学术学位博导
--> 职称：研究员
**
单位：办公室
binshen@njmu.edu.cn
专业：生殖医学
个人简介
发表论文:
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
Genetic dissection of TIE pathway in lymphatic maturation and valve development.
YTHDC1 Mediates Nuclear Export of N6-methyladenosine Methylated mRNAs
APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.
Off-target mutations are rare in Cas9-modified mice.
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting.
Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells.
Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys.
教材专著:
科研成果:
目前承担的科研项目:
小SpyCas9的合理设计和优化31571372
RNA m6A表观修饰在精子发生过程中的作用机制BK20160045
人类配子发生、成熟障碍与胚胎停育的分子机制2016YFC1000600
精子发生和RNA m6A表观修饰31622039
精子成熟过程中tsRNA生成机制及功能研究 校20180411
已经完成的科研项目:
