张海元
研究员
化学生物学实验室
中国科学院长春应用化学研究所
电话:
传真:
电子信箱: zhangh@ciac.ac.cn
工作经历：
2014年~至今：中科院长春应用化学研究所化学生物学实验室；
职位：研究员；
2009年~2013年：美国加州大学洛杉矶分校； 职位：研究助理
2008年~2009年：美国伦斯勒理工学院； 职位：博士后
2005年~2007年：美国韦恩州立大学；职位：博士后
教育背景：
1999年~2005年：中科院长春应用化学研究所；攻读博士学位
1995年~1999年：山西大学化学系；攻读学士学位
代表性文章
Cheng, Y.; Kong, X. P.; Chang, Y.; Feng, Y. L.; Zheng, R. X.; Wu, X. Q.; Xu, K. Q.; Gao, X. F.; Zhang, H. Y.*, Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials 2020, 32, 1908109.
Wang, L.; Chang, Y.; Feng, Y.; Li, X.*; Cheng, Y.; Jian, H.; Ma, X.; Zheng, R.; Wu, X.; Xu, K.; Zhang, H. Y.*, Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. Nano Letters 2019,19, 6800-6811.
Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Meng, H.; Zhang, H. Y.*; Shi, H. *, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials 2019, 29, 1806916.
Feng, Y.; Wang, G.; Chang, Y.; Cheng, Y.; Sun, B.; Wang, L.*; Chen, C.; Zhang, H. Y.*, Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@Ag Core–Shell Nanoparticles. Nano Letters 2019,19, 4478-4489.
Feng, Y.; Cheng, Y.; Chang, Y.; Jian, H.; Zheng, R.; Wu, X.; Xu, K.; Wang, L.; Ma, X.; Li, X.*; Zhang, H. Y.*, Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. Biomaterials 2019, 217, 119327.
Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Xu, K.; Zhang, H. Y.*, Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials 2019, 0, 1806808.
Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H. Y.*, Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science 2019, 6, 1900158
Cheng, Y.; Chang, Y.; Feng, Y. L.; Jian, H.; Tang, Z. H.; Zhang, H. Y.*, Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition 2018, 57, 246-251.
Chang, Y.; Cheng, Y.; Feng, Y. L.; Jian, H.; Wang, L.; Ma, X. M.; Li, X.; Zhang, H. Y.*, Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold- Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer. Nano Letters 2018, 18, 886-897.
Cheng, Y.; Chang, Y.; Feng, Y. L.; Liu, N.; Sun, X. J.; Feng, Y. Q.; Li, X.; Zhang, H. Y.*, Simulated Sunlight-Mediated Photodynamic Therapy for Melanoma Skin Cancer by Titanium-Dioxide-Nanoparticle-Gold-Nanocluster-Graphene Heterogeneous Nanocomposites. Small 2017, 13.
Chang, Y.; Li, K.; Feng, Y. L.; Cheng, Y.; Zhang, M.; Wang, Z. K.; Wu, Z. J.; Zhang, H. Y.*, Achievement of safer palladium nanocrystals by enlargement of {10crystallographic facets. Nanotoxicology 2017, 11, 907-922.
Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.*; Zhang, H. Y.*, Crystallographic Facet-Induced Toxicological Responses by Faceted Titanium Dioxide Nanocrystals. ACS Nano 2016, 10, 6062-6073.
Zhang, H. Y.; Wang, X.; Wang, M. Y.; Li, L. J.; Chang, C. H.; Ji, Z. X.; Xia, T.; Nel, A. E.*, Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression. Small 2015, 11, 3797-3805.
Zhang, H. Y.; Pokhrel, S.; Ji, Z. X.; Meng, H.; Wang, X.; Lin, S. J.; Chang, C. H.; Li, L. J.; Li, R. B.; Sun, B. B.; Wang, M. Y.; Liao, Y. P.; Liu, R.; Xia, T.; Madler, L.; Nel, A. E.*, PdO Doping Tunes Band-Gap Energy Levels as Well as Oxidative Stress Responses to a Co3O4 p-Type Semiconductor in Cells and the Lung. Journal of the American Chemical Society 2014, 136, 6406-6420.
Zhang, H. Y.; Lee, M. Y.; Hogg, M. G.; Dordick, J. S.; Sharfstein, S. T.*, High-Throughput Transfection of Interfering RNA into a 3D Cell-Culture Chip.Small 2012, 8, 2091-2098.
Zhang, H. Y.; Ji, Z. X.; Xia, T.; Meng, H.; Low-Kam, C.; Liu, R.; Pokhrel, S.; Lin, S. J.; Wang, X.; Liao, Y. P.; Wang, M. Y.; Li, L. J.; Rallo, R.; Damoiseaux, R.; Telesca, D.; Madler, L.; Cohen, Y.; Zink, J. I.; Nel, A. E.*, Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation. ACS Nano 2012, 6, 4349-4368.
Zhang, H. Y.; Dunphy, D. R.; Jiang, X. M.; Meng, H.; Sun, B. B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S. J.; Ji, Z. X.; Li, R. B.; Garcia, F. L.; Yang, J.; Kirk, M. L.; Xia, T.; Zink, J. I.; Nel, A.; Brinker, C. J.*, Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic. Journal of the American Chemical Society 2012, 134, 15790-15804.
Zhang, H. Y.; Xia, T.; Meng, H.; Xue, M.; George, S.; Ji, Z. X.; Wang, X.; Liu, R.; Wang, M. Y.; France, B.; Rallo, R.; Damoiseaux, R.; Cohen, Y.; Bradley, K. A.; Zink, J. I.; Nel, A. E.*, Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells. ACS Nano 2011, 5, 2756-2769.
Zhang, H. Y.; Lee, M. Y.; Hogg, M. G.; Dordick, J. S.; Sharfstein, S. T.*, Gene Delivery in Three-Dimensional Cell Cultures by Superparamagnetic Nanoparticles. ACS Nano 2010, 4, 4733-4743.
文章
1. Cheng, Y.; Kong, X. P.; Chang, Y.; Feng, Y. L.; Zheng, R. X.; Wu, X. Q.; Xu, K. Q.; Gao, X. F.; Zhang, H. Y., Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials 2020, 32, 1908109.
2. Zhang, H.; Xie, F.; Cheng, M.; Peng, F., Novel Meta-iodobenzylguanidine-Based Copper Thiosemicarbazide-1-guanidinomethylbenzyl Anticancer Compounds Targeting Norepinephrine Transporter in Neuroblastoma. Journal of Medicinal Chemistry 2019, 62, 6985-6991.
3. Xu, K. Q.; Cheng, Y.; Yan, J.; Feng, Y. L.; Zheng, R. X.; Wu, X. Q.; Wang, Y. J.; Song, P. P.; Zhang, H. Y., Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy. Nano Research 2019, 12, 2947-2953.
4. Wang, L.; Chang, Y.; Feng, Y.; Li, X.; Cheng, Y.; Jian, H.; Ma, X.; Zheng, R.; Wu, X.; Xu, K.; Zhang, H., Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. Nano Lett 2019, 19, 6800-6811.
5. Ma, X.; Cheng, Y.; Jian, H.; Feng, Y.; Chang, Y.; Zheng, R.; Wu, X.; Wang, L.; Li, X.; Zhang, H., Hollow, Rough, and Nitric Oxide-Releasing Cerium Oxide Nanoparticles for Promoting Multiple Stages of Wound Healing. Advanced Healthcare Materials 2019, 8, 1900256.
6. Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Meng, H.; Zhang, H.; Shi, H., MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials 2019, 0, 1806916.
7. Feng, Y.; Wang, G.; Chang, Y.; Cheng, Y.; Sun, B.; Wang, L.; Chen, C.; Zhang, H., Electron Compensation Effect Suppressed Silver Ion Release and Contributed Safety of Au@Ag Core-Shell Nanoparticles. Nano Lett 2019, 19, 4478-4489.
8. Feng, Y.; Cheng, Y.; Chang, Y.; Jian, H.; Zheng, R.; Wu, X.; Xu, K.; Wang, L.; Ma, X.; Li, X.; Zhang, H., Time-staggered delivery of erlotinib and doxorubicin by gold nanocages with two smart polymers for reprogrammable release and synergistic with photothermal therapy. Biomaterials 2019, 217, 119327.
9. Feng, Y.; Chang, Y.; Sun, X.; Cheng, Y.; Zheng, R.; Wu, X.; Wang, L.; Ma, X.; Li, X.; Zhang, H., Differential photothermal and photodynamic performance behaviors of gold nanorods, nanoshells and nanocages under identical energy conditions. Biomaterials Science 2019.
10. Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Xu, K.; Zhang, H., Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Adv Mater 2019, 31, e1806808.
11. Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Wang, L.; Ma, X.; Xu, K.; Song, P.; Wang, Y.; Zhang, H., Hierarchical Acceleration of Wound Healing through Intelligent Nanosystem to Promote Multiple Stages. ACS Applied Materials & Interfaces 2019.
12. Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H., Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science 2019, 6, 1900158.
13. Chang, Y.; Cheng, Y.; Feng, Y.; Li, K.; Jian, H.; Zhang, H., Upshift of the d Band Center toward the Fermi Level for Promoting Silver Ion Release, Bacteria Inactivation, and Wound Healing of Alloy Silver Nanoparticles. ACS Applied Materials & Interfaces 2019, 11, 12224-12231.
14. Zheng, R. X.; Tao, L.; Jian, H.; Chang, Y.; Cheng, Y.; Feng, Y. L.; Zhang, H. Y., NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter. Ecotoxicology and Environmental Safety 2018, 163, 612-619.
15. Wu, M. X.; Yan, H. J.; Gao, J.; Cheng, Y.; Yang, J.; Wu, J. R.; Gong, B. J.; Zhang, H. Y.; Yang, Y. W., Multifunctional Supramolecular Materials Constructed from Polypyrrole@UiO-66 Nanohybrids and Pillararene Nanovalves for Targeted Chemophotothermal Therapy. Acs Applied Materials & Interfaces 2018, 10, 34655-34663.
16. Wang, X.; Yang, J.; Sun, X. J.; Yu, H. L.; Yan, F.; Meguellati, K.; Cheng, Z. Y.; Zhang, H. Y.; Yang, Y. W., Facile surface functionalization of upconversion nanoparticles with phosphoryl pillar 5 arenes for controlled cargo release and cell imaging. Chemical Communications 2018, 54, 12990-12993.
17. Sun, X. J.; Chang, Y.; Cheng, Y.; Feng, Y. L.; Zhang, H. Y., Band Alignment-Driven Oxidative Injury to the Skin by Anatase/Rutile Mixed-Phase Titanium Dioxide Nanoparticles Under Sunlight Exposure. Toxicological Sciences 2018, 164, 300-312.
18. Cheng, Y.; Zhang, H. Y., Novel Bismuth-Based Nanomaterials Used for Cancer Diagnosis and Therapy. Chemistry-a European Journal 2018, 24, 17405-17418.
19. Cheng, Y.; Chang, Y.; Feng, Y. L.; Jian, H.; Tang, Z. H.; Zhang, H. Y., Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition 2018, 57, 246-251.
20. Chang, Y.; Cheng, Y.; Feng, Y. L.; Jian, H.; Wang, L.; Ma, X. M.; Li, X.; Zhang, H. Y., Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold- Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer. Nano Letters 2018, 18, 886-897.
21. Liu, N.; Chang, Y.; Feng, Y. L.; Cheng, Y.; Sun, X. J.; Jian, H.; Feng, Y. Q.; Li, X.; Zhang, H. Y., {101}-{001} Surface Heterojunction-Enhanced Antibacterial Activity of Titanium Dioxide Nanocrystals Under Sunlight Irradiation. Acs Applied Materials & Interfaces 2017, 9, 5907-5915.
22. Feng, Y. L.; Chang, Y.; Sun, X. J.; Liu, N.; Cheng, Y.; Feng, Y. Q.; Zhang, H. Y.; Li, X., Understanding the Property-Activity Relationships of Polyhedral Cuprous Oxide Nanocrystals in Terms of Reactive Crystallographic Facets. Toxicological Sciences 2017, 156, 480-491.
23. Cheng, Y.; Chang, Y.; Feng, Y. L.; Liu, N.; Sun, X. J.; Feng, Y. Q.; Li, X.; Zhang, H. Y., Simulated Sunlight-Mediated Photodynamic Therapy for Melanoma Skin Cancer by Titanium-Dioxide-Nanoparticle-Gold-Nanocluster-Graphene Heterogeneous Nanocomposites. Small 2017, 13.
24. Chang, Y.; Li, K.; Feng, Y. L.; Cheng, Y.; Zhang, M.; Wang, Z. K.; Wu, Z. J.; Zhang, H. Y., Achievement of safer palladium nanocrystals by enlargement of {100} crystallographic facets. Nanotoxicology 2017, 11, 907-922.
25. Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.; Zhang, H. Y., Crystallographic Facet-Induced Toxicological Responses by Faceted Titanium Dioxide Nanocrystals. Acs Nano 2016, 10, 6062-6073.
26. Chang, Y.; Li, K.; Feng, Y. L.; Liu, N.; Cheng, Y.; Sun, X. J.; Feng, Y. Q.; Li, X.; Wu, Z. J.; Zhang, H. Y., Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential "safe-by-design" approach. Nano Research 2016, 9, 3812-3827.
27. Zhang, H. Y.; Wang, X.; Wang, M. Y.; Li, L. J.; Chang, C. H.; Ji, Z. X.; Xia, T.; Nel, A. E., Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression. Small 2015, 11, 3797-3805.
28. Wang, X.; Duch, M. C.; Mansukhani, N.; Ji, Z. X.; Liao, Y. P.; Wang, M. Y.; Zhang, H. Y.; Sun, B. B.; Chang, C. H.; Li, R. B.; Lin, S. J.; Meng, H.; Xia, T.; Hersam, M. C.; Nel, A. E., Use of a Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach for Tiered Testing and Decision Analysis of Carbonaceous Nanomaterials. Acs Nano 2015, 9, 3032-3043.
29. Sun, B. B.; Wang, X.; Ji, Z. X.; Wang, M. Y.; Liao, Y. P.; Chang, C. H.; Li, R. B.; Zhang, H. Y.; Nel, A. E.; Xia, T., NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes. Small 2015, 11, 2087-2097.
30. Sun, B. B.; Pokhrel, S.; Dunphy, D. R.; Zhang, H. Y.; Ji, Z. X.; Wang, X.; Wang, M. Y.; Liao, Y. P.; Chang, C. H.; Dong, J. Y.; Li, R. B.; Madler, L.; Brinker, C. J.; Nel, A. E.; Xia, T., Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping. Acs Nano 2015, 9, 9357-9372.
31. Low-Kam, C.; Telesca, D.; Ji, Z. X.; Zhang, H. Y.; Xia, T.; Zink, J. I.; Nel, A. E., A BAYESIAN REGRESSION TREE APPROACH TO IDENTIFY THE EFFECT OF NANOPARTICLES' PROPERTIES ON TOXICITY PROFILES. Annals of Applied Statistics 2015, 9, 383-401.
32. Zhang, H.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C. H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Liao, Y. P.; Liu, R.; Xia, T.; Madler, L.; Nel, A. E., PdO doping tunes band-gap energy levels as well as oxidative stress responses to a Co(3)O(4) p-type semiconductor in cells and the lung. J Am Chem Soc 2014, 136, 6406-20.
33. Wang, X.; Ji, Z. X.; Chang, C. H.; Zhang, H. Y.; Wang, M. Y.; Liao, Y. P.; Lin, S. J.; Meng, H.; Li, R. B.; Sun, B. B.; Winkle, L. V.; Pinkerton, K. E.; Zink, J. I.; Xia, T.; Nel, A. E., Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential. Small 2014, 10, 385-398.
34. Patel, T.; Telesca, D.; Low-Kam, C.; Ji, Z. X.; Zhang, H. Y.; Xia, T.; Zinc, J. I.; Nel, A. E., Relating nano-particle properties to biological outcomes in exposure escalation experiments. Environmetrics 2014, 25, 57-68.
35. Liu, R.; France, B.; George, S.; Rallo, R.; Zhang, H. Y.; Xia, T.; Nel, A. E.; Bradley, K.; Cohen, Y., Association rule mining of cellular responses induced by metal and metal oxide nanoparticles. Analyst 2014, 139, 943-953.
36. Li, R. B.; Ji, Z. X.; Qin, H. Q.; Kang, X. D.; Sun, B. B.; Wang, M. Y.; Chang, C. H.; Wang, X.; Zhang, H. Y.; Zou, H. F.; Nel, A. E.; Xia, T., Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1 beta Producing Inflammasome. Acs Nano 2014, 8, 10280-10292.
37. Li, R. B.; Ji, Z. X.; Chang, C. H.; Dunphy, D. R.; Cai, X. M.; Meng, H.; Zhang, H. Y.; Sun, B. B.; Wang, X.; Dong, J. Y.; Lin, S. J.; Wang, M. Y.; Liao, Y. P.; Brinker, C. J.; Nel, A.; Xia, T., Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design. Acs Nano 2014, 8, 1771-1783.
38. Yuan, J. C.; Zhang, H. Y.; Kaur, H.; Oupicky, D.; Peng, F. Y., Synthesis and Characterization of Theranostic Poly(HPMA)-c(RGDyK)-DOTA-Cu-64 Copolymer Targeting Tumor Angiogenesis: Tumor Localization Visualized by Positron Emission Tomography. Molecular Imaging 2013, 12.
39. Xia, T.; Malasarn, D.; Lin, S. J.; Ji, Z. X.; Zhang, H. Y.; Miller, R. J.; Keller, A. A.; Nisbet, R. M.; Harthorn, B. H.; Godwin, H. A.; Lenihan, H. S.; Liu, R.; Gardea-Torresdey, J.; Cohen, Y.; Madler, L.; Holden, P. A.; Zink, J. I.; Nel, A. E., Implementation of a Multidisciplinary Approach to Solve Complex Nano EHS Problems by the UC Center for the Environmental Implications of Nanotechnology. Small 2013, 9, 1428-1443.
40. Sun, B. B.; Ji, Z. X.; Liao, Y. P.; Wang, M. Y.; Wang, X.; Dong, J. Y.; Chang, C. H.; Li, R. B.; Zhang, H. Y.; Nel, A. E.; Xia, T., Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles. Acs Nano 2013, 7, 10834-10849.
41. Nel, A.; Xia, T.; Meng, H.; Wang, X.; Lin, S. J.; Ji, Z. X.; Zhang, H. Y., Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening. Accounts of Chemical Research 2013, 46, 607-621.
42. Meng, H.; Zhao, Y.; Dong, J. Y.; Xue, M.; Lin, Y. S.; Ji, Z. X.; Mai, W. X.; Zhang, H. Y.; Chang, C. H.; Brinker, C. J.; Zink, J. I.; Nel, A. E., Two-Wave Nanotherapy To Target the Stroma and Optimize Gemcitabine Delivery To a Human Pancreatic Cancer Model in Mice. Acs Nano 2013, 7, 10048-10065.
43. Meng, H.; Mai, W. X.; Zhang, H. Y.; Xue, M.; Xia, T.; Lin, S. J.; Wang, X.; Zhao, Y.; Ji, Z. X.; Zink, J. I.; Nel, A. E., Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo. Acs Nano 2013, 7, 994-1005.
44. Liu, R.; Zhang, H. Y.; Ji, Z. X.; Rallo, R.; Xia, T.; Chang, C. H.; Nel, A.; Cohen, Y., Development of structure-activity relationship for metal oxide nanoparticles. Nanoscale 2013, 5, 5644-5653.
45. Lin, S. J.; Zhao, Y.; Ji, Z. X.; Ear, J.; Chang, C. H.; Zhang, H. Y.; Low-Kam, C.; Yamada, K.; Meng, H.; Wang, X.; Liu, R.; Pokhrel, S.; Madler, L.; Damoiseaux, R.; Xia, T.; Godwin, H. A.; Lin, S.; Nel, A. E., Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1. Small 2013, 9, 1776-1785.
46. Li, R. B.; Wang, X.; Ji, Z. X.; Sun, B. B.; Zhang, H. Y.; Chang, C. H.; Lin, S. J.; Meng, H.; Liao, Y. P.; Wang, M. Y.; Li, Z. X.; Hwang, A. A.; Song, T. B.; Xu, R.; Yang, Y.; Zink, J. I.; Nel, A. E.; Xia, T., Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity. Acs Nano 2013, 7, 2352-2368.
47. Zhang, H. Y.; Lee, M. Y.; Hogg, M. G.; Dordick, J. S.; Sharfstein, S. T., High-Throughput Transfection of Interfering RNA into a 3D Cell-Culture Chip. Small 2012, 8, 2091-2098.
48. Zhang, H. Y.; Ji, Z. X.; Xia, T.; Meng, H.; Low-Kam, C.; Liu, R.; Pokhrel, S.; Lin, S. J.; Wang, X.; Liao, Y. P.; Wang, M. Y.; Li, L. J.; Rallo, R.; Damoiseaux, R.; Telesca, D.; Madler, L.; Cohen, Y.; Zink, J. I.; Nel, A. E., Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation. Acs Nano 2012, 6, 4349-4368.
49. Zhang, H. Y.; Dunphy, D. R.; Jiang, X. M.; Meng, H.; Sun, B. B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S. J.; Ji, Z. X.; Li, R. B.; Garcia, F. L.; Yang, J.; Kirk, M. L.; Xia, T.; Zink, J. I.; Nel, A.; Brinker, C. J., Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic. Journal of the American Chemical Society 2012, 134, 15790-15804.
50. Wang, X.; Xia, T.; Duch, M. C.; Ji, Z. X.; Zhang, H. Y.; Li, R. B.; Sun, B. B.; Lin, S. J.; Meng, H.; Liao, Y. P.; Wang, M. Y.; Song, T. B.; Yang, Y.; Hersam, M. C.; Nel, A. E., Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury. Nano Letters 2012, 12, 3050-3061.
51. Ji, Z.; Wang, X.; Zhang, H.; Lin, S.; Meng, H.; Sun, B.; George, S.; Xia, T.; Nel, A. E.; Zink, J. I., Designed Synthesis of CeO2 Nanorods and Nanowires for Studying Toxicological Effects of High Aspect Ratio Nanomaterials. Acs Nano 2012, 6, 5366-5380.
52. George, S.; Lin, S. J.; Jo, Z. X.; Thomas, C. R.; Li, L. J.; Mecklenburg, M.; Meng, H.; Wang, X.; Zhang, H. Y.; Xia, T.; Hohman, J. N.; Lin, S.; Zink, J. I.; Weiss, P. S.; Nel, A. E., Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos. Acs Nano 2012, 6, 3745-3759.
53. Zhang, H. Y.; Xia, T.; Meng, H.; Xue, M.; George, S.; Ji, Z. X.; Wang, X.; Liu, R.; Wang, M. Y.; France, B.; Rallo, R.; Damoiseaux, R.; Cohen, Y.; Bradley, K. A.; Zink, J. I.; Nel, A. E., Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells. Acs Nano 2011, 5, 2756-2769.
54. Zhang, H. Y.; Cai, H. W.; Lu, X.; Muzik, O.; Peng, F. Y., Positron Emission Tomography of Human Hepatocellular Carcinoma Xenografts in Mice Using Copper (II)-64 Chloride as a Tracer. Academic Radiology 2011, 18, 1561-1568.
55. Wang, X.; Xia, T.; Ntim, S. A.; Ji, Z. X.; Lin, S. J.; Meng, H.; Chung, C. H.; George, S.; Zhang, H. Y.; Wang, M. Y.; Li, N.; Yang, Y.; Castranova, V.; Mitra, S.; Bonner, J. C.; Nel, A. E., Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung. Acs Nano 2011, 5, 9772-9787.
56. Meng, H.; Yang, S.; Li, Z. X.; Xia, T.; Chen, J.; Ji, Z. X.; Zhang, H. Y.; Wang, X.; Lin, S. J.; Huang, C.; Zhou, Z. H.; Zink, J. I.; Nel, A. E., Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism. Acs Nano 2011, 5, 4434-4447.
57. Lin, S. J.; Zhao, Y.; Xia, T.; Meng, H.; Ji, Z. X.; Liu, R.; George, S.; Xiong, S. J.; Wang, X.; Zhang, H. Y.; Pokhrel, S.; Madler, L.; Damoiseaux, R.; Lin, S.; Nel, A. E., High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles. Acs Nano 2011, 5, 7284-7295.
58. George, S.; Xia, T. A.; Rallo, R.; Zhao, Y.; Ji, Z. X.; Lin, S. J.; Wang, X.; Zhang, H. Y.; France, B.; Schoenfeld, D.; Damoiseaux, R.; Liu, R.; Lin, S.; Bradley, K. A.; Cohen, Y.; Nel, A. E., Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials. Acs Nano 2011, 5, 1805-1817.
59. Zhang, H. Y.; Lee, M. Y.; Hogg, M. G.; Dordick, J. S.; Sharfstein, S. T., Gene Delivery in Three-Dimensional Cell Cultures by Superparamagnetic Nanoparticles. Acs Nano 2010, 4, 4733-4743.
60. Wang, X.; Xia, T. A.; Ntim, S. A.; Ji, Z. X.; George, S.; Meng, H. A.; Zhang, H. Y.; Castranova, V.; Mitra, S.; Nel, A. E., Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells. Acs Nano 2010, 4, 7241-7252.
61. Ji, Z. X.; Jin, X.; George, S.; Xia, T. A.; Meng, H. A.; Wang, X.; Suarez, E.; Zhang, H. Y.; Hoek, E. M. V.; Godwin, H.; Nel, A. E.; Zink, J. I., Dispersion and Stability Optimization of TiO2 Nanoparticles in Cell Culture Media. Environmental Science & Technology 2010, 44, 7309-7314.
62. Geng, J.; Yu, H. J.; Zhang, H. Y.; Xu, H. X.; Qu, X. G., Interactions of Rare Earth-Amino Acid Complexes with Nucleic Acids. Progress in Chemistry 2009, 21, 866-872.
63. Zhang, H. Y.; Wu, J. S.; Peng, F. Y., Potent anticancer activity of pyrrolidine dithiocarbamate-copper complex against cisplatin-resistant neuroblastoma cells. Anti-Cancer Drugs 2008, 19, 125-132.
64. Zhang, H.; Thomas, R.; Oupicky, D.; Peng, F., Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells. Journal of Biological Inorganic Chemistry 2008, 13, 47-55.
65. Zhang, H. Y.; Yu, H. J.; Xu, H. X.; Ren, J. S.; Qu, X. G., Structural diversity of lanthanide-amino acid complexes under near physiological pH conditions and their recognition of single-stranded DNA. Polyhedron 2007, 26, 5250-5256.
66. Zhang, H. Y.; Yu, H. J.; Ren, J. S.; Qu, X. G., PolydA and polyrA self-structured by a europium and amino acid complex. Febs Letters 2006, 580, 3726-3730.
67. Zhang, H. Y.; Yu, H. J.; Ren, J. S.; Qu, X. G., Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex. Biophysical Journal 2006, 90, 3203-3207.
68. Xu, H. X.; Zhang, H. Y.; Qu, X. G., Interactions of the human telomeric DNA with terbium-amino acid complexes. Journal of Inorganic Biochemistry 2006, 100, 1646-1652.
专利
发明人：张海元. 程岩. 孙秀娟. 刘宁. 常赟. 冯艳林.
名称： 一种可用于可见光高效杀菌的金簇-二氧化钛-石墨烯复合材料及其制备方法和应用。
专利号：201610464635.6. 发明专利；中国
发明人：张海元. 孙秀娟. 常赟. 程岩.
名称： 一种用混合相二氧化钛抗菌的方法。
专利号：201610464637.5. 发明专利；中国
发明人：张海元. 刘宁. 程岩. 常赟. 冯艳林.
名称： 暴露可控高活性晶面的锐钛型二氧化钛纳米材料及其制备方法和应用。
专利号：201610464727.4. 发明专利；中国
发明人：程岩. 张海元. 冯艳林. 常赟. 孙秀娟. 菅慧.
名称： 用于近红外光激发下具有肿瘤光动力学治疗性质的硫化铋-锌原卟啉复合材料及制法和应用。
专利号：201711372308.9. 发明专利；中国
发明人：张海元. 冯艳林. 程岩. 常赟.
名称： 一种Au@Ag核壳结构纳米材料、制备方法及降低细胞毒性的方法
专利号：201810061367.2. 发明专利；中国
招募
感谢您对张海元课题组的兴趣。我们希望能够了解更多有关您的信息。
我们一直致力于招募充满科研活力的博士后加入我们的科研团队。候选人应当具有纳米材料合成、生物分子自组装 、毒理分析、免疫治疗或干细胞分化方面的技术和背景。 机会优先留给具有良好的文章背景及较强独立科研能力的候选人。请感兴趣者直接联系张海元老师 (email: zhangh@ciac.ac.cn)。
我们课题组将热烈欢迎对纳米生物学和化学生物学具有浓厚兴趣且致力于在交叉学科氛围下成长的学生报考我们的研究生。
对于渴望在合成化学和细胞生物学方面获得专业技能培训的本科生，同样鼓励联系我们，我们会择机筛选一部分学生参与到我们的研究过程当中，促进合作与交流。
