研究生导师介绍
姓名：邓国民性别:男院系：基础医学院
行政职务：系主任专业技术职称：任职年月：
从事专业1：免疫学从事专业2：导师类别：博士生导师
最后学历：博士毕业最后学位：博士任硕导年月：2012.5
任博导年月：2012.5是否院士：否是否国务院学科评议组成员：否
毕业院校：瑞典哥德堡大学毕业专业：100102免疫学毕业时间：2001.6
办公电话：02586862146E-mail：gmdeng@njmu.edu.cn在职信息：在岗
◇本人从事的主要研究方向的特点、意义及其水平:
1：自身免疫性疾病的发病机制和治疗2：细菌DNA导致炎性疾病的机制代表性成果：1.DengGM*,LiuL,TsokosGC.TargetedTumornecrosisfactorreceptor1preligandassemblydomainimprovesskininjuryinMRL/lprmice.ArthritisRheum.2010;62(8):2424-31.(*correspondingauthor).2.DengGM*,LiuL,KyttarisVC,TsokosGC.LupusserumIgGinducesskininflammationthroughTNFR1signalingpathway.JImmunol.2010;184(12):7154-61.(*correspondingauthor).3.DengGM*,LiuL,BahjatR,PinePR,TsokosGC.Suppressionofskinandkidneydiseasebyinhibitionofspleentyrosinekinaseinlupus-pronemice.ArthritisRheum.2010;62(7):2086-92.(*correspondingauthor).4.ShiT,MoultonVR,LapchakPH,DengGM,DalleLuccaJJ,TsokosGC.Ischemia-mediatedaggregationoftheactincytoskeletonisoneofthemajorinitialeventsresultinginischemia-reperfusioninjury.AmJPhysiolGastrointestLiverPhysiol.2009;296:G339-347.5.DengGM*,TsokosGC.CholeratoxinBacceleratesdiseaseprogressioninlupus-pronemicebypromotinglipidraftaggregation.JImmunol.2008;181:4019-4026.(*correspondingauthor).6.DengGM.TheroleofbacterialDNAininflammatoryandallergicdisease.RecentPatentsonInflammationandAllergyDrugDiscovery.2008;2:117-122.(*correspondingauthor).7.DengGM.Tumornecrosisfactorreceptorpre-ligandassemblydomainisanimportanttherapeutictargetininflammatoryarthritis.BioDrugs.2007;21:23-29.(*correspondingauthor).8.DengGM,LenardoM.Theroleofimmunecellsandcytokinesinthepathogenesisofrheumatoidarthritis.DrugDiscoveryToday:Diseasemechanism.2006;3:163-168.(*correspondingauthor).9.DengGM*,ZhengL,ChanFK,LenardoM.Ameliorationofinflammatoryarthritisbytargetingthepre-ligandassemblydomainoftumornecrosisfactorreceptors.NatMed.2005;11:1066-107210.LiuZQ,DengGM,FosterS,TarkowskiA.Staphylococcalpeptidoglycansinducearthritis.ArthritisRes.2001;3:375-380.11.DengGM*,LiuZQ,TarkowskiA.IntracisternallylocalizedbacterialDNAcontainingCpGmotifsinducesmeningitis.JImmunol.2001;167:4616-4626.(*correspondingauthor).12.DengGM*,TarkowskiA.SynovialcytokinemRNAexpressionduringarthritistriggeredbyCpGmotifsofbacterialDNA.ArthritisRes.2001;3:48-53.(*correspondingauthor).13.DengGM*,VerdrenghM,LiuZQ,TarkowskiA.ThemajorroleofmacrophagesandtheirproducttumornecrosisfactoralphaintheinductionofarthritistriggeredbybacterialDNAcontainingCpGmotifs.ArthritisRheum.2000;43:2283-2289.(*correspondingauthor).14.DengGM*,TarkowskiA.ThefeaturesofarthritisinducedbyCpGmotifsinbacterialDNA.ArthritisRheum.2000;43:356-364.(*correspondingauthor).15.DengGM,TarkowskiA.TheroleofbacterialDNAinsepticarthritis.IntJMolMed.2000;6:29-33.(*correspondingauthor).16.ZhuJ,NennesmoI,DengGM,LeviM,WahrenB,DiabA,MixE,ZhouJN,LjunggrenHG.InductionofexperimentalautoimmuneneuritisinCD4-8-C57BL/6Jmice.JNeuroimmunol.1999;94:196-203.17.DengGM*,NilssonIM,VerdrenghM,CollinsLV,TarkowskiA.Intra-articularlylocalizedbacterialDNAcontainingCpGmotifsinducesarthritis.NatMed.1999;5:702-705.(*correspondingauthor).18.ZouLP,ZhuJ,DengGM,LeviM,WahrenB,DiabA,HillertJ,LinkH.TreatmentwithP2proteinpeptide57-81bynasalrouteiseffectiveinLewisratexperimentalautoimmuneneuritis.JNeuroimmunol.1998;85:137-145.19.ZhuJ,DengGM,DiabA,ZwingenbergerK,BakhietM,LinkH.ThalidomideprolongsexperimentalautoimmuneneuritisinLewisrats.ScandJImmunol.1998;48:397-402.20.ZhuJ,DengGM,LeviM,WahrenB,DiabA,vanderMeidePH,LinkH.PreventionofexperimentalautoimmuneneuritisbynasaladministrationofP2proteinpeptide57-81.JNeuropatholExpNeurol.1998;57:291-301.21.MustafaW,ZhuJ,DengGM,DiabA,LinkH,FrithiofL,KlingeB.AugmentedlevelsofmacrophageandTh1cell-relatedcytokinemRNAinsubmandibularglandsofMRL/lprmicewithautoimmunesialoadenitis.ClinExpImmunol.1998;112:389-396.22.DiabA,MichaelL,WahrenB,DengGM,BjorkJ,HedlundG,ZhuJ.LinomidesuppressesacuteexperimentalautoimmuneencephalomyelitisinLewisratsbycounter-actingtheimbalanceofpro-inflammatoryversusanti-inflammatorycytokines.JNeuroimmunol.1998;85:146-154.23.DengGM*,BeltranJ,TsokosGC.NegativeregulationofTCRzetachainintissueinflammationofsystemiclupuserythematosisthroughlipidrafts.(Submitted),2012.(*correspondingauthor).24.DengGM*,BeltranJ.MechanismofSykinhibitorsuppressinglupusskininjury.(undersubmission),2012.(*correspondingauthor).25.邓国民等；国家发明专利：肿瘤坏死因子的受体一PLAD蛋白抑制关节炎（美国专利号：20100041596)。
书著
1.TarkowskiA,CollinsLV,DengGM,MolneL.InflammatogenicpropertiesofimmunostimulatoryDNAsequences.MicrobialDNAandHostImmunity.2002.November.28:351-361.

◇学术团体任职情况:

◇近五年在国内外核心期刊上发表学术论文情况:
论文题目刊物名称刊物国家收录情况卷期排名
TargetedTumornecrosisfactorreceptor1preligandassemblydomainimprovesskininjuryinMRL/lprmiceArthritisRheum.国外SCI8第一作者
LenardoM.Ameliorationofinflammatoryarthritisbytargetingthepre-ligandassemblydomainoftumornecrosisfactorreceptors.NatMed国外SCI11第一作者
LupusserumIgGinducesskininflammationthroughTNFR1signalingpathwayJImmunol国外SCI12第一作者，通讯作者
Suppressionofskinandkidneydiseasebyinhibitionofspleentyrosinekinaseinlupus-pronemiceArthritisRheum国外SCI7第一作者，通讯作者
◇出版专著教材情况(注：在书名后注明教材或专著):
名称类别出版单位日期排名
InflammatogenicpropertiesofimmunostimulatoryDNAsequences专著Totowa,N.J.:HumanaPress2002-11-013
◇成果获奖情况:
成果名称颁奖部门等级完成日期证书号排名
◇近五完成的科研项目:
项目名称任务来源完成形式完成日期鉴定验收单位主要结论排名
红斑狼疮发病机制的研究国家项目结题美国国立卫生研究院同意结题1
系统性红斑狼疮基因转录国家项目结题美国国立卫生研究院同意结题1
在器官损伤建立针对补体的抑制剂国家项目结题美国国防部同意结题1
发现新的治疗目标抑制组织损伤国家项目结题美国国防部同意结题1
◇目前承担的主要项目:
项目名称及下达编号项目类别项目来源起讫时间科研经费(万元)本人承担任务