学术学位硕导
--> 职称：副研究员
单位：第一附属医院
kuanfengxu@njmu.edu.cn
专业：内科学（内分泌与代谢病）
个人简介
1型和2型糖尿病遗传及免疫发病机制相关研究
发表论文:
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals
Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies
PAI-1 -675 4G/5G polymorphism in association with diabetes and diabetic complications susceptibility: a meta-analysis study
UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms in association with obesity susceptibility – a meta-analysis study
IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population
UCP2 -866G/A and Ala55Val, and UCP3 -55C/T polymorphisms in association with type 2 diabetes susceptibility: a meta-analysis study
Activating transcription factor 3 (ATF3) promotes sublytic C5b-9-induced glomerular mesangial cells apoptosis through up-regulation of Gadd45α and KLF6 gene expression
Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes-A meta-analysis
PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor- associated PD-L1 signaling by two functional monoclonal antibodies
Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian
教材专著:
科研成果:
ZnT8自身抗体用于1型糖尿病分型诊断新技术的建立和应用
抗人PD-L1单克隆抗体制备及应用
中国国家发明专利
目前承担的科研项目:
肿瘤干细胞和上皮细胞间质转化在甲状腺未分化癌耐药和转移中的作用
WFS1基因甲基化修饰在宫内发育迟缓大鼠胰岛功能损伤中的调控机制研究
FTO基因对胰岛β细胞功能的影响及其机制研究
甲状腺肿瘤干细胞的分离、鉴定、成瘤及侵袭性的基础研究
靶向CD13分子抑制非小细胞肺癌浸润Treg细胞免疫抑制功能及机理探讨
应用基于Tetramer技术的致病性CD8 T细胞免疫分型探讨1型糖尿病患者胰岛损伤异质性的研究（8167031269）
已经完成的科研项目:
江苏省政府出国留学基金
Gadd45α基因在应激诱导的胰岛β细胞凋亡中的作用及其相关机制研究（BK2012486）
