教授–徐德锋
Email:markxu@cczu.edu.cn
教育经历：
l1986年-1990年，江苏化工学院有机化工本科
l1997年-2000年南京理工大学应用化学工程硕士
l2003年-2006年上海交通大学药物化学博士

工作经历：
l1990年-1992年中石化抚顺分公司，助理工程师
l1992年-2000年江苏激素研究所，工程师
l2001年-2003年金坛希望化工有限公司，总经理/高级工程师
l2006年-2012年上海交通大学，副研究员/研究员级高工
l2009年-2011年罗切斯特大学，博士后/访问****
l2012年–至今南京慧博生物科技有限公司，董事长/研究员
l2013年–至今常州大学，教授/团队负责人
l2017年-2018年罗切斯特大学，访问教授

个人荣誉：
l2019年侯德榜化工科技创新奖，
l2019年第五届中国“互联网+”大学生创新创业大赛全国总决赛银奖
l2019年第五届“互联网+”大学生创新创业大赛江苏决赛一等奖，决赛季军，精准扶贫奖
l2018年中国发明协会发明创业成果奖-二等奖
l2018年优秀民营科技创新成果三等奖
l2018年中国产学研合作创新奖
l2018年科学中国人（2017）年度人物奖
l2018年度全国石油和化工优秀科技工作者
l2018年浙江台州市“500精英计划”A类人才
l2018年度常州优秀盟员
l2018年常州民盟第六届高校论坛论文比赛一等奖
l2017年江苏双创团队领军人才
l2017年优秀民营科技创新成果二等奖
l2017年中国产学研合作促进会优秀成果奖
l2015年江苏省双创人才
l2014年中国发明协会发明创业奖-人物奖
l2014年中国石油与化工联合会科技发明三等奖
l2012年南京市321引进人才
l2012年上海交通大学教学成果二等奖（排名第四）
l2010年上海药学会科技进步三等奖（排名第三）
l2009年,中国石油与化工联合会科技进步二等奖（排名第二）
l2008年上海交通大学晨星青年****二等奖
l2005年上海药学会科技论文三等奖
l1998年中国经贸部HP应用成果奖三等奖

社会兼职（社会兼职填是否担任过专业杂志编委、专业委员会委员、专业协会会员等）
l江苏双创人才联合会副秘书长，现代农业科技专委会秘书长
l中国发明家协会会员
l江苏省生物技术协会特邀理事
l中国农学会专业会员
l中国化工学会专业会员
lAgricultural and Biological Sciences 编委
lJournal the Journal of Agriculture and Food Chemistry编委
lInternational Journal of Oncology 编委

研究方向:
l绿色除草剂创新及新技术产业
l清洁工艺生产技术产业化研究
l新型抗雄激素受体和抗晚期前列腺癌机制研究
l药物设计、合成生物活性分子

教学科研项目:
l江苏省“双创团队”基金，“绿色除草剂创新、创制及新技术应用研究”，（2017-2022，主持)
l浙江省台州市“500精英计划”-A类创业基金，“高效除草剂嘧啶肟草醚绿色制造技术产业化”，（2018-2021，主持)
l江苏省科技厅苏北科技专项，(基金号:SZ-YC**) :“盐碱地灵芝栽培种植技术集成与示范应用研究”，（2017-2019，共同主持)
l常州市科技支撑计划,(基金号:CE**) :“高效绿色除草剂嘧啶肟草醚关键技术产业化及应用研究”，（2016-2017,主持)
l江苏省科技型中小企业技术创新资金(代号BC**)：“现代中药祛痘功能活性分子及功能化妆品研发”(2013-2016, 主持)
l浙江省嘉兴市“创新嘉兴·精英引领计划”A类创业基金：“生物靶向纳米分子活性研究及功能化妆品产业化”(2014-2016, 主持)
l江苏常州市“龙城英才计划”C类特别创业基金：“新型雄激素受体药物的创制研究及前列腺保健食品技术产业化”(2014-2016, 共同主持)
l江苏南京市321人才创新创业基金：“高效低毒水稻田除草剂双草醚新技术成果转化” (2013-2015,主持)
l国际合作项目:“国家一类新药ACS-J9临床前研究” (2013-2016, 主持)
l上海市闵行基金,(基金号:2012MH166) :“ 噁二嗪类杀虫剂SIOC-Y-047创制研究，（2012-2015,共同主持)。
发表论文
1.Defeng Xu*, H.Hu, J.G, J.Da, YP.Xie, YL. Li, R. Kong, GQ.Song, H.Zhou., Synthesis of Novel Tanshinone Derivatives TargetingAndrogen Receptor for Treatment ofCastration-resistant Prostate Cancer.Chem Biol Drug Des. 201994(3):1656-1663. doi: 10.1111/cbdd.13567.
2.Hang Hu,Huan Zhou, Zihan Zhen,ZheWu, Rong Zhang,and Defeng Xu*, Methoxylpoly(ethyleneglycol)-retinoic acid Micelles Loaded with Dimethylcurcumin for Efficient CastrationResistant Prostate Cancer Therapy, ChemistrySelect.2019, 4, 12015–12021.
3.Bin Wang,Xiangjian Xu,Shunze Gong,Qin Wang,Hang Hu*, Defeng Xu*, Synthesis and Herbicidal Activity of O-(2,6-Bis(4,6- dimethoxypyrimidin-2-yloxy) benzoyl)oxime3-Trifluoromethylacetophenone. ChemistrySelect.2019, 4, 11771– 11775.
4.Hu H, Wang B, Lai C, Xu X, Zhen Z, Zhou H,Defeng Xu*,iRGD-paclitaxel conjugate nanoparticles for targeted paclitaxel delivery.Drug Dev Res.2019,1-9. doi: 10.1002/ddr.21589.
5.Zhou H,Liu YL,Lv L , Wang WJ, Hu H,YangL, Defeng Xu*. Design and evaluation of a solid dispersion and thermosensitive hydrogel combined local delivery system of dimethoxycurcumin . Journal ofDrug Delivery Science and Technology, 2019, 53. UNSP 101150. DOI: 10.1016/j.jddst.2019.101150
6.LZhang, SB Cheng, H Hu,Defeng Xu*,A Facile Synthesis of 3-(Chloromethyl)-methyl-1,1′-biphenyl, Asian J. Chem.2019,31(12) : 3009-3011.
7.H.Zhou,WJ.Wang, H.Hu, X.Ni, S.Ni, Y.Xu, L.Yang,Defeng Xu*, Co-precipitation of calcium carbonate and curcumin in an ethanol medium as a novelapproach for curcumin dissolution enhancement. Journal ofDrug Delivery Science and Technology, 2019,19, 4-8.
8.Defeng Xu, WJ Wang,MMYang,SB Bhaduri,CCHuang,L Yang,ZYi Zhang,H Zhou*.Application of beta-CD/HA composite as a potential SD carrier to improve the dissolution of curcumin.Micro & NanoLetters,2019,14(40):353-8, DOI: 10.1049/mnl.2018.5096.
9.Defeng Xu, YL. Liu, WJ. Wang, H. Zhou*, Preparation and Characterization of Dimethylcurcumin Solid Dispersion. Chin. J.Pharmaceuticals.2019, 50(2),75-80.
10.Shen Mei-Hua, Qu Hong-Yu, Dai Ping, Zhou Hao, Liu TS, Bao Xiaoguang, Xu Defeng, Xu Hua-Dong. Intramolecular Imino-ene Reaction of Azirines: Regioselectivity, Diastereoselectivity, and Computational Insights. JOURNAL OF ORGANIC CHEMISTRY.2019,, 84(7):4095-4103. DOI: 10.1021/acs.joc.9b00087
11.YP. Bi, HM. Wang, HY. Qu, XC. Liang, Y. Zhou, XY. Li, Defeng Xu, MH. Shen *, HD. Xu*, Stereoselective synthesis of all-cis boryl tetrahydroquinolines via copper-catalyzed regioselective addition/cyclization of o-aldiminyl cinnamate with B(2)Pin(2).Org. Biomol. Chem.,2019, 17, 1542–1546.
12.Huang Xiu-Rong,Zhang Yu-Mei,Wan Ting-Biao,Zhang Piao, Zhang Xiu-Xiu, WangFang-Ming,Xu Defeng, Shen Mei-Hua, Xu Hua-Dong. Straightforward synthesis of 4,5-bifunctionalized 1,2-oxazinanes via Lewis acid promoted regio- and stereo-selective nucleophilic ring-opening of 3,6-dihydro-1,2-oxazine oxides.Tetrahedron,2019, 75(45):130336.DOI: 10.1016/j.tet.2019.05.015.
13.Max A. Cheng, Fu-Ju Chou , Keliang Wang, Rachel Yang, Jie Ding, Qiaoxia Zhang,Gonghui Li, Shuyuan Yeh, Defeng Xu*and Chawnshang Chang*,Androgen receptor (AR) degradation enhancer ASC-J9 ? in an FDA-approvedformulated solution suppresses castration resistant prostate cancer cellgrowth.Cancer Letters,2018,417:182-191.
14.Defeng Xu*, Xinhong Cai and Shunze Gong, Design, Synthesis and Evaluation of Insecticidal Activity of Novel Oxadiaz-ine Derivatives.Curr Bioact Compd,2018, 14, 9-20.
15.Mengmeng Yang,Fang Liang,Defeng Xu*,Yue Wang, Huan Zhou*,Tea Polyphenols Selectively Inhibit Proliferation andMigration of Airway Smooth Muscle Cells,Journal of Biology and Life Science,2018, 9(2), 39-51
16.H Zhou,YP Bi,MM Yang,WJ Wang,XY Ni, DF Xu*. Synthesis of mesoporous magnesium phosphates as dispersing carriers for cryptotanshinone solid dispersions.International Journal of Applied Ceramic Technology.2018,15(4):938-946.
17.Defeng Xu*, Qiulu Chen, Yalin Liu and Xingqiao Wen*,Baicalein suppresses the androgen receptor (AR)-mediatedprostate cancer progression via inhibiting the AR N-Cdimerization and AR-coactivators interaction, Oncotarget, 2017, 8(62),105561-105573.
18.Rui Li, Defeng Xu, Xingqun Yang, Shouxiu Ma, Xiaoai Ge, Shuwen Zhou *, Preparation and stability studies of dimethyl curcumin niosomes, J. Chin. Pharm. Sci. 2017, 26 (4), 265–270.
19.XinhingCai, Qiulu Chen, JingGuan, ShunzeGong, HaoFuandDefeng Xu*,A Convenient Synthesis of 2-Methoxycarbonyl-5-iodobenzene Sulfonamide,Asian Journal of Chemistry; Asian J. Chem., 2017,29(7),1622-1624.
20.Defeng Xu*,Shunze Gong, Xinhong Cai, Concise and Convenient Synthesis of 4-(Trifluoromethylthio) aniline, Asian J. Chem., 2017,29(11), 91-92.
21.Defeng Xu*, Jing Guan, Xing Xu, Shunze Gong andHui Xu, A New Method for the Synthesis of Oxadiazine Insecticide Indoxacarb, J.Heterocyclic.Chem2016, 53: 1469-1473.
22.Qiang Dang, Wenbin Song, Defeng Xu, Yanmin Ma, Feng Li, Jin Zeng, Xinyang Wang, Luke Chang, Dalin He, Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis, MOLECULAR CARCINOGENESIS, 2015, 54( 9): 831-840.
23.Wenbin Song, Qiang Dang, Defeng Xu, Yule Chen, Guodong Zhu, Kaijie Wu, Jin Zeng, Qingzhi Long, Xinyang Wang, Dalin He, Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling, ONCOLOGY REPORTS, 2014,31(3): 1350-1356.
24.Xu D, Lin TH, Yeh CR, Cheng MA, Chen LM, Chang C, Yeh S.The wedelolactone derivative inhibits estrogen receptor-mediated breast, endometrial, and ovarian cancer cells growth.Biomed Res Int. 2014, 713263.
25.DefengXu*, Xing Xu, Zhiling Zhu, A Convenient Synthesis of 4-Amino-2-fluoro-N-methyl- benzamide, J.Chem.Res.,2013,10,615-616.
26.Soh SF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C.Determination of androgen receptor degradation enhancer ASC-J9(?) in mouse sera and organs with liquid chromatography tandem mass spectrometry.J Pharm Biomed Anal. 2014, 88:117-22.
27.Zhou, SW, Xu, DF*, Wang, ZQ, Zhu, ZL , Zha, ZY , Fan, Y, Su, HK, An Efficient and Convenient Synthesis of 4,6-Dichloro-2-methyl-5-nitropyrimidine, Asian J. Chem., 2014,26(12), 3559-3561.
28.Defeng Xu*, Zhiling Zhu, Ziqiao Wang, A convenient synthesis of 4, 6-dimethyl-2-(methylsulfonyl)pyrimidine, J.Chem.Res.,2013, 12, 720-722.
29.Defeng Xu*, Zhiling Zhu, Hui Xu, Ziqiao Wang, A facile Synthesis of 4, 6-dimethoxy-2- methylsulfonyl-pyrimidine, Asian J. Chem.,2014, 26(1), 313-314.
30.Defeng Xu*,Ziqiao Wang,A Facile Synthesis of 4,6-Di methoxy-methylsulfonylpyrimidine,Asian J. Chem.,2014, 26 (1), 313-314.
31.MinLu, Shuwen Zhou, Jing Guan, Xing Xu, Yu Fan, Defeng Xu*, Synthesis of key intermediate of phosphonosulfonates (BPH-652), 1-(3-iodopropyl)-3-phenoxy benzene Asian J. Chem.,2014, 26(22), 7619-7621.
32.Lin TH, Lee SO, Niu Y, Xu D,Liang L, Li L, Yeh SD, Fujimoto N, Yeh S, Chang C*.,Differential Androgen Deprivation Therapies with Anti-androgens Casodex/Bicalutamide or MDV3100/ Enzalutamide versus Anti-androgen Receptor ASC-J9(R) Lead to Promotion versus Suppression of Prostate Cancer Metastasis. J Biol Chem.2013, 288(27):19359-69.
33.Hsu JW, Hsu I, Xu D, Miyamoto H, Liang L, Wu XR, Shyr CR, Chang C. Decreased tumorigenesis and mortality from bladder cancer in mice lacking urothelial androgen receptor. Am J Pathol. 2013, 182(5):1811-20.
34.Defeng Xu, Tzu-Hua Lin, Shaoshun Li, Jun Da, Xinquin Wen, Jiang Ding, Chawnshang Chang* and Shuyuan Yeh*, Cryptotanshinone Suppresses Androgen Receptor-mediated Growth in Androgen Dependent and Castration Resistant Prostate Cancer Cells. Cancer Letters.2012, 316 (1), 11-22.
35.Defeng Xu, Tzu-Hua Lin, Shaoshun Li, Jing Zhang, Min Yin, Shuyuan Yeh*, and Chawnshang Chang*,The Selective Inhibitory Effect of a Synthetic Tanshinone Derivative on Prostate Cancer Cells. The Prostate, 2012, 72(7):803-16. (IF: 3.843).
36.Shinichi Yamashita, Kuo-Pao Lai, Kun-Lung Chuang, Defeng Xu, Hiroshi Miyamoto, Tatsuo Tochigi, See-Tong Pang, Lei Li, Yoichi Arai, Hsing-Jien Kung, Shuyuan Yeh* and Chawnshang Chang*, ASC-J9? suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. Neoplasia, 2012, 14 (1): 74-83.
37.Xiaohai Wang, Wen-Jye Lin, Kouji Izumi, Qi Jiang, Kuo-Pao Lai, Defeng Xu,Lei-Ya Fang, Tianjing Lu, Lei Li, Shujie Xia, and Chawnshang Chang, Increased Infiltrated Macrophages in Benign Prostatic Hyperplasia (BPH): ROLE OF STROMAL ANDROGEN RECEPTOR IN MACROPHAGE-INDUCED PROSTATE STROMAL CELL PROLIFERATION. J. Biol. Chem.2012, 287: 18376-18385.
38.Qi Jiang, Shuyuan Yeh, Xiaohai Wang, Defeng Xu, Qiaoxia Zhang, Xinquin Wen, Shujie Xia, Chawnshang Chang et al. Targeting Androgen Receptor Leads to Suppression of Prostate Cancer via Induction of Autophagy.Journal of Urology, 2012. 188(4), 1361-1368.
39.Tianjing Lu, Wen-Jye Lin, Kouji Izumi, Xiaohai Wang, Defeng Xu, Lei-Ya Fang, Lei Li, Qi Jiang, Jie Jin, Chawnshang Chang, Targeting Androgen Receptor to Suppress Macrophage-induced EMT and Benign Prostatic Hyperplasia (BPH) Development. Molecular endocrinology.2012, 26(10):1707-15.
40.Rubing Wang, Runting Yin, Wen Zhou, Defeng Xu, Shaoshun Li.Shikonin and its derivatives: a patent review. Expert opinion on therapeutic patents.2012, 22 (9):977-97.
41.Jianzhong Zhang, Defeng Xu*, Jianpin Wu, Synthesis of 3-(2,2, 2-Trifluoroethoxy)-2 pyridine sulfonamide,Asian J. Chem.2010, 22 (1), 826-828.
42.Li-Ming Zhao, Xie, Tian-Pe, He, Yu-Qin, De-Feng Xu, and Shao-Shun Li; Synthesis and antitumor activity of 6-and 2-(1-substituted-thio-4-methylpent-3-enyl)-5,8-dimethoxynaphthalene-1,4-diones, Euro. J. Med. Chem.2009,44(4), 1410-1414.
43.Defeng Xu, Li-Ming Zhao, Zhi-Qiang Mao, and Shao-Shun Li; Regioselective Phenyl Anion Transfer:Application to the Total Synthesis of (±)-Shikonin,Org. Prep. Proced. Int. 2008, 41(1), 93-105.
44.Li-Ming Zhao, Defeng Xu, and Shao-Shun Li; Concise formal synthesis of (±)-Shikonin via a highly alpha-regioselective prenylation of 1,4,5,8-tetramethoxynaphthalene-2-carbaldehyde, Letts. Org. Chem.2008, 53(3), 234-236.
45.Wen Zhou, Defeng Xu, Ai-Hong Zhao, and Shao-Shun Li; A Mild and Efficient Semi-Synthesis of Leucoacetates, J Indian Chem. Soc.2008,85(1),1-3.
46.Li-Ming Zhao, Xie, Tian-Pe, He, Yu-Qin, De-Feng Xu, and Shao-Shun Li; Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphtha quinones. Chin. Chem. Lett., 2008, 19(10), 1206-1208.
47.Ai-Hong Zhao, Defeng Xu, Wen Zhou, and Shao-Shun Li; A Convenient Synthesis of 2-Formyl-1,8:4,5- bis(methylenedioxy)naphthalene, J. Chem. Res.2007,11,647-648.
48.Defeng Xu, Peng-Jian Guan, and Shao-Shun Li; A convenient synthesis of 2-formyl- 1,4,5,8-tetramethoxynaph thalene, J. Chem. Res.,2006, 12, 779–780.
49.Defeng Xu,Xiao-Juan Guo, Zhao-Hui, Xu, and Shao-Shun Li; A Novel Total Synthesis of (±)Shikonin，Chin. Chem. Lett., 2006, 7,871-873.


专著
l《天然产物全合成》，2005年化学工业出版社，参编
授权专利
总申请中国发明专利81件（国际专利1项），已授权24件
l一种2-(2,2-二氟乙氧基)-6-三氟甲基苯磺酰氯的制备方法，ZL20**
l一种植物源杀虫剂苦皮藤素微乳剂及其制备方法，ZL1.2
l从玛咖中提取纯化玛咖酰胺单体化合物的方法，ZL20**
l一种玛咖压片及其制备方法，ZL20**
l一种纯化法可林原药的制备方法，ZL2.5
l一种嘧啶水杨酸类除草剂嘧啶肟草醚的制备方法，ZL5.9
l一种从墨旱莲中提取蟛蜞菊内酯类单体化合物的制备方法，ZL2.8
l连续化生产除草剂2,4-二氯苯氧乙酸的方法，ZL0.9
l丹参酮类化合物、制备方法及其用途，ZL6.1
l新型除草活性的嘧啶水杨酸类化合物、其制备方法及其作为除草剂的用途，ZL4.5
l一种4，6-二氯-2-甲基-5-硝基嘧啶的制备方法，ZL20**
l一种二烷基姜黄素的制备方法，ZL20**
l一种4-氨基-2-氟-N-甲基苯甲酰胺的制备方法，ZL1.8
l一种男性保健食品及其制备方法，ZL6.4
l一种药物中间体1-（3-碘丙基）-3-苯氧基苯的制备方法，ZL6.7
l一种具有祛痘功效的药物组合物及其制备方法，ZL1.6
l一种治疗痤疮的植物复方凝胶剂及其制备方法，ZL3.9
lPYRIMIDYLSALICYLATE COMPOUND WITH NEWHERBICIDAL ACTIVITY, PREPARATION METHOD THEREFOR, AND USES THEREOF ASHERBICIDEWO (A1)
l具有除草活性的氟嘧肟草醚类化合物及其制备方法，ZL20**
l除草剂双草醚的制备方法，ZL10
l蟛蜞菊内酯的化学全合成方法，ZL0X
l紫草素二甲醚6-位侧链异构体及其衍生物和合成方法，ZL19
l紫草素二甲醚衍生物的合成方法，ZL75
l全合成法制备消旋体紫草素，ZL31