殷志敏简介殷志敏，男、汉族；毕业于南京大学（本科，硕士），获得德国吕贝克医学院生物化学系博士，美国MountSinai医学研究中心Ruttenberge癌症研究所及美国爱荷华大学病理系博士后，现为南京师范大学生命科学学院校特聘教授、博士生导师、江苏省优势特色学科带头人、省细胞生物学重点学科带头人、生物化学博士点负责人，指导的博士生获得2009年全国优秀博士论文提名奖。目前，主要从事炎症和肿瘤发生的分子机制、天然药物筛选及酶法生物合成氨基酸产业化方面的研究，主持和完成了国家重点基础研究“973”课题及六项国家自然科学基金。在国际著名刊物CancerResearch、JBiolChem、EMBOJ、Oncogene、CellularSignalling、Apoptosis、PLoSONE、MolecularImmunology、JCB发表多篇学术论文。完成了我国首个生物转化L-茶氨酸项目，得到了国家发改委2009年“微生物高技术产业化”专项500万元及常州市2007年第二批海归创新创业人才100万支持。学习经历：1982-1986年南京大学生物系学士学位;1986-1989年南京大学生物系硕士学位;1993-1994年同济大学留德预备部学习德语;1995-1997年德国吕贝克医学院生物化学系博士学位工作经历：1989-1992年南京化工学院应化系生化专业助教;1992-1995年南京化工学院应化系生化专业讲师;1998-2000年美国MountSinai医学研究中心Ruttenberge癌症研究所博士后;2000-2001年美国爱荷华大学病理系博士后;2001-现在南京师范大学生科院生化与分子生物学特聘教授已发表的主要论文：1.ShimeiQi,YinqiangXin,YingtaoGuo,YingDiao,XianjuanKou,LanLuo,ZhiminYin（通讯作者）.AmpelopsinreducesendotoxicinflammationviarepressingROS-mediatedactivationofPI3K/Akt/NF-κBsignalingpathways.InternationalImmunopharmacology12(2012)278–2872.JingjingKang,YushunZhang,XiangCao,JieFan,GuilanLi,QiWang,YingDiao,ZhihuiZhao,LanLuo,ZhiminYin（通讯作者）.Lycorineinhibitslipopolysaccharide-inducediNOSandCOX-2up-regulationinRAW264.7cellsthroughsuppressingP38andSTATsactivationandincreasesthesurvivalrateofmiceafterLPSchallenge.InternationalImmunopharmacology12(2012)249–2563.LiG,YeY,KangJ,YaoX,ZhangY,JiangW,GaoM,DaiY,XinY,WangQ,YinZ（通讯作者）,LuoLl-Theaninepreventsalcoholicliverinjurythroughenhancingtheantioxidantcapabilityofhepatocytes.2012，FoodChemToxicol.50(2):14.363-3724.GuilanLi•JingjingKang•XiangyangYao•YinqiangXin•QiWang•YinYe•LanLuo•5.ZhiminYin（通讯作者）Thecomponentofgreentea,L-theanineprotectshumanhepaticL02cellsfromhydrogenperoxide-inducedapoptosis.EurFoodResTechnol(2011)233:427–4356.YimiaoXu,YinqiangXin,YingDiao,ChangyanLu,JinFu,LanLuo,ZhiminYin（通讯作者）SynergisticEffectsofApigeninandPaclitaxelonApoptosisofCancerCells.PLoSONE2011.6(12)e291697.KouX,QiS,DaiW,LuoL,YinZ（通讯作者）.Arctigenininhibitslipopolysaccharide-inducediNOSexpressioninRAW264.7cellsthroughsuppressingJAK-STATsignalpathway.IntImmunopharmacol.2011Aug;11(8):1095-102.Epub2011Mar21.8.YaoX,ZhuF,ZhaoZ,LiuC,LuoL,YinZ（通讯作者）.ArctigeninenhanceschemosensitivityofcancercellstocisplatinthroughinhibitionoftheSTAT3signalingpathway.JCellBiochem.2011Oct;112(10):2837-49.doi:10.1002/jcb.231989.WangQ,MinC,ZhuF,XinY,ZhangS,LuoL,YinZ（通讯作者），ProductionofBioactiveγ-GlutamylTranspeptidaseinEscherichiacoliUsingSUMOFusionPartnerandApplicationoftheRecombinantEnzymetoL:-TheanineSynthesis.CurrMicrobiol.2011Feb17.［Epubaheadofprint］10.HuangH,PanY,YeY,GaoM,YinZ（通讯作者）,LuoL.Dipyrithioneattenuatesoleicacid-inducedacutelunginjury.PulmPharmacolTher.2011，24(1):74-80.(ScienceCitationIndexExpanded(SCI-EXPANDED))11.BenP,LiuJ,LuC,XuY,XinY,FuJ,HuangH,ZhangZ,GaoY,LuoL,YinZ（通讯作者）.CurcuminpromotesdegradationofinduciblenitricoxidesynthaseandsuppressesitsenzymeactivityinRAW264.7cells.intImmunopharmacol.2011，11(2):179-186(ScienceCitationIndexExpanded(SCI-EXPANDED))12.ZhangC,YuanX，MaoW，YueL，YinZ（通讯作者）.Inhibitionofcadmium－inducedapoptosisbyglutathioneS－transferaseP1viamitogen－activatedproteinkinasesandmitochondrialpathwaysEnvironmentalToxicologyandPharmacology2010，30（2）：202-208(ScienceCitationIndexExpanded(SCI-EXPANDED)).13.LiuJ,HongS,FengZ,XinY,WangQ,FuJ,ZhangC,LiG,LuoL,YinZ（通讯作者）.Regulationoflipopolysaccharide-inducedinflammatoryresponsebyheatshockprotein27inTHP-1cells.CellImmunol.2010264（2）：127–134(ScienceCitationIndexExpanded(SCI-EXPANDED)).14.ZhangC,YuanX,YueL,FuJ,LuoL,YinZ（通讯作者）.PIASyinteractswithp73alphaandregulatescellcycleinHEK293cells.CellImmunol.2010;263(2):235-40(ScienceCitationIndexExpanded(SCI-EXPANDED)).15.HanC,FuJ,LiuZ,HuangH,LuoL,YinZ（通讯作者）.DipyrithioneinhibitsIFN-gamma-inducedJAK/STAT1signalingpathwayactivationandIP-10/CXCL10expressioninRAW264.7cells.InflammRes.2010Oct;59(10):809-16(ScienceCitationIndexExpanded(SCI-EXPANDED)).16.GaoY,HanC,HuangH,XinY,XuY,LuoL,YinZ（通讯作者）.Heatshockprotein70togetherwithitsco-chaperoneCHIPinhibitsTNF-alphainducedapoptosisbypromotingproteasomaldegradationofapoptosissignal-regulatingkinase1Apoptosis.2010Jul;15(7):822-33.(ScienceCitationIndexExpanded(SCI-EXPANDED)).17.ZhangX,HuangH,YangT,YeY,ShanJ,YinZ（通讯作者）,LuoL.Chlorogenicacidprotectsmiceagainstlipopolysaccharide-inducedacutelunginjuryInjury.2010Jul;41(7):943-9(ScienceCitationIndexExpanded(SCI-EXPANDED)).18.Ge,Junchao,Feng,Youjun,Ji,Hongfeng,Zhang,Huimin,Zheng,Feng,Wang,Changjun,Yin,Zhimin（通讯作者）,Pan,Xiuzhen,Tang,Jiaqi.InactivationofDipeptidylPeptidaseIVAttenuatestheVirulenceofStreptococcussuisSerotype2thatCausesStreptococcalToxicShockSyndrome.CurrentMicrobiology,59(3),pp248-255,2009/9(ScienceCitationIndexExpanded(SCI-EXPANDED)).19.Shan,Jianhua,Fu,Jin,Zhao,Zhihui,Kong,Xiuqin,Huang,Huang,Luo,Lan,Yin,Zhimin（通讯作者）.Chlorogenicacidinhibitslipopolysaccharide-inducedcyclooxygenase-2expressioninRAW264.7cellsthroughsuppressingNF-kappaBandJNK/AP-1activation.InternationalImmunopharmacology,9(9),pp1042-1048,2009/8(ScienceCitationIndexExpanded(SCI-EXPANDED)).20.Zhang,Zhengping,Hao,Jiaying,Zhao,Zhihui,Ben,Peiling,Fang,Fang,Shi,Lijun,Gao,Yanhong,Liu,Junhong,Wen,Chuanjun,Luo,Lan,Yin,Zhimin（通讯作者）.beta-Arrestinsfacilitateubiquitin-dependentdegradationofapoptosissignal-regulatingkinase1(ASK1)andattenuateH2O2-inducedapoptosis.CellularSignalling,21(7),pp1195-1206,2009/7(ScienceCitationIndexExpanded(SCI-EXPANDED)).21.Kong,Xiuqin,Ge,Haitao,Chen,Li,Liu,Zhili,Yin,Zhimin,Li,Ping,Li,Mei.Gamma-linolenicacidmodulatestheresponseofmultidrug-resistantK562leukemiccellstoanticancerdrugs.ToxicologyinVitro,23(4),pp634-639,2009/6(ScienceCitationIndexExpanded(SCI-EXPANDED)).22.Pan,Xiuzhen,Ge,Junchao,Li,Ming,Wu,Bo,Wang,Changjun,Wang,Jing,Feng,Youjun,Yin,Zhimin,Zheng,Feng,Cheng,Gong,Sun,Wen,Ji,Hongfeng,Hu,Dan,Shi,Peiju,Feng,Xiaodan,Hao,Xina,Dong,Ruiping,Hu,Fuquan,Tang,Jiaqi.TheOrphanResponseRegulatorCovR:aGloballyNegativeModulatorofVirulenceinStreptococcussuisSerotype2.JournalofBacteriology,191(8),pp2601-2612,2009/4/15(ScienceCitationIndexExpanded(SCI-EXPANDED)).23.Shi,Lijun,Zhang,Zhengping,Fang,Shuping,Xu,Junfeng,Liu,Junhong,Shen,Jiayin,Fang,Fang,Luo,Lan,Yin,Zhimin（通讯作者）.Heatshockprotein90(Hsp90)regulatesthestabilityoftransforminggrowthfactorbeta-activatedkinase1(TAK1)ininterleukin-1beta-inducedcellsignaling.MolecularImmunology,46(4),pp541-550,2009/2(ScienceCitationIndexExpanded(SCI-EXPANDED)).24.Luo,Lan,Wang,Yu,Feng,Qin,Zhang,Hong,Xue,Bin,Shen,Jiayin,Ye,Yin,Han,Xiaodong,Ma,Hsiaoyen,Xu,Jun,Chen,Dan,Yin,Zhimin（通讯作者）.RecombinantproteinglutathioneS-transferasesP1attenuatesinflammationinmice.MolecularImmunology,46(5),pp848-857,2009/2(ScienceCitationIndexExpanded(SCI-EXPANDED)).25.Wu,Yifan,Liu,Junhong,Zhang,Zhengping,Huang,Huang,Shen,Jiayin,Zhang,Shuangquan,Jiang,Yong,Luo,Lan,Yin,Zhimin（通讯作者）.HSP27regulatesIL-1stimulatedIKKactivationthroughinteractingwithTRAF6andaffectingitsubiquitination.CellularSignalling,21(1),pp143-150,2009/1(ScienceCitationIndexExpanded(SCI-EXPANDED)).26.Chen,Li,Kong,Xiuqin,Fu,Jin,Xu,Yimiao,Fang,Shuping,Hua,Peng,Luo,Lan,Yin,Zhimin（通讯作者）.CHIPfacilitatesubiquitinationofinduciblenitricoxidesynthaseandpromotesitsproteasomaldegradation.CellularImmunology,258(1),pp38-43,2009(ScienceCitationIndexExpanded(SCI-EXPANDED)).27.Fang,Shuping,Fu,Jin,Yuan,Xia,Han,Cui,Shi,Lijun,Xin,Yinqiang,Luo,Lan,Yin,Zhimin（通讯作者）.Heatshockprotein90regulatesthestabilityofMEKK3inHEK293cells.CellularImmunology,259(1),pp49-55,2009(ScienceCitationIndexExpanded(SCI-EXPANDED)).28.Zhou,Xin,Zhang,Zhengping,Jia,Xiaohe,Wu,Yifan,Luo,Lan,Yin,Zhimin（通讯作者）.Mn2+enhancestheanine-formingactivityofrecombinantglutaminesynthetasefromBacillussubtilisinEscherichiacoli.WorldJournalofMicrobiology&Biotechnology,24(8),pp1267-1272,2008/8(ScienceCitationIndexExpanded(SCI-EXPANDED)).29.Feng,Qin,Ren,Yong,Wang,Yu,Ma,Hsiaoyen,Xu,Jun,Zhou,Chenrong,Yin,Zhimin（通讯作者）,Luo,Lan.Anti-inflammatoryeffectofSQC-beta-CDonlipopolysaccharide-inducedacutelunginjury.JournalofEthnopharmacology,118(1),pp51-58,2008/6/19(ScienceCitationIndexExpanded(SCI-EXPANDED)).30.Liu,Ziwen,Fan,Yumei,Wang,Yu,Han,Cui,Pan,Yu,Huang,Huang,Ye,Ying,Luo,Lan,Yin,Zhimin（通讯作者）.Dipyrithioneinhibitslipopolysaccharide-inducediNOSandCOX-2up-regulationinmacrophagesandprotectsagainstendotoxicshockinmice.FEBSLetters,582(12),pp1643-1650,2008/5/28(ScienceCitationIndexExpanded(SCI-EXPANDED)).31.Lu,Chen,Chen,Dan,Zhang,Zhengping,Fang,Fang,Wu,Yifan,Luo,Lan,Yin,Zhimin（通讯作者）.Heatshockprotein90regulatesthestabilityofc-juninHEK293cells.MoleculesandCells,24(2),pp210-214,2007/10/31(ScienceCitationIndexExpanded(SCI-EXPANDED)).32.Wu,Yifan,Shen,Jiayin,Yin,Zhimin（通讯作者）.Expression,purificationandfunctionalanalysisofhexahistidine-taggedhumanglutathioneS-Transferasep1-1anditscysteinylmutants.ProteinJournal,26(6),pp359-370,2007/9(ScienceCitationIndexExpanded(SCI-EXPANDED)).33.Shen,Jiayin,Wu,Yifan,Shi,Lijun,Liu,Junhong,Liu,Shunyi,Guan,Zhengbing,Yin,Zhimin（通讯作者）.ConstructionandcharacterizationoftwoversionsofbifunctionalEGFP-sTRAILfusionproteins.AppliedMicrobiologyandBiotechnology,76(1),pp141-149,2007/8(ScienceCitationIndexExpanded(SCI-EXPANDED)).34.Fan,Yumei,Chen,Hui,Qiao,Bo,Liu,Ziwen,Luo,Lan,Wu,Yifan,Yin,Zhimin（通讯作者）.c-JunNH2-terminalkinasedecreasesubiquitinationandpromotesstabilizationofp21(WAF1/CIP1)inK562cell.BiochemicalandBiophysicalResearchCommunications,355(1),pp263-268,2007/3/30(ScienceCitationIndexExpanded(SCI-EXPANDED)).35.Fan,Yumei,Chen,Hui,Qiao,Bo,Luo,Lan,Ma,Hsiaoyen,Li,Heng,Jiang,Jihong,Niu,Dezhong,Yin,Zhimin（通讯作者）.OpposingeffectsofERKandp38MAPkinasesonHeLacellapoptosisinducedbydipyrithione.MoleculesandCells,23(1),pp30-38,2007/2/28(ScienceCitationIndexExpanded(SCI-EXPANDED)).36.Sun,S.,Zhang,H.,Xue,B.,Wu,Y.,Wang,J.,Yin,Z（通讯作者）.,Luo,L..Protectiveeffectofglutathioneagainstlipopolysaccharide-inducedinflammationandmortalityinrats.InflammationResearch,55(11),pp504-510,2006/11(ScienceCitationIndexExpanded(SCI-EXPANDED)).37.Wu,Y.,Fan,Y.,Xue,B.,Luo,L.,Shen,J.,Zhang,S.,Jiang,Y.,Yin,Z（通讯作者）..HumanglutathioneS-transferaseP1-1interactswithTRAF2andregulatesTRAF2-ASK1signals.Oncogene,25(42),pp5787-5800,2006/9/21(ScienceCitationIndexExpanded(SCI-EXPANDED)).38.Zhao,Xin,Fan,Yumei,Shen,Jiayin,Wu,Yifan,Yin,Zhimin（通讯作者）.HumanglutathioneS-transferaseP1suppressesMEKK1-mediatedapoptosisbyregulatingMEKK1kinaseactivityinHEK293cells.MoleculesandCells,21(3),pp395-400,2006/6/30(ScienceCitationIndexExpanded(SCI-EXPANDED)).39.Chen,HQ,Wu,YF,Zhang,YQ,Jin,LN,Luo,L,Xue,B,Lu,C,Zhang,XR,Yin,ZM（通讯作者）.Hsp70inhibitslipopolysaccharide-inducedNF-kappaBactivationbyinteractingwithTRAF6andinhibitingitsubiquitination.FEBSLetters,580(13),pp3145-3152,2006/5/29(ScienceCitationIndexExpanded(SCI-EXPANDED)).40.Xue,B,Wu,YF,Yin,ZM,Zhang,H,Sun,SW,Yi,TS,Luo,L.Regulationoflipopolysaccharide-inducedinflammatoryresponsebyglutathioneS-transferaseP1inRAW264.7cells.FEBSLetters,579(19),pp4081-4087,2005/8/1(ScienceCitationIndexExpanded(SCI-EXPANDED)).41.Fan,YM,Wu,DM,Jin,LN,Yin,ZM（通讯作者）.HumanglutamylcysteinesynthetaseprotectsHEK293cellsagainstUV-inducedcelldeaththroughinhibitionofc-JunNH2-terminalkinase.CellBiologyInternational,29(8),pp695-702,2005/8(ScienceCitationIndexExpanded(SCI-EXPANDED)).42.Yin,ZM（通讯作者）,Sima,J,Wu,YF,Zhu,J,Jiang,Y.TheeffectofC-terminalfragmentofJNK2onthestabilityofp53andcellproliferation.CELLRESEARCH,14(5),pp434-438,2004/10(ScienceCitationIndexExpanded(SCI-EXPANDED)).43.Yin,ZM（通讯作者）,Chen,QY,Sima,J,Wu,YF,Zhang,SQ.TheexpressionregulationandcharacterizationofglutaminesynthetasefromthehyperthermoacidophiliccrenarcheonSulfolobusacidocaldarius.PROGRESSINBIOCHEMISTRYANDBIOPHYSICS,30(5),pp767-771,2003/10(ScienceCitationIndexExpanded(SCI-EXPANDED)).44.Yin,ZM（通讯作者）,Yan,SZ,Dai,G,Wu,YF,Zhang,SQ.Thecloning,inductionandactivityassayofglutaminesynthetasegenefromthermoacidophilicarchaebacteriumSulfolobusacidocaldarius.PROGRESSINBIOCHEMISTRYANDBIOPHYSICS,29(5),pp745-749,2002/10(ScienceCitationIndexExpanded(SCI-EXPANDED)).45.ZhiminYin,VladimirN.Ivanov,HasemHabelhah,KennethTew,andZe’evRonai.GSTP-elicitedprotectionagainstH2O2-inducedcelldeathismediatedbycoordinatedregulationofstresskinases.CANCERRESEARCH,60,pp4053-4057,2000/4/1(ScienceCitationIndexExpanded(SCI-EXPANDED)).46.ThomasBuschmann,ZhiminYin,AninditaBhoumik,Ze’evRonai.Amino-terminalderivedJNKFragmentAltersExpressionandActivityofc-Jun,ATF2andP53andincreasesH2O2inducedcellDeath.THEJOURNALOFBIOLOGICALCHEMISTRY,275(22),pp16590-16596,2000/6/2(ScienceCitationIndexExpanded(SCI-EXPANDED)).47.VictorAdler,ZhiminYin,KennethDTew,Ze'evRonai.Roleofredoxpotentialandreativeoxygenspeciesinstresssignaling.Oncogene,18(45),pp6104-6111,1999/11(ScienceCitationIndexExpanded(SCI-EXPANDED)).48.VictorAdler,ZhiminYin,SergeY.Fuchs,MiriamBenezra,LilliamRosario,KennethD.Tew,MatthewR.Pincus,MohinderSardana,ColinJ.Henderson,C.RolandWolf,RogerJ.Davis,Ze’evRonaiRegulationofJNKsignalingbyGSTp.EMBOJ,18(5),pp1321-1334,1999/3(ScienceCitationIndexExpanded(SCI-EXPANDED)).49.SergeY.Fuchs,VictorAdler,ThomasBuschmann,ZhiminYin,XiangweiWu,StephenN.Jones,Ze’evRonai.JNKtargetsp53ubiquitinationanddegradationinnonstressedcells.GenesDev,12(17),pp2658-2663,1998/9/1(ScienceCitationIndexExpanded(SCI-EXPANDED)).50.YinZ,PurschkeWG,SchaferG,SchmidtCLTheglutaminesynathetasefromthehyperthermoacidophiliccrenacheonSulfolobusacidocaldarius:isolation,characterizationandsequencingofthegenes.BiolChem,379(11),pp1349-1354,1998/11(ScienceCitationIndexExpanded(SCI-EXPANDED)).专利：［1］殷志敏,沈青红,吕志祥，王正才，傅珒，张正平.高效转化谷氨酰胺合成L-茶氨酸的大肠杆菌菌株及其应用。中华人民共和国国家知识产权局,CN200910035096.0,中国,2010/12/29(中国知识产权网)专利号：ZL200910035096.4［2］殷志敏,刘子文,樊玉梅,王宇,罗兰.2,2＇－二吡啶N－氧化物二硫在制备抗炎药物中的应用.中华人民共和国国家知识产权局,CN200710024828.0,中国,2007/6/29(中国知识产权网)专利号：ZL200710024828.0.［3］殷志敏,沈佳胤,罗兰,张泓,王宇.人谷胱甘肽－S－转移酶Pi的纯化方法及其该酶的应用.中华人民共和国国家知识产权局,CN200610040269.8,中国,2006/7/19(中国知识产权网)专利号：ZL200610040269.8.［4］任勇,董祥玉,殷志敏.中药双黄连的环糊精超分子化组合物.CN200510040908.6,中国,2005/7/6(中国知识产权网).公开(公告)号：CN1720969目前承担项目：起止年月科研项目名称项目来源及经费本人角色
2012-2015热休克蛋白27（HSP27）通过与p53相互作用调控LPS单核细胞激活的分子机制国家自然基金项目81172798（60万元）主持
2011-2013GSTp与iNOS结合而抑制LPS诱导的NO合成的机理研究国家自然基金项目81072433（35万元）主持
2012-2015HSP27磷酸化在细胞应激中通过激活Src保护细胞的新机制江苏省教育厅重点实验室重大项目12KJA180006（15万元）主持
2009-2013酶法工业化生产L-茶氨酸产业化项目2009年国家发改委微生物高技术产业化专项（与常州阿格罗生物科技有限公司合作）100万元主持

申请者已完成科研项目情况：起止年月科研项目名称项目来源及经费本人角色
2002-2008炎症的细胞信号转导网络及其调控机制：课题名称：SIRS过程中白细胞激活的信号转导网络及其调控机制国家973重点基础研究项目2002CB513004（225万元）主持
2008-2010热休克蛋白27通过与TRAF6相互作用促进IL－1诱导的TRAF6的泛素化及IKK激活的机理研究国家自然基金项目30770842（32万元）主持
2007-2009GSTp通过与TRAF2结合抑制TNFα诱导的ASK1激活和细胞凋亡机理研究国家自然基金项目30670825（28万元）主持
2007-2009热休克蛋白90调控IL-1刺激的TAK1稳定性研究江苏省重点实验室重大基础研究项目（15万元）主持
2008-2009生物发酵法生产茶氨酸研究江苏阿格罗生物技术有限公司（5万元）主持
2004-2006JNK泛素化降解与之相结合蛋白的分子机理研究国家自然基金项目30370556（23万元）主持
2003-2005谷胱甘肽S-转移酶与细胞中应激激酶（JNK,p38,ERK）在应激过程的作用研究国家自然基金项目30270527（20万元）主持
2002-2005TRAIL诱导前列腺癌细胞系凋亡的机理研究国家教委留学回国人员项目2002SWXSBJBC22（5万元）主持
2002-2004TRAIL诱导前列腺癌PC3细胞系凋亡的机理研究省教委重点项目2002SWXTSBJB113（6万元）主持
2002-2004利用基因工程方法高效转化谷氨酸生产谷氨酰胺江南大学高校高科技工业园项目（6万元）主持
2002-2004抗肿瘤基因工程药物TRAIL的开发研究河北长天药业集团（20万元）主持
联系方式：南京市仙林文苑路1号南京师范大学生命科学院（210046）电话：025-85891305E-mail:yinzhimin@njnu.edu.cn