程晓东，现任中国药科大学生命科学与技术学院****讲座教授、美国德州大学终身正教授，博士生导师。1985年毕业于北京大学生物系，1988年获中科院上海生物化学研究所硕士学位，1994年获美国德州大学博士学位。1995年至1999年，在美国加州大学圣地亚哥分校美国科学院院士SusanTaylor教授实验室从事博士后研究。1999年起在美国德州大学任教，主要从事肿瘤细胞信号转导过程和机制以及原癌基因调控等方面研究。
2001年后发表的论文：
1.Cheng,X.,Phelps,C.,andTaylor,S.S.DifferentialBindingofcAMP-dependentProteinKinaseRegulatorySubunitIsoformsIandIItotheCatalyticSubunit.J.Biol.Chem.276:4102-4108,2001.
2.Mei,F.,Qiao,J.,Tsygankova,O.M.,Meikoth,J.L.,Quilliam,L.A.,andCheng,X.DifferentialSignalingofcAMP:OpposingeffectofEpacandPKAonPKBPhosphorylationandActivation.J.Biol.Chem.,277:11497-11504,2002.
3.Qiao,J.,Mei,F.,Popov,V.L.,Vergare,L.A.,andCheng,X.CellCycleDependentSubcellularLocalizationofExchangeFactorDirectlyActivatedbycAMP.J.Biol.Chem.,277:26581-26586,2002.
4.Jabbur,J.R.,Tabor,A.D.,Cheng,X.,Wang,H.,Uesugi,M.,Lozano,G.,andZhang,W.PhosphorylationatThreonine18ofp53AltersHydrogenBondingAttenuatingmdm2BindingandTAFII31Recruitment.Oncogene,21:7100-7113,2002.
5.Li,J.,Cheng,X.,andLee,J.C.StructuralanddynamicsofthemodularhalvesofEscherichiacolicyclicAMPreceptorprotein.Biochemistry,41:14771-14778,2002.
6.Yu,S.,Mei,F.,Lee,J.C.,andCheng,X.ProbingcAMP-dependentproteinkinaseholoenzymecomplexesbyTF-IRandchemicalproteinfootprinting.Biochemistry,43:1908-1920,2004.
7.Young,T.W.,Mei,F.,Yang,G.,Thomspon-Lanza,J.A.,Liu,J.,andCheng,X.Activationofanti-oxidantpathwaysinRas-mediatedtransformationofhumanovarianepitheliacellrevealedbyfunctionalproteomicsandmassspectrometry.CancerResearch,64:4577-4584,2004.
8.Dipilato,L.,Cheng,X.,andZhang,J.FluorescentindicatorsofcAMPandEpacactivationrevealdifferentialdynamicsofcAMPsignalingwithindiscretesubcellularcompartments.Proc.Acad.Natl.Sci.USA.,101:16513-16518,2004.
9.Zhang,L.,Cui,R.,Cheng,X.,andDu,J.Anti-apoptoticeffectofserumandglucocorticoid-inducedproteinkinaseismediatedbyanovelmechanismactivatingIBKinase.CancerResearch,65:457-464,2005.
10.Cheng,X.Understandsignaltransductionthroughfunctionalproteomics.ExpertReviewinProteomics,2:103-116,2005.
11.Young,T.W.,Mei,F.,Liu,J.,Bast,R.C.,Jr.,Kurosky,A.,andCheng,X.ProteomicAnalysisofH-Ras-mediatedoncogenictransformationinageneticallydefinedhumanovariancancermodel.Oncogene,24:6174-6184,2005.
12.Mei,F.andCheng,X.InterplaybetweenexchangeproteindirectlyactivatedbycAMP(Epac)andmicrotubulecytoskeleton.MolecularBioSystems,1:325-331,2005.
13.Mei,F.Young,T.W.,andCheng,X.RAS-mediatedepigeneticinactivationofOPCMLinoncogenictransformationofhumanovariansurfaceepithelialcells.FASEBJ.,20:497-499,2006.
14.Brobey,R.K.Mei,F.C.,Cheng,X.,andSoongL.Comparativetwo-dimensionalgelelectrophoresismapsforpromastigotesofLeishmaniaamazonensisandLeishmaniamajor.Braz.J.Infect.Dis.,10:1-6,2006.
15.Yu,S.,Fan,F.,Mei,F.,andCheng,X.InvestigatingthemechanismofexchangeproteindirectlyactivatedbycAMPactivationbyFT-IRandstructuralmodeling.Biochemistry.45:15318-15326,2006.
16.Li,J.,O’Conner,K.L.,Cheng,X.,Mei,F.C.,Uchida,T.,Townsend,C.M.,andEvers,B.M.CyclicAMP-stimulatedneurotensinsecretionismediatedthroughRap1downstreamofbothEpacandPKAsignalingpathways.MolecularEndocrinology.21:159-171,2007.
17.Young,T.W.,Mei,F.C.,Rosen,D.G.,Yang,G.,Li,N.,Liu,J.,andCheng,X.Up-regulationofTumorSusceptibilityGene101ProteininHumanEpithelialOvarianCancerRevealedbyfunctionalproteomics.MolecularandCellularProteomics.6:294-304,2007.
18.Ji,Z.,Mei,F.C.,Xie.J.andCheng,X.OncogenicKRASsuppressesGLI1degradationandactivateshedgehogsignalingpathwayinpancreaticcancercells.J.Biol.Chem.282:14048-14055,2007.
19.Young,T.W.,Rosen,D.G.,Mei,F.,Li,N.,Liu,J.,andCheng,X.Up-regulationofTumorSusceptibilityGene101ConveyspoorPrognosisthroughSuppressionofp21ExpressioninOvarianCancer.ClinicalCancerResearch.13:3848-3854,2007.
20.Wayne,C.W.,Fan,H.Y.,Cheng,X.,andRichards,J.S.FSHinducesmultiplesignalingcascades:evidencethatactivationRAS,SRCandtheEGFreceptorarecriticalforgranulosacelldifferentiation.MolecularEndocrinology.21:1940-1957,2007.
21.Cheng,X.,Young,T.W.,andMei,F.C.Proteomicsanalysesofovariancancerusinggeneticallydefinedhumanovariancancermodels.FrontiersinBioscience.12:5166-5176,2007.
22.Brock,M.,Fan,F.,Mei,F.,Li,S.,Gessner,C.,WoodsJr.,V.L.,andCheng,X.ConformationalanalysisofEpacactivationrevealedusingamidehydrogen/deuteriumexchangemassspectrometry(DXMS).J.Biol.Chem.282:32256-32263,2007.
23.Ji,Z.,Mei,F.C.,Johnson,B.H.,Thompson,E.B.,andCheng,X.PKA,notEpac,suppresseshedgehogactivityandregulatesglucocorticoidsensitivityinacutelymphoblasticleukemiacells.J.Biol.Chem.282:37370-37377,2007.
24.Cheng,X.Silentassassin:OncogenicRasdirectsepigeneticinactivationoftargetgenes.ScienceSignaling.1:pe14,2008.
25.Ji,Z.,Mei,F.C.,Miller,A.L.,Thompson,E.B.,andCheng,X.ProteinkinaseA(PKA)isoformRIIβmediatesthesynergistickillingeffectofcAMPandglucocorticoidinacutelymphoblasticleukemiacells.J.Biol.Chem.283:21920-21925,2008.
26.Cheng,X.,Ji,Z.,Tsalkova,T.,andMei,F.C.EpacandPKA:ataleoftwointracellularcAMPreceptors.ActaBiochimicaetBiophysicaSinica.40:651-662,2008.
27.Ji,Z.,Mei,F.C.,Lory,P.L.,Gilbertson,S.R.,Chen,Y.,andCheng,X.ChemicalgeneticscreeningofKRAS-basedsyntheticlethalinhibitorsforpancreaticcancer.FrontiersinBioscience.14:2904-2910,2009.
28.Tsalkova,T.,BlumenthalD.R.,Mei,F.C.,andCheng,X.MechanismofEpacactivation:StructuralandfunctionalanalysesofEpac2hingemutantswithConstitutiveandreducedactivities.J.Biol.Chem.284:23644-23651,2009.
29.Ji,Z.,Mei,F.C.,andCheng,X.Epac,notPKAcatalyticsubunit,isrequiredfor3T3-L1preadipocytedifferentiation.FrontiersinBioscience(EliteEd).2:392-398,2010.

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