【姓名】全哲山
【性别】男
【民族】朝鲜族
【出生日期】**
【电子邮箱】zsquan@ybu.edu.cn
【导师简介】【学习经历】
1981.9-1985.7 延边医学院，药学专业，学士学位
1989.9-1991.7 北京医科大学，药物化学专业，博士学位
2003.9-2006.2 韩国圆光大学，药物化学专业，博士学位

【工作经历】
1981.7-1989.8 延边医学院，药学系，助教
1991.7-1996.12 延边医学院，药学系，讲师
1997.1-2000.12 延边大学，药学院，副教授
1997.1-1997.6 日本城西大学，药学系，访问学者
2001.1-现在 延边大学，药学院，教授

现任延边大学药学院药物化学学科主任，二级教授，博士生导师。兼任国家自然科学基金项目评审专家，吉林省药学会药物化学专业委员会委员。中国药物化学杂志编委，延边大学医学学报编委。国外“Bioorg Med Chem ”、“Eur J Med Chem”、”Arch Pharm”等期刊论文评审员。
近三十年致力于抗癫痫药物的研究与开发，还先后主持承担国家自然科学基金项目6项及教育重点项目、吉林省科技项目多项。于2011年和2012年分别获得2项国家科技重大专项“重大新药创制专项”资助。在国内外发表论文100多篇，其中以通讯作者在SCI收录的杂志上发表学术论70多篇，累计影响因子105, 被引用637次，H指数14。以第一发明人申请中国发明专利6项, 其中2项授权，并有2项在国家科技重大专项和制药企业的资助下进入临床前开发阶段。获得吉林省科学技术二等奖1项（第一名），吉林省科学技术三等奖1项（第一名），吉林省自然科学学术成果二等奖2项（第一名）。2008年获吉林省有突出贡献中青年专业技术人才，2012年获吉林省拔尖创新人才（第一层次）荣誉称号，2014年吉林省长白山学者特聘教授。
【研究方向与兴趣】
一直从事药物化学教学与科研工作，研究方向为先导化合物的寻找与结构优化，主讲《药物化学》、《药物合成反应》、《新药设计与开发》等课目。
【承担的科研项目】
项目名称（编号）
项目来源
承担时间
承担顺序

1
抗癫痫候选药物W112的研究（2012ZX09103-101-044）
国家重大科技专项
2012-2015
1

2
抗癫痫一类新药-Q808胶囊的临床前研究(2011ZX09102-003-03)
国家重大科技专项
2011-2013
2

3
喹啉并四唑类抗抑郁先导化合物的发现与结构优化（**）
国家自然科学基金
2014-2017
1

4
喹啉并三唑酮类衍生物的合成及抗癫痫作用研究（**）
国家自然科学基金
2012-2014
1

5
吡唑烷酮类衍生物的合成及抗癫痫作用研究（**）
国家自然科学基金
2005-2007
1

6
喹喔啉酮衍生物的合成及抗癫痫作用研究（**）
国家自然科学基金
2008-2010
1

7
二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究（**）
国家自然科学基金
2009-2011
1


【获奖】
1.“抗癫痫候选药物Q808的研究”，吉林省科学技术进步二等奖，吉林省科技厅，2011年，第一名。
2.“吡唑烷酮类抗癫痫先导化合物的寻找与结构优化”，吉林省科学技术进步三等奖，吉林省政府，2006年, 第一名。
3.三唑类衍生物的合成及抗癫痫作用研究, 吉林省自然科学学术二等奖，吉林省科学技术协会，2014年，第一名。
4. “7-烷氧基-4，5-二氢[1, 2, 4]三唑并[4, 3-a]喹啉的开链物4-(4-烷氧基苯基)-3-乙基-4H-1,2,4-三唑衍生物的合成及惊厥作用”，吉林省自然科学学术二等奖，吉林省科学技术协会，2009年，第一名。
5. “喹啉及酞嗪并杂环衍生物的合成及抗癫痫作用研究”，吉林省优秀博士论文，2012年，获奖人：孙先宇，指导教师：全哲山
6.“3,4-二氢-苯并[f][1,4]氧氮杂卓衍生物的抗惊厥活性研究”，吉林省优秀硕士论文，2011年，获奖人：邓先清，指导教师：全哲山
7.“三唑环类化合物的合成及其活性的研究”，吉林省优秀硕士论文，2010年，获奖人：陈敬，指导教师：全哲山
8.“7-苄氨基-2H-苯并[b][1,4]氧嗪-3（4H）-酮衍生物的合成及抗惊厥活性评价，2010年，获奖人：朴钟太，指导教师：全哲山
【申请专利】
1. 全哲山，金洪光，谢志峰，孙先宇，金云哲。用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐。中国专利，ZL**8.1，2006-07-26（已授权）
2. 全哲山，邓先清，关丽萍，魏成喜，孙先宇。用作抗抑郁药的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可药用盐，中国专利，**0.7
3. 全哲山，关丽萍，孙先宇，魏成喜，张昌浩。用作抗癫痫药的6-（取代苯氧基）-四唑并[5,1-a]酞嗪衍生物及其可药用盐，中国专利，**4.X，2010,3,24（已授权）
4. 全哲山，宫国华，魏成喜，邓先清，孙先宇。一类用作抗癫痫药的化合物及其可用药用盐，中国专利，**9.8，2012，12，19
5. 全哲山，于海玲，邓先清。化合物 6-（4-氯苯氧基）-四唑并[5,1-a]酞嗪在制备治疗抑郁症药物中的应用，中国专利，**1.3，2013，01，23
6. 全哲山，邓先清，刘大川。用作抗癫痫药的7-烷氧基-[1,2,4]三唑并[3,4-b]并噻唑-3（2H）-酮衍生物及其制备方法，中国专利，**6.9，2013，01，23

【发表论文】
2014年
79. Yu HL, Feng-Zhang, Tian-Lan, Quan ZS*. Effects of 6-(4-chlorophenoxy)-tetrazolo[5,1-a]phthalazine on anticoagulation in mice and the inhibition of experimental thrombosis in rats. J Cardiovasc Pharmacol. 2014, 64, on line
78. Shi-Ben WANG, Da-Chuan LIU, Xian-Qing DENG, Guo-Hua GONG* Zhe-Shan QUAN 1*. Synthesis and Evaluation of Antidepressant Activities of 5-Alkoxy-6,7,8,9-tetrahydro-benzothieno[3,2-e]tetrazolo[1,5-a]pyrimidine Derivatives. Lat Am J Pharm, 2014,33 (7): 1061-1068
77. Yan-Ping Yuan, Shi-Ben Wang, Guo-Hua Gong,* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antibacterial Activities of 1-Alkyl-4-(4H-1,2,4-triazol-4-yl)piperidine Derivatives. Lett Drug Des Dis, 2014, 11, (9): 1070 - 1078
76. Wang SB, Deng XQ, Liu DC, Zhang HJ, Quan ZS. Synthesis and evaluation of anticonvulsant and antidepressant activities of 7-alkyl-7H-tetrazolo[1,5-g]purine derivatives. Med Chem Res, 2014, 23(10): 4619-4626
75. Wang SB, Jin P, Li FN, Quan ZS. Synthesis and anticonvulsant activity of novel purine derivatives. Eur J Med Chem, 2014, 84, 574-583
74. Xian-Qing Deng; Ming-Xia Song; Shi-Ben Wang; Zhe-Shan Quan. Synthesis and Anticonvulsant Evaluation of some New 6-(Substitutedphenyl) thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice. Iran J Pharm Res, 2014, 12 (2): 459-469
73. Li-Jing Cui, Jun Guo, Cheng-Xi Wei*, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 2-Phenyl-2H-benzo[e][1, 3]oxazin-4(3H)-ones. Asian J Chem, 2014, 26(9), 2553-2556
72. Zi-Shi Zhu, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu and Zhe-Shan Quan. Synthesis and Anticonvulsant Activity Evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones. Lett Drug Des Dis, 2014, 11, (5): 628-635
71. Ming-Xia Song, Hong Zeng, Xian-Qing Deng and Zhe-Shan Quan. Synthesis and Evaluation of Anticonvulsant Activities of Triazole- Incorporated Benzothiazoles. Lett Drug Des Dis, 2014, 11, (4): 488-494
70. Xian-Qing Deng, Ming-Xia Song, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives. J Enzyme Inhib Med Chem, 2014, 29(2): 272-280
69. Da-Chuan Liu, Yan Zheng, Shi-Ben Wang, Zhe-Shan Quan*.Synthesis and Anticonvulsant activity of 7 - alkoxy [1,2,4] triazolo [3,4-b] benzothiazol-3 (2H) – ones. Arch Pharm, 2014, 347, 268-275
68. Xian-Qing Deng, Ming-Xia Song, Yan Zheng, Zhe-Shan Quan. Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. Eur J Med Chem, 2014; 73:217-224
67. Xu Cao, Shi-Ben Wang, Xian-Qing Deng, Da-Chuan Liu, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models. Med Chem Res, 2014, 23: 1829–1838
66. Yan Zheng, Shi-Ben Wang, Xu Cao, Da-Chuan Liu, Bing Shu, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of Novel 4-(4-Substitutedphenyl)-3-Methyl-1H-1,2,4-Triazol-5(4H)-Ones. Drug Res. (原名：Arzneimittelforschun） 2014, 64(1): 40-46
2013年
65. Guo-Hua Gong, Di Wang, J-F Zhang, Cheng-Xi Wei, Zhe-Shan Quan*. Anticonvulsant Activity of 2-(Substituted- imino) thiazolidin-4-ones. Drug Res (原名：Arzneimittelforschun）, 2014, 64(1): 5-9
64. Xu Cao, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 4-(2-alkoxy-phenyl)- 2,4-dihydro- 3H-1,2,4-triazol-3-ones in Various Experimental Seizure Models in Mice. Drug Res. 2013; 63(06): 319-325
63. Yan Zheng, Ming Bian, Xian-Qing Deng, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of 5-Phenyl- [1,2,4] tria-zolo [4,3-c] quinazolin-3-amines. Arch Pharm, 2013, 346(2):119-26
62. Bing Shu, Yan Zheng, Wang Shi-Ben, Xian-Qing Deng, Zhe-Shan Quan*. Design, Synthesis, and anticonvulsant activity evaluation of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones. Arch Pharm, 2013, 346(2):127-33
61. Yan Zheng, Xian-Qing Deng, Bing Shu, Shi-Ben Wang, Xu Cao and Zhe-Shan Quan*. Synthesis and Evaluation of the Anticonvulsant Activity of 5-alkylthio-4- phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one Derivatives. Lett Drug Des Dis, 2013, 10, (6): 543-549
60. Ming Bian, Xian-Qing Deng, Guo-Hua Gong, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-a](tetrazolo[5,1-a])phthalazine derivatives. J Enzyme Inhib Med Chem. 2013, 28(4): 792–800.
59. Lan Hong, Guo-Hua Gong, Li Yu, Ming-Xia Song, Xun Cui*, Zhe-Shan Quan*. Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones. Arch Pharm Res. 2013, 36(11): 1338-1344
58. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Hong-Jian Zhang, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 8-alkoxy-5-(4H-1,2,4-triazol-4-yl)quinoline derivatives. Arch Pharm Res. 2013, 36(1):32-40
2012年
57. Shi-Ben Wang, Xian-Qing Deng, Yan Zheng, Yan-Ping Yuan, Zhe-Shan Quan*, Li-Ping Guan*. Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c]thieno[2,3-e]pyrimidine derivatives. Eur J Med Chem, 2012, 56, 139-144
56. Xian-Qing Deng, Zheng-Qi Dong, Ming-Xia Song, Bing Shu, Shi-Ben Wang, Zhe-Shan Quan*. Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives. Arch Pharm . 2012, 345(7), 565-573
55. Hai-Ling Yu , Feng Zhang, Ying-Jun Li, Guo-Hua Gong, Zhe-Shan Quan*. Anti-inflammatory and antinociceptive effects of 6-(4- chlorophenoxy)-tetrazolo[5,1-a]phthalazine inmice. Pharmacol Rep, 2012, 64(5), 1155-1165
54. Chun-Bo Zhang, Chuan-Wen Yang, Xian-Qing Deng, Zhe-Shan Quan*. Design and synthesis of 6-alkyoxyl[1,2,4] triazolo[1,5-a] quinazoline derivatives with anticonvulsant activity. Med Chem Res, 2012, 21(10), 3294-3300
53. Shi-Ben Wang, Xian-Qing Deng, Ming-Xia Song and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity Evaluation of Some 1-alkoxy-4-(1H-1,2,4-triazol-1-yl)phthalazines. Lett Drug Des Dis, 2012, 9(4), 409-414
52. Nan Jiang, Xian-Qing Deng, Fu-Nan Li , Zhe-Shan Quan*. Synthesis of Novel 7-Substituted-5- Phenyl-[1,2,4] triazolo [1,5-a] pyrimidines with Anticonvulsant Activity. Iran J Pharm Res, 2012, 11 (3), 799-806
2011年
51. Xian-Qing Deng, Li-Na Quan, Ming-Xia Song, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Eur J Med Chem, 2011, 46, 2955-2963
50. Hai-Ling Yu, Xian Qing Deng, Ying-Jun Li, Ying Chun Li, Zhe-Shan Quan*, Xian-Yu Sun. N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. Pharmacol Rep. 2011, 63(3), 834-839
49. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Zhi-Gang Sun, Zhe-Shan Quan*. Synthes is and evaluation of 7-substituted-3,4- dihydrobenzo [f][1,4] oxazepin- 5(2H)-ones as anticonvulsant and hypnotic agents. Med Chem Res, 2011, 20，996-1004
48. Xian-Qing Deng, Di Wu, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and antidepressant-like action of N-(2-hydroxyethyl)cinnamamide derivatives in mice. Med Chem Res, 2011, 20, 1273-1279
47. Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines. Lett Drug Des Dis, 2011, 8 (9), 769-773
46. Li-Ping Guan, Xin Sui, Xian-Qing Deng, Dong-Hai Zhao, You-Le Qu, Zhe-Shan Quan*. N-palmitoylethanolamide derivatives: synthesis and studies on anticonvulsant and antidepressant activities. Med Chem Res, 2011, 20，601-605
45. Xian-Qing Deng, Chun-Rui Xiao, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 5-substituted- [1,2,4] triazolo[4,3-a]quinazolines. Chinese J Org Chem, 2011, 31(12), 2082-2087
44. Cheng-Xi Wei, Zhou Guo, Fu-Nan Li,Zhi-Gang Sun, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of 6-Alkoxy-[1,2,4]triazolo [3,4-a] phthalazin-3(2H)-ones. Asia J Chem, 2011, 24 (1), 127-131
2010年
43. Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li , Zhi-Gang Sun*, Zhe-Shan Quan*. Design and synthesis of 10-alkoxy-5, 6-dihydro- triazolo[4,3-d]benzo [f][1,4] oxazepine derivatives with anticonvulsant activity. Eur J Med Chem, 2010, 45(7), 3080-3086
42. Xian-Yu Sun, Chuan Hu, Cheng-Xi Wei, Zhi-Gang Sun* Zhe-Shan Quan*. Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem, 2010, 45(11), 4807-4812
41. Li-Ping Guan*, Xin Sui, Xian-Qing Deng, Ying-Chun Quan, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of a new 6-alkoxy- [1,2,4]triazolo[4,3-b]pyridazine. Eur J Med Chem, 2010, 45(5), 1746–1752
40. Cheng-Xi Wei, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun*, and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res, 2010, 33, 655-662
39. Li-Qiu Zhang, Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Dengand Zhe-Shan Quan*.Synthesis and Anticonvulsant Activity of Some 7-Alkoxy-2H-1,4- benzothiazin- 3(4H)-ones and 7-Alkoxy-4H-[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull, 2010, 58(3), 326—331
38. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qiang Deng, Zhi-Gang Sun*, Zhe-Shan Quan*. Evaluation of the anticonvulsant activity of 6-(4-chlorophenyoxy)- tetrazolo[5,1-a] phthalazine in various experimental seizure models in mice. Pharmacol Rep, 2010, 62, 273-277
37. Cheng-Xi Wei, Di Wu, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of 6-(3-substituted-4H-1,2,4-triazol-4-yl)- 2-phenylbenzo [d]oxazoles as potential anticonvulsant agents. Med Chem Res, 2010, 19, 925-935
36. Chuan Hu, Zhi-Gang Sun, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of Some Cinnamylpiperazine Derivatives. Lett Drug Des Discov，2010, 7(5), 661-664
35. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li,Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles. Med Chem. 2010, 6(5):313-320.
34. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai,Zhi-Gang Sun* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinolines. Bull Korean Chem Soc. 2010, 31, 447
33. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Zhe-Shan Quan*. Synthesis and antidepressant-like action of 9-alkoxy-7H-furo [3,2-g] chromen-7-ones in mice. Arzneimittelforschun, 2010, 29, 587
32. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl- tetrazolo [5,1-a] phthalazine derivatives. Arzneimittelforschung, 2010, 60, (6), 289.
2009年
31. Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Deng, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med Chem, 2009, 44(9), 3654-3657
30. Li-Jun Guo, Cheng-Xi Wei, Jing-Hao Jia, Li-Ming Zhao, Zhe-Shan Quan*. Design, Synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur J Med Chem, 2009, 44(3), 954-958
29. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Piao Huri, Quan Zhe Shan*. Synthesis of 8-Alkoxy-5,6- dihydro-[1,2,4]triazino [4,3-a] quinolin-1-ones With Anticonvulsant Activity, and Assessment of Their Acute Toxicity. Eur J Med Chem, 2009, 44(3), 1265-1270
28. Li-Ping Guan, Dong-Hai Zhao, Jing-Hui Xiu, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant activity of N-(2-hydroxyethyl) amide derivatives. Arch Pharm, 2009, 342, 34-40
27. Wang HJ, Xian-Qing Deng, Cheng-Xi Wei, Li FN, and Zhe-Shan Quan*. Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines. Arch. Pharm, 2009, 342, 671-675
26.Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao1, Zhe-Shan Quan*. Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice. Pharmacol Rep, 2009, 61, 245–251
25. Lei Zhang, Li-Ping Guan, Xian-Yu Sun, Kyu-Yun Chai and Zhe-Shan Quan*. Synthesis and Anticonvulsant activity Evaluation of 6-Alkoxy-[1,2,4] triazolo[3,4-a]phthalazines. Chem Biol Drug Des. 2009, 73, 313-319
24. Xiang-Shu Cui, Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee Young-Ae Ha and Zhe-Shan Quan*. Synthesis and anticonvulsant evaluation of 3- Substituted -4- (4-hexyloxyphenyl)-4H-1,2,4-triazoles. Med Chem Res, 2009, 18, 49-58
23. Cheng-Xi Wei, Li-Ping Guan, Jing-Hao Jia, Kyu-Yun Chai, and Zhe-Shan Quan*. Synthesis of 2-Substituted -6-(4H-1,2,4-triazol-4-yl) benzo[d]oxazoles as Potential Anticonvulsant Agents. Arch Pharm Res, 2009, 32，23-31
22. Xian-Yu Sun, Li-Ping Guan, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao and Zhe-Shan Quan*. Design. Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]phthalazin-4-one Derivatives. J Brazil Chem Soc, 2009, 20，826-836
21. Li-Ping Guan, Dong-Hai Zhao, Zhe Jiang, Hu-Ri Piao, Zhe-Shan Quan*.Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models. Pharmazie，2009，64，248-251
2008年
20. Zhong-Tai Piao,Li-Ping Guan, Li-Ming Zhao, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis of Novel 7-benzyl-amino-2H-benzo[b] [1,4]oxazin-3(4H)-ones as Anticonvulsant Agents. Eur J Med Chem, 2008, 43, 1216-1221
19. Xian-Yu Sun, Cheng-Xi Wei, KY Chai,Hu-Ri Piao and Zhe-Shan Quan*. Synthesis and anti-inflammatory activities of some novel 7-alkoxy-1-amino-4,5-dihydro-[1,2,4]triazole[4,3-a]quinolines. Arch Pharm, 2008, 341, 288-293
18. Li-Ping Guan, Qing-Hao Jin, Shou-Feng Wang, Fu-Nan Li, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Phenyl[1,2,4]triazolo[4,3-a]quinolines. Arch Pharm, 2008, 341, 774-779