1、简历
周长林，男，1964年1月生，1986、1989和1997年于华东理工大学生物工程专业分别获学士、硕士和博士学位，1999.4-2000.3年日本近畿大学药学部访问****，2004.12-2005.11年美国Providence College生物系博士后。现为中国药科大学生命科学与技术学院教授、博士生导师，国家新药评审专家，国家国际科技合作专项项目、中国博士后科学基金评审专家，江苏省生物工程学会副理事长，江苏省第九届生物化学和分子生物学学会常务理事,《中国药科大学学报》、《中国生化药物杂志》、《药物生物技术》杂志编委。2008年被评为江苏省“青蓝工程”中青年学术带头人。长期从事微生物与生化药学教学和研究工作，主要研究方向为抗感染药物药效及其机理、微生物代谢调控与药物生物合成。主持多项国家、省部级和横向科研课题。至今发表研究论文100余篇，其中SCI收录45篇，申请多项发明专利（授权12项），主编出版教材4部。
2、研究方向
抗感染药物药效及机理、微生物代谢调控与药物生物合成。
3、近年来发表研究论文（SCI）
（1）Zhou Wang, Lingman Ma, Mengqi Su, Yiran Zhou, Ke Mao, Chengqin Li, Guangyong Peng,Changlin Zhou*, Baiyong Shen* and Jie Dou*. Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. Cell Death and Disease (2018) 9:217, DOI 10.1038/s41419-017-0223-0 (IF 5.965)
（2）Yu C, Wei S, Han X, Liu H, Wang M, Jiang M, Guo M, Dou J,Zhou C*, Ma L*.Effective inhibition of Cbf-14 against Cryptococcus neoformans infection in mice and its related anti-inflammatory activity.Fungal Genet Biol. 2018 Jan;110:38-47. doi: 10.1016/j.fgb.2017.11.008. Epub 2017 Dec 6 (IF 3.072)
（3）Jing Jin, Shuo chen Dechuan Wang, Yuanjin Chen, Yuxu Wang, Ming Guo,Changlin Zhou*, Jie Dou*. Oroxylin A suppresses influenza A virus repplication correlating with neuraminidase inhibition and induction of IFNs. Biomedicine & Pharmacotherapy. (2017), 97:385-394
（4）Wei Kang1, Hanhan Liu1, Lingman Ma, Mengxiao Wang, Shanshan Wei, Pengbo Sun, Meiling Jiang, Min Guo,Changlin Zhou*, Jou Dou*. Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids. European Journal of Pharmaceutical Science. (2017), 105:169-177 (IF 3.756)
（5）Xin Xie, Yiran Zhou, Xue Wang, Jian Guo, Jingwen Li, Hongye Fan, Jie Dou, Baiyong Shenb*,Changlin Zhou*. Enhanced antitumor activity of gemcitabine bypolysaccharide-induced NK cell activation and immune cytotoxicityreduction in vitro/vivo.Carbohydrate Polymers, 173 (2017) 360–371 (IF 4.811)
（6）Wei Kang, Hanhan Liu, Lingman Ma, Mengxiao Wang, Shanshan Wei , Pengbo Sun, Meiling Jiang, Min Guo,Changlin Zhou*, Jie Dou*. Effective antimicrobial activity of a peptide mutant Cbf-14-2 against penicillin-resistant bacteria based on its unnatural amino acids.European Journal of Pharmaceutical Sciences,European Journal of Pharmaceutical Sciences, 105 (2017) 169–177 (IF 3.773)
（7）LI Jing-Wen^△, LIU Yang^△, LI Bao-Hui, Wang Yue-Yang, WANG Hui,ZHOU Chang-Lin^*. A polysaccharide component purified fromRadix Adenophoraepromotes cell activation and pro-inflammatory cytokine production of murine RAW264.7 macrophages.ChineseJournalofNaturalMedicines. 2016, 14(5): 0370-0376 (IF 1.382)
（8）Mengyun Ke, Hui Wang, Yiran Zhou, Jingwen Li, Yang Liu, Min Zhang, Jie Dou, Tao Xi, Baiyong Shen*,Changlin Zhou*. SEP enhanced the antitumor activity of 5-fluorouracilby up-regulating NKG2D/MICA and reversed immune suppressionviainhibiting ROS and caspase-3 in mice.Oncotarget(2016),DOI:10.18632/oncotarget.10375 (IF 5.008)
（9）Hailong Chen, Zhilai Wang, Haibo Cai,Changlin Zhou*. Progress in the Microbial Production of S-Adenosyl-L-methionine.World J Microbiol Biotechnol(2016),32(9), 1-8 (IF 1.532)
（10）Bo Li, Wei Kang,Hanhan Liu, Yanrong Wang, Changzhong Yu, Xinyi Zhu, Jie Dou,Haibo Cai,Changlin Zhou^*. The antimicrobial activity of Cbf-K₁₆against MRSA was enhanced by β-lactam antibiotics through cell wall non-integrity.Archives of Pharmacal Research(2016), DOI 10.1007/s12272-016-0769-x(IF 2.490)
（11）Lingman Ma, Yanrong Wang, Mengxiao Wang, Yuwei Tian, Wei Kang, Hanhan Liu, Hui Wang, Jie Dou*,Changlin Zhou^*. Effective antimicrobial activity of Cbf-14,derived froma cathelin-like domain, againstpenicillin-resistant bacteria.Biomaterials(2016). 87: 32-45 (IF 8.387)
（12）Jie Yu, Dechuan Wang, Jing Jin, Jun Xu, Mengwei Li, Hui Wang, Jie Dou,Changlin Zhou*, Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase.Antiviral Research. (2016), 127: 68-78 (IF 4.909)
（13）Hailong Chen, Jie Dou, Yang Yang, Baohui Li,Changlin Zhou*. Elevated intracellular acetyl-CoA availability byacs2overexpression andmls1deletion combined withmetK1introduction enhanced SAM accumulation inSaccharomyces cerevisiae.Biochemical Engineering Journal(2016), 107: 26-34. (IF 2.463)
（14）Hailong Chen, Zhou Wang, Zhilai Wang, Jie Dou,Changlin Zhou^*. Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation inSaccharomyces cerevisiae. World J Microbiol Biotechnol(2016), 32:56(IF 1.532)
（15）Yang Yang, Chao Yuan, Jie Dou, Xiaorong Han, Hui Wang, Hongqing Fang,Changlin Zhou*. Recombinant expression ofglpKandglpDgenes improves the accumulation of shikimic acid inE. coligrown on glycerol.World J Microbiol Biotechnol(2014), 30: 3263-3272(IF 1.779)
（16）Yue Ding, Jie Dou, Zaijin Teng, Jie Yu, Tingting Wang, Na Lu, Hui Wang,Changlin Zhou*. Antiviral activity of baicalin against influenza A (H1N1/ H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.Arch Virol(2014), 159 (12): 3269-3278 (IF 2.39)
（17）Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J,Zhou C*, Tong Y*.Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium.J Gen Virol. 2014 Nov; 95(Pt 11): 2565-75 (IF 3.183)
（18）Mengyun Ke, Hui Wang, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Tao Xi,Changlin Zhou*. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cellsviaTLR2/4 in vivo.Biochemical Pharmacology, 2014, 89: 119-130 (IF 5.009)
（19）Jing Wang, Bing Li, Yang Li, Jie Dou, Qingru Hao, Yuwei Tian, Hui Wang,Changlin Zhou*. BF-30 effectively inhibits ciprofloxacin-resistant bacteriain vitroand in a rat model of vaginosis.Arch Pharm Res. 2014, 37(7): 927-936 (IF 2.046)
4、联系方式
中国药科大学，生命科学与技术学院，微生物学教研室；
江苏省南京市中央路童家巷24号，邮编：210009；
Tel.: 025-8327-1323，Fax: 025-8327-1249；
E-mail: cl_zhou@cpu.edu.cn