基本信息


职称：教授、博导

学科专业：药物分析

讲授课程：药物分析、生化分析、药学导论、药学实验技术

研究方向：

1.现代药物分析方法学研究；

2.中药药效物质基础研究；

联系方式

电话号码：
Email：liuzy@jlu.edu.cn

通讯地址：长春市富锦路1266号，吉林大学药学院502室
邮编：130021

个人简介
  刘忠英，女，1964年出生。1985于吉林大学化学系获学士学位，1990于白求恩医科大学获硕士学位，2005于吉林大学化学院获博士研究学位。1985至今在吉林大学工作，2006,10-2007,10国家公派赴加拿大农业部食品研究所留学，访问学者。2016,11-2017,1国家留学基金委公派赴美国威斯康辛大学留学，高级研究学者。现任吉林大学药学院教授，博士生导师。多年来一直从事药物分析和生化分析科研和教学工作，主要开展现代药物分析方法研究，并利用这些先进技术进行中药化学成分分析、体内药物分析以及代谢通路分析，从药物吸收转运机制、代谢组学以及药效学等方面，深入开展中药药效物质基础和作用机制的研究。

代表性学术论文：
Men Lihui , Pi Zifeng, Zhou Yuan, Liu Yuanyuan, Wei Mengying,Song Fengrui , Liu Zhongying*. Metabolomics insights into diabetes nephropathyand protective effects of Radix Scutellariae on ratsusing ultra-high performance liquidchromatography coupled with quadrupole time-of-flight mass spectrometry. RSC Adv.2017, 7:16494-16504 .
Men Lihui, Pi Zifeng , Zhou Yuan, Wei Mengying , LiuYuanyuan, Song Fengrui, Liu Zhongying*. Urine metabolomics of high-fat diet induced obesity using UHPLC-Q-TOF-MS. Journal of Pharmaceutical and Biomedical Analysis. 2017,132:258-266.
Jiang Wenyue, Gao Lu, Li Pengdong, Kan Hong, Qu Jiale, Men Lihui,Zhiqiang Liu, Liu Zhongying*, Metabonomics study of the therapeutic mechanism of fenugreekgalactomannanon diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography B. 2017,8-16, 1044-1045.
Chen Weijia, Wu Yi, Zhao Xin, Liu Shu*, Song Fengrui , Liu Zhongying*, Liu Zhiqiang. Screening the anti-gout traditional herbs from TCM using an in vitro method. Chinese Chemical Letters,2016,27: 1701-1707.
Ding Ru, Jian Yong, Kan Hong, Liu Zhongying*, Liu Shu , Liu Zhiqiang , Zhou Jun. Studies on the intestinal absorption of the alkaloids in the Gancaofuzi decoction in a Caco-2 cell culture system using UPLC-MS/MS, Chinese Chemical Letters. 2016, 27 : 915-919 .
Lin He ，Pi Zifeng，Men Lihui，Chen Weijia，Liu Zhiqiang，Liu Zhongying* . Uinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Ethnopharmacology, 2016,184:10-17.
Ma Yinghui，Wei Mengying, Liu Yuanyuan，Song Fengrui，Liu Zhongying*，Zifeng Pi. Study on Intestinal Transportof Veratrum alkaloids Compatibled with Panax Ginseng across the Caco-2 Cell MonolayerModel by UPLC-ESI-MS Method，Chinese Chemical Letters，2016，27：215-220.
Ma Yinghui，Liu Yuanyuan，Wei Mengying ，Liu Zhiqiang，Liu Zhongying*, Pi Zifeng. Study on Intestinal Transport of Ginsenoside Compatibled with Veratrum nigrum acrossthe Caco-2 Cell Monolayer Model by UPLC-ESI-MS Method. Chemical Research in Chinese Universities，2015，31：914-918.
Chen Weijia, Wu Yi, Xu Chen , Liu Shu, Wang Wenzhe, Song Fengrui, Liu Zhongying*, LiuZhiqiang. Study on Therapeutic Effects of Ermiao Pill and Ermiao Pill Categorized Formula in Hyperuricemic Rats Using Spectroscopic Methods. Spectroscopy and Spectral Ananysis. 2015,35:956-960.
Jiang Wenyue, Kan Hong, Li Pengdong, Liu Zhongying*. Screening and structural characterization of potential α-glucosidase inhibitors from Radix Astragali flavonoids extract by ultrafiltration LC-DAD-ESI-MSn. Analytical Methods. 2015,7: 123-128.
Kan Hong, Jiang Wenyue，Ding Ru,Pi Zifeng，Liu Zhiqiang , Liu Zhongying *. Studies of the intestinal absorption of the alkaloids in the Wu-tou decoction combined with different incompatible medicinal herbs in a Caco-2 cell culture system using UPLC–MS/MS，Chinese Chemical Letters，2014，26（5）：590-594.
Kan Hong, Yue Yuan, Guo Lina, Li Xiaoping, Liu Zhongying*, Liu Zhiqiang. Microwave-Assisted Hydrolyzation of the Flavonoids in Epimedium Koreamum Nakai. Journal of Liquid Chromatography & Related Technologies 2014,7:2091-2101.
Ma Jingwei, Kan Hong, Ma Yinghui, Men Lihui, Pi Zifeng, Liu Zhiqiang, Liu Zhongying*. Qualitative and Quantitative Analysis of Drug Interactions: Fritillary Mediating the Transport of Alkaloids in Caco-2 Cells by P-Glycoprotein. Chemical Research In Chinses Universities.2014, 30:731-737.
Bai Yu, Jiang Wenyue, Lin He, Liu Zhiqiang, Liu Zhongying*. Identification of gamma-irradiated Chinese herbs by thermoluminescence analysis. Journal of Radioanalytical and Nuclear Chemistry. 2014, 301(1):125-131.
Li Haiyan, Pan Lang, Ke Yueshuang, Batnasan Enkhzaya, Jin Xiangqun, Liu Zhongying*, Ba Xueqing*. Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in|TNF-alpha-stimulated murine lung epithelial cells via depressing PARP-1|activity. Acta Pharmacologica Sinica. 2014,35:496-503.
Du Bin，Shen Guopeng, Wang Dandan, Pang Li, Chen, Zheng, Liu Zhongying*. Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats. Drug Delivery .2013, 20(1) : 25-33.
Sui Zhigang, Li Na, Liu Zhiqiang, Yan Jun , Liu Zhongying*. Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry. Xenobiotica.2013,43628-535.
Li Na, Tsao Rong, Sui Zhigang, Ma Jingwei, Liu Zhongying*. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med. 2012, 78:692-7

承担课题：
基于药物代谢组学研究五味子治疗阿尔茨海默症的药效物质基础及作用机制(**), 国家自然科学基金项目，2017.1-2020.12年。
“甘草附子汤”吸收转运机制及药效物质基础研究（**），国家自然科学基金项目，2012.1-2015.12年。
中药小分子与肿瘤相关生物靶分子相互作用的质谱研究（**），国家自然科学基金项目，2010.01-2010.12。
乌头类有毒中药炮制配伍减毒机理的体外模型研究（**），国家自然科学基金项目，2009.01-2011.12。
中药有效成分的吸收转运及其与生物分子相互作用的研究（**）国家自然科学基金项目，2004,1-2004,12。
复方中药吸收转运机制的体外实验研究（GH），吉林省科技厅国际合作项目，2015,1-2017，12。
胡芦巴辅助降血糖保健食品的开发研究（YY），吉林省科技厅重点项目，2013,1-2015，12。