学术学位博导
--> 职称：教授
**
单位：药物化学系
kldlf@njmu.edu.cn
专业：药物化学
个人简介
发表论文:
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95
Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95
Synthesis of Bosutinib from 3-Methoxy-4- hydroxybenzoic Acid
Construction of uniformly sized pseudo template imprinted polymers coupled with HPLC–UV for the selective extraction and determination of trace estrogens in chicken tissue samples
The Three Dimensional Quantitative Structure Activity Relationships (3D-QSAR) and Docking Studies of Curcumin Derivatives as Androgen Receptor Antagonists
Preparation of estriol–molecularly imprinted silica nanoparticles for determining oestrogens in milk tablets
Synthesis of 3-vinylphenyl ethyl (methyl) carbamate, a potential human metabolite of rivastigmine
Combined Three Dimensional Quantitative Structure Activity Relationships (3D-QSAR) Modeling and Molecular Docking Studies on Naphthoquinone Analogs as Proteasome Inhibitors
The Discovery of Potentially Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: A Combination of Pharmacophore Modelling, CoMFA, Virtual Screening and Molecular Docking Studies
教材专著:
药物化学(案例版)
科研成果:
一种炔雌醇类似物的分子印迹聚合物的制备方法
拉帕替尼合成中间体的制备工艺中国发明专利
一种博舒替尼的制备工艺中国发明专利
一类N-苄基苯胺衍生物及其用途
阿昔洛韦分子印迹聚合物及其制备方法和应用
PSD-95/nNOS解偶联剂分子印迹聚合物的制备方法中国发明专利
氨基水杨酸类衍生物及其作为神经保护剂的应用
多羟基二苯甲酮衍生物及其应用中国发明专利
用于治疗糖尿病的药物组合物及其应用
一类N-苄基取代的氨基水杨酸2-氨基乙醇酯衍生物及其药物用途
目前承担的科研项目:
nNOS-PSD-95解偶联剂的设计、合成及生物活性研究。编号：21172108
nNOS-PSD-95解偶联剂的设计、合成及生物活性研究
基于纳米硅胶表面分子印迹的固相微萃取技术用于雌激素残留分析的研究
脑缺血后成年脑神经元再生的分子调控机制
nNOS与脑损伤后的神经发生和突触形成
已经完成的科研项目:
基于nNOS-PSD-95解偶联作用机制的抗脑卒中新药的研究
