学术学位博导
--> 职称:教授
***
单位:病理生理学系
liangxiubin@njmu.edu.cn
专业:病理学与病理生理学(病理生理学)
个人简介
发表论文:
AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.
Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis.
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation.
Derlin-1 promotes ubiquitination and degradation of epithelial sodium channel (ENaC).
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation.
教材专著:
科研成果:
目前承担的科研项目:
Derlin-1在上皮细胞钠通道(ENaC)泛素化降解中的调控作用
AS160对上皮细胞钠通道(ENaC)转运调控的分子机制研究
基于iPS细胞的GIPRdn转基因猪的创制
AS160对上皮细胞钠通道(ENaC)转运调控的分子机制研究
Derlin-1在上皮细胞钠通道(ENaC)泛素化降解中的调控作用
钙调蛋白S100A16诱导细胞骨架重构参与肾脏上皮细胞间充 质转分化的分子机制
E3泛素连接酶HUWE1参与调节肾小管间质纤维化的分子机制研究
已经完成的科研项目: