一
基本信息：


姓 名：李纯锦
职 称：教 授
所在部门：动物科学学院
研究方向：动物繁殖调控和动物繁殖新技术的开发及应用
办公电话：
电子邮件：llcjj158@163.com

二学习与工作经历
1.受教育经历
2005.09-2010.07吉林大学动物遗传育种与繁殖农学博士
2001.09-2005.07甘肃农业大学动物科学农学学士
2.工作经历
2017.09-至今吉林大学动物科学学院教授
2012.12-2017.09吉林大学动物科学学院副教授
2011.10-2012.04 Texas A&M University，USA博士后
2010.09-2011.06 Weizmann Institute if Science, Israel博士后
三主要教学工作（承担的本科生、研究生课程）
主讲本科生课程：《动物繁殖学》、《动物繁殖生物技术》、《种畜繁殖管理》
研究生课程：《动物繁殖学专论》
四主要科研工作（包括科研项目）
1.NGF/TrkA通路对牛睾丸支持细胞增殖的调节机理，自然基金面上项目，2017.01-2020.12,70.8万元 主持
2.BDNF对睾丸间质细胞睾酮合成的影响及机理研究，自然基金青年基金，2014.01-2016.12,23万元 主持
3.奶牛乳腺炎快速检测及预防关键技术的研发，吉林省重点攻关项目，2017.01-2019.12，50万元，主持
4.大熊猫胚胎延迟着床机理及妊娠特征性物质筛选，国家重点研发，2017.07-2020.12，32万元，骨干
5.基于免疫调节的奶牛性别控制技术研究，吉林身青年基金，2016.01-2018.12，6万元，主持
6.通过调节氧化应激提高母猪胚胎发育和产仔数的技术研究，2019.09-2019.09, 30万元，主持
7.奶牛乳房炎致病菌检测技术的研发，一牧科技（北京）有限公司，2017.07-2018.08，10万元，主持
8.奶牛精液品质分子标记的筛选应用与精液保存技术开发，西藏畜牧兽医研究所，2015.12-2017.06,15万元 主持
9.不同添加剂对藏猪生长的影响，西藏畜牧兽医研究所，2016.06-2018.12,20万元，主持
10.卵母细胞成熟的调节机制，吉林大学优秀青年精英阶段培养项目，2018.06-2020.06，40万元，主持
11.NGF/TrkA在牛睾丸支持细胞增殖中的作用研究，2014.09-2017.09，吉林大学优秀青年重点阶段培养项目，18万元，主持
12.睾丸支持细胞增殖研究，吉林大学优秀青年后备人才项目，2015.09-2017.09, 10万元，主持
13.母猪卵泡囊肿检测技术研发，扬州市“绿扬金凤”项目，2014.09-2017.09, 6万元，主持
14.吉林大学人才引进启动项目，2013.01-2014.01，33万元，主持
五科研成果（著作、专利、论文）

论文
1.Shuxiong chen, Fengge Wang, Zhuo Liu, Yun Zhao, Yanwen Jiang, Lu Chen,Chunjin Li*,Xu Zhou. Brain‐derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells. Journal of cellular Physiology. 2018. DOI: 10.1002/jcp.27536.
2.Sun L, Chen L, Jiang Y, Zhao Y, Wang F, Zheng X, Chunjin Li*, Xu Zhou. Metabolomic profiling of ovary in mice treated with FSH using ultra performance liquid chromatography/mass spectrometry.Biosci Rep. 2018. pii: BSR**. doi: 10.1042/BSR**.
3.Deng L, Chunjin Li (co-first), Chen L, Liu Y, Hou R, Xu Zhou. Research advances on embryonic diapause in mammals.Anim Reprod Sci. 2018. pii: S0378-4320(18)30611-0. doi: 10.1016/j.anireprosci.
4.Wang F, Chen S, Jiang Y, Zhao Y, Sun L, Zheng B, Chen L, Liu Z, Zheng X, Yi K, Chunjin Li*, Xu Zhou. Effects of ammonia on apoptosis and oxidative stress in bovine mammary epithelial cells.Mutagenesis. 2018. doi: 10.1093/mutage/gey023.
5.Liu Z, Sun Y, Jiang Y, Qian Y, Chen S, Gao S, Chen L, Chunjin Li*, Xu Zhou. Follicle-stimulating hormone (FSH) promotes retinol uptake and metabolism in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):52.
6.Jiang Y, Zhao Y, Chen S, Chen L, Chunjin Li*, Xu Zhou. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.Reprod Biol Endocrinol. 2018;16(1):25.
7.Jiang Y, Chen L, Taylor RN, Chunjin Li*, Xu Zhou. Physiological and pathological implications of retinoid action in the endometrium.J Endocrinol. 2018;236(3):R169-R188.
8.Zhu X, Chen S, Jiang Y, Xu Y, Zhao Y, Chen L, Chunjin Li*, Xu Zhou. Analysis of miRNA expression profiles in melatonin-exposed GC-1 spg cell line.Gene. 2018;642:513-521.
9.Gao S, Chunjin Li (co-first), Xu Y, Chen S, Zhao Y, Chen L, Jiang Y, Liu Z, Fan R, Sun L, Wang F, Zhu X, Zhang J, Xu Zhou. Differential expression of microRNAs in TM3 Leydig cells of mice treated with brain-derivedneurotrophic factor.Cell Biochem Funct. 2017;35(7):364-371.
10.Chunjin Li, Zhu X, Chen S, Chen L, Zhao Y, Jiang Y, Gao S, Wang F, Liu Z, Fan R, Sun L, Xu Zhou. Melatonin promotes the proliferation of GC-1 spg cells by inducing metallothionein-2 expression through ERK1/2 signaling pathway activation.Oncotarget. 2017;8(39):65627-65641.
11.Chunjin Li, Gao S, Chen S, Chen L, Zhao Y, Jiang Y, Zheng X, Xu Zhou. Differential expression of microRNAs in luteinising hormone-treated mouse TM3 Leydig cells.Andrologia. 2018 ;50(1).
12.Shan Gao,Chunjin Li (co-first), Lu Chen,Xu Zhou, Actions and mechanisms of reactive oxygen species and antioxidative system in semen,Molecular & Cellular Toxicology, 2017, 13, 143–154.
13.Wang H, Chen L, Jiang Y, Gao S, Chen S, Zheng X, Liu Z, Zhao Y, Li H, Yu J, Wang F, Liu Y, Chunjin Li*, Xu Zhou. Association of gene polymorphisms of estrogen receptor, follicle-stimulating hormone β and leptin with follicular cysts in Large White sows,Theriogenology. 2017;103:143-148.
14.Jiang Y, Chunjin Li (co-first), Chen L, Wang F, Xu Zhou. Potential role of retinoids in ovarian physiology and pathogenesis of polycystic ovary syndrome.Clin Chim Acta. 2017;469:87-93.
15.Jiang YW, Zhao Y, Chen SX, Chen L, Chunjin Li*, Xu Zhou. NGF promotes mitochondrial function by activating PGC-1α in TM4 Sertoli cells.Andrologia. 2018;50(1).
16.Chunjin Li, Chen L, Zhao Y, Chen S, Fu L, Jiang Y, Gao S, Liu Z, Wang F, Zhu X, Rao J, Zhang J, Xu Zhou. Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.Gene. 2017;598:20-26.
17.Chunjin Li, Chen S, Li H, Chen L, Zhao Y, Jiang Y, Liu Z, Liu Y, Gao S, Wang F, Yu J, Wang H, Rao J, Xu Zhou. MicroRNA-16 Modulates Melatonin-Induced Cell Growth in the Mouse-Derived Spermatogonia Cell Line GC-1 spg Cells by Targeting Ccnd1.Biol Reprod. 2016 ;95(3):57.
18.Chunjin Li, Wang D, Xu Zhou. Sperm proteome and reproductive technologies in mammals.Anim Reprod Sci. 2016t;173:1-7.
19.Chunjin Li, Jiang YW, Chen SX, Li HJ, Chen L, Liu YT, Gao S, Zhao Y, Zhu XL, Wang HT, Wang FG, Zheng L, Xu Zhou. 4-Methylcatechol inhibits cell growth and testosterone production in TM3 Leydig cells by reducing mitochondrial activity.Andrologia. 2017;49(1).
20.Chunjin Li, Chao Chen, Lu Chen, Shuxiong Chen, Hongjiao Li, Yun Zhao,Jiahui Rao,Xu Zhou, BDNF-induced expansion of cumulus oocyte complexes in pigs was mediated by microRNA-205, Theriogenology, 2016, doi:10.1016/j.theriogenology.2016.01.004.
21.Chunqiang Wang, Chunjing Li(co-first),Hongjiao Li, Wei Ma, Shuxiong Chen, YunZhao, Jiahui Rao, Xu Zhou, Downregulation of the expression of inhibin αsubunit and betaglycan in porcine cystic follicles. Journal of Veterinary Medical Science, 2015, 77(11): 1419-1425.
22.Chunjin Li, Xu Zhou, Melatonin and male reproduction, Clinica Chemica Acta, 2015, 446(2015):175-180.
23.Wanhong Li, Lu Chen, Shuxiong Chen, Hongjiao Li, Zhuo Liu, Lina Sun, Yun Zhao, Lianwen Zheng,Chunjin Li*, Xu Zhou, Polymorphisms in inhibin α gene promoter associated with male infertility, GENE. 2015, 559(2): 172–176.
24.Chunjin Li, Wanhong Li, Shuxiong Chen, Zhichen Kang, Lina Sun, Hongjiao Li, Lu Chen, Jiahui Rao, Yun Zhao, Jiaxin Yu, Xu Zhou,4-Methylcatechol-induced cell damage in TM4 Sertoli cells, Cell Biology International, 2015, 36(6): 770-774.
25. Wanhong Li, Lina Sun, Shuxiong Chen, Chen Lu, Zhuo Liu, Xiaofeng Hou, Chao Chen, Yamei Han, Chunqiang Wang,Chunjin Li*, Xu Zhou, Association of inhibin-α gene polymorphisms with follicular cysts in large white sows, Theriogenology, 2015,84(6): 839-845.
26.Li D, Cheng J, Li W, Ma W, Zhou X, Zheng L, Chunjin Li*. Association between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population.Iran J Reprod Med. 2015 Jan;13(1):35-40.
27.Li W, Chen S, Li H, Liu Z, Zhao Y, Chen L, Zhou X, Chunjin Li*. A new insertion/deletion fragment polymorphism of inhibin-α gene associated with follicular cysts in Large White sows.J Vet Med Sci. 2016;78(3):473-6
28.Chunjin Li, Yonghe Ma, Kangle Yi, Chunqiang Wang, Wanhong Li, Zhuo Liu, Lina Sun, Shuxiong Chen, Jiaxin Yu, Hongjiao Li, Lu Chen, Xu Zhou, The interactions between nerve growth factor and gonadotrophins in bovine oviduct, Animal Reproduction Science, 2014, 149(3-4): 117-123.
29.Chunjin Li, Xu Zhou, The potential roles of neurotrophins in male reproduction, Reproduction, 2013, 145(4): R89-R95.
30.Chunjin Li, Chenjiao Li, Xiaoling Zhu, Chunqiang Wang, Zhuo Liu, Wanghong Li, Chen Lu, Xu Zhou, The expression and putative role of brain-derived neurotrophic factor and its receptor in bovine sperm,Theriogenolog, 2012, 77(3): 636-643.
31.Chunjin Li, Xu Zhou, Gene transcripts in spermatozoa: Markers of male infertility, Clinica Chemica Acta, 2012, 413(13-14): 1035-1038.
32.Chunjin Li, Lianwen. Zheng, Yongfeng. Sun, Chunqiang Wang,Wanhong Li, Chen Lu, Xu Zhou, No association between the G196A and C270T polymorphism of the brain-derived neurotrophic factor gene and male infertility,Russian Journal of Genetics, 2012, 48(3): 405-407.
33.Yongfeng Sun, Jing Zhang,Chunjin Li (co-first), Dong Wang，Yonghe Ma, Yanling Sun, Zhuo Liu, Chunqiang Wang, Xu Zhou*, Interaction between Neurotrophin 4 and gonadotrophin in bovine oviducts,Theriogenology, 2012, 78(1): 39-48.
34.Chunjin Li, Lu Chen, Yongfeng Sun, Hongyan Liang, Kangle Yi, Yanling Sun, Yonghe Ma, Xiaoyan Li, Wei Wu,Xu Zhou*, Molecular cloning, polymorphism and tissue distribution of the MHC class IIB gene in the Chinese goose (Anser cygnoides), British Poultry Science, 2011, 52(3): 318-327.
35.Chunjin Li, Yongfeng Sun, Kangle Yi, Chengjiao Li, Xiaoling Zhu, Lu Chen, Xu Zhou, Detection of the SRY transcript and protein in bovine ejaculated spermatozoa,Asian-Australian journal of animal science,2011, 24(10): 1358-1364.
36. Yongfeng Sun,Chunjin Li (co-first), Yanling Sun, Lu Chen, Zhuo Liu, Yonghe Ma, Chunqiang Wang, Wei Zhang, Xu Zhou*, Expression of neurotrophin 4 and its receptor tyrosine kinase B in reproductive tissues during the follicular and luteal phases in cows,Asian-Australian journal of animal science, 2011, 24(3): 336-343.
37. Lianwen Zheng,Chunjin Li (co-first), Yongfeng Sun, Zhuo Liu, Xu Zhou*, Expression of brain-derived neurotrophic factor in mature spermatozoa from fertile and infertile men,Clinica Chemica Acta,2011, 412(1-2): 44-47.
38.Chunjin Li, Lianwen Zheng, Chunqiang Wang, Xu Zhou*, Absence of nerve growth factor and comparison of tyrosine Kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men,Clinica Chemica Acta,2010, 411(19-20): 1482-1486.
39.Chunjin Li, Yongfeng Sun, Kangle Yi, Yonghe Ma,Yanling Sun, Wei Zhang, Xu Zhou, Detection of nerve growth factor (NGF) and its specific receptor (TrkA) in ejaculated bovine sperm, and the effects of NGF on sperm function,Theriogenology, 2010, 74(9): 1615-1622.
40. Xu Zhou,Chunjin Li (co-first), Yi K, Liang H, Chen L, Sun Y, Niu S, Wu W. Patterns of variation of the major histocompatibility complex class IIB loci in Chinese goose (Anser Cygnoides).Immunogenetics. 2009 ;61(6):443-50.
专利
1.一种奶牛乳房炎检测试剂盒（9.3）
2.INHA基因的单链核苷酸序列作为动物超数排卵分子标记的应用及检测方法（ZL5.X）
3.SRY抗体的应用（ZL7.7）
4.一种牛支原体检测试剂盒（4.9）
教材
1.动物繁殖学，2015，科学出版社，副主编
2.高级动物免疫学，2017，科学出版社，参编
六奖励与荣誉
1.吉林省优秀博士论文获得者（2012）
2.第五届“吉林大学师德先进个人”（2017）
3.吉林省自然科学学术二等奖（2013）
4.辽宁省畜牧业科技贡献一等奖（2017）
5.吉林大学教学成果二等奖（2013）