研究方向
中药治疗糖尿病药理学。
主要研究中药活性成分、单味药及复方防治胰岛素抵抗及糖尿病心血管并发症的效应、机制及物质基础。
研究成果
课题研究：
主持江苏省自然科基金项目“中药黄酮干预血管内膜胰岛素抵抗的分子靶位研究”，中央高校基本科研专项基金课题“多酌类物质双向调节胰岛素敏感性评价主法的建立及代表性多酚的双向调节机制分析”，负责中药新药改善胰岛素抵抗开发课题。
参与“炎症胰岛素抵抗实验模型的建立及在中药改善代谢综合征研究中的应用”等国家自然科学基金项目。
发表文章：
· Sun Y,Li J,Xiao N,Wang M,Kou J,Qi L,Huang F,Liu B,Liu K*.Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.Pharmacol Res, 89C:19-28, 2014
· Xiao N,Mei F,Sun Y,Pan G,Liu B,Liu K*.Quercetin, Luteolin, and EpigallocatechinGallate Promote Glucose Disposal in Adipocytes with Regulation of AMP-Activated Kinase and/or Sirtuin 1 Activity.Planta Med,80(12): 993-1000, 2014
· M Wang, XJ Gao, WW Zhao, WJ Zhao, S Jiang, F Huang, JP Kou, BL Liu and K Liu*. Opposite effects of genistein on regulation of insulin-mediated glucose homeostasis in adipose tissue. British Journal of Pharmacology(accepted)
· Liu K, Zhao W, Gao X, Huang F, Kou J*, Liu B*, Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways, Atherosclerosis, 223 (2): 350-358, 2012
· Liu K, Luo T, Zhang Z, Wang T, Kou J, Liu B, Huang F*, Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway, J Ethnopharmacol., 136 (3): 473-479, 2011
· Kang L, Heng W, Yuan A, Baolin L, Fang H*, Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses, Biochimie, 92 (7): 789-796, 2010
联系方式
Tel:
E-mail: liukangcpu@cpu.edu.cn