研究生导师介绍
姓名：苗登顺性别:男院系：基础医学院
行政职务：主任专业技术职称：教授任职年月：2005.10
从事专业1：人体解剖与组织胚胎学（人解）从事专业2：导师类别：博士生导师
最后学历：博士毕业最后学位：博士任硕导年月：
任博导年月：2002.10是否院士：否是否国务院学科评议组成员：否
毕业院校：英国Sheffield大学毕业专业：毕业时间：
办公电话：86862015E-mail：dsmiao@njmu.edu.cn在职信息：在岗
◇本人从事的主要研究方向的特点、意义及其水平:
1.骨生物学：利用基因敲除小鼠模型研究钙调激素在骨骼发育和代谢中的作用机制，为骨骼相关疾病的治疗提供理论依据，研究水平居国际先进水平。2.干细胞生物学：利用基因敲除小鼠模型研究不同基因在调节干细胞自我更新能力中的作用及机制。为干细胞疗法治疗不同疾病提供理论基础，研究水平居国内先进水平。

◇学术团体任职情况:

◇近五年在国内外核心期刊上发表学术论文情况:
论文题目刊物名称刊物国家收录情况卷期排名
Calcium-independentand1,25(OH)2D3-dependentregulationoftherenin-angiotensionsystemin1α-hydroxylaseknockoutmiceKidneyInt国外SCI74通讯作者
Therapeuticpotentialofnon-adherentBM-derivedmesenchymalstemcellsintissueregenerationBoneMarrowTransplant国外SCI43(1)通讯作者
ParathyroidHormoneContributestoRegulatingMilkCalciumContentandModulatesNeonatalBoneFormationCooperativelywithCalciumEndocrinology国外SCI150(2)通讯作者
Exogenous1,25-dihydroxyvitaminD3exertsaskeletalanaboliceffectandimprovesmineralionhomeostasisinmicethatarehomozygousforboththe1alpha-hydroxylaseandparathyroidhormonenullallelEndocrinology国外SCI147通讯作者
SeveregrowthretardationandearlylethalityinmicelackingthenuclearlocalizationsequenceandC-terminusofPTH-relatedproteinPNAS国外SCI105(51)1
EarlylethalityinHypmicewithtargeteddeletionofPthgeneEndocrinology国外SCI1482
ExogenousPTH-relatedproteinandPTHimprovemineralandskeletalstatusin25-hydroxyvitaminD-1alpha-hydroxylaseandPTHdoubleknockoutmiceJBoneMinerRes国外SCI20通讯作者
Geneticmodelsshowthatparathyroidhormoneand1,25-dihydroxyvitaminD3playdistinctandsynergisticrolesinpostnatalmineralionhomeostasisandskeletaldevelopmentHumMolGenet国外SCI14通讯作者
Osteoblast-derivedPTHrPisapotentendogenousboneanabolicagentthatmodifiesthetherapeuticefficacyofadministeredPTH1-34JClinInvest国外SCI1151
Inactivationofthe25-hydroxyvitaminD1alpha-hydroxylaseandvitaminDreceptordemonstratesindependentandinterdependenteffectsofcalciumandvitaminDonskeletalandmineralhomeostasisJBiolChem国外SCI2791
Megakaryocyte-bonemarrowstromalcellaggregatesdemonstrateincreasedcolonyformationandalkalinephosphataseexpressioninvitroTissueEng国外SCI101
ImpairedendochondralbonedevelopmentandosteopeniainGli2-deficientmiceExpCellRes国外SCI2941
Parathyroidhormone-relatedpeptideisrequiredforincreasedtrabecularbonevolumeinparathyroidhormone-nullmiceEndocrinology国外SCI1451
SkeletalabnormalitiesinPth-nullmiceareinfluencedbydietarycalciumEndocrinology国外SCI1451
CartilageabnormalitiesareassociatedwithabnormalPhexexpressionandwithalteredmatrixproteinandMMP-9localizationinHypmiceBone国外SCI341
ExogenousPTHandendogenous1,25-dihydroxyvitaminDarecomplementaryininducingananaboliceffectonboneJBoneMinerRes国外SCI23(8)3
Cellularandmolecularmechanismsofabnormalcalcificationfollowingischemia-reperfusioninjuryinhumanlivertransplantationModPathol国外SCI20(3)2
Regulatedexpressionoftheubiquitinproteinligase,E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1,duringspermatogenesisDevDyn国外SCI236(10)2
KlothoablationconvertsthebiochemicalandskeletalalterationsinFGF23(R176Q)transgenicmicetoaKlotho-deficientphenotypeAmJPhysiolEndocrinolMetab国外SCI2963
Alteredovarianfunctionaffectsskeletalhomeostasisindependentoftheactionoffollicle-stimulatinghormoneEndocrinology国外SCI1485
NKcellactivationandtumorinfiltrationareinvolvedintheantitumormechanismofVirulizinCancerImmunolImmunother国外SCI546
GrowthretardationandprematureagingphenotypesinmicewithdisruptionoftheSNF2-likegene,PASGGenesDev国外SCI187
Rosiglitazoneimpactsnegativelyonbonebypromotingosteoblast/osteocyteapoptosisJEndocrinol国外SCI1832
Gp130-mediatedsignalingisnecessaryfornormalosteoblasticfunctioninvivoandinvitroEndocrinology国外SCI1455
EffectsofcalciumandoftheVitaminDsystemonskeletalandcalciumhomeostasis:lessonsfromgeneticmodelsJSteroidBiochemMolBiol国外SCI89-902
Transgenicmiceoverexpressinghumanfibroblastgrowthfactor23(R176Q)delineateaputativeroleforparathyroidhormoneinrenalphosphatewastingdisordersEndocrinology国外SCI1452
FibroblastGrowthFactor23OverexpressionImpactsNegativelyonDentinMineralizationandDentinogenesisinMice.ClinExpPharmacolPhysiol国外SCI38(6)通讯作者
Defectivefemalereproductivefunctionin1,25(OH)2D-Alterationsinphosphorus,calciumandPTHrPcontributetodefectsindentalanddentalalveolarboneformationincalcium-sensing_receptor-deficienDevelopment国外SCI137(6)通讯作者
Defectsinmesenchymalstemcellself-renewalandcellfatedeterminationleadtoanosteopenicphenotypeinBmi-1nullmice.JBoneMinerRes国外SCI25(3)讯作者
Thecalcium-sensingreceptormediatesboneturnoverinducedbydietarycalciumandparathyroidhormoneinneonates.JBoneMinerRes国外SCI26(5)通讯作者
Transplantedhumanamnioticmembrane-derivedmesenchymalstemcellsamelioratecarbontetrachloride-inducedlivercirrhosisinmouse.PLoSOne国外SCI6(2)通讯作者
Zincsupplementationresultsinimprovedtherapeuticpotentialofbonemarrow-derivedmesenchymalstromalcellsinamouseischemiclimbmodel.Cytotherapy国外SCI13(2)通讯作者
Defectivefemalereproductivefunctionin1,25(OH)2D-deficientmiceresultsfromindirecteffectmediatedbyextracellularcalciumand/orphosphorus.AmJPhysiolEndocrinolMetab国外SCI299(6)通讯作者
TheAbnormalPhenotypesofCartilageandBoneinCalcium-SensingReceptorDeficientMiceAreDependentontheActionsofCalcium,Phosphorus,andPTH.PLoSGenet.国外SCISep;7(9)通讯作者
1,25-DihydroxyvitaminD3contributestoregulatingmammarycalciumtransportandmodulatesneonatalskeletalgrowthandturnovercooperativelywithcalciumAmJPhysiolEndocrinolMetab国外SCI2011.301通讯作
AnImprovedTransplantationStrategyforMouseMesenchymalStemCellsinanAcuteMyocardialInfarctionModel.PLoSOne国外SCI6(6)通讯作者
EndogenousPTHDeficiencyImpairsFractureHealingandImpedestheFracture-HealingEfficacyofExogenousPTH(1-34)PLoSOne国外SCI6(7)通讯作者
Impairmentofspatiallearningandmemoryintransgenicmiceoverexpressinghumanfibroblastgrowthfactor-23BrainResearch国外SCI1412(2011)通讯作者
Sodium/myo-InositolCotransporter1andmyo-InositolAreEssentialforOsteogenesisandBoneFormation.JBoneMinerRes国外SCI26(3)3
Endogenousparathyroidhormonerelatedproteincompensatesfortheabsenceofparathyroidhormoneinpromotingboneaccrualinvivoinamodelofbonemarrowablation.JBoneMinerRes国外SCIMay29通讯作者
1,25-dihydroxyvitaminD3ontributestoregulatingMammaryCalciumTransportandModulatesNeonatalSkeletalGrowthandTurnoverCooperativelywithCalcium.AmJPhysiolEndocrinolMetab国外SCI301通讯作者
Bonemarrowablationdemonstratesthatexcessendogenousparathyroidhormoneplaysdistinctrolesintrabecularandcorticalbone.AmJPathol国外SCI2012.181通讯作者
AbsenceofPTHrPNuclearLocalizationandCarboxylTerminusSequencesLeadstoAbnormalBrainPLoSOne国外SCI7(7)通讯作者
◇出版专著教材情况(注：在书名后注明教材或专著):
名称类别出版单位日期排名
MolecularBiologyoftheParathyroid专著Naveh-Many,Tally(Ed.)2005-01-011
Alkalinephosphatase专著theEncyclopediaofEndocrineDiseasesAcademicPress/Elsevier2004-01-012
Novelapproachestotreatmentofosteoporosis专著ErnstScheringResearchFoundationWorkshop251998-01-014
◇成果获奖情况:
成果名称颁奖部门等级完成日期证书号排名
骨增量牙种植技术在复杂颌骨缺损功能重建中的应用省部三等奖2011-3-120-R22
◇近五完成的科研项目:
项目名称任务来源完成形式完成日期鉴定验收单位主要结论排名
甲状旁腺素和钙在促进骨形成中的相互作用及机制研究国家自然基金实验结束，论文发表国家基金委甲状旁腺素和钙不但能够各自发挥促进骨形成的作用，而且两者具有协同作用。1
活性维生素D和钙在促进骨形成中的协同作用部,省项目实验结束，论文发表江苏省卫生厅活性维生素D和钙不但能够各自发挥促进骨形成的作用，而且两者具有协同作用。1
甲状旁腺素相关肽85-139在抗衰老中作用机制研究部,省项目实验结束，论文发表教育部PTHrPKI可导致生长阻滞和成熟前衰老，可能与p16和p27表达上调及核转位增加、Bmi-1表达下调及核转位减少有1
甲状旁腺素相关肽在抗衰老中的作用机制研究部,省项目实验结束，论文发表江苏省科技厅PTHrPKI可导致生长阻滞和成熟前衰老，Bmi-1可能介导了PTHrPNLS和C-末端的抗衰老作用。1
◇目前承担的主要项目:
项目名称及下达编号项目类别项目来源起讫时间科研经费(万元)本人承担任务
Bmi1和其它表观遗传学调节分子在介导甲状旁腺素相关肽抗衰老中的作用（30911120486）自然基金国家项目2010-201345主要负责人
甲状旁腺素相关肽核定位序列和C末端在抗衰老中的作用机制研究（30830103）自然基金国家自然基金2009-2012160主要负责人
MSC自我更新与分化的信号调控机制自然基金国家项目2012-2016293主要负责人
活性维生素D通过调节细胞衰老发挥抗衰老和抗肿瘤双重作用自然基金国家项目2012-2017270主要负责人