吉林大学研究生导师教师简介-陈志俊

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基本信息

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陈志俊Zhijun Chen

(教授) 博士生导师硕士生导师
学位：博士
性别：男
毕业院校：其他国家高等学校或研究机构
学历：博士研究生毕业
在职信息：在职
所在单位：理论化学研究所
电话：邮箱：

个人简介

陈志俊教授2000年在北京大学生命科学学院生物化学与分子生物学专业开展兰花转基因及水稻矮缩病毒相关研究并获得理学硕士学位（导师: 李毅教授和陈章良教授）。2001 - 2008年在芬兰奥鲁大学Biocenter Oulu与生物化学系运用多学科交叉的方法研究哺乳动物线粒体脂肪酸代谢并获博士学位（导师: Kalervo Hiltunen教授）。2009-2010年在美国哈佛大学干细胞与再生生物学系进行Hedgehog结合膜蛋白相关的博士后研究（导师: Andy McMahon教授）。2010年9月开始在吉林大学超分子结构与材料国家重点实验室任副教授、课题组组长，开展生物技术与生物材料研究。2016年9月晋升为教授、博导。

教育经历

工作经历

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研究方向

[1]生物技术与生物材料

我们正在设计新型淀粉样蛋白识别分子，用于纤维状蛋白组装的监控、抑制或干扰。我们的兴趣在于运用这些分子进行淀粉样蛋白示踪与细胞功能调控。此外，我们也构筑各种“人工病毒”，用于基因编辑相关的大分子递送。我们的长远目标是开发新方法，深入研究蛋白聚集、细胞代谢相关生理、病理。

团队成员

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基本信息

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陈志俊Zhijun Chen

(教授) 博士生导师硕士生导师
学位：博士
性别：男
毕业院校：其他国家高等学校或研究机构
学历：博士研究生毕业
在职信息：在职
所在单位：理论化学研究所

科学研究

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Chen Z, Pudas R, Sharma S, Smart O, Juffer A, Hiltunen JK, Wierenga RK,Haapalainen AM. Structure and enzymology of 2-enoyl thioester reductase of human FAS II: New insights into substrate binding and catalysis. J. Mol. Biol. 379:830–844, 2008.

Chen Z, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ, Hassinen IE, Hiltunen JK. Overexpression of 2-enoyl thioester reducatse of mitochondrial FASII in heart leads to cardiac dysfunction in mouse. PLoS ONE 4:e5589, 2009.

Chen Z, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK. 17β-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. FASEB J. 23:3682-91, 2009.

Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK and Kastaniotis AJ. Mitochondrial fatty acid synthesis - an adopted set of enzymes making a pathway of major importance for the cellular metabolism. Prog. in Lipid Res. 49:27-45, 2010.

Ma Y, Zhou M, Walter S, Liang J, Chen Z, Wu L. Selective adhesion and controlled activity of yeast cells on honeycomb-patterned polymer films via a microemulsion approach. Chem. Commun. 2014, 50: 15882-85.

Chen Z, Pudas R, Sharma S, Smart O, Juffer A, Hiltunen JK, Wierenga RK,Haapalainen AM. Structure and enzymology of 2-enoyl thioester reductase of human FAS II: New insights into substrate binding and catalysis. J. Mol. Biol. 379:830–844, 2008.

Chen Z, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ, Hassinen IE, Hiltunen JK. Overexpression of 2-enoyl thioester reducatse of mitochondrial FASII in heart leads to cardiac dysfunction in mouse. PLoS ONE 4:e5589, 2009.

Chen Z, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK. 17β-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. FASEB J. 23:3682-91, 2009.

Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK and Kastaniotis AJ. Mitochondrial fatty acid synthesis - an adopted set of enzymes making a pathway of major importance for the cellular metabolism. Prog. in Lipid Res. 49:27-45, 2010.

Ma Y, Zhou M, Walter S, Liang J, Chen Z, Wu L. Selective adhesion and controlled activity of yeast cells on honeycomb-patterned polymer films via a microemulsion approach. Chem. Commun. 2014, 50: 15882-85.

Ding H, Liang C, Sun K, Wang H, Hiltunen JK, Chen Z*, Shen J. Dithiothreitol-capped fluorescent gold nanoclusters: An efficient probe for detection of copper(II) ions in aqueous solution. Biosens. Bioelectron. 2014, 59:216–20.

Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nat. Comm. 2014, 5: 4805, 1-12.

Ding H, Yang D, Zhao C, Song Z, Liu P, Wang Y, Chen Z*, Shen J. Protein–gold hybrid nanocubes for cell imaging and drug delivery. ACS Appl. Mater. Interfaces 2015, 7, 4713-4719.

Ding H, Du F, Liu P, Chen Z*, Shen J. DNA–carbon dots function as fluorescent vehicles for drug delivery. ACS Appl. Mater. Interfaces 2015, 7, 6889-6897.

Liu P, Wang X, Hiltunen K, Chen Z*. Controllable drug release system in living cells triggered by enzyme-substrate recognition. ACS Appl. Mater. Interfaces 2015, 7, 26811?26818.

Wang X, Zhang J, Wang Y, Liu Y, Li Z, Xie Z, Chen Z. Fluorescent protein nanovessels: a new platform to generate bio-abiotic hybrid materials for bioimaging, Adv. Funct. Mater. 2017, 1702051, 1-8.

Ding H, Li H, Wang X, Zhou Y, Li Z, Hiltunen JK, Shen J, Chen Z. Expanding toolbox of imagable protein-Gold hybrid materials. Chem. Mater. 2017, 29 (19), pp 8440–8448

Zhenhua Li, Han Ding, Fei Yan, Hongwei * and Zhijun Chen* .Transformable protein–gold hybrid materials serve as supramolecular vehicles for gene delivery. RSC Adv., 2017, 7, 51252-51256

基本信息

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陈志俊Zhijun Chen

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