姓名：张 琪
职称：教授，博士生导师
职务：药学院 副院长；
药动药效研究与评价中心主任
学术兼职：
江苏省高校医药教育研究会副理事长
中国药学会应用药理学会常务理事
江苏省药理学会常务理事
药学核心期刊《中国临床药理学与治疗学》、《中华男科学杂志》编委
江苏省食品药品监督管理局新药审评与现场核查专家
教育简历：
美国纽约州立大学布法罗分校（State University of New York at Buffalo）博士后；
中国药科大学药理学博士。
研究领域：药理学、药物动力学、代谢组学。
在基础研究领域着重于各类新药的临床前与临床的药物动力学、药效学筛选、药理学机制靶点、药效-药动学模型研究，以及骨质疏松症、高脂血症等重大疾病的代谢组学研究。尤其是代谢组学方法学及其应用的研究成果处于国内外前列。
近年来承担国家自然科学基金面上项目5项（主持3项，联合单位负责人2项）；“十三五”国家重大新药创制专项1项；国家973预研项目1项；国际合作项目2项（美国纽约州立大学、美国FDA-马里兰大学）；江苏省人才基金1项（抗骨质疏松一类新药的临床前研究）；江苏省临床医学专项1项（骨质疏松生物标记物研究）；参与国家973、省部科研项目8项。申请专利8项（3项授权）。发表学术文章约80篇（56篇被SCI收录）；参与编写英文论著1部，中文著作、化工辞典各1部。
主持建立了“南京工业大学 药动药效研究与评价中心”，中心拥有药物分析、药效评价、分子生物学、细胞培养、动物实验等先进技术平台，按照国家食品药品监督管理局颁布的“药物临床试验生物样本分析实验室管理指南”的要求进行建设、管理和运行。有资质从事新药药学、临床前药物动力学、药理学以及临床药物动力学研究（一致性评价与生物等效性实验等）与新药报批工作。
近年来，与美国FDA-马里兰大学、美国纽约州立大学、美国费城儿童医院、美国爱荷华大学、新西兰奥克兰大学等国外高校院所，在代谢组学、PK-PD模型等领域开展国际课题合作。
与中国军事科学院、中国医学科学院、上海第二军医大学、上海华山医院、南京军区总院、山东鲁抗集团、南京白敬宇制药公司等几十家医药科研、企业单位合作研发，主持了碱性成纤维细胞生长因子、黄芪甲苷、磷酸二果糖锶等一类新药的药理学、药动学研究及Etanercept、银杏提取物、硝苯地平缓释片、阿斯匹林缓释片、氢可酮-氯苯那敏缓释胶囊等50多种新药的药理学、药物动力学、生物等效性研究，新药资料全部通过省局现场核查。
所获荣誉：
江苏省“333高层次人才培养工程”培养对象
江苏省“六大人才高峰”培养对象
南京市“321”领军型科技创业人才
讲授课程：
药理学、药物动力学（本科生课程）；现代药理学（研究生课程）
科研成果：
参与编写的中英文论著：
英文论著：《Strontium: Chemical Properties, Applications and Health Effects》一书中的第一章节“The Effects of Strontium on Physiology, Pharmacology and Toxicity of the Human”出版社：NOVA Publishers出版日期：2013年，ISBN：978-1-62257-631-9
中文论著：《10000个科学难题（医学卷）》， “药动学-药效学结合模型—连接体内药物浓度与药效关系的桥梁”，科学出版社，2011年8月正式出版，P955-958。 “十一五”国家重点图书出版规划项目。
辞典：《化工辞典（第五版）》，化学工业出版社，2014年5月
近年来以通讯作者发表的SCI代表性文章：
[1] Diketopyrrolopyrrole–Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy [J]. ACS Nano, 2017, 11 (1): 1054–1063
[2] Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy [J]. Nano Research, 2017, 10 (3): 794-801
[3] Aza-Bodipy Photosensitizer for Photoacoustic and Photothermal Imaging Guided Dual Modal Cancer Phototherapy [J]. Journal of Materials Chemistry B, 2017, 5(8):1566-1573.
[4]SynthesisandpreclinicalpharmacokineticstudyofDHA-10,anovelpotentialantifungalpogostoneanalogue [J].JournalofPharmacyandPharmacology, 2017, 69 (9): 1084-1090
[5]Metabonomic analysis of fatty acids in seminal plasma between healthy and asthenozoospermic men based on gas chromatography mass spectrometry [J]. Andrologia, 2017, 49 (9): e12744.
[6] Tumor-targeting, enzyme-activated nanoparticles for simultaneous cancer diagnosis and photodynamic therapy [J]. Journal of Materials Chemistry B, 2016, 4(1): 113-120.
[7] Bromo-substituted diketopyrrolopyrrole derivative with specific targeting and high efficiency for photodynamic therapy [J]. ACS applied materials & interfaces, 2016, 8(17): 10737-10742.
[8] Association between the metabolome and bone mineral density in pre-and post-menopausal Chinese women using GC-MS [J]. Molecular BioSystems, 2016, 12(7): 2265-2275
[9]A Thienyl‐Substituted Diketopyrrolopyrrole Derivative with Efficient Reactive Oxygen Species Generation for Photodynamic Therapy [J]. ChemPlusChem, 2016, 81(6): 515-520.
[10] Diketopyrrolopyrrole Derivatives Grafting Hyaluronic Acid for Targeted Photodynamic Therapy [J]. ChemistrySelect, 2016, 1(12): 3071-3074.
[11] Wnt/β-catenin signaling plays an important role in the protective effects of FDP-Sr against oxidative stress induced apoptosis in MC3T3-E1 cell [J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26(19): 4720-4723.
[12]Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GC–MS based metabolomics study [J]. Toxicology, 2015, 336: 84-95.
[13] Strontium fructose 1, 6‐diphosphate alleviate cyclophosphamide‐induced oligozoospermia by improving antioxidant and inhibiting testicular apoptosis via FAS/FASL pathway [J]. Andrologia, 2015, 47(9): 995-1003.
[14]PharmacokineticsandtissuedistributionofAucubin,AjugolandCatalpolinratsusingavalidatedsimultaneousLC-ESI-MS/MSassay.[J].JournalofChromatographyB,2015,1002:245-253.
[15] A pre-clinical pharmacokinetic study in rats of three naturally occurring iridoid glycosides, Picroside-I, II and III, using a validated simultaneous HPLC–MS/MS assay[J]. Journal of Chromatography B, 2015, 993: 47-59.
[16] Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: Application to pharmacokinetic and tissue distribution study [J]. Journal of pharmaceutical and biomedical analysis, 2014, 88: 191-200.
[17] Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography–tandem mass spectrometry [J]. Journal of Chromatography B, 2014, 970: 77-85.
[18] Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats [J]. Acta Pharmacologica Sinica, 2014, 35(10): 1265-1273.
[19] Comparative pharmacokinetics with single substances and Semen Cuscutae extract after oral administration and intravenous administration Semen Cuscutae extract and single hyperoside and astragalin to rats [J]. Analytical Methods, 2014, 6(18): 7250-7259.
[20] Metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by GC-TOF/MS [J]. PLoS One, 2013, 8(2): e54965.
[21] Simultaneous determination of Eleutheroside B and Eleutheroside E in rat plasma by high performance liquid chromatography–electrospray ionization mass spectrometry and its application in a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 917: 84-92.
[22]Rapid analysis of tadalafil in human blood plasma and seminal plasma by liquid chromatography/tandem mass spectrometry [J]. Journal of pharmaceutical and biomedical analysis, 2013, 77: 149-157.
[23] Simultaneous Determination of Oridonin, Ponicidin and Rosmarinic Acid from Herba Isodi Rubescentis Extract by LC–MS-MS in Rat Plasma [J]. Journal of chromatographic science, 2013, 51(10): 910-918.
[24] Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of raddeanin A in rat plasma and its application to a pharmacokinetic study [J]. Journal of Chromatography B, 2013, 912: 16-23.
[25] Changes in expression and distribution of attractin in the testes of rats at different developmental stages [J]. International journal of molecular medicine, 2013, 32(3): 599-606.
[26] Metabonomic profiling in studying anti-osteoporosis effects of strontium fructose 1, 6-diphosphate on estrogen deficiency-induced osteoporosis in rats by GC/TOF-MS [J]. European journal of pharmacology, 2013, 718(1): 524-532.
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电子邮箱：zhangqi@njtech.edu.cn