佘金雄教授阅读次数:9299添加时间:2009-8-7姓名：佘金雄职称：南京工业大学首席教授，博士生导师美国佐治亚州医科大学教授，佐治亚州科研联盟杰出学者职务：南京工业大学药学院院长Director,CenterforBiotechnology&GenomicMedicine,MedicalCollegeofGeorgia教育简历:1978-1982年就读于中国华中农业大学，获得学士学位；1982-1983年就读于中山大学生物学系；1983-1984就读于法国图卢兹国家农业大学，获硕士学位；1984-1987年获得法国蒙彼利埃大学分子及群体遗传学博士学位；1988年-1990年在美国佛罗里达大学病理学系从事博士后研究；研究经历简介：1992-2002年任美国佛罗里达大学病理学系助理教授，副教授，教授，首席教授，和糖尿病研究中心主任2002年后任美国佐治亚医科大学生物技术与基因组医学研究中心主任、佐治亚州科研联盟杰出学者，佐治亚医科大学病理学系教授和副主任，担任佛罗里达大学医学院，北京协和医科大学，武汉大学生命科学学院等知名高校的兼职教授2007年起任美国SuperArray公司科学顾问，在世界知名学者，PhysiologicalGenomics，InternationalJournalofClinicalandExperimentalMedicine，TheOpenDiabetesJournal，TheOpenAutoimmunityJournal国际期刊杂志编委，并应邀成为JournalofExperimentalMedicine,ProceedingsoftheNationalAcademyofSciences,PloSBiology,Diabetes,Hepatology，AmericanJournalofHumanGenetics等国际知名期刊的特约审稿人，担任世界多国课题评委和博士论文评审专家。从1983年起，佘教授先后从事多种学科和跨学科的研究，包括分子生物学，群体遗传学，人类遗传学，基因组学，蛋白组学，生物信息学，分子流行病学，疾病预测与预防，和新药研发。发表150多篇学术论文，共获得七千多万美元的科研经费，建立了世界上最大、最完善的糖尿病标本库，克隆多个基因并阐述在疾病中的作用，发现多个可用于疾病预测和诊断的生物标志物，发现多个新药物靶点，发明十几个新药先导化合物，即将进入临床试验。学术兼职：学术组织名称担任职务参加时间青少年糖尿病基金会委员1993?至今美国糖尿病协会委员1993?至今美国人类遗传学会SteeringCommitte委员1993?至今美洲华人遗传学会主席2002-2003美国糖尿病协会，免疫学主席2003-2005HumanBiologicalDataInterchangeDiabetesGeneticResourceSteeringCommittee主席2001?2005研究方向：GeneticsandGenomics遗传学与基因组学Proteomics蛋白质组学DrugDevelopment新药研发MolecularEpidemiology分子流行病学Autoimmunity自身免疫Type1DiabetesI型糖尿病Cancer肿瘤科研项目：FundingasprincipleinvestigatorTotalcosts:$30,429,953PINameAgencyGrant#TitleDurationShe,JXUFLNewfacultyAward1992-1992She,JXUFLNewfacultyAward1992-1994She,JXUFLGraduatestudentsupport1993-1994She,JXJDRFJDF193182Sib-pairanalysisofinsulin-dependentdiabetes1993-1996She,JXJDRFJDF195094GeneticandFunctionalAnalysisofHLAClassIAntigenProcessingGenesinIDDM1995-1997She,JXJDRFJDF196113ConfirmationofIDDMsusceptibilitygenes1996-1998She,JXNIH1RO1DK50220AffectedsibpairanddisequilibriummappingofIDDMgenes1996-1998She,JXJDRFJDF197052AnalysesofanIDDMsusceptibilitygeneintheCTLA4/CD28region1997-1999She,JXUFLGeneticscreeningofhighrisksubjectstoIDDMinnewbornbabies1997-2000She,JXNIH1R01DK53266Identificationandanalysesoftheurofacialsyndromegene1998-2002She,JXChineseScienceFoundation39928020LinkagestudiesonHashimoto'sthyroiditis2000-2004She,JXNIH1R01DK53103GeneticandfunctionalanalysesofIDDM12intheCTLA4/CD28region1997-2001She,JXNIAI2P01AI-42288Blymphocytesubsetsintype1diabetes1997-2006She,JXNIAI2P01AI-42288LaboratoryCore.1997-2006She,JXJDRFJDF1-1998-187LinkagedisequilibriumMappingofIDDM81998-2000She,JXNICHD2RO1HD37800Prospectivestudiesininfantsoftheimmunopathogenesisoftype1diabetes1999-2008She,JXNIDDK5U24DK58778NIDDKbiotechnologycenteratU.ofFlorida2000-2003She,JXNICHD1R21HD050196Proteomicchanges/progressionofhumantype1diabetes2004-2006She,JXNIDDK1R21DK069878Developmentofmicroarray-basedbiomarkersfortype1diabetes2004-2006She,JXNIDDK1U01DK063865Consortiumforidentificationofenvironmentaltriggersfortype1diabetes:MCG/UFclinicalcenter2003-2008She,JX1-2004-661Validationofmicroarray-basedbiomarkersfortype1diabetes2004-2008She,JXNIH/UF1R01CRGeneticcontrolofautoimmuneexocrinopathyinNODmice2003-2008Fundingasco-PIorco-ITotalcosts:$16,370,404PINameAgencyGrant#TitleDurationRutledge,DMerckPharmaceuticalGeneticsofHypertensioninAfricanAmericans1993-1994Rutledge,DAm.HeartAssAssociationstudyofACEgenewithhypertensioninBlacksWakeland,ENIH1R01HL47138HLAclassIIgenotypingbyDGGEanddirectsequencing1991-1996Maclaren,NNIHRO1HD19469IsletcellautoantibodiesandthenaturalhistoryofIDD1992-1997Maclaren,NNIHUO1DK46636TheeffectsoforalantigentherapyinIDD1993-1998Treiber,FNIHMCG’sclinicalandtranslationalresearchtransformation2006-2007Mi,QSJDRF1-2005-1039FineMappingandfunctionalDissectionofMouseDiabetesSusceptibilityIdd4Locus2005-2008Wang,CYJDRFLinkagestudiesofIDDM52004-2007Mi,QSJDRF5-2006-396RoleofmicroRNAsinisletapoptosis2006-2007Ferris,DGCCSerologicOvarianCancerbiomarkersthatpredicttherapeuticresponse2004-2005Mi,QSJDRFJDRF5-2006-403microRNAsanddiabetessusceptibilityinNOD2006-2007Wang,CYNIHR21DK074957CharacterizationoftheUrofacialSynsdromeGene2006-2008Peck,ANIH1R01CR1R01CR2003-2008SponsoredpostdoctoralfellowshipsTotalcosts:$586,246PINameAgencyGrant#TitleDurationMarron,MichelleJDRFJDF3-1999-348GeneticandfunctionalanalysesofIDDM121999-2000Semiromi-Davoodi,R.JDRFJDF3-1999-671Fine-mappingandcloningoftheIDDM8geneonchromosome6q271999-2001Eckert,MarkNIH1F32DC00393Heritabilityofananatomicalriskfactorfordyslexia1999-2001Semiromi-Davoodi,R.JDRFJDF10-2001-589MutationdetectioninmurineSTATgenefamily:identificationandcharacterizationofanovelpointmutationinDNAbindingdomainofStat5binNOD2001-2004Purohit,SharadJDRFIdentificationofSerumProteinMarkersforType-1DiabetesUsingMass-SpectrometryTechniques2001-2006SponsoredcareerdevelopmentawardsTotalcosts:$1,637,910PINameAgencyGrant#TitleDurationLiu,ChenNIHKO8RoleoflivercytokinesinhepatitisCviralinfection2002-2007Mi,Qing-shengADA7-05-JF-30FinemappingandfunctionaldissectionofmousediabetessusceptibilityIdd4locus2005-2008Wang,CongyiADA1-05JF-47GeneticandfunctionalstudiesoftheIDDM5locus2005-2007ActiveFundingTotalcosts:$25,096,431PINameAgencyGrant#TitleDurationShe,JXNIDDK2U01DK063865Consortiumforidentificationofenvironmentaltriggersfortype1diabetes:MCG/UFclinicalcenter2008-2013She,JXNIDDK4R33DK069878Developmentofmicroarray-basedbiomarkersfortype1diabetes2006-2009She,JXNIDDK4R33HD050196Proteomicchanges/progressionofhumantype1diabetes2006-2009She,JXNIDDK/USFTEDDYRNALaboratory2008-2013Wang,CongyiJDRF1-2007-181TheimapctofM55VofSUMO4onDCfunctionintype1diabetes2007-2010Pacholczyk,RafelJDRF1-2008-494TcellactivityinSTZ-induceddiabetesusingTCRminimice2008-2011Purohit,SharadJDRF10-2006-792IdentificationandvalidationofserumbiomarkersforT1D2006-2010Zhi,WenboJDRF3-2009-275High-ThroughputConfirmationofSerumBiomarkersforType1Diabetes2009-2011代表性论文：1.She,J.X.,Autem,M.,Kotulas,G.,Pasteur,N.andBonhomme,F.MultivariateanalysisofgeneticexchangesbetweenSoleaaegyptiacaandSoleasenegalensis(Teleosts,Soleidae).Biol.J.Linn.Soci.,1987,32:357-371.2.Wakeland,E.K.,Boehme,S.,andShe,J.X.ThegenerationandmaintenanceofMHCclassIIgenepolymorphisminrodents.ImmunologicReview,113,1990,p.207-226.3.She,J.X.,Boehme,S.,Wang,T.W.,Bonhomme,F.andWakeland,E.K.AmplificationofmajorhistocompatibilitycomplexclassIIgenediversitybyintra-exonicrecombination.PNAS,88,1991,p.453-457.4.Lamers,S.A.,Leasman,J.W.,She,J.X.,Kimberly,A.,Barrie,K.A.,Pomeroy,S.M.,Barrett,D.J.andGoodenow,M.M.Persistenceofmultiplematernalgenotypesofhumanimmuno-deficiencyvirustypeIininfantsinfectedbyverticaltransmission.J.Clin.Invest.93,1994,p.380-390.5.Deng,Y.G.,Muir,A.,Maclaren,N.K.,andShe,J.X.AssociationofLMP2andLMP7inthemajorhistocompatibilitycomplexwithinsulin-dependentdiabetesmellitus:Populationandfamilystudies.Am.J.Hum.Genet.1995,56:528-534.6.Luo,D.F.,Bui,M,Muir,A.,Maclaren,N.K.,Thomson,G.,andShe,J.X.,Affectedsibpairmappingofanovelsusceptibilitygenetoinsulin-dependentdiabetesmellitus(IDDM8)onchromosome6q25-q27.Am.J.Hum.Genet.1995,57:911-919.7.LuoD.F.,Buzzetti,R.,Rotter,J.,Maclaren,N.K.,Raffael,L.,Nistico,L.,Giovannini,C.,Pozzilli,P.,Thomson,G.andShe,J.X.Confirmationofthreesusceptibilitygenestoinsulin-dependentdiabetesmellitus:IDDM4,IDDM5andIDDM8.HumanMolecularGenetics,1996,5(5):693-698.8.She,J.X.SusceptibilitytotypeIdiabetes:HLA-DQand-DRrevisited.ImmunologyToday,1996,17(7):323-329.9.Wang,CY.,Hawkins-Lee,B.,Ochoa,B.,andShe,J.X.1997.HomozygositymappingoftheOchoa(Urofacial)SndromeGeneto1cMregiononchromosome10q23-q24.Am.J.Hum.Genet.60:1461-1467.10.Marron,M.,L.J.Raffel,H.J.Garchon,C.O.Jacob,M.T.MartinezLarrad,W.-P.Teng,Y.S.Park,Z.-X.Zhang,D.R.Goldstein,Y.-W.Tao,G.Beaurain,M.S.Rios,J.-F.Bach,H.-S.Huang,D.F.Luo,A.Zeidler,J.I.Rotter,M.C.K.Yang,N.K.MaclarenandJ.X.She,Insulin-dependentdiabetesmellitus(IDDM)isassociatedwithCTLA4polymorphismsinmultipleethnicgroups.Hum.Mol.Genet.1997,8:1275-1282.11.She,J.X.andMarron,M.P.1998,GeneticSusceptibilityfactorsintype1diabetes:linkage,disequilibriumandfunctionalanalyses,Curr.Opin.Immunol.,10:682-689.12.WangCY,JDShi,ADavoodi-SemiromiandJXShe,1999,CloningofAire,themousehomologueofAutoimmuneRegulator(AIRE)GeneResponsibleforAutoimmunePolyglandularSyndromeType1(APS1),Genomics,55:322-326.13.She,J.X.,TamirM.Ellis,S.BrianWilson,CliveH.Wasserfall,MicheleMarron,SharonReimsnider,SallyC.Kent,DavidA.Hafler,DonnaS.Neuberg,AndyMuir,JackL.StromingerandMarkA.Atkinson.HeterophileantibodiessegregateinfamiliesandareassociatedwithprotectionfromType1diabetes.Proc.Natl.Acad.Sci.USA,1999,96(14),8116-8119.14.LitherlandSA,XieXT,HutsonAD,WasserfallC,WhittakerDS,SheJX,HofigA,DennisMA,FullerK,CookR,SchatzD,MoldawerLL,Clare-SalzlerMJ.Aberrantprostaglandinsynthase2expressiondefinesanantigen-presentingcelldefectforinsulin-dependentdiabetesmellitus.J.Clin.Invest.104(4):515-523.15.WangCY,ShiJD,OchoaB,Hawkins-LeeB,HuangYQandSheJX,Constructionofaphysicalmapfora1-Mbgenomicregioncontainingtheurofacial(Ochoa)syndromegeneon10q23-q24.Genomics.60:12-19.16.MarronMP,ZeidlerA,RaffelLJ,GarchonHJ,JacobCO,Serrano-RiosM,LarradMTM,ParkYS,BachJF,RotterJI,YangMCK,SheJX,Geneticandphysicalfine-mappingofaType1diabetessusceptibilitygene(IDDM12)nearCTLA4onchromosome2q33.Diabetes.2000,49:492-499.17.ShiJD,TKukar,CYWang,QZLi,PECruz,ADavoodi-Semiromi,PYang,YRGu,WLian,DHWuandJXShe,MolecularCloningandCharacterizationofANovelMammalianEndo-Apyrase(LALP1)JBC,2001:276(20):17474-17478.18.LiQZ,EckenrodeS,RuanQG,WangCY,ShiJD,McIndoeRA,SheJX:RapiddecreaseofRNAlevelofanovelmousemitochondriasolutecarrierprotein(Mscp)geneat4-5weeksofage.MammGenome.2001Nov;12(11):830-619.Kumar,P.G.,Laloraya,M.,Wang,C.Y.,Ruan,Q.G.,Davoodi-Semiromi,A.,Kao,K.J.,andShe,J.X.(2001).TheAutoimmuneRegulator(AIRE)IsaDNA-bindingProtein.JBiolChem276:41357-41364.20.Yang,M.C.,Ruan,Q.G.,Yang,J.J.,Eckenrode,S.,Wu,S.,McIndoe,R.A.,andShe,J.X.(2001).Astatisticalmethodforflaggingweakspotsimprovesnormalizationandratioestimatesinmicroarrays.PhysiolGenomics7:45-53.21.LiQZ,WangCY,ShiJD,RuanQG,EckenrodeS,Davoodi-SemiromiA,KukarT,GuY,LianW,WuD,SheJX.MolecularcloningandcharacterizationofthemouseandhumanTUSPgene,anovelmemberofthetubbysuperfamily.Gene.2001Aug8;273(2):275-84.22.LiSW,TangD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48.LiShuiyi,LynsaNguyen,HairongXiong,MeiyaoWang,TomC.-C.Hu,Jin-XiongShe,StevenM.Serkiz,GeorgeG.Wicks,andWilliamS.Dynan,Porous-wallhollowglassmicrospheresasnovelpotentialnanocarriersforbiomedicalapplications,Nanomedicine,2009(inpress).专利1.AncientConservedDomainProteins(ACDP),afamilyofdivalentiontransportersinmammaliancells.USandInternationalPatent:S/No.10/199,2292.AnovelSUMO4genefortype1diabetessusceptibility.USandInternationalPatent:011-04本文共分1页