个人简历

---

2017年 南京工业大学,先进化学制造研究院,副教授 2015-2016年 新加坡南洋理工大学,化学与生物化学系,博士后(导师: Teck-PengLoh教授)
2014-2015年 新加坡南洋理工大学,化学与生物化学系,研究助理
2010-2014年 新加坡南洋理工大学,化学与生物化学系,博士(导师: Teck-PengLoh教授)
2007-2010年 苏州大学,材料与化学化工学部,硕士(导师:纪顺俊教授)
2003-2007年 苏州大学,材料与化学化工学部,学士




研究方向

---

新型靶向抗癌药物Antibody-drug conjugates (ADCs)的设计和合成以及相关的化学生物学研究;过渡金属催化的不对称C-C键成键反应研究,包括不对称1,4及1,2-加成反应,不对称环加成反应等;廉价过渡金属催化的C-H官能化反应及其应用。




学术成绩

---

在博士及博士后期间, 主要从事靶向抗癌药物的设计和合成以及过渡金属催化的不对称合成等方面的研究, 并担任新加坡NRF2015NRF-POC001-024: “Allenamide: Platform Technology for Antibody-Drug Conjugates (ADC) 2.0的共同负责人, 开发了新型键联技术，用以改善靶向抗癌药物的选择性及稳定性，取得了突出的成果。近年来，在Chemical Science，Green Chemistry，Chemical Society reviews, Organic Letters, Journal of the American Chemical Society, Organic Chemistry Frontiers, Advanced Synthesis and Catalysis, Organic Chemistry Frontiers，Chemistry-An European journal, Chemical Communications等国际著名期刊上发表多篇高质量学术论文, 累计被引用230余次。目前，主持2018年度国家自然科学基金青年科学基金项目一项(**)，江苏省高等学校自然科学研究面上项目(18KJB150018)一项，江苏省有机合成重点实验室开放课题(KJS1945)一项，国家级重点大学生创新创业项目一项。获得2018年度江苏省双创博士称号，获2020年度第五届江苏省科协青年会员(化学化工领域)创新创业大赛一等奖及第十一届南京工业大学青年教师授课竞赛一等奖。



代表性论文

---

Zhao, K.; Shen, L.; Shen, Z.-L.^*; Loh, T.-P.^*, Transition Metal-Catalyzed Cross-Coupling Reactions Using Organoindium Reagents, Chem. Soc. Rev. 2017, 46, 586?602. (SCI一区; Back cover; 第一作者; Impact factor 40.182; 南京工业大学第一单位)
Guo, J.-Y.; Zhang, Z.-Y.; Guan, T.; Mao, L.-W.; Ban, Q.; Zhao, K.^*; Loh, T.-P.^*; Photoredox-Catalyzed Stereoselective Alkylation of Enamides with N-Hydroxyphthalimide Esters via Decarboxylative Cross-Coupling Reactions, Chem. Sci. 2019, 10, 8792?8798. (SCI一区; 通讯作者; Impact factor 9.556; 南京工业大学第一单位)
Zhao, K.*; Zhang, X.-C.; Tao, J-Y.; Wu, X.-D.; Wu, J.-X.; Li, W.-M.; Zhu, T.-H.*; Loh, T.-P. *; Regio- and Stereoselective C(sp²)-H Acylation of Enamides with Aldehydes via Transition-Metal Free Photoredox Catalysis, Green Chem. 2020, 22, 5497?5503. (SCI一区; 第一作者; Impact factor 9.480; 南京工业大学第一单位)
Zhao, K.*; Zhang, Z.-Y.; Cui, X.-L.; Wang, Y.-X.; Wu, X.-D.; Li, W.-M.; Wu, J.-X.; Zhao, L.-L.*; Guo, J.-Y.*; Loh, T.-P.*; Visible-Light-Induced Regio- and Stereoselective C(sp²)?H Trifluoroethylation of Enamides with 2,2,2-Trifluoroethyl Iodide, Org. Lett. 2020, 22, 9029?9035. (SCI一区; 第一作者; Impact factor 6.091; 南京工业大学第一单位)
Guo, J.-Y.; Guan, T.; Tao, J.-Y.; Zhao, K.*; Loh, T.-P.*; Stereoselective C(sp²)-H Alkylation of Enamides with Unactivated Aliphatic Carboxylic Acids via Decarboxylative Cross-Coupling Reactions, Org. Lett. 2019, 21, 8395?8399. (SCI一区; 通讯作者; Impact factor 6.555; 南京工业大学第一单位)
Zhu, T.-H.; Zhang, Z.-Y.; Tao, J.-Y.; Zhao, K.^*; Loh, T.-P.^*; Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenyl-phosphonium Bromide via Photoredox Catalysis, Org. Lett. 2019, 21, 6155?6159. (SCI一区; 通讯作者; Impact factor 6.555; 南京工业大学第一单位)
Zhang, Y.-H.; Zhang, W.-W.; Zhang, Z.-Y.; Zhao, K.^*; Loh, T.-P.^*, Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones, Org. Lett. 2019, 21, 5101?5105. (SCI一区; Impactor factor 6.555; 通讯作者; 南京工业大学第一单位)
Zhu, T.-H.; Zhang, X.-C.; Zhao, K.^*, Loh, T.-P.^*, Cu(OTf)₂-Mediated C(sp²)-H Arylsulfonylation of Enamides via the Insertion of Sulfur Dioxide, Org. Chem. Front. 2019, 6, 94?98. (SCI一区; Impact factor 5.076; 通讯作者; 南京工业大学第一单位)
Zhu, T.-H.; Zhang, X.-C.; Zhao, K.^*, Loh, T.-P.^* Direct C(sp²)?H Arylsulfonylation of Enamides via iridium(III)-Catalyzed Insertion of Sulfur Dioxide with Aryldiazonium Tetrafluoroborates. Adv. Syn. & Catal. 2019, 361, 3593?3598. (SCI一区; Impact factor 5.451; 通讯作者; 南京工业大学第一单位)
Zhao, K.; Loh, T.-P.^*, Asymmetric Conjugate Addition of Grignard Reagents to 3-silyl Unsaturated Esters for the Facile Preparation of Enantioenriched β-Silylcarbonyl Compounds and Allylic Silanes, Chem. Eur. J. 2014, 20, 16764?16772. (Impact factor 5.731; 第一作者)
Shen, L.; Zhao, K.; Doitomi, K.; Ganguly, R.; Li, Y.-X.; Shen, Z.-L.^*; Hirao, H.; Loh, T.-P.^*, Lewis Acid-Catalyzed Selective [2+2]-Cycloaddition and Dearomatizing Cascade Reaction of Aryl Alkynes With Acrylates. J. Am. Chem. Soc. 2017, 139, 13570?13578.
Wu, L.-H.; Zhao, K.; Shen, Z.-L.^*; Hirao, H.; Loh, T.-P.^*, Copper-Catalyzed Trifluoromethylation of Styrene Derivatives With CF₃SO₂Na, Org. Chem. Front. 2017, 4, 1872?1875.
Zhao, K.; Zhu, S.-L.; Shi, D.-Q.; Xu, X.-P.^*; Ji, S.-J.^*, Regioselective Synthesis of Highly Functionalized 3-Spiropyrrolidine/pyrrolizidine Oxindoles and Acenaphthenones via one-Pot Four-Component [3+2] Cycloaddition, Synthesis 2010, 1793?1803.
Zhao, K.; Xu, X.-P.; Zhu, S.-L.; Shi, D.-Q.; Zhang, Y.; Ji, S.-J.^*, Facile and Efficient Synthesis of a New Class of Indole-Substituted Pyridine Derivatives via One-pot Multicomponent Reactions, Synthesis 2009, 2697?2708.
Xiao, J.; Zhao, K.; Loh, T.-P.*, Acid Free Asymmetric Intermolecular α-Alkylation of Aldehydes in Fluorinated Alcohols, Chem. Commun. 2012, 48, 3548?3550.
Xiao, J.; Zhao, K.; Loh, T.-P.*, Highly Enantioselective Intermolecular Alkylation of Aldehydes with Alcohols By Cooperative Catalysis of Diarylprolinol Silyl Ether with Br?nsted acid, Chem. Asian J. 2011, 6, 2890?2894.
Zhu, S.-L.; Ji, S.-J.;* Zhao, K.; Liu, Y. Multicomponent Reactions for The Synthesis of New 3’-Indolyl Substituted Heterocycles Under Microwave Irradiation, Tetrahedron Lett. 2008, 49, 2578?2582.
Zhu, S.-L.; Ji, S.-J.;* Zhao, K.; Zhang, Y. A Simple and Efficient One-Pot Synthesis of Spirooxindoles in Water Under Microwave Irradiation Conditions, Lett. Org. Chem. 2008, 5, 319?323.
Zhu, S.-L.; Zhao, K.; Su, X.-M.; Ji, S .-J.*, Microwave-Assisted Synthesis of New Spiro[indoline-3,4’-quinoline] Derivatives via A One-pot Multicomponent Reaction, Synth Commun. 2009, 39, 1355?1366.
Zhu, X.; Xu, X.-P.; Sun, C.; Wang, H.-Y.; Zhao, K.; Ji, S.-J.*, Direct Construction of Imino-Pyrrolidine-Thione Scaffold via Isocyanide-Based Multicomponent Reactions, ACS Comb. Sci. 2010, 12, 822?828.






赵恺 副教授
Email:Ias_kzhao@njtech.edu.cn