赵哲，男，教授，研究生学历，博士学位,博士生导师
（Email: zhezhao@hhu.edu.cn；Tel:）

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工作学习简历

工作经历：
2016年09月-至今 河海大学海洋学院 教授
2012年10月-2015年06月 华盛顿州立大学Allen center 访问****/博士后
2010年12月-2016年08月 中国科学院南海海洋研究所 副研究员
2010年07月-2010年12月 中国科学院南海海洋研究所 助理研究员
2008年10月-2010年07月 中国科学院南海海洋研究所 博士后
2008年07月-2008年10月 南方医科大学生物技术学院 讲师
学习经历：
2003年09月-2008年07月 中国科学院水生生物研究所 研究生/博士学位
1999年09月-2003年07月 安徽师范大学生命科学学院 本科/学士学位




研究方向：

海洋生物技术，近期主要聚焦于海洋病原微生物与宿主互作机制、环境适应性机制和防控技术（快速检测技术和新型细菌素）、海洋微生物耐药性机理研究。



主讲课程：

本科生专业课程《海洋微生物学》
新生研讨课《海洋环境、资源与气候变化》海洋生物学部分
研究生专业课程《分子微生物学前沿》和《海洋生物技术原理与应用》





主持的科研项目：




15.江苏省自然科学基金面上项目， 2017.07-2020.06
14.江苏省科技计划项目---重点研发计划（现代农业）子课题， 2017.07-2020.06
13.中央高校基本科研业务费项目， 2017.01-2019.12
12.广东特支计划”科技创新青年拔尖人才项目，2016.06-2019.05
11.国家自然科学基金面上项目，2013.01-2016.12
10.广州市珠江科技新星专项项目，2013.07-2016.06
9.中国科学院青年创新促进会会员专项，2012.01-2015.12
8.国家自然科学基金青年项目，2010.01-2012.12
7.广东省自然科学基金面上项目，2011.10-2013.09
6.广东省科技计划项目（农业攻关），2012.10-2014.09
5.广东省中科院全面战略合作项目，2011.07-2013.12
4.广东省海洋渔业局鱼病专项项目，2013.01-2014.12
3.中国博士后基金特别资助项目，2010.05-2012.04
2.中国科学院院长优秀奖启动资金项目，2010.09-2011.08
1.中国博士后基金一等资助项目，2010.05-2012.04



代表性论文：
34.Zhao Z^*, Liu JX, Deng YQ, Huang W, Ren CH, Call DR,Hu CQ. The Vibrio alginolyticus T3SS effectors, Val1686 and Val1680, induce cell rounding, apoptosis and lysis of fish epithelial cells. Virulence.2018; 9(1):318-330. (*Corresponding author)
33.Shi Y, Shen S, Hu S, Ding T, Hong X, Chen C, Zhu X, Zhao Z^*. Comparativestudyof twoimmunity-relatedGTPasegenesin Chinesesoft-shellturtlerevealstheir molecularcharacteristicsand functionalactivityin immunedefense. Dev Comp Immunol. 2018; 81:63-73. ( ^*Corresponding author)
32.Zhao Z, Orfe LH, Liu J, Lu SY, Besser TE, Call DR. Microcin PDI regulation and proteolytic cleavage are unique among known microcins. Sci Rep. 2017; 7:42529.
31.Liu J, Zhao Z^*, Deng Y, Shi Y, Liu YP, Wu C, Luo P, Hu CQ. CompleteGenomeSequenceof VibriocampbelliiLMB29Isolated from Red Drum with Four Native Megaplasmids.Front Microbiol. 2017; 8:2035. (^*Corresponding author)
30.Lu SY, Zhao Z, Avillan JJ, Liu J, Call DR. Autoinducer-2 Quorum Sensing Contributes to Regulation of Microcin PDI in Escherichia coli. Front Microbiol. 2017; 8:2570.
29.Liu J, Lu SY, Orfe LH, Ren CH, Hu CQ, Call DR, Avillan JJ, Zhao Z^*. ExsE Is a Negative Regulator for T3SS Gene Expression in Vibrio alginolyticus. Front Cell Infect Microbiol. 2016; 6:177.( ^*Corresponding author)
28.Zhao Z, Eberhart LJ, Orfe LH, Lu SY, Besser TE, Call DR. Genome-wide screening identifies six genes that are associated with susceptibility to Escherichia coliMicrocin PDI. Appl Environ Microbiol. 2015; 81(20):6953-63.
27.Zhao Z, Zhang LP, Ren CH, Zhao JJ, Chen C, Jiang X, Luo P, Hu CQ. 2011. Autophagy is induced by the type III secretion system of Vibrio alginolyticus in several mammalian cell lines. Archives of microbiology, 193: 53-61.
26.Zhao Z, Chen C, Hu CQ, Ren CH, Zhao JJ, Zhang LP, Jiang X, Luo P, Wang Q. 2010. The type III secretion system of Vibrio alginolyticusinduces rapid apoptosis, cell rounding, and osmotic lysis of fish cells. Microbiology-SGM, 156: 2864-2872.
25.Zhao Z, Ke F, Shi Y, Zhou GZ, Gui JF, Zhang QY. Rana gryliovirus thymidine kinase gene: an early gene of iridovirus encoding for a cytoplasmic protein. Virus genes, 2009;38: 345-352.
24.Zhao Z, Ke F, Huang YH, Zhao JG, Gui JF, Zhang QY. Identification and characterization of a novel envelope protein in Rana grylio virus. Journal of General Virology,2008; 89:1866 -1872.
23.Zhao Z, Shi Y, Ke F, Sun W, Gui JF, Zhang QY. Constitutive expression of thymidylate synthase from LCDV-C induces a transformed phenotype in fish cells. Virology, 2008; 372:118-126.
22.Zhao Z, Ke F, Li ZQ, Gui JF, Zhang QY. Isolation, characterization and genome sequence of a birnavirus strain from flounder Paralichthys olivaceusin China. Archives of Virology,2008; 153: 1143-1148.
21.Zhao Z, Ke F, Gui JF, Zhang QY. Characterization of an early gene encoding for dUTPase in Rana gryliovirus. Virus Research,2007; 123: 128-137.
20.Liu J, Zhao Z, Orfe L, Subbiah M, Call DR. Soil-borne reservoirs of antibiotic-resistant bacteria are established following therapeutic treatment of dairy calves. Environ Microbiol. 2016; 18(2):557-64.
19.Zhang H, Li L, Zhao Z, Peng D, Zhou XH. Polar flagella rotation in Vibrio parahaemolyticus confers resistance to bacteriophage infection. Sci Rep. 2016; 6:26147.
18.Deng Y, Chen C,Zhao Z, Zhao J, Jacq A, Huang X, Yang Y. The RNA Chaperone Hfq Is Involved in Colony Morphology, Nutrient Utilization and Oxidative and Envelope Stress Response in Vibrio alginolyticus. PLoS One.2016; 11(9):e**.
17.Deng Y, Chen C, Zhao Z, Huang X, Yang Y, Ding X. Complete Genome Sequence of Vibrio alginolyticus ZJ-T. Genome Announc.2016; 4(5). pii: e00912-16.
16.Wen J, Zeng L,SunYL, Chen DH, Xu YH, Luo P,Zhao Z, Yu ZH, Fang SG. Authentication and traceability of fish maw products from the market using DNA sequencing. Food Control, 2015. 55:185–189.
15.Jiang HY, Hu CQ, Yang HP, Zhang LP, Peng PF, Luo P, Zhao Z, Xia JJ. Morphology and phylogeny of Halamphora yongxingensissp. nov. (Bacillariophyta), a new marine benthic diatom isolated from Yongxing Island, South China Sea. Phytotaxa2015; 195 (1): 053–064.
14.Wang YH, Zhao Z, Zhang LP, Hu CQ, Ren CH, Yuan LH. Molecular characterization of metallothionein from white shrimp, Litopenaeus vannameiand its expression response to salinity stress. Marine Biology Research.2014; 10(7), 731–737.
13.Shi Y, Zhao Z, Hong XY, Chen KC, Zhu XP. Characterization and Functional Analysis of Voltage-Dependent Anion Channel 1 (VDAC1) from Orange-Spotted Grouper (Epinephelus coioides). J Biochem Mol Toxicol,2014; 28(7):292-301.
12.Jiang X, Ren CH, Hu CQ, Zhao Z. Isolation and algicidal characterization of Bowmanella denitrificansS088 against Chlorella vulgaris. World J Microbiol Biotechnol. 2014; 30(2):621-629.
11.Yu M, Ren CH, Qiu J, Luo P Zhu R, Zhao Z*. Draft Genome Sequence of the Opportunistic Marine Pathogen Vibrio harveyiStrain E385. Genome Announc. 2013; 1 (6): e00677-13. (* corresponding author)
10.Shi Y, Zhao Z, Zhu XP, Chen KC, Zhang QY. Expression and functional characterization of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) from orange-spotted grouper (Epinephelus coioides). Fish Shellfish Immunol.2013. 34(1):273-279.
9.Ren CH, Jiang X, Sun HY, Luo P, Zhao Z, Hu CQ. 2012. Detection and characterization of two insertion sequences in Vibrio alginolyticus. Annals of Microbiology. 2012, 62: 69-75.
8.Zhao JJ, Chen C, Luo P, Ren CH, Jiang X, Zhao Z,Hu CQ.2011. SYBR Green I-based real-time PCR targeting the rpoX gene for sensitive and rapid detection of Vibrio alginolyticus.Mol Cell Probes. 25(2-3):137-41.
7.Wen J, Hu CQ, Zhang LP, Luo P, Zhao Z, Fan SG, Su T. 2010. The application of PCR–RFLP and FINS for species identification used in sea cucumbers (Aspidochirotida: Stichopodidae) products from the market. Food Control, 21: 403-407.
6.Shi Y, Zhao Z, Yin JK, Zhu XP, Chen KC, Pan DB, Gui JF. Interferon regulatory factor-2 in orange-spotted grouper (Epinephelus coioides): gene, inductive expression pattern and subcellular localization.Comp Biochem Physiol., 2010, 155:110-117.
5.Zhao JG. Zhou L, Jin JY, Zhao Z, Lan J, Zhang YB, Zhang QY, Gui JF. Antimicrobial activity-specific to Gram-negative bacteria and immune modulation -mediated NF-κB and Sp1 of a medaka β-defensin.Dev Comp Immunol, 2009; 33: 624-637.
4.Ke F, Zhao Z, Zhang QY. Cloning, expression and subcellular distribution of a Rana gryliovirus late gene encoding ERV1 homologue. Molecular Biology Reports,2009; 36: 1651-1659.
3.Shi Y, Zhang YB,Zhao Z, Jiang J, Zhang QY, Gui JF. Molecular characterization and subcellular localization ofCarassius auratus interferon regulatory factor-1. Dev Comp Immunol,2008; 32: 134–146.
2.Zhang QY, Zhao Z, Xiao F, Li ZQ, Gui JF. Molecular characterization of three Rana grylio virus (RGV) isolates and Paralichthys olivaceuslymphocystis disease virus in (LCDV-C) iridoviruses. Aquaculture,2006;251:1-10.
1.Sun W, Huang YH, Zhao Z, Gui JF, Zhang QY. Characterization of the Rana gryliovirus 3β-HSD and its novel role in suppressing virus-induced cytopathic effect. Biochemical & Biophysical Research Communications,2006;351: 44-50.

参编论著：
张奇亚, 赵哲. 2013. 第三节鱼类病毒分子生物学. pp259-274. In 鱼病学(汪建国主编), 中国农业出版社, 北京.


授权专利：




4. 赵哲，任春华，胡超群，张吕平，罗鹏，江晓。一种用于检测对虾白斑综合症病毒的试剂盒及检测方法。 授权号：ZL5.5
3. 赵哲，任春华，胡超群，江晓，张吕平，罗鹏。一种用于检测对虾桃拉病毒的LAMP试剂盒及其检测方法。授权号：ZL2.6
2. 赵哲，李红梅，刘助红，江晓，任春华，胡超群。传染性皮下及造血组织坏死病毒的LAMP检测引物组、检测试剂盒及检测方法。授权号：ZL7.6
1. 赵哲，胡超群， 任春华， 江晓， 邓益琴。一种受渗透压调控的启动子PmccPDI及其重组表达载体及应用。申请号：3.2





奖励及个人荣誉：



7. 2016年 广东省培养高层次人才特殊支持计划（青年拔尖人才）
6. 2013年 广东省技术发明一等奖（排名第六）

5. 2012年 广州市珠江科技新星称号

4. 2011年 中国科学院青年创新促进会会员

3. 2010年 中国科学院王宽诚人才奖

2. 2009年 湖北省优秀博士学位论文奖
1. 2008年 中国科学院院长优秀奖





学术兼职：
美国微生物学会\中国微生物学会\中国水产学会等学会会员；
Frontier in Microbiology 客座副主编