自我简介
简历：薛晓文，中国药科大学药物化学教研室副教授。2005年获美国迈阿密大学化学系有机化学专业博士学位 (Ph.D.)，2005-2006年美国迈阿密大学化学系博士后。目前主要从事药物化学以及有机合成领域的研究，在国外杂志发表了多篇SCI论文，同时申请中国发明专利数项。
研究方向：具有抗纤维化或抗肿瘤活性的天然产物的合成、结构修饰及活性评价；药物新合成路线的设计与开发。
主要论著：
1.Zhengyuan Xin, Yunlong Lu, Xiaolan Xing, Jingjie Long, Jiabin Li, Xiaowen Xue*, “Synthesis of (-)-agathic acid and (-)-copalic acid from andrographolide via a regioselective Barton-McCombie reaction”, Tetrahedron 2016, 72, 555-562.
2.Yong Ai, Fenghua Kang, Zhangjian Huang*, Xiaowen Xue, Yisheng Lai, Sixun Peng, Jide Tian, and Yihua Zhang*, “Synthesis of CDDO–Amino Acid–Nitric Oxide Donor Trihybrids as Potential Antitumor Agents against Both Drug-Sensitive and Drug-Resistant Colon Cancer”, J. Med. Chem. 2015, 58, 2452?2464.
3.Yaping Song, Zhengyuan Xin, Yumeng Wan, Jiabin Li, Boping Ye, Xiaowen Xue*, “Synthesis and anticancer activity of some novel indolo[3,2-b]andrographolide derivatives as apoptosis-inducing agents”, European Journal of Medicinal Chemistry 2015, 90, 695-706.
4.Dongsheng Chen, Yaping Song, Yunlong Lu, and Xiaowen Xue*, “Synthesis and in vitro cytotoxicity of andrographolide-19-oic acid analogues as anti-cancer agents”, Bioorg. & Med. Chem. Lett. 2013, 23, 3166-3169.
5.Qiao Sun, Yiwu Yao, Chunping Liu, Hua Li, Hequan Yao, Xiaowen Xue, Jinsong Liu, Zhengchao Tu*, Sheng Jiang*, “Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry”, Bioorg. & Med. Chem. Lett. 2013, 23, 3295-3299.
6.Lutai Wang, Jiabin Li, Xiaowen Xue*, “ A concise Synthesis of Ximenynic Acid”, Synth. Commun. 2012, 42, 3540-3543.
7.Lei Yang, Xiaowen Xue*, Yihua Zhang, “Simple and Efficient Synthesis of Belinostat”, Synth. Commun. 2010, 40, 2520-2524.
8.Xueqing Zhao, Fei Li, Weiping Zhuang, Xiaowen Xue*, Yuanyang Lian, Jianhui Fan, Dongsheng Fang, “A New Method for Synthesis of Nolatrexed Dihydrochloride”, Org. Process Res. Dev. 2010, 14, 346-350.
9.Xueqing Zhao*, Weiping Zhuang, Dongsheng Fang, Xiaowen Xue*, Jingming Zhou, “A Highly Efficient Conversion of Primary or Secondary Alcohols into Fluorides with n-Perfluorobutanesulfonyl Fluoride-Tetrabutylammonium Triphenyldifluorosilicate”, Synlett 2009, 779-782.
10.Benjamin W. Gung*, Xiaowen Xue and Zou Yan, “Enthalpy (H) and Entropy (S) for -Stacking Interactions in Near-Sandwich Configurations: Relative Importance of Electrostatic, Dispersive, and Charge-Transfer Effects”, J. Org. Chem. 2007, 72, 2469-2475.
11.Benjamin W. Gung*, Mehul Patel and Xiaowen Xue, “A Threshold for Charge-Transfer Effects in Aromatic Interactions? Quantitative Study of π-Stacking Interactions ” (article, J. Org. Chem. 2005, 70, 10532-10537.
12.Benjamin W. Gung*, Xiaowen Xue and Hans J. Reich, “Off Center Oxygen-Arene Interactions in Solution: A Quantitative Study” (article), J. Org. Chem. 2005, 70, 7232-7237.
13.Benjamin W. Gung*, Xiaowen Xue and Hans J. Reich, “The Strength of Parallel- Displaced Arene-Arene Interactions in Chloroform” (article), J. Org. Chem. 2005, 70, 3641-3644.
14.Benjamin W. Gung,* Xiaowen Xue, Nina Knatz, and James A. Marshall, “Addition of chiral allenylzinc reagent to acetaldehyde: diastereotopic cyclic transition states with a tetrahedral zinc atom located by ab initio and density functional theory”, Organometallics 2003, 22, 3158.
15.Benjamin W. Gung,* Xiaowen Xue, and William R. Roush, “The origin of diastereofacial control in allyboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen”, J. Am. Chem. Soc. 2002, 124, 10692.
16.Benjamin W. Gung* and Xiaowen Xue, “Asymmetric transition states of allylation reaction: an ab initio molecular orbital study”, Tetrahedron: Asymmetry 2001, 12, 2955.
联系方式：xwenxue@cpu.edu.cn