黄宜兵
姓名： 黄宜兵

职称： 副教授
最高学位： 博士
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工作地点： 长春市前进大街2699号吉林大学生命科学楼244室
研究方向： 1)多肽的修饰与改造：对生物活性多肽进行适当的修饰与改造（氨基酸取代，异构体，穿透肽，靶向分子等），提高其生物活性，增强其稳定性和靶向选择性。2)多肽自组装及药物缓释：合理设计小分子多肽，结合肿瘤等疾病相关的细胞微环境因素（酶，pH，温度等），构建多肽自组装体系，实现药物的靶向缓释和癌症的诊断与治疗。
教育经历： 2001.09-2006.12 吉林大学 生物化学与分子生物学 博士
1997.09 -2001.06中南民族学院生物化学学士
工作经历： 2012.10-至今 吉林大学 分子酶学工程教育部重点实验室 副教授
2012.02 -2013.02 美国布兰迪斯大学化学系 访问学者
2010.10 -2013.11 吉林大学 组合化学研究中心 博士后
2006.10 -2012.09 吉林大学 分子酶学工程教育部重点实验室 讲师
2004.07 -2006.09 吉林大学 分子酶学工程教育部重点实验室 助教
荣誉称号： 2016年 首届全国大学生生命科学创新实验大赛 指导教师一等奖
2012年 吉林大学优秀博士后二等奖

研究成果： 1)Hu C, Ma N, Li F, Fang Y, Liu Y, Zhao L, Qiao S, Li X, Jiang X, Li T, Shen F, Huang Y*, Luo Q*, Liu J. Cucurbit[8]uril-Based Giant Supramolecular Vesicles: Highly Stable, Versatile Carriers for Photoresponsive and Targeted Drug Delivery. ACS Appl Mater Interfaces. 2018,10(5):4603-4613.
2)Zhao W, Han L, Peng Y, Wang X, Liu S, Li P, Huang Y*, Chen Y. The Effect of Basic Amino Acids on the Biological Activity of Helical Antimicrobial Peptide. Chem. J. Chin. Univ, 2018, 39:681-687.
3)Yan, Q.Y., Hao,X.Y., Huang, Y.B.*, Chen, Y.X.*. Self-assembly of alpha-helical cationic antimicrobial peptide with different length of hydrophobic alkyl tails.Nanomedicine: Nanotechnology, Biology, and Medicine ,2016,12 : 552-552.
4)Zhao J, Hao X, Liu D, Huang Y*, Chen Y*, In vitro characterization of the rapid cytotoxicity of anticancer peptide HPRP-A2 through membrane destruction and intracellular mechanism against gastric cancer cell lines. PLoS One, 2015, 10(9), e**.
5)Hao X, Yan Q, Zhao J, Wang W, Huang Y*, Chen Y*, TAT modification of alpha-helical anticancer peptides to improve specificity and efficacy. PLoS One, 2015, 10(9), **
6)Huang Y B, Feng Q, Yan Q Y, Hao X Y and Chen Y X*, Alpha-helical cationic anticancer peptides: a promising candidate of novel anticancer drugs. Mini-Rev. Med. Chem., 2015, 15(1), 73-81.
7)Huang Y, He L, Li G, Zhai N, Jiang H*, Chen Y*, Role of helicity of α-helical antimicrobial peptides to improve specificity.Protein Cell, 2014, 5(8), 631-642.
8)Huang Y, Pan L, Zhao L, Mant CT, Hodges RS, Chen Y*, Structure-guided RP-HPLC chromatography of diastereomeric α-helical peptide analogs substituted with single amino acid stereoisomers. Biomed Chromatogr., 2014, 28, 511–517.
9)Huang Y B, Shi J F, Yuan D, Zhou N, Xu B*, Length-dependent proteolytic cleavage of short oligopeptides catalyzed by matrix metalloprotease-9. Biopolymers: Peptide Sci., 2013, 100(6), 790-795. (Co-author)
10)Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y*, Yang W*, Screening and rational design of HCV entry inhibitory peptides derived from GBV-A NS5A. J Virol., 2013，87(3), 1649-1657. (Co-author)
11)Huang YB, He LY, Jiang HY*, Chen YX*, Role of helicity on the anticancer mechanism of action of cationic-helical peptides. Int. J. Mol. Sci., 2012, 13, 6849-6862.
12)Huang YB, Zhai NC, Gao G, Chen YX*. Effects of Net Charge on Biological Activities of Alpha helical Anticancer Peptides. Chem. J. Chin. Univ. 2012, 33 (6): 1252-1258
13)Huang YB, Wang XF, Wang HY, Liu Y*, Chen YX*, Studies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework. Molecular Cancer Therapeutics, 2011, 10,416-426.
14)Huang YB, Huang JF, Chen YX*, Alpha-helical cationic antimicrobial peptides: relationships of structure and function. Protein & Cell, 2010, 1, 143-152.
15)Huang YB, Yang S, Cai Y, Wang H, Gao G, Wu XX, Xu Li*, Zhang XZ*, Alcalase-catalysed synthesis of the presursor tetrapeptide N-benzoylarginylglycylaspartylserinamide (Bz-RGDS-NH2) of the cell-adhesion peptide argininylglycylaspartylserine (RGDS)，Biotechnol. Appl. Bioc. 2008, 51（3）：119-127
16)Huang YB, Cai Y, Yang S, Wang H, Hou RZ, Xu L, Wu XX , Zhang XZ*. Synthesis of tetrapeptide Bz-RGDS-NH2 by a combination of chemical and enzymatic methods. J Biotechnol, 2006，125(3):311-318
17)Huang YB, Cai Y, Yang S, Wang H, Hou RZ, Xu L, Wu XX , Zhang XZ*. Chemo-enzymatic synthesis of precursor tetrapeptide Bz-RGDS-NH2 of cellular adhesion motif in low water organic media. Enzyme Microb.Techn., 2006，39 (5): 1150-1165
18)Huang YB, Xiao YP, Wang H, Hou RZ, Zhang N, Wu XX, Xu L, Zhang XX*, Chemo-enzymatic synthesis of tripeptide RGD diamide in organic solvents. J Biotechnol, 2005，116(1): 51-59