焦宇，男，药物化学专业博士，副教授，硕士生导师。2011年毕业于中科院上海药物研究所获得药物化学博士学位同年留校任教于理学院有机化学教研室。于2016年9月至2017年9月作为访问****赴美国明尼苏达大学药学院进行为期一年的研修。现主要研究方向为抗肿瘤小分子靶向药物的设计、结构优化、生物活性及作用机制研究; 以及质谱衍生化增敏试剂的开发。先后主持国家自然科学基金青年项目1项，江苏省自然科学基金青年项目1项，中央高校科研业务基金2项。参与国家自然科学基金面上项目2项。以第一作者或通讯作者在Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、Analytical Chemistry等专业领域国际著名刊物上发表多篇SCI研究论文。
代表性研究论文:
Yezhen Huang^#, Yu Jiao^#, Yiqiao Gao, Pei Zhang, Wanqiu Huang, Yong Liu, Yin Huang, Yuan Tian, Jian-Bo Wan, Zunjian Zhang, Kun Hao, Fengguo Xu.An extendable all-in-one injection twin derivatization LC-MS/MS strategy for the absolute quantification of multiple chemical-group-based submetabolomes. Anal Chim Acta. 2019, 1063(31): 99-109.
Yanming Zhang, Yadong Chen, Danfeng Zhang, Lu Wang, Tao Lu^*,Yu Jiao^*. Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2018, 61(1) 140-157.
Huimin Guo^#, Yu Jiao^#, Xu Wang, Tao Lu, Zunjian Zhang, Fengguo Xu. Twins labeling-liquid chromatography/mass spectrometry based metabolomics for absolute quantification of tryptophan and its key metabolites. J Chromatogr A., 2017,1504: 83-90.
Ruiqi Jiang^#, Yu Jiao^#, Pei Zhang, Yong Liu, Xu Wang, Yin Huang , Zunjian Zhang*, and Fengguo Xu*.Twin Derivatization Strategy for High-Coverage Quantification of Free Fatty Acids by Liquid Chromatography-Tandem Mass Spectrometry. Anal. Chem., 2017,89 (22): 12223–12230.
Yu Jiao, Fei Huang, Pengfei Xu , Yanming Zhang Y, Shangyan Yang, Danfeng Zhang , Tao Lu, Weifang Tang^*. Discovery and Optimization of 1-(4-chloro-3-(trifluoromethyl)- phenyl)-3-(2-(amino)pyridin-3-yl)ureas as Novel KDR Kinase Inhibitors. Med Chem. 2016,12(4): 328-37.
Yu Jiao, Botao Xin, Yanmin Zhang, Jianbing Wu, Xiaolin Lu, Ying Zheng, Weifang Tang, Xiang Zhou^*. Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents. Euro J Med Chem. 2015, 90: 170-83.
Yu Jiao, Hongchun Liu, Meiyu Gen^*, Wenhu Duan^*. Synthesis and antitumor activity of 10-arylcamptothecin derivatives. Bioorg Med Chem Lett. 2011, 21(7): 2071-2074.