-co-glycolic) acid nanoparticles improve oral bioavailability of hypocrellin A in rat.?RSC Advances.2017; 7: 42073-42082?【SCI, IF=3.15】
Dan-Dan Zhang, Yan-Yan Kong, Jia-Hui Sun, Shao-JieHuo, Min Zhou, Yi-Ling Gui,?Shu-Qin Yu*, QianXu*. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance.?International Journal of Nanomedicine.2017;12:20181-2108 【SCI, TOP, IF=4.30】
Hai-Tao Gao,?Run Xu,?Wei-Xin Cao,?Liang-Liang Qian,?Min Wang,?Lingeng Lu,?QianXu*,Shu-Qin Yu*,?Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats.?Food and Chemical Toxicology. 2017;101:94-104【SCI, TOP, IF=3.584】【ESI热点论文/?ESI高被引论文】
Ying-Ying Wang, Dan-Dan Zhang, Yan-Yan Kong, Luan-Luan Shao, Fen-Yi Zhang, Yu Gao, Xu Mu, Jie Wang, Hao-Fan Li,?Shu-Qin Yu*, QianXu*. CS/PAA@TPGS/PLGA nanoparticles with intracellular pH-sensitivesequential release for delivering drug to the nucleus of MDR cells.?Colloids and Surfaces B: Biointerfaces.?2016; 145:716-727【SCI, IF=4.12】
Wang Dong-Fang, Rong Wen-Ting, Lu Yu, HouJie, Qi Shan-Shan, Xiao Qing, Zhang Jue, You Jin,Shu-QinYu*,?XuQian*. TPGS_2k/PLGA nanoparticles for overcoming multidrug resistance by interfering mitochondria of human alveolar adenocarcinoma cells.?ACS Applied Materials & Interfaces.2015; 7(7): 3888-3901 【SCI, TOP, IF=5.93】?
Lu Yu,?Wang Ying-Ying,?Yang Nan,?Zhang Dan,?Zhang Feng-Yi,?GaoHai-Tao, Rong Wen-Ting,?Shu-Qin Yu*, XuQian. Food emulsifier polysorbate 80 increases intestinal absorption of di-(2-ethylhexyl) phthalate in rats.Toxicological Sciences.2014: 139 (2): 317-327【SCI, IF=4.50】
Rong Wen-Ting, Lu Ya-Peng,?Tao Qing,?Guo Miao, Lu Yu,?RenYong?,?Shu-Qin Yu*.Hydroxypropyl-sulfobutyl-β-cyclodextrin improves the oral bioavailability?of edaravone by modulating?drug efflux pump of?enterocytes.?Journal of Pharmaceutical Sciences.?2014;?103(2): 730-742 【SCI, IF=3.3】
Qi Shan-Shan, Lin Xi, Zhang Miao-Miao, Yan Shu-Zhen,?Shu-Qin Yu*, Chen Shuang-Lin*.??Preparation and evaluation of hypocrellin A loaded poly(lactic-co-glycolic acid) nanoparticles for photodynamic therapy.?RSC Advances.2014; 4 (75): 40085-40094? 【SCI, IF=3.8】
Ya-Peng Lu,?Si-Yuan Liu,?Yu Zhao,?Li Zhu*,?Shu-Qin Yu*. Complexation of?Z-ligustilide with hydroxypropyl-b-cyclodextrin to improve stability and oral bioavailability.?Acta Pharmaceutica.2014; 64:211-222?【SCI, IF=1.0】
Guo Miao,?Rong Wen-Ting, HouJie, Wang Dong-Fang,?Lu Yu,?Wang Ying,Shu-Qin Yu*, XuQian*.? Mechanisms on chitosan-coated?poly (lactic-co-glycolic acid)?nanoparticles?for improving?oral?absorption of 7-ethyl-10-hydroxycamptothecin.?Nanotechnology.?2013; 24: 245101 (15pp) 【SCI, TOP, IF=3.90】
Wang Ying, Guo Miao, Lu Yu, Ding Li-Ying, Ron Wen-Ting, Liu Ya-Qing, Song Fei-Fei,?Shu-Qin Yu*.?Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro.?Nanotechnology.2012; 23:495103 (14pp) 【SCI, TOP, IF=3.90】
Chen Cheng, Xie Xiao-Xia, Zhou Qian, Zhang Feng-Yi, Wang Qiao-Lin, Liu Ya-Qing, Zou Yi-Na, Tao Qing, JiXue-Mei,?Shu-Qin Yu*. EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide.?Nanotechnology.?2012; 23: 045104 (12pp) 【SCI, TOP, IF=3.90】
XuQian, Wang Min,?Shu-Qin Yu*, Tao Qing, Tang Meng*. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry.?Analyst.2011; 136 (23): 5030-5037 【SCI, IF=3.90】
Huang Xing-Xing, Zhou Cheng-Liang, Wang Hui, Chen Cheng,?Shu-Qin Yu*, XuQian, Zhu Yin-Yan, Ren Yong. Pharmacokinetics, efficacy, and safety evaluation of docetaxel/hydroxypropyl-sulfobutyl-beta-cyclodextrin inclusion complex.?AAPS PharmSciTech.?2011; 12(2): 665-672 【SCI, IF=1.24】
Xie Xiao-Xia, Tao Qing, Zou Yi-Na, Zhang Feng-Yi, Guo Miao, Wang Ying, Wang Hui, Zhou Qian,?Shu-Qin Yu*. PLGA nanoparticles improve the oral bioavailability of curcumin in rats: characterizations and mechanisms.Journal of Agricultural and Food Chemistry.?2011; 59 (17): 9280-9289 【SCI, TOP, IF=2.93】【ESI高被引论文】
Wang Hui, Xie Xiao-Xia, Zhang Feng-Yi, Zhou Qian, Tao Qing, Zou Yi-Na, Chen Cheng,?Shu-Qin Yu*. Evaluation of cholesterol depletion as a marker of nephrotoxicity in vitro for novel β-cyclodextrin derivatives.?Food and Chemical Toxicology.2011; 49(6): 1387-1393【SCI, TOP, IF=2.80】
国际会议论文
Ying Wang, Miao Guo, Yu Lu, LiYing Ding,?Shu-Qin Yu*. PLGA nanoparticles containing SN-38 for reversing multiple drug resistance of A549/DDP Cells.?Journal?Control Release.2013; 172(1):e67
Miao Guo, Ying Wang, Wen-Ting Rong, Li-ying Ding,?Shu-Qin Yu*. Chitosan-modified PLGA nanoparticles as drug delivery carrier for modulating P-glycoprotein of enterocytes.?Journal?Control Release.2013; 172(1):e112-3
发明专利（国际专利公开?PCT）
Yong Ren,Xue-Qin Ma, Shu-Qin Yu, Xia-Dong-Sun.Hydroxypropyl-sulfobutyl-beta-cyclodextrin, the preparation method, the analytical method, and the pharmacutical application thereof. Patent No: US**B2, Application No:?12/092273, Publication Date:?**
Yong Ren, Jing-FengGao,?Shu-Qin Yu, Ling Wu. Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof, Patent No: US**B2, Application No:?12/440792, Publication date:?**
Yong Ren, Jing-FengGao,?Shu-Qin Yu, Ling Wu. Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process, Patent No: US**B2, Application No:?12/440942, Publication date:?**
科研项目：
主持：国家自然科学基金，非离子型食品乳化剂增加邻苯二甲酸酯类吸收的效应及机制研究?。批准号**。
子题负责：国家科技重大专项（新药创制）项目，一类以CD11b为靶的抗白细胞-内皮细胞粘附乳糖衍生物候选药物研究。批准号2009ZX09103-44。
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