胡燚（yi）：教授，博士生导师，江苏省高校“青蓝工程”中青年学术带头人，获南京工业大学“南工精英九思奖”、“张家港市政府奖教金”等奖励。主要研究方向为生物催化、化学催化、生物-化学组合合成技术在生物炼制、药物及其中间体等精细化学品绿色合成中的应用研究，以及酶法治理有机污染物的研究。2005年3月获得浙江大学有机化学专业博士学位（师从陈振初教授），2012-2013年在美国斯克利普斯研究所（The Scripps Research Institute）Jin-Quan Yu教授课题组做访问****研究工作。
讲授课程：
《生物炼制》，《高等有机化学》与《药物合成反应》。
科研项目：
作为负责人完成了国家863计划重大项目子课题—左旋帕罗醇的生物不对称合成技术（2011AA02A209）、国家自然科学基金青年基金项目—功能化离子液体修饰介孔材料在酶固定化中的应用研究（**），材料化学工程国家重点实验室课题—基于天然高分子与介孔材料的有机-无机纳米复合材料固定化酶研究（ZK201603），江苏省自然科学基金项目—生物乙醇脱水制乙烯高性能分子筛催化剂及其反应器研究（BK**），中石化科技开发项目—熔盐循环等温固定床数值模拟及中试实验研究（L411003），材料化学工程国家重点实验室重点项目—生物乙醇脱水制乙烯高性能分子筛催化剂复合改性和反应器设计研究（ZK200815），国家发改委高技术产业化项目—酶法生产百吨级左旋帕罗醇示范工程等项目的研究工作。目前承担国家自然科学基金面上项目—基于分子模拟的功能性离子液体化学修饰脂肪酶分子改造研究（**），江苏先进生物制造协同创新中心自主研究项目—有机-无机纳米复合材料固定化酶及其处理有机工业废水研究。共发表SCI论文90余篇，获授权发明专利10余项。
部分论文：
(1) Xiang Qiu, Ying Wang, Yu Xue, Wenxuan Li, Yi Hu *. Laccase immobilized on magnetic nanoparticles modified by aminofunctionalized ionic liquid via dialdehyde starch for phenolic compounds biodegradation. Chemical Engineering Journal, doi.org/10.1016/j.cej.2019.123564.
(2) Hongbo Suo, Lili Xu, Yu Xue, Xiang Qiu, Hongyue Chen, He Huang,* Yi Hu *. Ionic liquids-modified cellulose coated magnetic nanoparticles for enzyme immobilization: Improvement of catalytic performance. Carbohydrate Polymers, 2020, 234, 115914.(3) Yajie Fu, Zeping Lu, Ke Fang, Xinyi He, Huajin Xu*, Yi Hu*. Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water. RSC Advances, 2020, 10, 10848-10853.
(4) Yu Xue, Hongyue Chen, Chao Xu, Dinghua Yu, Huajin Xu, Yi Hu*. Synthesis of hyaluronic acid hydrogels by crosslinking the mixture of high-molecular-weight hyaluronic acid and low-molecular-weight hyaluronic acid with 1,4-butanediol diglycidyl ether. RSC Advances, 2020, 12, 7206-7213.
(5)徐超,薛誉,陈虹月,胡燚.*手性脯氨酸类离子液体化学修饰猪胰脂肪酶催化性能研究.化工学报,2019,70(6):2221-2228.(5) Hongbo Suo, Lili Xu, Chao Xu, Xiang Qiu, Hongyue Chen, He Huang,*Yi Hu *. Enhanced catalytic performance of lipase covalently bonded on ionic liquids modified magnetic alginate composites. Journal of Colloid and Interface Science, 2019, 553, 494-502.
(6) Xiang Qiu, Jing Qin, Min Xu, Lifeng Kang, Yi Hu*. Organic-inorganic nanocomposites fabricated via functionalionic liquidas the bridging agent for Laccase immobilization and its application in 2,4-dichlorophenol removal. Colloids and Surfaces B Biointerfaces, 2019, 179, 260-269.
(7) Yajie Fu, Zeping Lu, Ke Fang, Xinyi He, He Huang, Yi Hu*. Promiscuous enzyme-catalyzed cascade reaction in water: Synthesis of dicoumarol derivatives. Bioorganic & Medicinal Chemistry Letters. 2019, 29(10): 1236-1240.
(8) Song Ding, Yang Sun, Hongyue Chen, Chao Xu, Yi Hu*. An ultrasonic-ionic liquid process for the efficient acid catalyzed hydrolysis of feather keratin. Chinese Journal of Chemical Engineering. 2019, 27(3): 660-667.
(9) Hongbo Suo, Lili Xu, Chao Xu, Xiang Qiu, Hongyue Chen, He Huang,*Yi Hu *. Graphene oxide nanosheets shielding of lipase immobilized on magnetic composites for the improvement of enzyme stability. ACS Sustainable Chemistry & Engineering, 2019, 7 (4): 4486–4494.
(10) Hongyue Chen, Jing Qin, Yi Hu.* Efficient degradation of high-molecular-weight hyaluronic acid by a combination of ultrasound, hydrogen peroxide, and copper ion. Molecules, 2019, 24, 617-279.
(11) Hongbo Suo, Zhen Gao, Lili Xu, Chao Xu, Dinghua Yu, Xinran Xiang, He Huang*, Yi Hu*. Synthesis of functional ionic liquid modified magnetic chitosan nanoparticles for porcine pancreatic lipase immobilization. Materials Science & Engineering C-Materials for Biological Applications, 2019, 96, 356-364.
(12) Hongbo Suo, Lili Xu, Chao Xu, Hongyue Chen, Dinghua Yu, Zhen Gao, He Huang*, Yi Hu*. Enhancement of catalytic performance ofporcine pancreatic lipase immobilized on functional ionic liquid modified Fe₃O₄-Chitosan nanocomposites. International Journal of Biological Marcomolecules, 2018, 119, 624-632.
(13) Xinran Xiang, Song Ding, Hongbo Suo, Chao Xu, Zhen Gao,Yi Hu*. Fabrication of chitosan-mesoporous silica sba-15 nanocomposites via functional ionic liquid as the bridging agent for PPL immobilization. Carbohydrate Polymers, 2018, 182, 245-253.
(14) Xinran Xiang, Hongbo Suo, Chao Xu,Yi Hu*. Covalent immobilization of lipase onto chitosan-mesoporous silica hybrid nanomaterials by carboxyl functionalized ionic liquids as the coupling agent. Colloids and Surfaces B Biointerfaces, 2018, 504, 186.
(15) Yajie Fu , Bingbing Fan , Hongyue Chen , He Huang,Yi Hu*. Promiscuous enzyme-catalyzed cascade reaction: synthesis of xanthone derivatives. Bioorganic Chemistry, 2018, 80, 555-559.
(16) Chao Xu, Xuhan Yin , Chuan Zhang , Hongyue Chen, He Huang, Yi Hu *. Improving catalytic performance of Burkholderia cepacia lipase by chemical modification with functional ionic liquids. Chemical Research in Chinese University, 2018, 34(2): 279-284.
(17) 相欣然, 万晓梅, 索红波, 胡燚*. 功能化离子液体修饰多壁碳纳米管固定化Candida antarctic lipase B. 物理化学学报, 2018, 34(1): 99-107.
(18) Yang Sun, Yemin Yu, Hongbo Suo, Yinglan Zhu, He Huang,Yi Hu*. Research on extracting technology of chlorogenic acid from Honeysuckle. Lecture Notes in Electrical Engineering. 2018, 444, 811-812.
(19) Chuan Zhang, Yigang Jia, He Huang,Yi Hu*. Study on the different replacing groups of trans-paroxol for enzymatic resolution using molecular simulations. Lecture Notes in Electrical Engineering. 2018, 444, 365-374.
(20) Xiaomei Wan, Xinran Xiang, Susu Tang, Dinghua Yu, He Huang,Yi Hu*. Immobilization ofCandida antarctic lipase B on MWNTs modified by ionic liquids with different functional groups. Colloids and Surfaces B Biointerfaces, 2017, 160, 416-422.
(21) Yang Sun, Song Ding, He Huang,Yi Hu*. Ionic liquid-based enzyme-assisted extraction of chlorogenic acid fromFlos Lonicera Japonicae. Bioresources and Bioprocessing. 2017, 4(1): 45-52.
(22) Xiaomei Wan, Susu Tang, Xinran Xiang, He Huang,Yi Hu*. Immobilization ofCandida antarctic lipase B on functionalized ionic liquid modified MWNTs. Applied Biochemistry Biotechnology. 2017,183(3): 807-819.
(23) 相欣然, 黄和, 胡燚*. 纳米复合材料固定化酶的研究进展. 无机化学学报，2017, 33(1): 1-15.
(24) Yan Ding, Xinran Xiang, Mengjie Gu, Haoran Xu, He Huang *,Yi Hu^*. Efficient lipase-catalyzed Knoevengael condensation: utilization of biocatalytic promiscuity for synthesis of benzylidene-indolin-2-ones. Bioprocess and Biosystems Engineering, 2016, 39(1): 125-131.
(25) 张川, 张鲁嘉, 张洋, 黄和, 胡燚*. 基于分子模拟的离子液体修饰Porcine pancreas脂肪酶催化性能和稳定性的相关研究. 化学学报, 2016, 74(1): 74-80.
(26)丁雁, 黄和, 吴素文, 李霜, 胡燚*. 水相中脂肪酶Lipase lipoprotein催化的Aldol缩合反应. 高校化学工程学报, 2016, 30(1): 121-126.
(27) 马燕, 刘维明, 黄和, 李霜, 胡燚*. Novozym435催化不对称水解3-(4-氟苯基)-戊二酸二甲酯的动力学研究. 高校化学工程学报, 2015, 29(1): 145-150.
(28) Li Xiujuan, Zhang Chuan, Li Shuang, Huang He*, Hu Yi^*. Improving catalytic performance ofCandida rugosa lipase by chemical modification with polyethylene glycol functional ionic liquids. Industrial & Engineering Chemistry Research, 2015, 54(33): 8072-8079.
(29) Ding Yan, Ni Xiao, Gu Meijie, Li Shuang, Huang He*,Hu Yi^*. Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase. Catalysis Communication, 2015, 64, 101-104.
(30) Tetsuya Toba^#,Yi Hu^#, AnhT Tran, Jinquan Yu *. beta-C-(sp(3))-H arylation of alpha-hydroxy acid derivatives utilizing amino acid as a directing group. Organic Letters, 2015, 17(24): 5966-5969.（共同一作）
(31) Yigang Jia, Yang Zhang,Hongman Zhang, He Huang, Lujia Zhang,Yi Hu*. Prediction of lysine acetylation sites in Porcine pancreas lipase modified by the ionic liquids usingmolecular dynamics simulations. Lecture Notes in Electrical Engineering, 2015, 333, 365-379.
(32) 万晓梅, 张川, 余定华, 黄和, 胡燚*. 碳纳米管固定化酶.化学进展, 2015, 27(9): 1251-1259.
(33) Weiming Liu,Yi Hu, Yang Zhang, Yan Ma, He Huang*. Enzymatic desymmetrization of 3-(4-fluorophenyl)glutaric anhydride|through enantioselective alcoholysis in organic solvents. Biotechnology and Bioprocess Engineering, 2014, 19(3): 449-455.
(34) Weiming Liu, Hongmin Ma, Jixing Luo, Wenhe Shen, Xian Xu, Shuang Li,Yi Hu^*, Huang He*. Efficient synthesis of L-tert-leucine dehydrogenase and formate dehydrogenase coexpressed in recombinantE. coli. Biochemical Engineering Journal, 2014, 91, 204-209.
(35) Weiming Liu, Jixing Luo, Xiaojian Zhuang, Shuang Li,Yi Hu^*, He Huang *. Efficient preparation of enantiopure L-tert-leucine through immobilized penicillin G acylase catalyzed kinetic resolution in aqueous medium, Biochemical Engineering Journal, 2014, 83, 116-120.
(36)YiHu，Jia Yango, Ru Jia, Yan Ding, Shuang Li, He Huang *. Chemical modification with functionalized ionic liquids: a novel method to improve the enzymatic properties of Candida rugosalipase. Bioprocess and Biosystems Engineering, 2014, 37 (8): 1617-1626.
(37) Ru Jia,Yi Hu*, He Huang*. Improving the catalytic performance of Porcine pancreatic lipase in the presence of [MMIm][MeSO₄] with the modification of functional ionic liquids. Process Biochemistry, 2014, 49(4): 668-672.
(38) Bin Zou,Yi Hu*, Fengjie Cui, Ling Jiang, Dinghua Yu, He Huang*. Effect of surface modification of low cost mesoporous SiO₂carriers on the properties of immobilized lipase. Journal of Colloid and Interface Science, 2014, 417, 210-216.
(39) Ru Jia,Yi Hu*, Ling Jiang, He Huang*. Chemical modification for improving activity and stability of lipase B from Candida antarctica with imidazolium functional ionic liquids. Organic & Biomolecular Chemistry, 2013, 11(41): 7192-7198.
(40) Ru Jia^#, Yi Hu^#, Luo Liu, Ling Jiang, Bin Zou, He Huang*. Enhancing catalytic performance of Porcine pancreatic lipase by covalent modification using functional ionic liquids. ACS Catalysis, 2013, 3(9): 1976.（共同一作）
(41) Bin Zou,Yi Hu, Ling Jiang, Jiao Yang, Ru Jia, He Huang*. Mesoporous material SBA-15 modified by amino acid ionic liquid to immobilize lipase via ionic bonding and cross-linking method. Industrial & Engineering Chemistry Research, 2013, 52(8): 2844-2851.
(42) Jiao Yang,Yi Hu, Ling Jiang, Bin Zou, Ru Jia, He Huang*. Enhancing the catalytic properties of porcine pancreatic lipase by immobilization on SBA-15 modified by functionalized ionic liquid. Biochemical Engineering Journal, 2013, 70, 46.
(43) Xiangjun Jiang,Yi Hu, Lin Jiang, Bin Zou, He Huang*. Optimization of enzymatic synthesis of L-ascorbyl palmitate by solvent engineering and statistical experimental designs. Biotechnology and Bioprocess Engineering, 2013, 18(2): 350-357.
(44) Xiangjun Jiang,Yi Hu, Lin Jiang, Jihong Gong, He Huang*. Synthesis of vitamin E succinate using Candida rugosa lipase in organic medium. Chemical Research in Chinese University, 2013, 29(2): 223-226.
(45) Yi Hu, Xiangjun Jiang, Suwen Wu, Ling Jian, He Huang*.Synthesis of vitamin E succinate by interfacial activated Candida rugosa lipase encapsulated in sol-gel materials. Chinese Journal of Catalysis, 2013, 34(8): 1608-1616.
(46) Xiaochen Wang,Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, Jinquan Yu*. Pd(II)-Catalyzed C?H iodination using molecular I₂ as the sole oxidant. Journal of the American Chemical Society, 2013, 135(28): 10326-10329.
(47) 胡燚, 杨姣, 唐苏苏, 初旭明, 邹彬, 黄和*. 氨基功能化离子液体修饰的SBA-15共价固定Burkholderia cepacia脂肪酶. 高等学校化学学报, 2013, 34(5): 1195-1202.
(48)丁雁, 黄和, 胡燚*. 脂肪酶催化C-C键形成反应研究进展. 有机化学, 2013, 33(05): 905-914.
(49) Yi Hu, Susu Tang, Ling Jiang, Bin Zou, Jiao Yang, He Huang*. Immobilization of Burkholderia cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Process Biochemistry, 2012, 47(12): 2291-2299.
(50) Susu Tang, Yi Hu*, Dinghua Yu, Bin Zou, Ling Jiang. Immobilization of Burkholderia cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Chinese Journal of Catalysis, 2012, 33(9): 1565-1571.
(51) Weiming Liu,Yi Hu, Ling Jiang, Bin Zou, He Huang*, Synthesis of methyl (R)-3-(4-fluorophenyl)glutarate via enzymatic desymmetrization of a prochiral diester. Process Biochemistry, 2012, 47(7): 1037-1041.
(52) Bin Zou, Yi Hu*, Dinghua Yu, Ling Jiang, Weiming Liu, Ping Song, Functional ionic liquid modified mesoporous silica SBA-15: a novel, designable and efficient carrier for porcine pancreas lipase. Colloids and Surface B: Biointerfaces, 2011, 88(1): 93-99.
(53) 黄鑫江, 胡燚*, 余定华, 胡耀池, 韩毓旺. 杂醇对La/HZSM-5催化乙醇脱水制乙烯反应的影响. 化工学报, 2011, 62(1): 97-102.
(54) Bin Zou, Yi Hu, Dinghua Yu, Jiaojiao Xia, Susu Tang, Weiming Liu, He Huang*. Immobilization of porcine pancreatic lipase onto ionic liquid modified mesoporous silica SBA-15. Biochemical Engineering Journal, 2010, 53(1): 15-153.
(55) Yi Hu, Weiming Liu, Bin Zou, Susu Tang, He Huang*. Enzyme immobilization on mesoporous materials. Progress in Chemistry, 2010, 22(8): 1656-1664.
(56) Yaochi Hu, Nina Zhan, Chang Dou, He Huang, Yuwang Han, Dinghua Yu, Yi Hu*. Selective dehydration of bio-ethanol to ethylene catalyzed by lanthanum-phosphorous-modified HZSM-5: influence of the fusel. Biotechnology Journal, 2010, 5(11): 1186-1191.
(57) Nina Zhan, Yi Hu, Heng Li, Dinghua Yu, Yuwang Han, He Huang*. Lanthanum-phosphorous modified HZSM-5 catalysts in dehydration of ethanol to ethylene: A comparative analysis. Catalysis Communications, 2010, 11(7): 633-637.
(58) Yi Hu, Tao Xie, Kaimei Fu, Hui Kang, Ping Wei, He Huang*. A convenient synthesis of 5-arylidenethiazolidine-2,4-diones catalyzed by alkaline ionic liquid. Heterocycles, 2009, 78(3): 757-761.
(59) 黄鑫江, 付凯妹, 胡耀池, 邹彬, 胡燚*. Fe、La改性beta沸石催化苯/正丁烯烷基化反应. 化工学报, 2009, 60(10): 2497-2502.
(60) Yi Hu, Hui Kang, Biwen Zeng, Ping Wei, He Huang*. Facile synthesis of 3-arylidene-1,3-dihydroindol-2-ones catalyzed by br?nsted acidic ionic liquids. Journal of Chemical Research, 2008, (11): 642-643.
(61) Yi Hu*, Heng Li, He Huang, Ping Wei. Advance of liquid-phase organic synthesis using functional ionic liquids as supports. Chinese Journal of Organic Chemistry, 2007, 27(10): 1188-1194.
(62) Yi Hu*, Ping Wei, Hua Zhou, Zhenchu Chen. Organic synthesis in ionic liquids: condensation of 3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds catalyzed by ethylenediammonium diacetate (EDDA). Chinese Chemical Letters, 2006, 17(3): 299-301.
(63) Yi Hu*, Ping Wei, He Huang, Shiqing Han. Synthesis of 2-aminothiophenes on ionic liquid phase support using the Gewald reaction. Synthetic Communications, 2006, 36(11): 1543-1548.
(64) Yi Hu*, Ping Wei, He Huang, Shiqing Han. Microwave-assisted Gewald synthesis of 2-aminothiophenes using functional ionic liquid as soluble support. Heterocycles, 2006, 68(2): 375-380.
(65) Yi Hu*, Ping Wei, He Huang, Zhanggao Le, Zhenchu Chen. Organic reactions in ionic liquids: ionic liquids ethylammonium nitrate promoted Knoevenagel condensation of Meldrum’s acid with aromatic adehydes. Synthetic Communications, 2005, 35(23): 2955-2960.
(66) Yi Hu, Jue Chen, Zhanggao Le, Zhenchu Chen*, Qinguo Zheng. Organic Reactions in ionic liquids: An efficient method for the synthesis of phenacyl esters by Rraction of carboxylic acids with α-bromoacetophenone promoted by potassium fluoride. Chinese Chemical Letters, 2005, 16(7): 903-905.
(67) Yi Hu*, Jue Chen, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: ionic liquid ethylammonium nitrate promoted Knoevenagel condensation of aromatic aldehydes with active methylene compounds. Synthetic Communications, 2005, 35(5): 739-744.
(68) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. N-alkylation of N-monosubstituted sulfonamides in ionic liquids. Organic Preparations and Procedures International. 2004, 36(4): 347-351.
(69) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: an efficient method for the N-alkylation of benzotriazole. Journal of Chemical Research, 2004, (5): 344-346.
(70)Yi Hu,Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: an efficient method for the synthesis of aryl sulfones by alkylation of sodium arenesulfinates with alkyl halides. Journal of Chemical Research, 2004, (4): 267-269.
(71) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: N-alkylation of cyclic imides with alkyl halides promoted by potassium fluoride. Journal of Chemical Research, 2004, (4): 276-278.
(72) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: A new method for the synthesis of alkyl aryl sulfones by alkylation of sodium arenesulfinates with unactivated alkyl chlorides. Synthetic Communications, 2004, 34(21): 4031-4035.
(73) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: ionic liquid promoted Knoevenagel condensation of aromatic aldehydes with (2-thio)-barbituric acid. Synthetic Communications, 2004, 34(24): 4521-4529.
(74) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: Gewald synthesis of 2-aminothiophenes catalyzed by ethylenediammonium diacetate.Synthetic Communications, 2004, 34(20): 3801-3806.
(75) Yi Hu, Zhenchu Chen*, Zhanggao Le, Qinguo Zheng. Organic reactions in ionic liquids: an efficient method for selective S-alkylation of 2-mercaptobenzothia(xa)zole with alkyl halides. Synthetic Communications, 2004, 34(11): 2039-2046.
部分授权发明专利：
(1) 胡燚, 黄和, 贾儒. 一种功能化离子液体修饰的脂肪酶及其修饰方法. 2013.04.10,中国, ZL5.6
(2) 胡燚, 黄和, 邹彬, 唐苏苏, 刘维明. 一种功能化离子液体修饰的介孔分子筛在酶固定化中的应用. 2012.02.01,中国, ZL2.X
(3) 胡燚, 黄和, 贾儒. 一种氨基葡萄糖硫酸盐的制备方法.中国, ZL8.7
(4) 胡燚, 刘维明, 黄和, 邹彬. 一种离子液体中酶拆分制备帕罗西汀中间体的方法. 中国, ZL3.1
(5) 胡燚, 黄和, 丁雁, 顾梦婕, 李浩然, 倪潇. 脂肪酶催化合成3-取代-2-吲哚酮类化合物的方法. 中国, ZL 9.7
联系方式：，huyi@njtech.edu.cn