王立生
博士，教授
邮箱地址：lishengwang@jlu.edu.cn
教育经历
2001-2004，军事医学科学院,博士
1989-1992，军事医学科学院，硕士
1981-1986，青岛医学院医学系，学士
工作经历
2016–， 吉林大学护理学院康复教研室
2009-2011，美国洛杉矶国家医学中心
2001-2009 军事医学科学院放射与辐射医学研究所
1997–2000，美国印第安那大学医学院
1992–1997，军事医学科学院放射与辐射医学研究所
研究方向
1、干细胞基因治疗与再生医学
2、生物治疗与组织再生康复
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近五年主持或参加科研项目情况
1、国家重点研发计划、2017YFA**、“iPSC-RPE治疗AMD和Stargardt病的多中心临床试验”、负责人。
2、国家863项目、2012AA020807、“心血管疾病基因治疗的临床试验方案研究”、负责人。
3、国家863项目、2012AA02A211、“白血病的’组学’研究”、科研骨干。
4、国家973项目、2012AA02A211、“低氧相关的细胞分子与基因调控网络”、科研骨干。
5、国家自然科学基金面上项目、**、“MicroRNA-486-5P调节CML干细胞生物学特性的作用与机制研究”、负责人。
6、国家自然科学基金面上项目、**、“CML细胞鞘氨醇激酶去SUMO化修饰及在发病中的作用研究”、负责人。

近五年发表SCI研究论文情况
1、Wang L, Wang H, Zhang Q, Yang Z, Kong F, Wu CT.Hepatocyte Growth Factor Gene Therapy for Ischemic Diseases.Hum Gene Ther. 2018. doi: 10.1089/ hum. 2017. 217. [Epub ahead of print]

2、Liu Z, Yang Y, Zhang X, Wang H, Xu W, Wang H, Xiao F, Bai Z, Yao H, Ma X, Jin L, Wu CT, Seth P, Zhang Z, Wang L*. An oncolytic adenovirus encoding decorin and GM-CSF inhibits tumor growth in a colorectal tumor model by targeting pro-tumorigenic signals and via immune-activation. Hum Gene Ther. 2017 Aug; 28(8): 667-680.

3、Jia Q, Sun H, Xiao F, Sai Y, Li Q, Zhang X, Yang S, Wang H, Wang H, Yang Y, Wu CT, Wang L*. miR-17-92 promotes leukemogenesis in chronic myeloid leukemia via targeting A20 and activation of NF-κB signaling. Biochem Biophys Res Commun. 2017;487(4):868-874.

4、Zhang X, Wang H, Wang H, Xiao F, Seth P, Xu W, Jia Q, Wu C, Yang Y, Wang L*. SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation. Int J Mol Sci. 2017；12;18(4).

5、Shi XF, Wang H, Kong FX, Xu QQ, Xiao FJ, Yang YF, Ge RL,Wang LS*. Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. Exp Cell Res 2017;351(1):74-81.

6、Gao Z, Wang H, Xiao FJ, Shi XF, Zhang YK, Xu QQ, Zhang XY, Ha XQ,Wang LS*. SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells. Int J Biochem Cell Biol. 2016 S1357-2725(16)30042-5

7、Shi XF, Wang H, Xiao FJ, Yin Y, Xu QQ, Ge RL,Wang LS*. MiRNA-486 regulates angiogenic activity and survival of mesenchymal stem cells under hypoxia through modulating Akt signal. Biochem Biophys Res Commun. 2016. pii: S0006-291X(16)30084-5.

8、Wang H, Sun RT, Li Y, Yang YF, Xiao FJ, Zhang YK, Wang SX, Sun HY, Zhang QW, Wu CT,Wang LS*. HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity. PLoS One. 2015 ;10(5):e**.

9、Sun H, Cui C, Xiao F, Wang H, Xu J, Shi X, Yang Y, Zhang Q, Zheng X, Yang X, Wu C,Wang L*. miR-486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON. Hepatol Res.

10、Yang Y, Liu X, Xiao F, Xue S, Xu Q, Yin Y, Sun H, Xu J, Wang H, Zhang Q, Wang H,Wang L*. Spred2 modulates the erythroid differentiation induced by imatinib in chronic myeloid leukemia cells. PLoS One. 2015 ;10(2):e**. IF3.23

11、Xu J, Sun HY, Xiao FJ, Wang H, Yang Y, Wang L, Gao CJ, Guo ZK, Wu CT,Wang LS*. SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling. Biochem Biophys Res Commun. 2015 ;460(2):409-15. IF2.30

12、Wang LS, Li L, Li L, Chu S, Shiang KD, Li M, Sun HY, Xu J, Xiao FJ, Sun G, Rossi JJ, Ho Y, Bhatia R. MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors. Blood. 2015 Feb 19;125(8):1302-13.

13、Yin Y, Sun H, Xu J, Xiao F, Wang H, Yang Y, Ren H, Wu CT, Gao C,Wang L*. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2014 Sep 22:1-8.

14、Yang YF, Xue SY, Lu ZZ, Xiao FJ, Yin Y, Zhang QW, Wu CT, Wang H,Wang LS*. Antitumor effects of oncolytic adenovirus armed with PSA-IZ-CD40L fusion gene against prostate cancer. Gene Ther. 2014;21(8):723-31.

15、Xu FF, Zhu H, Li XM, Yang F, Chen JD, Tang B, Sun HG, Chu YN, Zheng RX, Liu YL,Wang LS*, Zhang Y*. Intercellular adhesion molecule-1 inhibits osteogenic differentiation of mesenchymal stem cells and impairs bio-scaffold-mediated bone regeneration in vivo. Tissue Eng Part A. 2014 Oct;20(19-20):2768-82. IF4.64

16、Wang H, Yang YF, Zhao L, Xiao FJ, Zhang QW, Wen ML, Wu CT, Peng RY,Wang LS*. Hepatocyte Growth Factor Gene-Modified Mesenchymal Stem Cells Reduce Radiation-Induced Lung Injury. Hum Gene Ther. 2013:24:343-35. IF3.76

17、Liu Y, Saiyan S, Men TY, Gao HY, Wen C, Liu Y, Zhou X, Wu CT,Wang LS*, Cui CP*. Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. J Pathol. 2013 Aug;230(4):365-76. doi: 10.1002/path.4194. IF7.43

18、Yang Y, Xiao F, Lu Z, Li Z, Zuo H, Zhang Q, Li Q, Wang H,Wang LS*. Development of a novel adenovirus-alphavirus hybrid vector with RNA replicon features for malignant hematopoietic cell transduction. Cancer Gene Ther. 2013;20(8):429-36.

参编书稿
1、《再生医学学科发展战略》,科学出版社，2015（秘书组组长）
2.《 再生医学研究与转化应用》科学出版社，2017（秘书组组长）

参加社会组织
1、中国医药生物技术协会理事
2、中国医药生物技术协会再生医学专业委员会常委
3、中国医药生物技术协会基因治疗专业委员会常委
4.《中国实验血液学杂志》编委
5.《中国医药生物技术杂志》编委
6.《中国高原医学与生物学杂志》特邀编委
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