柳东，男，副教授，硕士研究生导师。2014年获南京工业大学博士学位并以人才引进留校工作。2017-2018年国家公派留学赴美国劳伦斯伯克利国家实验室（Lawrence Berkeley National Laboratory）世界合成生物学先驱Jay D. Keasling实验室进行研究。2020年入选江苏省“青蓝工程”优秀骨干教师。主讲《代谢工程》、《现代生物技术》等课程。目前主要研究方向包括：
1）微生物代谢重构及辅因子工程：在理解微生物代谢原理与生命规律的基础上，开展新型生物质能源及化学品合成路径的创新设计并通过代谢网络（系统生物学）、辅因子体系构建与调控等手段获得原子得率与能量效率更经济可行的人工细胞；
2）细胞生理过程研究与应用开发：仿自然生态建立起基于细胞集群效应的工业微生物应用新技术，开展以微生物种群、界面及信号等为研究对象的细胞应用新方向，由此开发更高级的微生物发酵工程、蛋白质药物制造工程、植物细胞培养工程等应用新技术。
迄今为止已主持国家自然科学基金、江苏省青年基金等项目，作为主要研究骨干参与完成了国家基金委重大项目、国家基金委重点项目、国家科技部973计划、863计划等多个国家大型科研项目。以第一作者或通讯作者在国内外主流学术期刊发表论文20余篇；其中，在微生物代谢工程与应用领域权威期刊Metabolic Engineering发表研究长文2篇、微生物生理领域权威期刊mBio发表论文1篇；已获国家授权发明专利19项，并获美国授权专利3项。


代表性论文：
1.Sun W, Yu Y, Chen J, Yu B, Chen T, Ying H, Zhou S, Ouyang P, Liu D*, Chen Y*. Light signaling regulates Aspergillus niger biofilm formation by affecting melanin and extracellular polysaccharide biosynthesis. mBio 2021, 12:e03434-20
2.Liu, L, Yu, B, Sun, W,… & Liu D*, Che Y*. Calcineurin signaling pathway influences aspergillus niger biofilm formation by affecting hydrophobicity and cell wall integrity. Biotechnology for Biofuels 2020, 13:54.
3.Zhang D, Chang Z, …& Liu D*, ChenY*. PH-neutralization, redox-balanced process with coupled formate dehydrogenase and glucose dehydrogenase supports efficient xylitol production in pure water. J. Agric. Food Chem. 2020, 68, 235?241
4.Dong H , Zhang W, …, Wang Y*, Liu D*, & Wang, P. Biofilm polysaccharide display platform: a natural, renewable, and biocompatible material for improved lipase performance. Journal of Agricultural and Food Chemistry, J. Agric. Food Chem. 2020, 68, 1373?1381.
5.Liu D, Yang Z, Wang P, et al. Towards acetone-uncoupled biofuels production in solventogenic Clostridium through reducing power conservation[J]. Metabolic engineering, 2018, 47: 102-112.
6.Liu D, Chen Y, Ding F, et al. Simultaneous production of butanol and acetoin by metabolically engineered Clostridium acetobutylicum[J]. Metabolic engineering, 2015, 27: 107-114.
7.Liu D, Yang Z, Chen Y, et al. Clostridium acetobutylicum grows vegetatively in a biofilm rich in heteropolysaccharides and cytoplasmic proteins[J]. Biotechnology for biofuels, 2018, 11(1): 315.
8.Liu D, Chen Y, Ding F Y, et al. Biobutanol production in a Clostridium acetobutylicum biofilm reactor integrated with simultaneous product recovery by adsorption[J]. Biotechnology for biofuels, 2014, 7(1): 5.
9.Chang Z, Liu D*, Yang Z, et al. Efficient xylitol production from cornstalk hydrolysate using engineered Escherichia coli whole cells[J]. Journal of agricultural and food chemistry, 2018.
10.Liu D, Chen Y, Li A, et al. Enhanced butanol production by modulation of electron flow in Clostridium acetobutylicum B3 immobilized by surface adsorption[J]. Bioresource technology, 2013, 129: 321-328.
11.Shen X, Liu D*, Liu J, et al. Enhanced production of butanol and acetoin by heterologous expression of an acetolactate decarboxylase in Clostridium acetobutylicum[J]. Bioresource technology, 2016, 216: 601-606.
12.Liu D, Xu J, Wang Y, et al. Comparative transcriptomic analysis of Clostridium acetobutylicum biofilm and planktonic cells[J]. Journal of biotechnology, 2016, 218: 1-12.
联系方式
国家生化中心科技楼5楼，邮箱：liudong@njtech.edu.cn