学术学位博导
--> 职称：教授
单位：办公室
xinwu@njmu.edu.cn
专业：生殖医学
个人简介
吴鑫，男，1993年至1998年毕业于江西医学院，本科学历，医学学士学位；1998年至2003年毕业于复旦大学，研究生学历，医学博士学位；2005年至2006年在美国韦恩州立大学，博士后研究员；2007年至2012年初在美国宾夕法尼亚大学，助理研究员；2012年起至今任南京医科大学，教授,博士研究生导师， 生殖医学国家重点实验室PI等工作职务。研究兴趣：以精原干细胞体外培养增殖及功能移植为平台，研究干细胞的自我更新，体外分化和去分化机制；研究雄性性腺内生殖细胞发育所需微环境的信号传导及转录调控；从雄性生殖干细胞角度发展转基因或基因纠正技术。代表性论文（5篇）1.Wu X, Goodyear SM, Abramowitz LK, Bartolomei MS, Tobias JW, Avarbock MR and Brinster RL. Fertile Offspring Derived from Mouse Spermatogonial Stem Cells Cryopreserved for more than 14 Years. Human Reproduction. 2012 Feb; doi:10.1093/humrep/des077 2. Wu X, Peppi M, Vengalil MJ, Maheras KJ, Southwood CM, Bradley M, Gow A Transgene-Mediated Rescue of Spermatogenesis in Claudin 11-null Mice. Biology of Reproduction. 2012 Jan; doi:10.1095/biolreprod.111.**.Wu X, Goodyear SM, Tobias JW, Avarbock MR and Brinster RL. Spermatogonial Stem Cell Self-Renewal Requires ETV5-Mediated Downstream Activation of Brachyury in Mice. Biology of Reproduction. 2011 Dec; 85(6):1114-11234. Wu X, Oatley JM, Oatley MJ, Kaucher AV, Avarbock MR, and. Brinster RL. The POU domain transcription factor OCT6 is an important intrinsic regulator of GDNFinduced survival and self-renewal of mouse spermatogonial stem cells. Biology of Reproduction. 2010 Jun; 82(6):1103-11115. Wu X, Schmidt JA, Avarbock MR, Tobias JW, Carlson CA, Kolon TF, Ginsberg JP, Brinster RL. Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules. Proceedings of the National Academy of Sciences USA. 2009 Dec; 106(51):21672-21677.
发表论文:
Fertile Offspring Derived from Mouse Spermatogonial Stem Cells Cryopreserved for more than 14 Years
Transgene-Mediated Rescue of Spermatogenesis in Claudin 11-null Mice
Spermatogonial Stem Cell Self-Renewal Requires ETV5-Mediated Downstream Activation of Brachyury in Mice
The POU domain transcription factor POU3F1 is an important intrinsic regulator of GDNFinduced survival and self-renewal of mouse spermatogonial stem cells
Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules
Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties
In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function
The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
MicroRNA-21 Regulates the Self-Renewal of Mouse Spermatogonial Stem Cells
Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis
教材专著:
科研成果:
目前承担的科研项目:
ETV5介导的小鼠精原干细胞自我更新转录调控机制研究
血脂紊乱影响精子发生和成熟过程的关键基因的调控机制
小鼠精原干细胞中转录因子蛋白ETV5下游基因的筛选研究
小鼠精原干细胞自我更新转录调控研究
血脂紊乱影响精子发生和成熟过程的关键基因的调控机制
已经完成的科研项目:
