学位：博士
学科：物理化学
在职信息：在职
所在单位：理论化学研究所
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个人简介
韩晓霞，副教授，博士/硕士研究生导师。2003年毕业于长春师范大学生物系获生物科学学士学位；2009年毕业于吉林大学理论化学研究所获物理化学博士学位 （导师赵冰教授）；2009年8月-2011年10月，日本关西学院大学理工学部博士后 （日本学术振兴会JSPS博士后奖学金，导师 Prof.Yukihiro Ozaki）; 2011年11月-2013年12月，德国柏林工业大学化学系博士后（德国亚历山大-洪堡博士后奖学金，导师 Prof.Peter Hildebrandt）；2013年12月至今，吉林大学超分子结构与材料国家重点实验室 （吉林大学引进学术骨干）。
研究方向：功能性生物纳米材料的表面增强拉曼散射（SERS）效应及其在生物物理和生物分析化学领域的应用。
研究成果：
(1) Zhu, J.; Jiang, M.; Ma, H.; Zhang, H.; Cheng, W.; Li, J.; Cai, L.; Han, X. X.*; Zhao, B., Redox-State-Mediated Regulation of Cytochrome c Release in Apoptosis Revealed by Surface-Enhanced Raman Scattering on Nickel Substrates. Angew. Chem. Int. Ed. 2019(DOI: 10.1002/anie.**).
(2) Zhang, H.; Kou, Y.; Li, J.; Chen, L.; Mao, Z.; Han, X. X.*; Zhao, B.; Ozaki, Y. Nickel nanowires combined with surface-enhanced Raman spectroscopy: application in label-free detection of cytochrome c-mediated apoptosis. Anal. Chem. 2019, 91, 1213-1216.
(3) Ma, H.; Tang, X.; Liu, Y.; Han, X. X.*; He, C.; Lu, H.*; Zhao, B.* surface-enhanced raman scattering for direct protein function investigation: controlled immobilization and orientation. Anal. Chem. 2019, 91, 8767-8771.
(4) Li, Y.; Gao, T.; Xu, G.; Xiang, X.; Zhao, B.; Han, X. X.*; Guo, X.* Direct Approach toward Label-Free DNA Detection by Surface-enhanced Raman spectroscopy: discrimination of a single-base mutation in 50 base-paired double helixes. Anal. Chem. 2019, 91, 7980-7984.
(5) Li, Y.; Han, X.*; Zhou, S.; Yan, Y.; Xiang, X.; Zhao, B.; Guo, X.* Structural features of DNA G-quadruplexes revealed by surface-enhanced Raman spectroscopy. J. Phys. Chem. Lett., 2018, 9, 3245-3252.
(6) Ma, H.; Sun, X.; Chen, L.; Han, X. X.*; Zhao, B.; Lu, H.; He, C.* Antibody-free discrimination of protein biomarkers in human serum based on surface-enhanced Raman spectroscopy. Anal. Chem., 2018, 90, 12342-12346.
(7) Li, Y.; Han, X.*; Yan, Y.; Cao, Y.; Xiang, X.; Wang, S.; Zhao, B.; Guo, X.* Label-free detection of tetramolecular i-motifs by surface-enhanced Raman spectroscopy. Anal. Chem., 2018, 90, 2996-3000.
(8) Su, X.; Ma, H.; Wang, H.; Li, X.; Han, X. X.*; Zhao, B.* Surface-enhanced Raman scattering on organic-inorganic hybrid perovskites. Chem. Commun., 2018, 54, 2134-2137.
(9) Mao, Z.; Liu, Z.; Yang, J.; Han, X.*; Zhao, B.*; Zhao, C. In situ semi-quantitative assessment of single-cell viability by resonance Raman spectroscopy. Chem. Commun., 2018, 54, 7135-7138.
(10) Han, X. X.; Ji, W.; Zhao, B.; Ozaki, Y. Semiconductor-enhanced Raman scattering: active nanomaterials and applications. Nanoscale, 2017, 9, 4847-4861.
(11) Ma, H.; Sun, X.; Chen, L.; Cheng, W.; Han, X. X.*; Zhao, B.; He, C.* Multiplex immunochips for high-accuracy detection of AFP-l3% based on surface-enhanced Raman scattering: implications for early liver cancer diagnosis. Anal. Chem., 2017, 89, 8877-8883.
(12) Han, X. X.; Chen, L.; Kuhlmann, U.; Schulz, C.; Weidinger, I. M.; Hildebrandt, P.: Magnetic titanium dioxide nanocomposites for surface-enhanced resonance Raman spectroscopic determination and degradation of toxic anilines and phenols. Angew. Chem. Int. Ed., 2014, 53, 2481-2484.
(13) Han, X. X.; K?hler, C.; Kozuch, J.; Kuhlmann, U.; Paasche, L.; Sivanesan, A.; Weidinger, I. M.; Hildebrandt, P.: potential-dependent surface-enhanced resonance Raman spectroscopy at nanostructured TiO2: a case study on cytochrome b5. Small, 2013, 9, 4175-4181.
(14) Han, X. X.; Schmidt, A. M.; Marten, G.; Fischer, A.; Weidinger, I. M.; Hildebrandt, P. Magnetic Ag hybrid nanoparticles for SERR spectroscopic detection and decontamination of small toxic molecules, ACS Nano, 2013, 7, 2013, 3212–3220.
(15) Han, X. X.; Zhao, B.; Ozaki, Y. Label-free detection in biological applications of surface-enhanced Raman scattering, TrAC-Trend. Anal. Chem., 2012, 38, 67-78.
(16) Han, X. X.; Pienpinijtham, P.; Zhao, B.; Ozaki, Y. Coupling reaction-based ultrasensitive of phenolic estrogens using surface-enhanced resonance Raman scattering. Anal. Chem., 2011, 83, 8582-8588.
(17) Han, X. X.; Chen, L.; Ji, W.; Xie, Y. F.; Zhao, B.; Ozaki, Y. Label-free indirect immunoassay using an avidin-induced surface-enhanced Raman scattering substrate. Small, 2011, 7, 316-320.
(18) Han, X. X.; Xie, Y.; Zhao, B.; Ozaki, Y. Highly sensitive protein concentration assay over a wide range via surface-enhanced Raman scattering of Coomassie brilliant blue. Anal. Chem., 2010, 82, 4325-4328.
(19) Han, X. X.; Chen, L.; Guo, J.; Zhao, B.; Ozaki, Y. Coomassie brilliant dyes as surface-enhanced Raman scattering probes for protein- ligand recognitions. Anal. Chem., 2010, 82, 4102-4106.
(20) Han, X. X.; Kitahama, Y.; Itoh, T.; Wang, C. X.; Zhao, B.; Ozaki, Y. Protein-mediated sandwich strategy for surface-enhanced Raman scattering: application to versatile protein detection. Anal. Chem., 2009, 81, 3350-3355.
(21) Han, X. X.; Huang, G. G.; Zhao, B.; Ozaki, Y. Label-free highly sensitive detection of proteins in aqueous solutions using surface-enhanced Raman scattering. Anal. Chem., 2009, 81, 3329-3333.
(22) Han, X. X.; Kitahama, Y.; Tanaka, Y.; Guo, J.; Xu, W. Q.; Zhao, B.; Ozaki, Y. Simplified protocol for detection of protein-ligand interactions via surface-enhanced resonance Raman scattering and surface-enhanced fluorescence. Anal. Chem., 2008, 80, 6567-6572.(23) Han, X. X.; Cai, L. J.; Guo, J.; Wang, C. X.; Ruan, W. D.; Han, W. Y.; Xu, W. Q.; Zhao, B.; Ozaki, Y. Fluorescein isothiocyanate linked immunoabsorbent assay based on surface-enhanced resonance Raman scattering. Anal. Chem., 2008, 80, 3020-3024.
(24) Han, X. X.; Jia, H. Y.; Wang, Y. F.; Lu, Z. C.; Wang, C. X.; Xu, W. Q.; Zhao,B.; Ozaki, Y. Analytical technique for label-free multi-protein detection based on Western blot and surface-enhanced Raman scattering. Anal. Chem., 2008, 80, 2799-2804.
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工作经历
2013.12--至今吉林大学>超分子结构与材料国家重点实验室>副教授 2011.11--2013.12德国柏林工业大学>化学系>博士后 2009.8--2011.10日本关西学院大学>理工学部，化学系>博士后
教育经历
2004.9--2009.6 吉林大学>物理化学1999.9--2003.6 长春师范学院>生物学
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功能性生物纳米材料的SERS效应及其应用研究
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功能性生物纳米材料的SERS效应及其在生物物理和生物分析化学等方面应用。
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