专业学位博导
--> 职称：教授
单位：东部战区总医院
zq_zhou@163.com
专业：麻醉学
个人简介
发表论文:
Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex contributes to the antidepressant and propsychotic effects of ketamine.
.Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.
Inhibition of the L-arginine-nitric oxide pathway mediates the antidepressant effects of ketamine in rats in the forced swimming test
Akt mediates GSK-3β phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions.
Fast-spiking interneurons and gamma oscillations may be involved in the antidepressant effects of ketamine.
NF-κB is involved in the phenotype loss of parvalbumin-interneurons in vitro.
Acute increases in plasma mammalian target of rapamycin, glycogen synthase kinase-3β, and eukaryotic elongation factor 2 phosphorylation after ketamine treatment in three depressed patients.
Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-related kinase B in rat hippocampus.
Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test.
Ketamine exerts antidepressant effects probably via mediating the kynurenine pathway.
教材专著:
科研成果:
目前承担的科研项目:
PV中间神经元介导“赢家统吃”机制在神经病理性疼痛与抑郁共病中作用
81571083
已经完成的科研项目:
Fast-spiking 中间神经元NMDA受体在氯胺酮引起精神症状中的作用
Fast-spiking 中间神经元NMDA受体在氯胺酮引起精神症状中的作用
