学术学位博导
--> 职称：教授
-3568
单位：第一附属医院
yanning_qian@163.com
专业：麻醉学
个人简介
曾任中华医学会麻醉学分会第八、九、十届委员会委员、江苏省麻醉学会副主任委员和中国医师协会麻醉分会常委。曾为江苏省医学重点人才，“333工程”的第二层次培养对象；《中华麻醉学杂志》、《Anesthesia & Analgesia》(中文版)、《国际麻醉与复苏杂志》、《南京医科大学学报》等6本中文杂志编委；《中华医学杂志》（英文版CMJ）、《Neuroscience Letter》、《Brain Research》、《Briain Research Bulletin》、《Canadian Journal of Physiology and Pharmacolog》等7本英文期刊评阅人。发表论文100余篇，近五年以通讯作者或共同通信作者发表SCI收录论文20余篇，其中大于5分的7篇。曾获省政府科技进步三等奖4项；近8年以第一负责人获国家自然科学基金资助课题4项，目前在研的为2014年获得国家自然科学基金项目“探讨肥大细胞对小胶质细胞活化的调控及其在POCD中的作用机制（** ）”，2016年获得国家自然科学基金项目“HMGB1激活脑内肥大细胞对BBB的影响在POCD中的作用及机制探讨（**）”。参与编写专著12部，其中著名的专著有《现代麻醉学》、《急诊外科学》；副主编《脊柱手术麻醉学》和《外科危重病学》各1部；主译《妇产科麻醉学》和《区域麻醉并发症》各1部。两次以高访学者身份赴美进修学习。 近五年以通讯作者或共同通信作者发表SCI收录论文清单如下： 1．Xu J, Zhang X, Qian Q, Wang Y, Dong H, Li N, Qian Y (共同通讯作者), Jin W: Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes. J Neuroinflammation, 2018, 15:41-51.（IF: 5.102） 2．Wang Y, Zhou Q, Zhang X, Qian Q, Xu J, Ni P, Qian Y (通讯作者): Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization. J Neuroinflammation, 2017, 14(1):233-251.（IF: 5.102） 3．Xu J, Dong H, Qian Q, Zhang X, Wang Y, Jin W, Qian Y (共同通讯作者): Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation. Behav Brain Res, 2017, 332:145-153. （IF: 3.002） 4．Li N, Zhang X, Dong H, Hu Y, Qian Y(通讯作者): Bidirectional relationship of mast cells-neurovascular unit communication in neuroinflammation and its involvement in POCD. Behav Brain Res, 2017,322(Pt A):60-69.（IF: 3.002） 5．Zhang X, Dong H, Li N, Zhang S, Sun J, Zhang S, Qian Y(通讯作者): Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis. J Neuroinflammation, 2016, 13(1):1-15. （IF: 5.102） 6．Zhang X, Yao H, Qian Q, Li N, Jin W, Qian Y(通讯作者): Cerebral mast cells participate in postoperative cognitive dysfunction by promoting astrocyte activation. Cell Physiol Biochem, 2016,40(1-2):104-116.（IF: 5.104） 7．Zhang S, Dong H, Zhang X, Li N, Sun J, Qian Y(共同通讯作者): Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption. Behav Brain Res, 2016, 298:158-166. （IF: 3.002） 8． Li N, Zhang X, Dong H, Zhang S, Sun J, Qian Y(通讯作者): Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression. Cell Physiol Bi
发表论文:
Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes
IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation
Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation
Bidirectional relationship of mast cells-neurovascular unit communication in neuroinflammation and its involvement in POCD
Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis
Cerebral mast cells participate in postoperative cognitive dysfunction by promoting astrocyte activation
Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption
Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation
Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3K/Akt Pathway
教材专著:
妇产科麻醉学
脊柱外科麻醉学
区域麻醉并发症
科研成果:
麻醉和手术创伤后红细胞丙酮酸激酶活性改变与糖代谢障碍关系
手术应激后红细胞糖代谢限速酶活性的改变及其机制
术前静注氯诺昔康对子宫切除术病人围术期趋化因子表达的影响
7. 急性高容量血液稀释在全髋关节置换术患者免疫功能的影响
8. 以提高医学生外科基础综合能力为核心的实践教学改革与建设
目前承担的科研项目:
探讨肥大细胞对小胶质细胞活化的调控及其在POCD中的作用机制
HMGB1致脑内肥大细胞脱颗粒对BBB的影响与POCD的关系
已经完成的科研项目:
锂对小胶质细胞 TLR4 的影响和防治POCD 机制的探讨
探讨GSK-3β活性与小胶质细胞TLR4受体在POCD发生机制中的作用
