学术学位博导
--> 职称：主任医师
学院：上海市第一人民医院
zhengzhi139@163.com
专业：眼科学
个人简介
主任医师/教授，博士生导师，上海市第一人民医院眼科（松江）执行主任。国家百千万人才工程人选、有突出贡献中青年专家、上海市领军人才，上海市卫生局优秀学科带头人，享受国务院津贴。中华眼科学会眼外伤学组委员，上海市眼科学会委员，上海市眼科学会玻璃体视网膜手术学组副组长。专业领域是眼底病临床诊治，擅长复杂性视网膜脱离、糖尿病视网膜病变、黄斑病变、眼外伤等手术治疗，年手术量1000余台，主攻方向是糖尿病视网膜病变发病机制及其临床防治。主持国家自然基金面上项目4项、973前期项目1项及省部级项目共10项等，已发表SCI论文43篇，其中，以第一作者/通讯作者在眼科及糖尿病领域A类期刊发表论著10篇，包括国际糖尿病领域顶级期刊《Diabetes》（IF 8.3）3篇、《Diabetologia》（IF 6.7）1篇，国际眼科重要期刊《AJO》1篇、《IOVS》2篇、《Retina》1篇等，被国际著名期刊《PNAS》等他引517次。获得国家科技进步二等奖等省部级奖5项等。
发表论文:
Diabetes Onset at 31-45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes
Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma.
miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin
Correlation between ficolin-3 and vascular endothelial growth factor-to-pigment epithelium-derived factor ratio in the vitreous of eyes with proliferative diabetic retinopathy
Improvement of retinal vascular injury in diabetic rats by statins is associated with the inhibition of mitochondrial reactive oxygen species pathway mediated by peroxisome proliferator-activated rece
Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro.
Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-react
Effects of angiotensin-converting enzyme inhibitors and beta-adrenergic blockers on retinal vascular endothelial growth factor expression in rat diabetic retinopathy.
教材专著:
科研成果:
基于社区的糖尿病视网膜病变高危人群筛查、代谢记忆机制及干预
上海基于社区的糖尿病视网膜病变高危人群筛查、代谢记忆机制及干预
糖尿病视网膜病变早期发病机制及临床防治
目前承担的科研项目:
ANGPTL3通路在糖尿病视网膜病变发病中的作用
已经完成的科研项目:
SOCS-3在糖尿病性视网膜病变发病中作用机制及意义
PGC-1a调控的线粒体ROS通路在2型糖尿病视网膜病变早期发病中的作用
