徐云根，教授，博士生导师，药学院药物化学系主任，江苏省药物分子设计与成药性优化重点实验室副主任，江苏省高校优秀科技创新团队负责人，江苏省第六届十大杰出专利发明人，江苏省高校“青蓝工程”中青年学术带头人。兼任中国药学会药物化学专业委员会副主任委员，国家执业药师资格考试命审题专家；《中国药物化学杂志》、《中国药科大学学报》、《中国现代应用药学》等期刊编委；参编教材和著作10余本。
近年来，先后主持承担各类科研项目20余项，包括国家“重大新药创制”科技重大专项2项、国家自然科学基金5项、省部级科技计划和横向开发项目多项；组建校企联合实验室1个。申请发明专利90余件，已授权国内外发明专利60余件。有多个专利产品或技术实施转让或产业化，取得了良好的经济效益。发表SCI论文100余篇。
研究领域：抗肿瘤、镇痛、抗炎及免疫治疗药物。
招生方向：
（1）靶向药物的设计与合成（博士、硕士）；
（2）免疫治疗药物的设计与合成（博士、硕士）；
（3）药物合成新技术和新工艺研究（硕士）。
近期发表的代表性论文：
（1）Junwei Wang, Hui Li, Guangchao He, Zhaoxing Chu, Kewen Peng, Yiran Ge, Qihua Zhu*, Yungen Xu*. Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3Kinase Inhibitors as a Promising Strategy for Cancer Therapy. Journal of Medicinal Chemistry, 2020,63(1):122-139.
（2）Jian Yang^#, Fantian Zeng^#, Xiaofang Li, Chongzhao Ran, Yungen Xu*, Yuyan Li*. Highly Specific Detection of Aβ Oligomers in Early Alzheimer’s Disease by Near-infrared Fluorescent Probe with a “V-shaped” Spatial Conformation. Chemical Communications, 2020, 56(4):583-586.
（3）Jian Yang^#, Fantian Zeng^#, Yiran Ge, Kewen Peng, Xiaofang Li, Yuyan Li*, Yungen Xu*. Development of Near-Infrared Fluorescent Probes for Use in Alzheimer’s Disease Diagnosis. Bioconjugate Chemistry.2020,31(1):2-15.
（4）Dezhong Ji^#, Lingzhi Zhang^#, Qihua Zhu*, Ying Bai, Yaoyao Wu, Yungen Xu*. Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design. European Journal of Medicinal Chemistry,2019,164:334-341.
（5）Peng Kewen, Bai Ying, Zhu Qihua, Hu Bin, Xu Yungen*. Targeting VEGF-neuropilin interactions: a promising antitumor strategy. Drug Discovery Today, 2019, 24(2): 656-664.
（6）Tingting Liang^#, Xin He^#, Dezhong Ji, Huanhuan Wu, Yizhu Xu, Yuyan Li, Zhibin Wang, Yungen Xu*, Qihua Zhu*. Transition Metal-Free C5 Tosyloxylation of 8-Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2-Disulfonyl Hydrazides. European Journal of Organic Chemistry, 2019,14:2513-2519.
（7）Shaochi Wang^#, Yun Yang^#, Jing Liu, Aidou Jiang, Zhaoxing Chu, Siying Chen, Guoqing Gong*, Guangwei He, Yungen Xu*, Qihua Zhu*. Discovery of Novel Limonin Derivatives as Potent Anti-inflammatory and Analgesic Agents. Chinese Journal of Natural Medicines, 2018,16(3):231-240.
（8）Shuwei Jin^#, Jingqi Wang^#,Siying Chen, Aidou Jiang, Meiling Jiang, Yourui Su, Wei Yan, Yungen Xu*,Guoqing Gong*. A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway. Biomedicine & Pharmacotherapy, 2018,100:501-508.
（9）Qiufang Chen, Shuang Cui, Huiliang Shen, Xiang Chen, Yunzhan Li, Qian Wu, Yungen Xu*, Guoqing Gong*. Dual inhibition of HY023016 based on binding properties of platelet membrane receptor subunit glycoprotein Ibα and thrombin exosites. European Journal of Pharmacology, 2018,822:51-58.
（10）Lingzhi Zhang^#, Tantan Bu^#, Xiaobo Bao, Tingting Liang, Yiran Ge, Yungen Xu*, Qihua Zhu*. Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters,2017,27(15):3395-3398.
（11）Haiqi Zhang, Feihu Gong, Jiqing Ye, Chi Zhang, Xiaohong Yue，Chuangui Li, Yungen Xu*, Liping Sun*. Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2. European Journal of Medicinal Chemistry,2017,125:245-254.
（12）Xin He^#,Yizhu Xu^#,Lingxuan Kong,Huanhuan Wu,Dezhong Ji,Zhibin Wang,Yungen Xu*,Qihua Zhu*. Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position. Organic Chemistry Frontiers,2017,4(6):1046-1050.
（13）Junwei Wang^#, Qiao Song^#, Anhua Xu, Yu Bao, Yungen Xu*, Qihua Zhu*,Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective k opioid receptor antagonists. European Journal of Medicinal Chemistry, 2017,130(1):15–25.
（14）Dongxing Chen^#, Jinyu Shi^#, Jing Liu, Xueying Zhang, Xiaoying Deng, Yanyan Yang, Shuang Cui, Qihua Zhu*, Guoqing Gong, Yungen Xu*. Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.Bioorganic & Medicinal Chemistry, 2017, 25(2):458-470.
（15）Hui Li, Yan Hu, Xueyan Wang, Guangwei He, Yungen Xu*, Qihua Zhu*.Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters, 2016, 24 (19):4731-4740.
（16）Jian Yang, Jing Yang, Steven H. Liang, Yungen Xu*, Anna Moore, Chongzhao Ran*. Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification. Scientific Reports, 2016, 6: 35613.
（17）Junwei Wang,Xuyan Wang,Hui Li,Dezhong Ji,Yuyan Li,?Yungen Xu*,Qihua Zhu*. Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2016, 26:4127–4132.
（18）Dezhong Ji^#, Xin He^#, Yizhu Xu, Ziyue Xu, Yuchen Bian, Weixing Liu, Qihua Zhu*, Yungen Xu*. Metal-Free Remote CH Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions. Organic Letters,2016, 18(18):4478-4481.
（19）Ting Guo^#,Zongjie Gan^#,Jie Chen,Dechuan Wang,Ling He,Qiao Song,Yungen Xu*. Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists. Bioorganic & Medicinal Chemistry, 2016, 24(13): 2964-2970.
（20）Fanwei Peng^#,Ji Xuan^#,Tingting Wu,Jiayu Xue, Ziwei Ren,Dake Liu,Xiuqi Wang,Xinhang Chen,Jiawei Zhang,Yungen Xu*, Lei Shi*. Design, synthesis and biological evaluation ofN-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. European Journal of Medicinal Chemistry,2016, 109:1-12.
联系方式（Email）：xyg64@126.com；xyg@cpu.edu.cn